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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q92736 New Search
24PDB entries
24Biological assembly
90chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
4JKQ Crystal structure of the N-terminal region of the human ryanodine receptor 2 Deposited 2013-03-11 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–606（606 aa） Fragment：N-terminal region
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；295 K；20 mM TRIS-HCl, 150 mM NaCl, 10% glycerol, 7mM mercaptoethanol, 1 mM CHAPS, 0.1% betaine, 100 mM HEPES, 200 mM ammonium formate, 21% PEG 3350, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 2.39 Å R-free 0.261
7KL5 Structure of Calmodulin Bound to the Cardiac Ryanodine Receptor (RyR2) at Residues: Phe4246 to Val4271 Deposited 2020-10-29 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 4246–4275（30 aa） Fragment：Phe4246 to Thr4275
Not recorded CA CALCIUM ION × 5 EDO 1,2-ETHANEDIOL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；0.2M sodium acetate, 0.1M Tris pH 8.5, 30%(w/v) PEG 4000
Resolution 1.65 Å R-free 0.245
7U9Q Structure of PKA phosphorylated human RyR2 in the closed state Deposited 2022-03-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–4967（4967 aa）
Chain B 1–4967（4967 aa）
Chain C 1–4967（4967 aa）
Chain D 1–4967（4967 aa）
Not recorded ZN ZINC ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；Xanthine was made fresh to avoid aggregation. Xanthine stock solution was 10 mM in NaOH 0.5 N.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.11 Å
7U9R Structure of PKA phosphorylated human RyR2 in the open state Deposited 2022-03-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–4967（4967 aa）
Chain B 1–4967（4967 aa）
Chain C 1–4967（4967 aa）
Chain D 1–4967（4967 aa）
Not recorded ZN ZINC ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 8 CA CALCIUM ION × 4 XAN XANTHINE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；Xanthine was made fresh to avoid aggregation. Xanthine stock solution was 10 mM in NaOH 0.5 N.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.69 Å
7U9T Structure of PKA phosphorylated human RyR2 in the closed state in the presence of Calmodulin Deposited 2022-03-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 1–4967（4967 aa）
Chain B 1–4967（4967 aa）
Chain C 1–4967（4967 aa）
Chain D 1–4967（4967 aa）
Not recorded ZN ZINC ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；Xanthine was made fresh to avoid aggregation. Xanthine stock solution was 10 mM in NaOH 0.5 N.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.68 Å
7U9X Structure of PKA phosphorylated human RyR2-R2474S in the closed state Deposited 2022-03-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–4967（4967 aa）
Chain B 1–4967（4967 aa）
Chain C 1–4967（4967 aa）
Chain D 1–4967（4967 aa）
Not recorded ZN ZINC ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；Xanthine was made fresh to avoid aggregation. Xanthine stock solution was 10 mM in NaOH 0.5 N.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.58 Å
7U9Z Structure of PKA phosphorylated human RyR2-R2474S in the open state Deposited 2022-03-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–4967（4967 aa）
Chain B 1–4967（4967 aa）
Chain C 1–4967（4967 aa）
Chain D 1–4967（4967 aa）
Not recorded ZN ZINC ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 8 CA CALCIUM ION × 4 XAN XANTHINE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；Xanthine was made fresh to avoid aggregation. Xanthine stock solution was 10 mM in NaOH 0.5 N.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.29 Å
7UA1 Structure of PKA phosphorylated human RyR2-R2474S in the closed state in the presence of ARM210 Deposited 2022-03-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–4967（4967 aa）
Chain B 1–4967（4967 aa）
Chain C 1–4967（4967 aa）
Chain D 1–4967（4967 aa）
Not recorded ZN ZINC ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 8 KVR 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；Xanthine was made fresh to avoid aggregation. Xanthine stock solution was 10 mM in NaOH 0.5 N.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.99 Å
7UA3 Structure of PKA phosphorylated human RyR2-R2474S in the closed state in the presence of Calmodulin Deposited 2022-03-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 1–4967（4967 aa）
Chain B 1–4967（4967 aa）
Chain C 1–4967（4967 aa）
Chain D 1–4967（4967 aa）
Not recorded ZN ZINC ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；Xanthine was made fresh to avoid aggregation. Xanthine stock solution was 10 mM in NaOH 0.5 N.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.97 Å
7UA4 Structure of PKA phosphorylated human RyR2-R2474S in the open state in the presence of Calmodulin Deposited 2022-03-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 1–4967（4967 aa）
Chain B 1–4967（4967 aa）
Chain C 1–4967（4967 aa）
Chain D 1–4967（4967 aa）
Not recorded ZN ZINC ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 8 CA CALCIUM ION × 4 XAN XANTHINE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；Xanthine was made fresh to avoid aggregation. Xanthine stock solution was 10 mM in NaOH 0.5 N.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.93 Å
7UA5 Structure of dephosphorylated human RyR2 in the closed state Deposited 2022-03-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–4967（4967 aa）
Chain B 1–4967（4967 aa）
Chain C 1–4967（4967 aa）
Chain D 1–4967（4967 aa）
