Current Protein Identity：Q96KQ7
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 2O8J Human euchromatic histone methyltransferase 2 Deposited 2006-12-12 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
913–1193（281 aa）
Fragment：residues 913-1193
|
Not recorded | ZN ZINC ION × 4 SAH S-ADENOSYL-L-HOMOCYSTEINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；300 K；peg 3350, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 300K
|
Resolution 1.80 Å R-free 0.221 |
| 2O8J Human euchromatic histone methyltransferase 2 Deposited 2006-12-12 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
913–1193（281 aa）
Fragment：residues 913-1193
|
Not recorded | ZN ZINC ION × 4 SAH S-ADENOSYL-L-HOMOCYSTEINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；300 K；peg 3350, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 300K
|
Resolution 1.80 Å R-free 0.221 |
| 2O8J Human euchromatic histone methyltransferase 2 Deposited 2006-12-12 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
913–1193（281 aa）
Fragment：residues 913-1193
|
Not recorded | ZN ZINC ION × 4 SAH S-ADENOSYL-L-HOMOCYSTEINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；300 K；peg 3350, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 300K
|
Resolution 1.80 Å R-free 0.221 |
| 2O8J Human euchromatic histone methyltransferase 2 Deposited 2006-12-12 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
913–1193（281 aa）
Fragment：residues 913-1193
|
Not recorded | ZN ZINC ION × 4 SAH S-ADENOSYL-L-HOMOCYSTEINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；300 K；peg 3350, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 300K
|
Resolution 1.80 Å R-free 0.221 |
| 3DM1 Crystal structure of the complex of human chromobox homolog 3 (CBX3) with peptide Deposited 2008-06-30 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
179–190（12 aa）
Fragment：UNP residues 179-190
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；1.5 microliter of the protein solution mixed with with 1.5 microliter of the reservoir solution containing 40% PEG 550 MME, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.40 Å R-free 0.267 |
| 3DM1 Crystal structure of the complex of human chromobox homolog 3 (CBX3) with peptide Deposited 2008-06-30 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
179–190（12 aa）
Fragment：UNP residues 179-190
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；1.5 microliter of the protein solution mixed with with 1.5 microliter of the reservoir solution containing 40% PEG 550 MME, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.40 Å R-free 0.267 |
| 3DM1 Crystal structure of the complex of human chromobox homolog 3 (CBX3) with peptide Deposited 2008-06-30 | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain F
179–190（12 aa）
Fragment：UNP residues 179-190
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；1.5 microliter of the protein solution mixed with with 1.5 microliter of the reservoir solution containing 40% PEG 550 MME, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.40 Å R-free 0.267 |
| 3DM1 Crystal structure of the complex of human chromobox homolog 3 (CBX3) with peptide Deposited 2008-06-30 | Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain H
179–190（12 aa）
Fragment：UNP residues 179-190
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；1.5 microliter of the protein solution mixed with with 1.5 microliter of the reservoir solution containing 40% PEG 550 MME, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.40 Å R-free 0.267 |
| 3DM1 Crystal structure of the complex of human chromobox homolog 3 (CBX3) with peptide Deposited 2008-06-30 | Assembly 5 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count |
Chain B
179–190（12 aa）
