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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q9XSM3 New Search
28PDB entries
28Biological assembly
113chain/assembly records
Main Difference Dimensions in This Set
Different mutation/modification Different assembly state Different ligand/ion Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
6B5V Structure of TRPV5 in complex with econazole Deposited 2017-09-29 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–730（730 aa）
Chain B 1–730（730 aa）
Chain C 1–730（730 aa）
Chain D 1–730（730 aa）
Not recorded ECL 1-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole × 4 CA CALCIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.80 Å
6DMR Lipid-bound full-length rbTRPV5 Deposited 2018-06-05 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–730（730 aa）
Chain B 1–730（730 aa）
Chain C 1–730（730 aa）
Chain D 1–730（730 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å
6DMU PI(4,5)P2 bound full-length rbTRPV5 Deposited 2018-06-05 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–730（730 aa）
Chain B 1–730（730 aa）
Chain C 1–730（730 aa）
Chain D 1–730（730 aa）
Not recorded PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.00 Å
6DMW Calmodulin-bound full-length rbTRPV5 Deposited 2018-06-05 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain A 1–730（730 aa）
Chain B 1–730（730 aa）
Chain C 1–730（730 aa）
Chain D 1–730（730 aa）
Not recorded CA CALCIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 8.8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.40 Å
6O1N Cryo-EM structure of TRPV5 (1-660) in nanodisc Deposited 2019-02-21 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–730（730 aa）
Chain B 1–730（730 aa）
Chain C 1–730（730 aa）
Chain D 1–730（730 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.90 Å
6O1P Cryo-EM structure of full length TRPV5 in nanodisc Deposited 2019-02-21 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–730（730 aa）
Chain B 1–730（730 aa）
Chain C 1–730（730 aa）
Chain D 1–730（730 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
6O1U Cryo-EM structure of TRPV5 W583A in nanodisc Deposited 2019-02-21 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–730（730 aa）
Chain B 1–730（730 aa）
Chain C 1–730（730 aa）
Chain D 1–730（730 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.80 Å
6O20 Cryo-EM structure of TRPV5 with calmodulin bound Deposited 2019-02-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–730（730 aa）
Chain B 1–730（730 aa）
Chain C 1–730（730 aa）
Chain D 1–730（730 aa）
Chain E 1–730（730 aa）
Not recorded CA CALCIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
6PBE ZINC17988990-bound TRPV5 in nanodiscs Deposited 2019-06-13 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–730（730 aa）
Chain B 1–730（730 aa）
Chain C 1–730（730 aa）
Chain D 1–730（730 aa）
Not recorded O6S (4-oxo-5-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)methyl 3-(3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)propanoate × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.78 Å
6PBF ZINC9155420-bound TRPV5 in nanodiscs Deposited 2019-06-13 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–730（730 aa）
Chain B 1–730（730 aa）
Chain C 1–730（730 aa）
Chain D 1–730（730 aa）
Not recorded O6V (1S)-1-(4-oxo-5-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)ethyl [(2S)-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.20 Å
7T6J Cryo-EM structure of TRPV5 at pH8 in nanodiscs Deposited 2021-12-14 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–730（730 aa）
Chain B 1–730（730 aa）
Chain C 1–730（730 aa）
Chain D 1–730（730 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
7T6K Cryo-EM structure of TRPV5 at pH6 in nanodiscs Deposited 2021-12-14 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–730（730 aa）
Chain B 1–730（730 aa）
Chain C 1–730（730 aa）
Chain D 1–730（730 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
7T6L Cryo-EM structure of TRPV5 at pH5 in nanodiscs Deposited 2021-12-14 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–730（730 aa）
Chain B 1–730（730 aa）
Chain C 1–730（730 aa）
Chain D 1–730（730 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.70 Å
7T6M Cryo-EM structure of TRPV5 in nanodiscs with PI(4,5)P2 at pH6 state 1 Deposited 2021-12-14 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–730（730 aa）
Chain B 1–730（730 aa）
Chain C 1–730（730 aa）
Chain D 1–730（730 aa）
Not recorded PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.80 Å
7T6N Cryo-EM structure of TRPV5 in nanodiscs at pH6 state 2 Deposited 2021-12-14 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–730（730 aa）
Chain B 1–730（730 aa）
Chain C 1–730（730 aa）
Chain D 1–730（730 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.90 Å