Not recorded ZN ZINC ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；Xanthine was made fresh to avoid aggregation. Xanthine stock solution was 10 mM in NaOH 0.5 N.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.83 Å
7UA9 Structure of dephosphorylated human RyR2 in the open state Deposited 2022-03-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–4967（4967 aa）
Chain B 1–4967（4967 aa）
Chain C 1–4967（4967 aa）
Chain D 1–4967（4967 aa）
Not recorded ZN ZINC ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 8 CA CALCIUM ION × 4 XAN XANTHINE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；Xanthine was made fresh to avoid aggregation. Xanthine stock solution was 10 mM in NaOH 0.5 N.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.59 Å
8UQ2 Structure of human RyR2-S2808D in the subprimed state Deposited 2023-10-23 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–4967（4967 aa）
Chain B 1–4967（4967 aa）
Chain C 1–4967（4967 aa）
Chain D 1–4967（4967 aa）
Mutation：S2808D Mutation：S2808D Mutation：S2808D Mutation：S2808D ZN ZINC ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.98 Å
8UQ3 Structure of human RyR2-S2808D in the closed state in the presence of ARM210 Deposited 2023-10-23 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–4967（4967 aa）
Chain B 1–4967（4967 aa）
Chain C 1–4967（4967 aa）
Chain D 1–4967（4967 aa）
Not recorded ZN ZINC ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 8 KVR 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.18 Å
8UQ4 Structure of human RyR2-S2808D in the subprimed state in the presence of H2O2/NOC-12/GSH Deposited 2023-10-23 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–4967（4967 aa）
Chain B 1–4967（4967 aa）
Chain C 1–4967（4967 aa）
Chain D 1–4967（4967 aa）
Not recorded ZN ZINC ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；30 minute incubation with H2O2/NOC-12/GSH was stopped by flash freezing (vitrobot)
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.64 Å
8UQ5 Structure of human RyR2-S2808D in the primed state in the presence of Rapamycin Deposited 2023-10-23 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–4967（4967 aa）
Chain B 1–4967（4967 aa）
Chain C 1–4967（4967 aa）
Chain D 1–4967（4967 aa）
Not recorded ZN ZINC ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；30-minute incubation with rapamycin was stopped by flash freezing (vitrobot)
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.96 Å
8UXC Structure of PKA phosphorylated human RyR2-R420Q in the primed state Deposited 2023-11-09 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–4967（4967 aa）
Chain B 1–4967（4967 aa）
Chain C 1–4967（4967 aa）
Chain D 1–4967（4967 aa）
Mutation：R420Q Mutation：R420Q Mutation：R420Q Mutation：R420Q ZN ZINC ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.86 Å
8UXE Structure of PKA phosphorylated human RyR2-R420Q in the closed state in the presence of ARM210 Deposited 2023-11-09 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–4967（4967 aa）
Chain B 1–4967（4967 aa）
Chain C 1–4967（4967 aa）
Chain D 1–4967（4967 aa）
Not recorded ZN ZINC ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 8 KVR 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.53 Å
8UXF Structure of PKA phosphorylated human RyR2-R420W in the primed state Deposited 2023-11-09 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–4967（4967 aa）
Chain B 1–4967（4967 aa）
Chain C 1–4967（4967 aa）
Chain D 1–4967（4967 aa）
Not recorded ZN ZINC ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.13 Å
8UXG Structure of PKA phosphorylated human RyR2-R420W in the closed state in the presence of ARM210 Deposited 2023-11-09 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–4967（4967 aa）
Chain B 1–4967（4967 aa）
Chain C 1–4967（4967 aa）
Chain D 1–4967（4967 aa）
Not recorded ZN ZINC ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 8 KVR 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.08 Å
8UXH Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium Deposited 2023-11-09 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–4967（4967 aa）
Chain B 1–4967（4967 aa）
Chain C 1–4967（4967 aa）
Chain D 1–4967（4967 aa）
Not recorded ZN ZINC ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 8 CA CALCIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.52 Å
8UXI Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium Deposited 2023-11-09 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–4967（4967 aa）
Chain B 1–4967（4967 aa）
Chain C 1–4967（4967 aa）
Chain D 1–4967（4967 aa）
Not recorded ZN ZINC ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 8 CA CALCIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.29 Å
8UXL Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium and calmodulin Deposited 2023-11-09 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 1–4967（4967 aa）
Chain B 1–4967（4967 aa）
Chain C 1–4967（4967 aa）
Chain D 1–4967（4967 aa）
Not recorded ZN ZINC ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 8 CA CALCIUM ION × 20 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；0.020 mM Calmodulin was added to the final sample
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.12 Å
8UXM Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium and calmodulin Deposited 2023-11-09 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 1–4967（4967 aa）
Chain B 1–4967（4967 aa）
Chain C 1–4967（4967 aa）
Chain D 1–4967（4967 aa）
Not recorded CA CALCIUM ION × 20 ZN ZINC ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；0.020 mM Calmodulin was added to the final sample
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.56 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.