Fragment：UNP residues 179-190
Chain D
179–190（12 aa）
Fragment：UNP residues 179-190
Chain F
179–190（12 aa）
Fragment：UNP residues 179-190
Chain H
179–190（12 aa）
Fragment：UNP residues 179-190
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；1.5 microliter of the protein solution mixed with with 1.5 microliter of the reservoir solution containing 40% PEG 550 MME, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.40 Å R-free 0.267 |
| 3K5K Discovery of a 2,4-Diamino-7-aminoalkoxy-quinazoline as a Potent Inhibitor of Histone Lysine Methyltransferase, G9a Deposited 2009-10-07 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
913–1193（281 aa）
Fragment：UNP residues 913-1193, SET domain
|
Not recorded | ZN ZINC ION × 4 SAH S-ADENOSYL-L-HOMOCYSTEINE × 1 DXQ 7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine × 1 CL CHLORIDE ION × 2 UNX UNKNOWN LIGAND × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；0.2M sodium fluoride, 0.1M Bis-Tris phosphate pH 6.0, 18% polyethylene glycol 3350 and 10% ethylene glycol, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 1.70 Å R-free 0.264 |
| 3K5K Discovery of a 2,4-Diamino-7-aminoalkoxy-quinazoline as a Potent Inhibitor of Histone Lysine Methyltransferase, G9a Deposited 2009-10-07 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
913–1193（281 aa）
Fragment：UNP residues 913-1193, SET domain
|
Not recorded | ZN ZINC ION × 4 SAH S-ADENOSYL-L-HOMOCYSTEINE × 1 DXQ 7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine × 1 CL CHLORIDE ION × 2 UNX UNKNOWN LIGAND × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；0.2M sodium fluoride, 0.1M Bis-Tris phosphate pH 6.0, 18% polyethylene glycol 3350 and 10% ethylene glycol, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 1.70 Å R-free 0.264 |
| 3K5K Discovery of a 2,4-Diamino-7-aminoalkoxy-quinazoline as a Potent Inhibitor of Histone Lysine Methyltransferase, G9a Deposited 2009-10-07 | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
913–1193（281 aa）
Fragment：UNP residues 913-1193, SET domain
Chain B
913–1193（281 aa）
Fragment：UNP residues 913-1193, SET domain
|
Not recorded | ZN ZINC ION × 8 SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 DXQ 7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine × 2 CL CHLORIDE ION × 4 UNX UNKNOWN LIGAND × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；0.2M sodium fluoride, 0.1M Bis-Tris phosphate pH 6.0, 18% polyethylene glycol 3350 and 10% ethylene glycol, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 1.70 Å R-free 0.264 |
| 3RJW Crystal structure of histone lysine methyltransferase g9a with an inhibitor Deposited 2011-04-15 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
913–1193（281 aa）
Fragment：Sequence database residues 913-1193
Chain B
913–1193（281 aa）
Fragment：Sequence database residues 913-1193
|
Not recorded | ZN ZINC ION × 8 SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 CIQ 2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)piperidin-4-yl]-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine × 2 UNX UNKNOWN LIGAND × 29 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；291 K；0.2M SODIUM FORMATE, 10% ETHYLENE GLYCOL, 25% PEG-3350, 0.1M BIS-TRIS PROPANE, pH 6.5, vapor diffusion, temperature 291K
|
Resolution 2.56 Å R-free 0.245 |
| 4NVQ Human G9a in Complex with Inhibitor A-366 Deposited 2013-12-05 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
913–1193（281 aa）
Chain B
913–1193（281 aa）
|
Not recorded | 2OD 5'-methoxy-6'-[3-(pyrrolidin-1-yl)propoxy]spiro[cyclobutane-1,3'-indol]-2'-amine × 2 SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 ZN ZINC ION × 8 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.75；277 K；0.1 M BIS-TRIS, 17.0% PEG3350, pH 5.75, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 2.03 Å R-free 0.239 |
