← Back to search

Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q99728 New Search
11PDB entries
17Biological assembly
18chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1JM7 Solution structure of the BRCA1/BARD1 RING-domain heterodimer Deposited 2001-07-17 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 26–140（115 aa） Fragment：RING-Domain
Not recorded ZN ZINC ION × 4 SOLUTION NMR
NMR measurement conditions pH 6.8；315 K；Ionic strength (raw mmCIF value) 0.2M NaCl；Pressure ambient
NMR measurement conditions pH 6.8；315 K；Ionic strength (raw mmCIF value) 0.2M NaCl；Pressure ambient
NMR measurement conditions pH 6.8；315 K；Ionic strength (raw mmCIF value) 0.2M NaCl；Pressure ambient
NMR measurement conditions pH 6.8；315 K；Ionic strength (raw mmCIF value) 0.2M NaCl；Pressure ambient
NMR sample composition sample 1: 0.8-1.1mM U-15N,13C BRCA1; unlabeled BARD1, 25mM sodium phosphate, 0.2M NaCl, 2mM DTT. Sample 2: 0.8-1.1mM U-15N,13C BARD1; unlabeled BRCA1, 25mM sodium phosphate, 0.2M NaCl, 2mM DTT. Sample 3: 0.8-1.1mM U-15N,13C,85%-2H BRCA1; unlabeled BARD1, 25mM sodium phosphate, 0.2M NaCl, 2mM DTT. SAMPLE 4: 0.8-1.1mM U-15N,13C,85%-2H BARD1; unlabeled BRCA,1 25mM sodium phosphate, 0.2M NaCl, 2mM DTT. | 90% H2O/10% D2O
NMR sample composition 0.8-1.1mM U-15N,13C BARD1; unlabeled BRCA1 25mM sodium phosphate 0.2M NaCl 2mM DTT | 90% H2O/10% D2O
NMR sample composition 0.8-1.1mM U-15N,13C,85%-2H BRCA1; unlabeled BARD1 25mM sodium phosphate 0.2M NaCl 2mM DTT | 90% H2O/10% D2O
NMR sample composition 0.8-1.1mM U-15N,13C,85%-2H BARD1; unlabeled BRCA1 25mM sodium phosphate 0.2M NaCl 2mM DTT | 90% H2O/10% D2O
Resolution not provided
2NTE Crystal Structure of the BARD1 BRCT Domains Deposited 2006-11-07 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 568–777（210 aa） Fragment：BRCT domain
Not recorded SO4 SULFATE ION × 1 CL CHLORIDE ION × 1 EDO 1,2-ETHANEDIOL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；100mM MES, 20% PEG 8K, 150mM Ammonium Sulfate, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 1.90 Å R-free 0.247
2NTE Crystal Structure of the BARD1 BRCT Domains Deposited 2006-11-07 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 568–777（210 aa） Fragment：BRCT domain
Not recorded SO4 SULFATE ION × 1 CL CHLORIDE ION × 2 EDO 1,2-ETHANEDIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；100mM MES, 20% PEG 8K, 150mM Ammonium Sulfate, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 1.90 Å R-free 0.247
2R1Z Crystal Structure of the BARD1 BRCT Repeat Deposited 2007-08-23 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 569–777（209 aa）
Not recorded GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；pSDDE peptide, 20% PEG 3350, 0.2 M ammonium chloride, 100 mM NaCl, 5 mM tris-HCl, 1 mM DTT, pH 7.5, temperature 298K, VAPOR DIFFUSION, HANGING DROP
Resolution 2.10 Å R-free 0.262
2R1Z Crystal Structure of the BARD1 BRCT Repeat Deposited 2007-08-23 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 569–777（209 aa）
Not recorded GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；pSDDE peptide, 20% PEG 3350, 0.2 M ammonium chloride, 100 mM NaCl, 5 mM tris-HCl, 1 mM DTT, pH 7.5, temperature 298K, VAPOR DIFFUSION, HANGING DROP
Resolution 2.10 Å R-free 0.262
3C5R Crystal Structure of the BARD1 Ankyrin Repeat Domain and Its Functional Consequences Deposited 2008-02-01 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 425–555（131 aa） Fragment：BARD1 Ankyrin Repeat Domain (UNP residues 425-555)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；0.2 Mg Chloride, 0.1 M Tris Hydrochloride pH 8.5, 25% w/v PEG 3350, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.00 Å R-free 0.268
