Current Protein Identity：Q8NFG4
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 3V42 Crystal structure of renal tumor suppressor protein, folliculin Deposited 2011-12-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
341–566（226 aa）
Fragment：C-TERMINAL DOMAIN, UNP RESIDUES 341-566
|
Mutation：YES | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；293 K；100 MM BIS-TRIS, PH5.5, 200 MM LISO4, 25% PEG 3350, VAPOR DIFFUSION, TEMPERATURE 293K, VAPOR DIFFUSION, HANGING DROP
|
Resolution 2.00 Å R-free 0.268 |
| 3V42 Crystal structure of renal tumor suppressor protein, folliculin Deposited 2011-12-14 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
341–566（226 aa）
Fragment：C-TERMINAL DOMAIN, UNP RESIDUES 341-566
|
Mutation：YES | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；293 K；100 MM BIS-TRIS, PH5.5, 200 MM LISO4, 25% PEG 3350, VAPOR DIFFUSION, TEMPERATURE 293K, VAPOR DIFFUSION, HANGING DROP
|
Resolution 2.00 Å R-free 0.268 |
| 3V42 Crystal structure of renal tumor suppressor protein, folliculin Deposited 2011-12-14 | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
341–566（226 aa）
Fragment：C-TERMINAL DOMAIN, UNP RESIDUES 341-566
Chain B
341–566（226 aa）
Fragment：C-TERMINAL DOMAIN, UNP RESIDUES 341-566
|
Mutation：YES Mutation：YES | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；293 K；100 MM BIS-TRIS, PH5.5, 200 MM LISO4, 25% PEG 3350, VAPOR DIFFUSION, TEMPERATURE 293K, VAPOR DIFFUSION, HANGING DROP
|
Resolution 2.00 Å R-free 0.268 |
| 6NZD Cryo-EM Structure of the Lysosomal Folliculin Complex (FLCN-FNIP2-RagA-RagC-Ragulator) Deposited 2019-02-13 | Assembly 1 Protein heterocomplex Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain H
1–579（579 aa）
|
Not recorded | GDP GUANOSINE-5'-DIPHOSPHATE × 1 L8S 9-{5-O-[(S)-hydroxy{[(R)-hydroxy(thiophosphonooxy)phosphoryl]oxy}phosphoryl]-alpha-L-arabinofuranosyl}-3,9-dihydro-1H-purine-2,6-dione × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE；Whatman 597
|
Resolution 3.60 Å |
| 6ULG Cryo-EM structure of the FLCN-FNIP2-Rag-Ragulator complex Deposited 2019-10-08 | Assembly 1 Protein heterocomplex Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain L
1–579（579 aa）
|
Not recorded | GDP GUANOSINE-5'-DIPHOSPHATE × 1 GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.31 Å |
| 8DHB Active FLCN GAP complex Deposited 2022-06-25 | Assembly 1 Insufficient information Heteromer；Protein × 10 PDB declaration: decameric（10） Consistent with protein count |
Chain J
1–579（579 aa）
|
Not recorded | CZC [(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(oxidanylidene)-3~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphono hydrogen phosphate × 1 BEF BERYLLIUM TRIFLUORIDE ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.53 Å |