| 5JHN Structure of G9a SET-domain with Histone H3K9Ala mutant peptide and bound S-adenosylmethionine Deposited 2016-04-21 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
882–1155（274 aa）
Fragment：UNP residues 882-1155
Chain B
882–1155（274 aa）
Fragment：UNP residues 882-1155
|
Not recorded | ZN ZINC ION × 8 SAM S-ADENOSYLMETHIONINE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 7；298 K；0.2 M Tri-ammonium citrate pH 7 and 20% w/v polyethylene glycol 3350
|
Resolution 1.67 Å R-free 0.237 |
| 5JIN Structure of G9a SET-domain with Histone H3K9M mutant peptide and bound S-adenosylmethionine Deposited 2016-04-22 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
882–1155（274 aa）
Fragment：UNP residues 882-1155
Chain B
882–1155（274 aa）
Fragment：UNP residues 882-1155
|
Not recorded | ZN ZINC ION × 8 SAM S-ADENOSYLMETHIONINE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 7；298 K；0.2 M Tri-ammonium citrate pH 7 and 20% w/v polyethylene glycol 3350
|
Resolution 1.85 Å R-free 0.240 |
| 5JIY Structure of G9a SET-domain with Histone H3K9norLeucine mutant peptide and bound S-adenosylmethionine Deposited 2016-04-22 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
882–1155（274 aa）
Fragment：UNP residues 882-1155
Chain B
882–1155（274 aa）
Fragment：UNP residues 882-1155
|
Not recorded | ZN ZINC ION × 8 SAM S-ADENOSYLMETHIONINE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；298 K；0.2 M Tri-ammonium citrate pH 7 and 20% w/v polyethylene glycol 3350
|
Resolution 1.48 Å R-free 0.233 |
| 5JJ0 Structure of G9a SET-domain with Histone H3K9M peptide and excess SAH Deposited 2016-04-22 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
882–1155（274 aa）
Fragment：SET domain of Histone-lysine N-methyltransferase EHMT2 G9a, UNP residues 882-1155
Chain B
882–1155（274 aa）
Fragment：SET domain of Histone-lysine N-methyltransferase EHMT2 G9a, UNP residues 882-1155
|
Not recorded | ZN ZINC ION × 8 SAM S-ADENOSYLMETHIONINE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；298 K；0.2 M Tri-ammonium citrate pH 7 and 20% w/v polyethylene glycol 3350
|
Resolution 1.72 Å R-free 0.252 |
| 5T0K Structure of G9a SET-domain with H3K9M mutant peptide and SAM Deposited 2016-08-16 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
879–1159（281 aa）
|
Not recorded | ZN ZINC ION × 4 SAM S-ADENOSYLMETHIONINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293.15 K；0.1 M Bis-Tris propane (pH 7.5), 18% (w/v) PEG3350, 0.2 M NaF, and 5% (v/v) ethylene glycol
|
Resolution 1.70 Å R-free 0.193 |
| 5T0K Structure of G9a SET-domain with H3K9M mutant peptide and SAM Deposited 2016-08-16 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
879–1159（281 aa）
|
Not recorded | ZN ZINC ION × 4 SAM S-ADENOSYLMETHIONINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293.15 K；0.1 M Bis-Tris propane (pH 7.5), 18% (w/v) PEG3350, 0.2 M NaF, and 5% (v/v) ethylene glycol
|
Resolution 1.70 Å R-free 0.193 |
| 5T0M A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading Deposited 2016-08-16 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
879–1159（281 aa）
Fragment：unp residues 879-1159
|
Not recorded | ZN ZINC ION × 4 SAM S-ADENOSYLMETHIONINE × 1 SAH S-ADENOSYL-L-HOMOCYSTEINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293.15 K；0.1 M Bis-Tris propane (pH 7.5), 18% (w/v) PEG3350, 0.2 M NaF, and 5% (v/v) ethylene glycol
|
Resolution 1.90 Å R-free 0.224 |
| 5T0M A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading Deposited 2016-08-16 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
879–1159（281 aa）
Fragment：unp residues 879-1159
|
