当前蛋白身份：Q9RXJ4
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差异标签只比较当前检索结果；所有PDB和assembly原始记录仍分别保留。
相关结构差异明细
一行代表一个 PDB 条目中的一个 biological assembly；同一蛋白的多个单体会分别列出。
| PDB 条目 | Assembly / 聚集状态 | 构建体 | 突变与修饰 | 配体、离子与非聚合物 | 实验方法 | 实验环境 | 结构质量 |
|---|---|---|---|---|---|---|---|
| 1NKW Crystal Structure Of The Large Ribosomal Subunit From Deinococcus Radiodurans 提交 2003-01-05 | Assembly 1 蛋白–RNA 异源复合物；蛋白 × 29 PDB 声明：31-meric（31） 与全部聚合物一致 |
链 W
1–67（67 aa）
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；ETHANOL, DIMETHYLHEXANEDIOL, MGCL2, KCL, HEPES, NH4CL, VAPOR DIFFUSION, SITTING DROP
|
分辨率 3.10 Å R-free 0.274 |
| 1NWX COMPLEX OF THE LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS WITH ABT-773 提交 2003-02-07 | Assembly 1 蛋白–RNA 异源复合物；蛋白 × 29 PDB 声明：31-meric（31） 与全部聚合物一致 |
链 W
1–67（67 aa）
|
未记录 | 773 CETHROMYCIN × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.8；281 K；ETHANOL, DIMETHYLHEXANEDIOL, MGCL2, KCL, HEPES, NH4CL, pH 7.80, VAPOR DIFFUSION, HANGING DROP, temperature 281K
|
分辨率 3.50 Å R-free 0.313 |
| 1NWY COMPLEX OF THE LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS WITH AZITHROMYCIN 提交 2003-02-07 | Assembly 1 蛋白–RNA 异源复合物；蛋白 × 29 PDB 声明：31-meric（31） 与全部聚合物一致 |
链 W
1–67（67 aa）
|
未记录 | ZIT AZITHROMYCIN × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.8；291 K；ETHANOL, DIMETHYLHEXANEDIOL, MGCL2, KCL, HEPES, NH4CL, pH 7.80, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
分辨率 3.30 Å R-free 0.304 |
| 1SM1 COMPLEX OF THE LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS WITH QUINUPRISTIN AND DALFOPRISTIN 提交 2004-03-08 | Assembly 1 蛋白–RNA 异源复合物；蛋白 × 30 PDB 声明：32-meric（32） 与全部聚合物一致 |
链 W
1–67（67 aa）
|
未记录 | DOL 5-(2-DIETHYLAMINO-ETHANESULFONYL)-21-HYDROXY-10-ISOPROPYL-11,19-DIMETHYL-9,26-DIOXA-3,15,28-TRIAZA-TRICYCLO[23.2.1.00,255]OCTACOSA-1(27),12,17,19,25(28)-PENTAENE-2,8,14,23-TETRAONE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
pH 7.8；ETHANOL, DIMETHYLHEXANEDIOL, MGCL2, KCL, HEPES, NH4CL , PH 7.80, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 290K
|
分辨率 3.42 Å R-free 0.348 |
| 1XBP Inhibition of peptide bond formation by pleuromutilins: The structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with Tiamulin 提交 2004-08-31 | Assembly 1 蛋白–RNA 异源复合物；蛋白 × 29 PDB 声明：31-meric（31） 与全部聚合物一致 |
链 W
1–67（67 aa）
|
未记录 | MUL TIAMULIN × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.8；280 K；ETHANOL, DIMETHYLHEXANEDIOL, MGCL2,KCL, HEPES, NH4CL, pH 7.80, VAPOR DIFFUSION, HANGING DROP, temperature 280K
|
分辨率 3.50 Å R-free 0.360 |
| 2AAR Structure of trigger factor binding domain in biologically homologous complex with eubacterial ribosome. 提交 2005-07-14 | Assembly 1 蛋白–RNA 异源复合物；蛋白 × 3 PDB 声明：tetrameric（4） 与全部聚合物一致 |
链 W
1–67（67 aa）
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.8；293 K；pH 7.8, VAPOR DIFFUSION, HANGING DROP, temperature 20K
|
分辨率 3.50 Å R-free 0.320 |
| 2D3O Structure of Ribosome Binding Domain of the Trigger Factor on the 50S ribosomal subunit from D. radiodurans 提交 2005-09-30 | Assembly 1 蛋白–RNA 异源复合物；蛋白 × 4 PDB 声明：pentameric（5） 与全部聚合物一致 |
