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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q9C005 New Search
12PDB entries
14Biological assembly
42chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
3G36 Crystal structure of the human DPY-30-like C-terminal domain Deposited 2009-02-02 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 45–99（55 aa） Fragment：C-terminal domain, UNI residues 45-99
Chain C 45–99（55 aa） Fragment：C-terminal domain, UNI residues 45-99
Mutation：L69M Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：L69M Non-standard monomer：Yes (specific site not provided by mmCIF) DTU (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL × 1 DTT 2,3-DIHYDROXY-1,4-DITHIOBUTANE × 1 DTV (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；291 K；0.1M Bis-Tris, 28% PEG-MME 2000, 3% 1,6 hexanediol (additive), pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
Resolution 1.20 Å R-free 0.227
3G36 Crystal structure of the human DPY-30-like C-terminal domain Deposited 2009-02-02 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 45–99（55 aa） Fragment：C-terminal domain, UNI residues 45-99
Chain D 45–99（55 aa） Fragment：C-terminal domain, UNI residues 45-99
Mutation：L69M Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：L69M Non-standard monomer：Yes (specific site not provided by mmCIF) HEZ HEXANE-1,6-DIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；291 K；0.1M Bis-Tris, 28% PEG-MME 2000, 3% 1,6 hexanediol (additive), pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
Resolution 1.20 Å R-free 0.227
4RIQ Crystal structure of DPY-30 dimerization/docking domain in complex with Ash2L Sdc1-DPY-30 Interacting region (SDI) Deposited 2014-10-07 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 45–99（55 aa） Fragment：UNP RESIDUES 45-99
Chain B 45–99（55 aa） Fragment：UNP RESIDUES 45-99
Chain D 45–99（55 aa） Fragment：UNP RESIDUES 45-99
Chain E 45–99（55 aa） Fragment：UNP RESIDUES 45-99
Chain J 45–99（55 aa） Fragment：UNP RESIDUES 45-99
Chain K 45–99（55 aa） Fragment：UNP RESIDUES 45-99
Chain V 45–99（55 aa） Fragment：UNP RESIDUES 45-99
Chain Z 45–99（55 aa） Fragment：UNP RESIDUES 45-99
Not recorded SO4 SULFATE ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；323 K；0.2M MgCl2, 25% PEG 3350, 0.1M Tris pH 8.5 and 10 mM spermidine, VAPOR DIFFUSION, SITTING DROP, temperature 323K
Resolution 2.23 Å R-free 0.284
4RIQ Crystal structure of DPY-30 dimerization/docking domain in complex with Ash2L Sdc1-DPY-30 Interacting region (SDI) Deposited 2014-10-07 Assembly 2 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain G 45–99（55 aa） Fragment：UNP RESIDUES 45-99
Chain H 45–99（55 aa） Fragment：UNP RESIDUES 45-99
Chain M 45–99（55 aa） Fragment：UNP RESIDUES 45-99
Chain N 45–99（55 aa） Fragment：UNP RESIDUES 45-99
Chain P 45–99（55 aa） Fragment：UNP RESIDUES 45-99
Chain Q 45–99（55 aa） Fragment：UNP RESIDUES 45-99
Chain S 45–99（55 aa） Fragment：UNP RESIDUES 45-99
Chain T 45–99（55 aa） Fragment：UNP RESIDUES 45-99
Not recorded SO4 SULFATE ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；323 K；0.2M MgCl2, 25% PEG 3350, 0.1M Tris pH 8.5 and 10 mM spermidine, VAPOR DIFFUSION, SITTING DROP, temperature 323K
Resolution 2.23 Å R-free 0.284
4RT4 Crystal structure of Dpy30 complexed with Bre2 Deposited 2014-11-12 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain A 41–99（59 aa） Fragment：C terminal domain, UNP residues 41-99
Chain B 41–99（59 aa） Fragment：C terminal domain, UNP residues 41-99
Chain C 41–99（59 aa） Fragment：C terminal domain, UNP residues 41-99
Chain D 41–99（59 aa） Fragment：C terminal domain, UNP residues 41-99
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；291 K；0.1M Tris-HCl, pH 8.5, 2.0M NH4H2PO4, EVAPORATION, temperature 291K
Resolution 2.00 Å R-free 0.224
4RTA Cystal structure of the Dpy30 for MLL/SET1 COMPASS H3K4 trimethylation Deposited 2014-11-14 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–99（99 aa）
Chain B 1–99（99 aa）
Not recorded FMT FORMIC ACID × 6 X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 5.9；291 K；0.1M COCADYLATE SODIUM, SODIUM FORMATE 4.2M, pH 5.9, EVAPORATION, temperature 291K
Resolution 2.12 Å R-free 0.235
6E2H Crystal structure of human Ash2L (SPRY domain and SDI motif) in complex with full length DPY-30 Deposited 2018-07-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain E 1–99（99 aa）
Chain F 1–99（99 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；293 K；20mM citrate pH 4.7 and polyethylene glycol (PEG) 6000
Resolution 2.24 Å R-free 0.200
6PWV Cryo-EM structure of MLL1 core complex bound to the nucleosome Deposited 2019-07-23 Assembly 1 Protein–DNA Heteromer；Protein × 14 PDB declaration: hexadecameric（16） Consistent with all polymers
Chain E 1–99（99 aa）
Chain F 1–99（99 aa）
Not recorded SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 ZN ZINC ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 6.20 Å
7UD5 Complex between MLL1-WRAD and an H2B-ubiquitinated nucleosome Deposited 2022-03-18 Assembly 1 Protein–DNA Heteromer；Protein × 15 PDB declaration: heptadecameric（17） Consistent with all polymers
Chain P 1–99（99 aa）
Chain Q 1–99（99 aa）
Not recorded SAH S-ADENOSYL-L-HOMOCYSTEINE × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.25 Å
9YL3 State 1 MLL4FC bound to a nucleosome premodified with H2BK120ub and H4K16ac Deposited 2025-10-08 Assembly 1 Insufficient information Heteromer；Protein × 15 PDB declaration: 17-meric（17） Consistent with all polymers
Chain P 1–99（99 aa）
Chain Q 1–99（99 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 3.50 Å
9YLE State 3 MLL4FC bound to a nucleosome premodified with H2BK120ub and H4K16ac Deposited 2025-10-08 Assembly 1 Insufficient information Heteromer；Protein × 15 PDB declaration: 17-meric（17） Consistent with all polymers
Chain P 1–99（99 aa）
Chain Q 1–99（99 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 3.63 Å
9YLY MLL4FC bound to a nucleosome with p53 RE Deposited 2025-10-09 Assembly 1 Insufficient information Heteromer；Protein × 14 PDB declaration: 16-meric（16） Consistent with all polymers
Chain P 1–99（99 aa）
Chain Q 1–99（99 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 3.77 Å
9YM8 State 2 focused on PHD FYR of MLL4FC bound to a nucleosome premodified with H2BK120ub and H4K16ac Deposited 2025-10-09 Assembly 1 Insufficient information Heteromer；Protein × 16 PDB declaration: 18-meric（18） Consistent with all polymers
Chain P 1–99（99 aa）
Chain Q 1–99（99 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 3.43 Å
9YMF State 2 focused on H3 N terminal tail of MLL4FC bound to a nucleosome premodified with H2BK120ub and H4K16ac Deposited 2025-10-09 Assembly 1 Insufficient information Heteromer；Protein × 16 PDB declaration: 18-meric（18） Consistent with all polymers
Chain P 1–99（99 aa）
Chain Q 1–99（99 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 3.45 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.