Not recorded | ZN ZINC ION × 4 SAM S-ADENOSYLMETHIONINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293.15 K；0.1 M Bis-Tris propane (pH 7.5), 18% (w/v) PEG3350, 0.2 M NaF, and 5% (v/v) ethylene glycol
|
Resolution 1.90 Å R-free 0.224 |
| 5TTF Crystal structure of catalytic domain of G9a with MS012 Deposited 2016-11-03 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
879–1159（281 aa）
Fragment：UNP residues 879-1159
Chain C
879–1159（281 aa）
Fragment：UNP residues 879-1159
|
Not recorded | ZN ZINC ION × 8 SAM S-ADENOSYLMETHIONINE × 2 7KZ N4-(1-methylpiperidin-4-yl)-N2-hexyl-6,7-dimethoxyquinazoline-2,4-diamine × 2 CL CHLORIDE ION × 1 UNX UNKNOWN LIGAND × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；291 K；25% PEG 3350, 0.2 M NaCl, 0.1 M Bis-Tris pH6.5
|
Resolution 1.72 Å R-free 0.247 |
| 5TTF Crystal structure of catalytic domain of G9a with MS012 Deposited 2016-11-03 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
879–1159（281 aa）
Fragment：UNP residues 879-1159
Chain D
879–1159（281 aa）
Fragment：UNP residues 879-1159
|
Not recorded | ZN ZINC ION × 8 SAM S-ADENOSYLMETHIONINE × 2 7KZ N4-(1-methylpiperidin-4-yl)-N2-hexyl-6,7-dimethoxyquinazoline-2,4-diamine × 2 UNX UNKNOWN LIGAND × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；291 K；25% PEG 3350, 0.2 M NaCl, 0.1 M Bis-Tris pH6.5
|
Resolution 1.72 Å R-free 0.247 |
| 5TUY Structure of human G9a SET-domain (EHMT2) in complex with inhibitor MS0124 Deposited 2016-11-07 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
887–1154（268 aa）
Fragment：UNP residues 887-1154
Chain B
887–1154（268 aa）
Fragment：UNP residues 887-1154
|
Not recorded | ZN ZINC ION × 8 SAM S-ADENOSYLMETHIONINE × 2 7L6 6,7-dimethoxy-N-(1-methylpiperidin-4-yl)-2-(morpholin-4-yl)quinazolin-4-amine × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；290 K；20% (w/v) PEG 3,350, 0.2 M NaF, 0.1 M Bis-Tris propane (pH 6.5)
|
Resolution 2.60 Å R-free 0.234 |
| 5V9I Crystal structure of catalytic domain of G9a with MS0105 Deposited 2017-03-23 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
913–1193（281 aa）
Fragment：residues 913-1193
Chain B
913–1193（281 aa）
Fragment：residues 913-1193
|
Not recorded | ZN ZINC ION × 8 SAM S-ADENOSYLMETHIONINE × 2 90P N~2~-cyclohexyl-N~4~-(1-ethylpiperidin-4-yl)-6,7-dimethoxy-N~2~-methylquinazoline-2,4-diamine × 2 GOL GLYCEROL × 6 UNX UNKNOWN LIGAND × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；291 K；25% PEG 3350, 0.2 M NaCl, 0.1 M Bis-Tris pH6.5
|
Resolution 1.74 Å R-free 0.275 |
| 5V9I Crystal structure of catalytic domain of G9a with MS0105 Deposited 2017-03-23 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
913–1193（281 aa）
Fragment：residues 913-1193
Chain D
913–1193（281 aa）
Fragment：residues 913-1193
|
Not recorded | ZN ZINC ION × 8 SAM S-ADENOSYLMETHIONINE × 2 90P N~2~-cyclohexyl-N~4~-(1-ethylpiperidin-4-yl)-6,7-dimethoxy-N~2~-methylquinazoline-2,4-diamine × 2 GOL GLYCEROL × 3 UNX UNKNOWN LIGAND × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；291 K；25% PEG 3350, 0.2 M NaCl, 0.1 M Bis-Tris pH6.5
|
Resolution 1.74 Å R-free 0.275 |
| 5VSC Structure of human G9a SET-domain (EHMT2) in complex with inhibitor 13 Deposited 2017-05-11 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
916–1190（275 aa）
Fragment：G9a catalytic SET-domain residues 916-1190
Chain B
916–1190（275 aa）
Fragment：G9a catalytic SET-domain residues 916-1190
|
Not recorded | ZN ZINC ION × 8 SAM S-ADENOSYLMETHIONINE × 2 9HJ 6,7-dimethoxy-N~2~-methyl-N~4~-(1-methylpiperidin-4-yl)-N~2~-propylquinazoline-2,4-diamine × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 7.5；290 K；20 % PEG3350, 10% glycerol, 0.2 M Sodium bromide
|
Resolution 1.40 Å R-free 0.182 |