链 W
1–67（67 aa）
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.8；290 K；ETHANOL, DIMETHYLHEXANEDIOL, MGCL2, KCL, HEPES, NH4CL, pH 7.8, VAPOR DIFFUSION, SITTING DROP, temperature 290K
|
分辨率 3.35 Å R-free 0.322 |
| 2ZJP Thiopeptide antibiotic Nosiheptide bound to the large ribosomal subunit of Deinococcus radiodurans 提交 2008-03-07 | Assembly 1 蛋白–RNA 异源复合物；蛋白 × 29 PDB 声明：31-meric（31） 与全部聚合物一致 |
链 V
1–67（67 aa）
|
未记录 | ZN ZINC ION × 2 NO1 4-(hydroxymethyl)-3-methyl-1H-indole-2-carboxylic acid × 1 MG MAGNESIUM ION × 35 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP
|
分辨率 3.70 Å R-free 0.340 |
| 2ZJQ Interaction of L7 with L11 induced by Microccocin binding to the Deinococcus radiodurans 50S subunit 提交 2008-03-08 | Assembly 1 蛋白–RNA 异源复合物；蛋白 × 29 PDB 声明：31-meric（31） 与全部聚合物一致 |
链 V
1–67（67 aa）
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；VAPOR DIFFUSION, HANGING DROP
|
分辨率 3.30 Å R-free 0.339 |
| 2ZJR Refined native structure of the large ribosomal subunit (50S) from Deinococcus radiodurans 提交 2008-03-08 | Assembly 1 蛋白–RNA 异源复合物；蛋白 × 28 PDB 声明：30-meric（30） 与全部聚合物一致 |
链 V
1–67（67 aa）
|
未记录 | MG MAGNESIUM ION × 35 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；VAPOR DIFFUSION, HANGING DROP
|
分辨率 2.91 Å R-free 0.311 |
| 3CF5 Thiopeptide antibiotic Thiostrepton bound to the large ribosomal subunit of Deinococcus radiodurans 提交 2008-03-02 | Assembly 1 蛋白–RNA 异源复合物；蛋白 × 29 PDB 声明：31-meric（31） 与全部聚合物一致 |
链 V
1–67（67 aa）
|
未记录 | MG MAGNESIUM ION × 36 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP
|
分辨率 3.30 Å R-free 0.318 |
| 3DLL The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning 提交 2008-06-27 | Assembly 1 蛋白–RNA 异源复合物；蛋白 × 28 PDB 声明：30-meric（30） 与全部聚合物一致 |
链 V
1–67（67 aa）
|
未记录 | MG MAGNESIUM ION × 35 ZLD N-{[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide × 1 ZN ZINC ION × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.8；10mM MgCl2, 60mM NH4Cl, 5mM KCl, 10mM HEPES, pH7.8, VAPOR DIFFUSION, HANGING DROP
|
分辨率 3.50 Å R-free 0.280 |
| 3PIO Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit 提交 2010-11-07 | Assembly 1 蛋白–RNA 异源复合物；蛋白 × 28 PDB 声明：30-meric（30） 与全部聚合物一致 |
链 V
1–67（67 aa）
|
未记录 | LMA Lankamycin × 1 MG MAGNESIUM ION × 154 NA SODIUM ION × 42 K POTASSIUM ION × 15 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP. 15% 2:1 ethanol:methylpentanediol was diffused to a hanging drop of 180 AU/ml solution of D50S.
|
分辨率 3.25 Å R-free 0.294 |
| 3PIP Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit 提交 2010-11-07 | Assembly 1 蛋白–RNA 异源复合物；蛋白 × 28 PDB 声明：30-meric（30） 与全部聚合物一致 |
链 V
1–67（67 aa）
|
未记录 | LC2 N-[(1S,2R,3E,5E,7S,9E,11E,13S,15R,19R)-7,13-dihydroxy-1,4,10,19-tetramethyl-17,18-dioxo-16-oxabicyclo[13.2.2]nonadeca-3,5,9,11-tetraen-2-yl]-2-oxopropanamide × 1 LMA Lankamycin × 1 MG MAGNESIUM ION × 73 K POTASSIUM ION × 4 NA SODIUM ION × 5 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP. 15% 2:1 ethanol:methylpentanediol was diffused to a hanging drop of 180 AU/ml solution of D50S.