7T6O Cryo-EM structure of TRPV5 in nanodiscs at pH6 state 3 Deposited 2021-12-14 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–730（730 aa）
Chain B 1–730（730 aa）
Chain C 1–730（730 aa）
Chain D 1–730（730 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.60 Å
7T6P Cryo-EM structure of TRPV5 T709D in nanodiscs Deposited 2021-12-14 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–730（730 aa）
Chain B 1–730（730 aa）
Chain C 1–730（730 aa）
Chain D 1–730（730 aa）
Mutation：T709D Mutation：T709D Mutation：T709D Mutation：T709D No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.80 Å
7T6Q Cryo-EM structure of TRPV5 T709D with PI(4,5)P2 in nanodiscs Deposited 2021-12-14 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–730（730 aa）
Chain B 1–730（730 aa）
Chain C 1–730（730 aa）
Chain D 1–730（730 aa）
Mutation：T709D Mutation：T709D Mutation：T709D Mutation：T709D PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
7T6R Cryo-EM structure of TRPV5 T709D in nanodiscs in the presence of Calmodulin Deposited 2021-12-14 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–730（730 aa）
Chain B 1–730（730 aa）
Chain C 1–730（730 aa）
Chain D 1–730（730 aa）
Mutation：T709D Mutation：T709D Mutation：T709D Mutation：T709D No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
8FFN RR-bound wildtype rabbit TRPV5 in nanodiscs Deposited 2022-12-09 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–730（730 aa）
Chain B 1–730（730 aa）
Chain C 1–730（730 aa）
Chain D 1–730（730 aa）
Not recorded R2R ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2) × 1 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 8 ERG ERGOSTEROL × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.96 Å
8FFO Cryo-EM structure of wildtype rabbit TRPV5 with PI(4,5)P2 in nanodiscs Deposited 2022-12-09 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–730（730 aa）
Chain B 1–730（730 aa）
Chain C 1–730（730 aa）
Chain D 1–730（730 aa）
Not recorded ERG ERGOSTEROL × 8 CPL 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.50 Å
8FFQ Wildtype rabbit TRPV5 into nanodiscs in the presence of PI(4,5)P2 and ruthenium red Deposited 2022-12-09 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–730（730 aa）
Chain B 1–730（730 aa）
Chain C 1–730（730 aa）
Chain D 1–730（730 aa）
Not recorded ERG ERGOSTEROL × 8 R2R ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2) × 1 CPL 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.65 Å
8FHH Wildtype rabbit TRPV5 in nanodiscs in the presence of oleoyl coenzyme A, Closed stated Deposited 2022-12-14 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–730（730 aa）
Chain B 1–730（730 aa）
Chain C 1–730（730 aa）
Chain D 1–730（730 aa）
Not recorded POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 4 ERG ERGOSTEROL × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.09 Å
8FHI Wildtype rabbit TRPV5 in nanodiscs in complex with oleoyl coenzyme A, Open stated Deposited 2022-12-14 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–730（730 aa）
Chain B 1–730（730 aa）
Chain C 1–730（730 aa）
Chain D 1–730（730 aa）
Not recorded ERG ERGOSTEROL × 8 3VV S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name) × 4 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.25 Å
8TF2 Wildtype rabbit TRPV5 into nanodiscs in Apo state Deposited 2023-07-07 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–730（730 aa）
Chain B 1–730（730 aa）
Chain C 1–730（730 aa）
Chain D 1–730（730 aa）
Not recorded ERG ERGOSTEROL × 8 CPL 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.57 Å
8TF3 Wildtype rabbit TRPV5 into nanodiscs in complex with econazole Deposited 2023-07-07 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–730（730 aa）
Chain B 1–730（730 aa）
Chain C 1–730（730 aa）
Chain D 1–730（730 aa）
Not recorded ERG ERGOSTEROL × 8 CPL 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 8 ECN 1-[(2S)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.94 Å
8TF4 Wildtype rabbit TRPV5 into nanodiscs in the presence of PI(4,5)P2 and econazole Deposited 2023-07-07 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–730（730 aa）
Chain B 1–730（730 aa）
Chain C 1–730（730 aa）
Chain D 1–730（730 aa）
Not recorded ERG ERGOSTEROL × 8 CPL 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 8 ECN 1-[(2S)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.86 Å
9O6G Wildtype rabbit TRPV5 in nanodics in the presence of Menthol and PI(4,5)P2 Deposited 2025-04-13 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–730（730 aa）
Chain B 1–730（730 aa）
Chain C 1–730（730 aa）
Chain D 1–730（730 aa）
Not recorded ERG ERGOSTEROL × 8 CPL 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 16 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 IT9 (-)-Isopiperitenone × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.37 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.