| 5VSE Structure of human G9a SET-domain (EHMT2) in complex with inhibitor 17: N~2~-cyclopentyl-6,7-dimethoxy-N~2~-methyl-N~4~-(1-methylpiperidin-4-yl)quinazoline-2,4-diamine Deposited 2017-05-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
883–1156（274 aa）
Fragment：G9a catalytic SET-domain (913-1193)
|
Not recorded | ZN ZINC ION × 4 SAM S-ADENOSYLMETHIONINE × 1 9HG N~2~-cyclopentyl-6,7-dimethoxy-N~2~-methyl-N~4~-(1-methylpiperidin-4-yl)quinazoline-2,4-diamine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；290 K；20 % PEG3350, 10% glycerol, 0.2 M Sodium fluoride, Bis-Tris propane pH6.5
|
Resolution 1.60 Å R-free 0.191 |
| 5VSE Structure of human G9a SET-domain (EHMT2) in complex with inhibitor 17: N~2~-cyclopentyl-6,7-dimethoxy-N~2~-methyl-N~4~-(1-methylpiperidin-4-yl)quinazoline-2,4-diamine Deposited 2017-05-11 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
883–1156（274 aa）
Fragment：G9a catalytic SET-domain (913-1193)
|
Not recorded | ZN ZINC ION × 4 SAM S-ADENOSYLMETHIONINE × 1 9HG N~2~-cyclopentyl-6,7-dimethoxy-N~2~-methyl-N~4~-(1-methylpiperidin-4-yl)quinazoline-2,4-diamine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；290 K；20 % PEG3350, 10% glycerol, 0.2 M Sodium fluoride, Bis-Tris propane pH6.5
|
Resolution 1.60 Å R-free 0.191 |
| 5VSE Structure of human G9a SET-domain (EHMT2) in complex with inhibitor 17: N~2~-cyclopentyl-6,7-dimethoxy-N~2~-methyl-N~4~-(1-methylpiperidin-4-yl)quinazoline-2,4-diamine Deposited 2017-05-11 | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
883–1156（274 aa）
Fragment：G9a catalytic SET-domain (913-1193)
Chain B
883–1156（274 aa）
Fragment：G9a catalytic SET-domain (913-1193)
|
Not recorded | ZN ZINC ION × 8 SAM S-ADENOSYLMETHIONINE × 2 9HG N~2~-cyclopentyl-6,7-dimethoxy-N~2~-methyl-N~4~-(1-methylpiperidin-4-yl)quinazoline-2,4-diamine × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；290 K；20 % PEG3350, 10% glycerol, 0.2 M Sodium fluoride, Bis-Tris propane pH6.5
|
Resolution 1.60 Å R-free 0.191 |
| 6MM1 Structure of the cysteine-rich region from human EHMT2 Deposited 2018-09-28 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
419–552（134 aa）
Fragment：residues 419-552
|
Not recorded | ZN ZINC ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.2M potassium sodium tartrate
18% PEG 3350
0.1M HEPES, pH 8.0
|
Resolution 1.90 Å R-free 0.223 |
| 6MM1 Structure of the cysteine-rich region from human EHMT2 Deposited 2018-09-28 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
419–552（134 aa）
Fragment：residues 419-552
|
Not recorded | ZN ZINC ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.2M potassium sodium tartrate
18% PEG 3350
0.1M HEPES, pH 8.0
|
Resolution 1.90 Å R-free 0.223 |
| 6MM1 Structure of the cysteine-rich region from human EHMT2 Deposited 2018-09-28 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
419–552（134 aa）
Fragment：residues 419-552
|
Not recorded | ZN ZINC ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.2M potassium sodium tartrate
18% PEG 3350
0.1M HEPES, pH 8.0
|
Resolution 1.90 Å R-free 0.223 |
| 6MM1 Structure of the cysteine-rich region from human EHMT2 Deposited 2018-09-28 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
419–552（134 aa）
Fragment：residues 419-552
|
Not recorded | ZN ZINC ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.2M potassium sodium tartrate
18% PEG 3350
0.1M HEPES, pH 8.0
|
Resolution 1.90 Å R-free 0.223 |
| 7BTV Crystal structure of EHMT2 SET domain in complex with compound 5. Deposited 2020-04-03 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
913–1193（281 aa）
Chain B
913–1193（281 aa）
|
Not recorded | ZN ZINC ION × 8 SAM S-ADENOSYLMETHIONINE × 2 N47 N~2~-{4-methoxy-3-[3-(pyrrolidin-1-yl)propoxy]phenyl}-N~4~,6-dimethylpyrimidine-2,4-diamine × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M ammonium acetate, 20% PEG 3350