|
分辨率 3.45 Å R-free 0.301 |
| 4IO9 Crystal structure of compound 4d bound to large ribosomal subunit (50S) from Deinococcus radiodurans 提交 2013-01-07 | Assembly 1 蛋白–RNA 异源复合物；蛋白 × 28 PDB 声明：30-meric（30） 与全部聚合物一致 |
链 V
1–67（67 aa）
|
未记录 | MG MAGNESIUM ION × 35 1F2 (3aS,4R,7R,8S,9S,10R,11R,13R,15R,15aR)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,14-trioxo-10-{[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy}tetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-8-yl (2R)-2-(pyridin-3-yl)pyrrolidine-1-carboxylate × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；VAPOR DIFFUSION, HANGING DROP
|
分辨率 3.20 Å R-free 0.235 |
| 4IOA Crystal structure of compound 4e bound to large ribosomal subunit (50S) from Deinococcus radiodurans 提交 2013-01-07 | Assembly 1 蛋白–RNA 异源复合物；蛋白 × 28 PDB 声明：30-meric（30） 与全部聚合物一致 |
链 V
1–67（67 aa）
|
未记录 | MG MAGNESIUM ION × 35 1F3 (3aS,4R,7R,8S,9S,10R,11R,13R,15R,15aR)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,14-trioxo-10-{[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy}tetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-8-yl (2R)-2-[4-(acetylamino)phenyl]-2,3-dihydro-1H-pyrrole-1-carboxylate × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；VAPOR DIFFUSION, HANGING DROP
|
分辨率 3.20 Å R-free 0.230 |
| 4IOC Crystal structure of compound 4f bound to large ribosomal subunit (50S) from Deinococcus radiodurans 提交 2013-01-07 | Assembly 1 蛋白–RNA 异源复合物；蛋白 × 28 PDB 声明：30-meric（30） 与全部聚合物一致 |
链 V
1–67（67 aa）
|
未记录 | MG MAGNESIUM ION × 35 1F4 (3aS,4R,7R,8S,9S,10R,11R,13R,15S,15aR)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,14-trioxo-10-{[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy}tetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-8-yl (2R)-4,4-dimethyl-2-(pyridin-3-yl)pyrrolidine-1-carboxylate × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；VAPOR DIFFUSION, HANGING DROP
|
分辨率 3.60 Å R-free 0.239 |
| 4U67 Crystal structure of the large ribosomal subunit (50S) of Deinococcus radiodurans containing a three residue insertion in L22 提交 2014-07-28 | Assembly 1 蛋白–RNA 异源复合物；蛋白 × 26 PDB 声明：28-meric（28） 与全部聚合物一致 |
链 V
1–67（67 aa）
|
未记录 | MG MAGNESIUM ION × 51 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.8；293 K；Magnesium chloride, HEPES, ammonium chloride, ethanol, 2-ethyl-1,3-hexandiol
|
分辨率 3.65 Å R-free 0.270 |
| 4WFN Crystal structure of the large ribosomal subunit (50S) of Deinococcus radiodurans containing a three residue insertion in L22 in complex with erythromycin 提交 2014-09-16 | Assembly 1 蛋白–RNA 异源复合物；蛋白 × 26 PDB 声明：28-meric（28） 与全部聚合物一致 |
链 V
1–67（67 aa）
|
未记录 | MG MAGNESIUM ION × 70 ERY ERYTHROMYCIN A × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.8；293 K；Magnesuim chloride, Hepes, ammonium chloride, ethanol, 2-ethyl-1,3-hexadiol
|
分辨率 3.54 Å R-free 0.282 |
| 5DM6 Crystal structure of the 50S ribosomal subunit from Deinococcus radiodurans 提交 2015-09-08 | Assembly 1 蛋白–RNA 异源复合物；蛋白 × 28 PDB 声明：30-meric（30） 与全部聚合物一致 |
链 V
1–66（66 aa）
|
未记录 | MG MAGNESIUM ION × 198 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；292 K；HEPES, sodium hydroxide, magnesium chloride, ammonium chloride, 2-mercaptoethanol, spermidine, 2-ethyl-1, 3-hexanediol, ethanol
|
分辨率 2.90 Å R-free 0.270 |
| 5DM7 Crystal structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with hygromycin A 提交 2015-09-08 | Assembly 1 蛋白–RNA 异源复合物；蛋白 × 28 PDB 声明：30-meric（30） 与全部聚合物一致 |
链 V
1–66（66 aa）
|
未记录 | MG MAGNESIUM ION × 186 HGR Hygromycin A × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；292 K；HEPES, sodium hydroxide, magnesium chloride, ammonium chloride, 2-mercaptoethanol, spermidine, 2-ethyl-1,3-hexanediol, ethanol
|
分辨率 3.00 Å R-free 0.326 |
| 5JVG The large ribosomal subunit from Deinococcus radiodurans in complex with avilamycin 提交 2016-05-11 | Assembly 1 蛋白–RNA 异源复合物；蛋白 × 27 PDB 声明：29-meric（29） 与全部聚合物一致 |
链 V
1–67（67 aa）
|
未记录 | 6NO Avilamycin × 1 MG MAGNESIUM ION × 446 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 5 SPD SPERMIDINE × 3 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.8；293.15 K；Ribosome solution containing 0.0065 mM (180 A/ml) of D50S in 10 mM Hepes pH=7.8, 15 mM MgCl2 and 75 mM NH4Cl crystallization buffer was mixed with 10 mM spermidine, 1 % ethanol and 0.5 % 2-ethyl-1,3-hexanediol precipitants.
