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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q9BSQ5 New Search
8PDB entries
14Biological assembly
17chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
4FQN Crystal structure of the CCM2 C-terminal Harmonin Homology Domain (HHD) Deposited 2012-06-25 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 283–379（97 aa） Fragment：C-terminal domain (unp residues 283-379)
Chain B 283–379（97 aa） Fragment：C-terminal domain (unp residues 283-379)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；2.072M ammonium sulfate, 0.2M potassium formate, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 1.90 Å R-free 0.219
4FQN Crystal structure of the CCM2 C-terminal Harmonin Homology Domain (HHD) Deposited 2012-06-25 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain C 283–379（97 aa） Fragment：C-terminal domain (unp residues 283-379)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；2.072M ammonium sulfate, 0.2M potassium formate, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 1.90 Å R-free 0.219
4FQN Crystal structure of the CCM2 C-terminal Harmonin Homology Domain (HHD) Deposited 2012-06-25 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain D 283–379（97 aa） Fragment：C-terminal domain (unp residues 283-379)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；2.072M ammonium sulfate, 0.2M potassium formate, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 1.90 Å R-free 0.219
4TVQ CCM3 in complex with CCM2 LD-like motif Deposited 2014-06-27 Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain E 224–239（16 aa） Fragment：INTERDOMAIN LINKER LD-LIKE MOTIF RESIDUES 224-239
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；15-20% PEG3350, 0.1-0.2M POTASSIUM FLUORIDE, PH 7.0, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 298K
Resolution 2.80 Å R-free 0.277
4WJ7 CCM2 PTB domain in complex with KRIT1 NPxY/F3 Deposited 2014-09-29 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 51–228（178 aa） Fragment：PTB domain (UNP residues 51-228)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；20% (w/v) PEG 6000, 0.1M HEPES
Resolution 2.75 Å R-free 0.251
4WJ7 CCM2 PTB domain in complex with KRIT1 NPxY/F3 Deposited 2014-09-29 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 51–228（178 aa） Fragment：PTB domain (UNP residues 51-228)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；20% (w/v) PEG 6000, 0.1M HEPES
Resolution 2.75 Å R-free 0.251
4WJ7 CCM2 PTB domain in complex with KRIT1 NPxY/F3 Deposited 2014-09-29 Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 51–228（178 aa） Fragment：PTB domain (UNP residues 51-228)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；20% (w/v) PEG 6000, 0.1M HEPES
Resolution 2.75 Å R-free 0.251
4WJ7 CCM2 PTB domain in complex with KRIT1 NPxY/F3 Deposited 2014-09-29 Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain D 51–228（178 aa） Fragment：PTB domain (UNP residues 51-228)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；20% (w/v) PEG 6000, 0.1M HEPES
Resolution 2.75 Å R-free 0.251
4Y5O CCM2 HHD in complex with MEKK3 NPB1 Deposited 2015-02-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 304–400（97 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M potassium phosphate and 20% PEG 3350
Resolution 2.35 Å R-free 0.232
4YKC Crystal structure of cerebral cavernous malformation 2 C-terminal adaptor domain Deposited 2015-03-04 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 290–444（155 aa） Fragment：C-terminal adaptor domain, UNP residues 290-444
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；45% Tacsimate
Resolution 2.70 Å R-free 0.267
4YKD Crystal structure of truncated cerebral cavernous malformation 2 C-terminal adaptor domain Deposited 2015-03-04 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 290–376（87 aa） Fragment：truncated fragment of C-terminal adaptor domain, UNP residues 290-376
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M Bis-Tris, 30%(w/v) polyethylene glycol 550, 50 mM calcium chloride
Resolution 1.93 Å R-free 0.235
4YL6 Crystal structure of truncated cerebral cavernous malformation 2 C-terminal adaptor domain in complex with an internal helix of mitogen-activated protein kinase kinase kinase 3 Deposited 2015-03-05 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 290–376（87 aa） Fragment：truncated fragment of C-terminal adaptor domain, UNP residues 290-376
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；3.5 M Sodium Formate
Resolution 2.10 Å R-free 0.237
9PVG Co-crystal structure of two CCM2 PTB domains bound to a KRIT1 peptide encompassing NPxF2 and NPxF3 Deposited 2025-08-01 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 51–228（178 aa） Fragment：PTB domain (UNP residues 51-228)
Chain D 51–228（178 aa） Fragment：PTB domain (UNP residues 51-228)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M TrisHCl pH 7, 20% PEG3350
Resolution 3.00 Å R-free 0.297
9PVG Co-crystal structure of two CCM2 PTB domains bound to a KRIT1 peptide encompassing NPxF2 and NPxF3 Deposited 2025-08-01 Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain B 51–228（178 aa） Fragment：PTB domain (UNP residues 51-228)
Chain C 51–228（178 aa） Fragment：PTB domain (UNP residues 51-228)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M TrisHCl pH 7, 20% PEG3350
Resolution 3.00 Å R-free 0.297

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.