|
Resolution 2.00 Å R-free 0.245 |
| 7BUC Crystal structure of EHMT2 SET domain in complex with compound 13 Deposited 2020-04-06 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
913–1193（281 aa）
Chain B
913–1193（281 aa）
|
Not recorded | ZN ZINC ION × 8 SAM S-ADENOSYLMETHIONINE × 2 F80 N2-[4-methoxy-3-(2,3,4,7-tetrahydro-1H-azepin-5-yl)phenyl]-N4,6-dimethyl-pyrimidine-2,4-diamine × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M magnesium acetate, 20% polyethyleneglycol 3350
|
Resolution 2.60 Å R-free 0.262 |
| 7DCF Crystal structure of EHMT2 SET domain in complex with compound 10 Deposited 2020-10-26 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
913–1193（281 aa）
Chain B
913–1193（281 aa）
|
Not recorded | ZN ZINC ION × 8 SAM S-ADENOSYLMETHIONINE × 2 H30 5'-methoxy-6'-(1-methyl-2,3,4,7-tetrahydroazepin-5-yl)spiro[cyclobutane-1,3'-indole]-2'-amine × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.2M NaOAc, pH 7, 20% PEG 3350
|
Resolution 1.80 Å R-free 0.246 |
| 7T7L Structure of human G9a SET-domain (EHMT2) in complex with covalent inhibitor (Compound 1) Deposited 2021-12-15 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
913–1193（281 aa）
Fragment：residues 913-1193
Chain C
913–1193（281 aa）
Fragment：residues 913-1193
|
Not recorded | ZN ZINC ION × 8 SAM S-ADENOSYLMETHIONINE × 2 G5U N-(6-methoxy-4-{[1-(propan-2-yl)piperidin-4-yl]amino}-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-2-yl)propanamide × 1 G4R N-(6-methoxy-4-{[1-(propan-2-yl)piperidin-4-yl]amino}-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-2-yl)prop-2-enamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；290.15 K；2% v/v 1,4-Dioxane, 10% w/v Polyethylene glycol 20,000
|
Resolution 2.20 Å R-free 0.251 |
| 7T7L Structure of human G9a SET-domain (EHMT2) in complex with covalent inhibitor (Compound 1) Deposited 2021-12-15 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
913–1193（281 aa）
Fragment：residues 913-1193
Chain D
913–1193（281 aa）
Fragment：residues 913-1193
|
Not recorded | ZN ZINC ION × 8 SAM S-ADENOSYLMETHIONINE × 2 G5U N-(6-methoxy-4-{[1-(propan-2-yl)piperidin-4-yl]amino}-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-2-yl)propanamide × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；290.15 K；2% v/v 1,4-Dioxane, 10% w/v Polyethylene glycol 20,000
|
Resolution 2.20 Å R-free 0.251 |
| 7X73 Structure of G9a in complex with RK-701 Deposited 2022-03-09 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
913–1193（281 aa）
Chain B
913–1193（281 aa）
|
Not recorded | ZN ZINC ION × 8 SFG SINEFUNGIN × 2 J26 N-[(2S)-1-[(4-cyanophenyl)amino]-4-cyclopropyl-1-oxidanylidene-butan-2-yl]-3,6,6-trimethyl-4-oxidanylidene-5,7-dihydro-1H-indole-2-carboxamide × 2 EDO 1,2-ETHANEDIOL × 3 TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；293 K；0.1M Bis-Tris propane (pH 7.4), 0.2M sodium formate, 10% ethylene glycol, 25% PEG3350
|
Resolution 1.49 Å R-free 0.193 |
| 7XUA Structure of G9a in complex with compound 10a Deposited 2022-05-18 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
913–1193（281 aa）
Chain B
913–1193（281 aa）
|
Not recorded | ZN ZINC ION × 8 SFG SINEFUNGIN × 2 I5X ~{N}-[(1~{S})-1-(1~{H}-benzimidazol-2-yl)-3-methylsulfanyl-propyl]-3,6,6-trimethyl-4-oxidanylidene-5,7-dihydro-1~{H}-indole-2-carboxamide × 2 TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 EDO 1,2-ETHANEDIOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1M Bis-Tris propane (pH7.5), 0.2M Sodium Formate, 10% Ethylene Glycol, 23.5% PEG3350
|
Resolution 1.87 Å R-free 0.224 |
| 7XUB Structure of G9a in complex with compound 10d Deposited 2022-05-18 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
913–1193（281 aa）
Chain B
913–1193（281 aa）
|