3C5R Crystal Structure of the BARD1 Ankyrin Repeat Domain and Its Functional Consequences Deposited 2008-02-01 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 425–555（131 aa） Fragment：BARD1 Ankyrin Repeat Domain (UNP residues 425-555)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；0.2 Mg Chloride, 0.1 M Tris Hydrochloride pH 8.5, 25% w/v PEG 3350, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.00 Å R-free 0.268
3C5R Crystal Structure of the BARD1 Ankyrin Repeat Domain and Its Functional Consequences Deposited 2008-02-01 Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 425–555（131 aa） Fragment：BARD1 Ankyrin Repeat Domain (UNP residues 425-555)
Chain B 425–555（131 aa） Fragment：BARD1 Ankyrin Repeat Domain (UNP residues 425-555)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；0.2 Mg Chloride, 0.1 M Tris Hydrochloride pH 8.5, 25% w/v PEG 3350, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.00 Å R-free 0.268
3FA2 Crystal Structure of the BRCA1 Associated Ring Domain (BARD1) Tandem BRCT Domains Deposited 2008-11-14 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 566–777（212 aa） Fragment：Tandem BRCT Domains
Not recorded PO4 PHOSPHATE ION × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.1M MES 15% w/v PEG3350, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.20 Å R-free 0.298
3FA2 Crystal Structure of the BRCA1 Associated Ring Domain (BARD1) Tandem BRCT Domains Deposited 2008-11-14 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 566–777（212 aa） Fragment：Tandem BRCT Domains
Not recorded PO4 PHOSPHATE ION × 2 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.1M MES 15% w/v PEG3350, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.20 Å R-free 0.298
6M14 Crystal Structure of the BARD1 BRCT Mutant Deposited 2020-02-24 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 568–777（210 aa）
Mutation：V695L No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；295 K；0.1 M MES pH 6.5, 0.2 M ammonium sulfate,22% PEG 5000
Resolution 1.88 Å R-free 0.198
6M14 Crystal Structure of the BARD1 BRCT Mutant Deposited 2020-02-24 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 568–777（210 aa）
Mutation：V695L SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；295 K；0.1 M MES pH 6.5, 0.2 M ammonium sulfate,22% PEG 5000
Resolution 1.88 Å R-free 0.198
7E8I Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin Deposited 2021-03-01 Assembly 1 Protein–DNA Heteromer；Protein × 10 PDB declaration: dodecameric（12） Consistent with all polymers
Chain K 425–777（353 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
7JZV Cryo-EM structure of the BRCA1-UbcH5c/BARD1 E3-E2 module bound to a nucleosome Deposited 2020-09-02 Assembly 1 Insufficient information Heteromer；Protein × 10 PDB declaration: dodecameric（12） Consistent with all polymers
Chain B 26–140（115 aa）
Not recorded ZN ZINC ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å
7LYB Cryo-EM structure of the human nucleosome core particle in complex with BRCA1-BARD1-UbcH5c Deposited 2021-03-06 Assembly 1 Protein–DNA Heteromer；Protein × 11 PDB declaration: tridecameric（13） Consistent with all polymers
Chain N 26–122（97 aa） Fragment：RING domain (UNP residues 26-122)
Not recorded ZN ZINC ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.28 Å
7LYC Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A Lys13 and Lys15 in complex with BARD1 (residues 415-777) Deposited 2021-03-06 Assembly 1 Protein–DNA Heteromer；Protein × 10 PDB declaration: dodecameric（12） Consistent with all polymers
Chain N 415–777（363 aa） Fragment：Ankyrine repeat domain and the tandem BRCT domain (UNP residues 415-777)
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.94 Å
8GRQ Cryo-EM structure of BRCA1/BARD1 bound to H2AK127-UbcH5c-Ub nucleosome Deposited 2022-09-02 Assembly 1 Protein–DNA Heteromer；Protein × 11 PDB declaration: tridecameric（13） Consistent with all polymers
Chain M 26–117（92 aa）
Not recorded ZN ZINC ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.87 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.