A 0.005 ml crystallization drop was hanged over 10 % ethanol and 5% 2-ethyl-1,3-hexanediol in ddw reservoir.
|
分辨率 3.43 Å R-free 0.253 |
| 5JVH The crystal structure large ribosomal subunit (50S) of Deinococcus radiodurans in complex with evernimicin 提交 2016-05-11 | Assembly 1 蛋白–RNA 异源复合物；蛋白 × 26 PDB 声明：28-meric（28） 与全部聚合物一致 |
链 V
1–67（67 aa）
|
未记录 | 6O1 Evernimicin × 1 MG MAGNESIUM ION × 123 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.8；293 K；Magnesium chloride, HEPES, ammonium chloride, ethanol, 2-ethyl-1,3-hexandiol
|
分辨率 3.58 Å R-free 0.247 |
| 7A0R 50S Deinococcus radiodurans ribosome bounded with mycinamicin I 提交 2020-08-10 | Assembly 1 蛋白–RNA 异源复合物；蛋白 × 26 PDB 声明：28-meric（28） 与全部聚合物一致 |
链 V
6–66（61 aa）
|
未记录 | QTZ mycinamicin II × 1 MG MAGNESIUM ION × 345 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；293.15 K；Ribosome solution containing 0.0065 mM (180 A/ml) of D50S in 10 mM Hepes pH=7.8, 15 mM MgCl2 and 75 mM NH4Cl crystallization buffer was mixed with 10 mM spermidine, 1 % ethanol and 0.5 % 2-ethyl-1,3-hexanediol precipitants. A 0.005 ml crystallization drop was hanged over 10 % ethanol and 5% 2-ethyl-1,3-hexanediol in ddw reservoir.
|
分辨率 3.30 Å R-free 0.249 |
| 7A0S 50S Deinococcus radiodurans ribosome bounded with mycinamicin I 提交 2020-08-10 | Assembly 1 蛋白–RNA 异源复合物；蛋白 × 26 PDB 声明：28-meric（28） 与全部聚合物一致 |
链 V
6–66（61 aa）
|
未记录 | QU2 mycinamicin I × 1 MG MAGNESIUM ION × 367 SPD SPERMIDINE × 8 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 4 NA SODIUM ION × 1 EOH ETHANOL × 1 CA CALCIUM ION × 5 K POTASSIUM ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；293.15 K；Ribosome solution containing 0.0065 mM (180 A/ml) of D50S in 10 mM Hepes pH=7.8, 15 mM MgCl2 and 75 mM NH4Cl crystallization buffer was mixed with 10 mM spermidine, 1 % ethanol and 0.5 % 2-ethyl-1,3-hexanediol precipitants. A 0.005 ml crystallization drop was hanged over 10 % ethanol and 5% 2-ethyl-1,3-hexanediol in ddw reservoir.
|
分辨率 3.22 Å R-free 0.253 |
| 7A18 50S Deinococcus radiodurans ribosome bounded with mycinamicin IV 提交 2020-08-12 | Assembly 1 蛋白–RNA 异源复合物；蛋白 × 26 PDB 声明：28-meric（28） 与全部聚合物一致 |
链 V
13–66（54 aa）
|
未记录 | MIV MYCINAMICIN IV × 1 MG MAGNESIUM ION × 277 SPD SPERMIDINE × 7 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.8；293.15 K；Ribosome solution containing 0.0065 mM (180 A/ml) of D50S in 10 mM Hepes pH=7.8, 15 mM MgCl2 and 75 mM NH4Cl crystallization buffer was mixed with 10 mM spermidine, 1 % ethanol and 0.5 % 2-ethyl-1,3-hexanediol precipitants. A 0.005 ml crystallization drop was hanged over 10 % ethanol and 5% 2-ethyl-1,3-hexanediol in ddw reservoir.
|
分辨率 3.40 Å R-free 0.318 |