Not recorded | ZN ZINC ION × 8 SFG SINEFUNGIN × 2 I6L ~{N}-[(1~{S})-1-(1~{H}-benzimidazol-2-yl)pentyl]-3,6,6-trimethyl-4-oxidanylidene-5,7-dihydro-1~{H}-indole-2-carboxamide × 2 EDO 1,2-ETHANEDIOL × 3 TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1M Bis-Tris propane (7.75), 0.2M Sodium Formate, 10% Ethylene Glycol, 26% PEG3350
|
Resolution 2.00 Å R-free 0.215 |
| 7XUC Structure of G9a in complex with compound 11a Deposited 2022-05-18 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
913–1193（281 aa）
Chain B
913–1193（281 aa）
|
Not recorded | ZN ZINC ION × 8 SFG SINEFUNGIN × 2 I6S 3,6,6-trimethyl-4-oxidanylidene-~{N}-[(2~{S})-1-oxidanylidene-1-phenylazanyl-hexan-2-yl]-5,7-dihydro-1~{H}-indole-2-carboxamide × 2 EDO 1,2-ETHANEDIOL × 3 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1M Bis-Tris propane (pH7.5), 0.2M Sodium Fluoride, 10% Ethylene Glycol, 25% PEG3350
|
Resolution 1.67 Å R-free 0.186 |
| 7XUD Structure of G9a in complex with compound 26a Deposited 2022-05-18 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
913–1193（281 aa）
Chain B
913–1193（281 aa）
|
Not recorded | ZN ZINC ION × 8 CL CHLORIDE ION × 1 SFG SINEFUNGIN × 2 I6Z ~{N}-[(2~{S})-4-cyclopropyl-1-oxidanylidene-1-phenylazanyl-butan-2-yl]-3,6,6-trimethyl-4-oxidanylidene-5,7-dihydro-1~{H}-indole-2-carboxamide × 2 EDO 1,2-ETHANEDIOL × 3 TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1M Bis-Tris propane (pH7.5), 0.2M Sodium Fluoride, 10% Ethylene Glycol, 22% PEG3350
|
Resolution 1.45 Å R-free 0.177 |
| 8VV8 Crystal Structure of EHMT2 bound to EZM8266 Deposited 2024-01-30 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
913–1193（281 aa）
Fragment：residues 913-1193
|
Not recorded | SAM S-ADENOSYLMETHIONINE × 1 A1AEB (2R)-1-(azetidin-1-yl)-3-(2-methoxy-5-{[4-methyl-6-(methylamino)pyrimidin-2-yl]amino}phenoxy)propan-2-ol × 1 ZN ZINC ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.2 M Potassium fluoride, 20 %(w/v) PEG 3350
|
Resolution 2.00 Å R-free 0.247 |
| 8VV8 Crystal Structure of EHMT2 bound to EZM8266 Deposited 2024-01-30 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
913–1193（281 aa）
Fragment：residues 913-1193
|
Not recorded | SAM S-ADENOSYLMETHIONINE × 1 A1AEB (2R)-1-(azetidin-1-yl)-3-(2-methoxy-5-{[4-methyl-6-(methylamino)pyrimidin-2-yl]amino}phenoxy)propan-2-ol × 1 ZN ZINC ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.2 M Potassium fluoride, 20 %(w/v) PEG 3350
|
Resolution 2.00 Å R-free 0.247 |
| 8Z7C Structure of G9a in complex with compound 7i Deposited 2024-04-20 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
913–1193（281 aa）
Chain B
913–1193（281 aa）
|
Not recorded | ZN ZINC ION × 8 SFG SINEFUNGIN × 2 A1L07 3,6,6-trimethyl-~{N}-[(2~{S})-1-[[4-(1-methylpiperidin-4-yl)oxyphenyl]amino]-1-oxidanylidene-hexan-2-yl]-4-oxidanylidene-5,7-dihydro-1~{H}-indole-2-carboxamide × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1M Bis-Tris propane (pH~7.5), 0.2M Sodium Formate or Fluoride, 10% Ethylene Glycol, ~25% PEG3350
|
Resolution 1.52 Å R-free 0.196 |
| 8Z7D Structure of G9a in complex with compound 9a Deposited 2024-04-20 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
913–1193（281 aa）
Chain B
913–1193（281 aa）
|
Not recorded | ZN ZINC ION × 8 SFG SINEFUNGIN × 2 A1L08 3,6,6-trimethyl-4-oxidanylidene-~{N}-[(2~{S})-1-oxidanylidene-1-[(phenylmethyl)amino]hexan-2-yl]-5,7-dihydro-1~{H}-indole-2-carboxamide × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1M Bis-Tris propane (pH~7.5), 0.2M Sodium Formate or Fluoride, 10% Ethylene Glycol, ~25% PEG3350
|
Resolution 1.58 Å R-free 0.183 |
| 8Z7E Structure of G9a in complex with compound 9b Deposited 2024-04-20 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
913–1193（281 aa）
Chain B
913–1193（281 aa）
|
Not recorded | ZN ZINC ION × 8 SFG SINEFUNGIN × 2 A1L09 ~{N}-[(2~{S})-1-[[4-[(dimethylamino)methyl]phenyl]methylamino]-1-oxidanylidene-hexan-2-yl]-3,6,6-trimethyl-4-oxidanylidene-5,7-dihydro-1~{H}-indole-2-carboxamide × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1M Bis-Tris propane (pH~7.5), 0.2M Sodium Formate or Fluoride, 10% Ethylene Glycol, ~25% PEG3350
|
Resolution 1.54 Å R-free 0.195 |
| 9KLB G9a in complex with RK-133232 (compound 16g) Deposited 2024-11-14 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
913–1193（281 aa）
Chain B
913–1193（281 aa）
|
Not recorded | ZN ZINC ION × 8 SFG SINEFUNGIN × 2 A1L57 ~{N}-[(~{E},2~{S})-4-cyclopropyl-1-[(6-ethoxypyridin-3-yl)amino]-1-oxidanylidene-but-3-en-2-yl]-4-(pyridin-4-ylamino)benzamide × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1M Bis-Tris propane (pH~7.5), 0.2M Sodium Formate or Fluoride, 10% Ethylene Glycol, ~25% PEG3350
|
Resolution 1.81 Å R-free 0.221 |
| 9KLC G9a in complex with the S-isomer of RK-131902 (racemic compound rac-10a) Deposited 2024-11-14 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
913–1193（281 aa）
Chain B
913–1193（281 aa）
|
Not recorded | ZN ZINC ION × 8 SFG SINEFUNGIN × 2 A1L58 ~{N}-[(2~{S})-1-[[6-(1-methylpiperidin-4-yl)oxypyridin-3-yl]amino]-1-oxidanylidene-hexan-2-yl]-3-(pyridin-4-ylamino)benzamide × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1M Bis-Tris propane (pH~7.5), 0.2M Sodium Formate or Fluoride, 10% Ethylene Glycol, ~25% PEG3350
|
Resolution 2.15 Å R-free 0.253 |
| 9LUS Structure of human G9a SET-domain in complex with FLAV27 inhibitor Deposited 2025-02-10 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
913–1193（281 aa）
Chain B
913–1193（281 aa）
|
Not recorded | ZN ZINC ION × 2 A1L7O 3-[1-[[(2~{S})-4-(phenylmethyl)-1,4-oxazepan-2-yl]methyl]piperidin-4-yl]phenol × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277.15 K；peg3350 20%, 10% Tacsimate (ph-8), Tris (ph-8.2), Glycerol 6%, 5 mM KSCN
|
Resolution 2.70 Å R-free 0.309 |
| 9WRI Crystal structure of CtBP2 in complex with G9a Deposited 2025-09-12 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain C
881–893（13 aa）
|
Not recorded | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；291 K；0.1 M HEPES pH 7.5, 6% PVP, 30% pentaerythritol ethoxylate
|
Resolution 1.85 Å R-free 0.202 |
| 9YKS Crystal structure of the G9a (EHMT2) SET domain in complex with SAM and TNG917 Deposited 2025-10-07 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
912–1193（282 aa）
Fragment：catalytic SET domain (UNP residues 912-1193)
Chain B
912–1193（282 aa）
Fragment：catalytic SET domain (UNP residues 912-1193)
|
Not recorded | ZN ZINC ION × 8 SAM S-ADENOSYLMETHIONINE × 2 A1CXM N~2~-[(7M)-6-fluoro-7-(2,5,6,7-tetrahydro-1H-azepin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]-N~4~,6-dimethylpyrimidine-2,4-diamine × 2 EDO 1,2-ETHANEDIOL × 7 GOL GLYCEROL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；291 K；33% PEG4000, 200 mM sodium acetate, 100 mM MES, pH 6.5
|
Resolution 1.79 Å R-free 0.252 |
| 9YKS Crystal structure of the G9a (EHMT2) SET domain in complex with SAM and TNG917 Deposited 2025-10-07 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
912–1193（282 aa）
Fragment：catalytic SET domain (UNP residues 912-1193)
Chain D
912–1193（282 aa）
Fragment：catalytic SET domain (UNP residues 912-1193)
|
Not recorded | ZN ZINC ION × 8 SAM S-ADENOSYLMETHIONINE × 2 A1CXM N~2~-[(7M)-6-fluoro-7-(2,5,6,7-tetrahydro-1H-azepin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]-N~4~,6-dimethylpyrimidine-2,4-diamine × 2 EDO 1,2-ETHANEDIOL × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；291 K；33% PEG4000, 200 mM sodium acetate, 100 mM MES, pH 6.5
|
Resolution 1.79 Å R-free 0.252 |