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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q9Y2R2 New Search
14PDB entries
32Biological assembly
32chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
2P6X Crystal structure of human tyrosine phosphatase PTPN22 Deposited 2007-03-19 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–302（302 aa） Fragment：PTPN22, Tyrosine-protein phosphatase catalytic domain
Not recorded EDO 1,2-ETHANEDIOL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.9；293 K；100 mM Bicine pH 7.9, 25% PEG 10000, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 1.90 Å R-free 0.217
2P6X Crystal structure of human tyrosine phosphatase PTPN22 Deposited 2007-03-19 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1–302（302 aa） Fragment：PTPN22, Tyrosine-protein phosphatase catalytic domain
Not recorded EDO 1,2-ETHANEDIOL × 1 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.9；293 K；100 mM Bicine pH 7.9, 25% PEG 10000, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 1.90 Å R-free 0.217
2QCJ Native Structure of Lyp Deposited 2007-06-19 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–294（294 aa） Fragment：catalytic domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 5.6；293 K；20% PEG 3350, pH 5.6, EVAPORATION, temperature 293K
Resolution 3.00 Å R-free 0.307
2QCJ Native Structure of Lyp Deposited 2007-06-19 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1–294（294 aa） Fragment：catalytic domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 5.6；293 K；20% PEG 3350, pH 5.6, EVAPORATION, temperature 293K
Resolution 3.00 Å R-free 0.307
2QCT Structure of Lyp with inhibitor I-C11 Deposited 2007-06-19 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–294（294 aa） Fragment：catalytic domain
Not recorded 561 6-HYDROXY-3-{(4R)-1-[4-(1-NAPHTHYLAMINO)-4-OXOBUTYL]-1,2,3-TRIAZOLIDIN-4-YL}-1-BENZOFURAN-5-CARBOXYLIC ACID × 1 EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 7.2；293 K；0.2M sodium formate, 20% PEG3350, 2.5% ethyl glycerol, pH 7.2, EVAPORATION, temperature 293K
Resolution 2.80 Å R-free 0.275
2QCT Structure of Lyp with inhibitor I-C11 Deposited 2007-06-19 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1–294（294 aa） Fragment：catalytic domain
Not recorded EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 7.2；293 K；0.2M sodium formate, 20% PEG3350, 2.5% ethyl glycerol, pH 7.2, EVAPORATION, temperature 293K
Resolution 2.80 Å R-free 0.275
3BRH Protein Tyrosine Phosphatase PTPN-22 (Lyp) bound to the mono-Phosphorylated Lck active site peptide Deposited 2007-12-21 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–310（310 aa） Fragment：Substrate Trapped Catalytic Domain
Mutation：D195A, C227S PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；100mM Bicine, 20% PEG6000, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.20 Å R-free 0.264
3BRH Protein Tyrosine Phosphatase PTPN-22 (Lyp) bound to the mono-Phosphorylated Lck active site peptide Deposited 2007-12-21 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 1–310（310 aa） Fragment：Substrate Trapped Catalytic Domain
Mutation：D195A, C227S PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；100mM Bicine, 20% PEG6000, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.20 Å R-free 0.264
3H2X Crystal Structure of The Human Lymphoid Tyrosine Phosphatase Catalytic Domain Deposited 2009-04-14 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–302（302 aa） Fragment：Catalytic Domain
Not recorded PO4 PHOSPHATE ION × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.2；291.15 K；2.0 M (NH4)2SO4, 0.1 M MES, 0.2 M Na/KPO4, pH 6.2, VAPOR DIFFUSION, HANGING DROP, temperature 291.15K
Resolution 2.20 Å R-free 0.204
3OLR PTPN22 in complex with consensus phospho-tyrosine peptide 1 Deposited 2010-08-26 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–294（294 aa） Fragment：UNP residues 1-294
Mutation：C227S No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；20% PEG 3350, 0.1M Tris-Hcl, pH 7, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.50 Å R-free 0.210
3OLR PTPN22 in complex with consensus phospho-tyrosine peptide 1 Deposited 2010-08-26 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 1–294（294 aa） Fragment：UNP residues 1-294
Mutation：C227S No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；20% PEG 3350, 0.1M Tris-Hcl, pH 7, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.50 Å R-free 0.210
3OLR PTPN22 in complex with consensus phospho-tyrosine peptide 1 Deposited 2010-08-26 Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 1–294（294 aa） Fragment：UNP residues 1-294
Mutation：C227S No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；20% PEG 3350, 0.1M Tris-Hcl, pH 7, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.50 Å R-free 0.210
3OLR PTPN22 in complex with consensus phospho-tyrosine peptide 1 Deposited 2010-08-26 Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain D 1–294（294 aa） Fragment：UNP residues 1-294
Mutation：C227S No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；20% PEG 3350, 0.1M Tris-Hcl, pH 7, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.50 Å R-free 0.210
3OMH Crystal structure of PTPN22 in complex with SKAP-HOM pTyr75 peptide Deposited 2010-08-26 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–294（294 aa） Fragment：Tyrosine-protein phosphatase domain residues 1-294
Mutation：C227S No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；293 K；20% PEG 3350, 0.1M Tris-Hcl, pH 7, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.90 Å R-free 0.260
3OMH Crystal structure of PTPN22 in complex with SKAP-HOM pTyr75 peptide Deposited 2010-08-26 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 1–294（294 aa） Fragment：Tyrosine-protein phosphatase domain residues 1-294
Mutation：C227S No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；293 K；20% PEG 3350, 0.1M Tris-Hcl, pH 7, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.90 Å R-free 0.260
3OMH Crystal structure of PTPN22 in complex with SKAP-HOM pTyr75 peptide Deposited 2010-08-26 Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 1–294（294 aa） Fragment：Tyrosine-protein phosphatase domain residues 1-294
Mutation：C227S No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；293 K；20% PEG 3350, 0.1M Tris-Hcl, pH 7, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.90 Å R-free 0.260
3OMH Crystal structure of PTPN22 in complex with SKAP-HOM pTyr75 peptide Deposited 2010-08-26 Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain D 1–294（294 aa） Fragment：Tyrosine-protein phosphatase domain residues 1-294
Mutation：C227S No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；293 K；20% PEG 3350, 0.1M Tris-Hcl, pH 7, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.90 Å R-free 0.260
4J51 Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with small molecular inhibitor L75N04 Deposited 2013-02-07 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–303（303 aa）
Not recorded N75 3-[(3-chlorophenyl)ethynyl]-2-{4-[2-(cyclopropylamino)-2-oxoethoxy]phenyl}-6-hydroxy-1-benzofuran-5-carboxylic acid × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.2；298 K；0.2 M sodium formate (pH 7.2) and 20% PEG3350, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.30 Å R-free 0.238
4J51 Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with small molecular inhibitor L75N04 Deposited 2013-02-07 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1–303（303 aa）
Not recorded N75 3-[(3-chlorophenyl)ethynyl]-2-{4-[2-(cyclopropylamino)-2-oxoethoxy]phenyl}-6-hydroxy-1-benzofuran-5-carboxylic acid × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.2；298 K；0.2 M sodium formate (pH 7.2) and 20% PEG3350, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.30 Å R-free 0.238
7AAM Crystal structure of the F-BAR domain of PSTIPIP1 bound to the CTH domain of the phosphatase LYP Deposited 2020-09-04 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 787–807（21 aa）
Not recorded GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；100 mM Bis-Tris-propane (pH=6.0), 20% (w/v) PEG 3350, 200 mM sodium citrate. LYP-CTH peptide was soaked into preformed crystals of the F-BAR domain of PSTPIP1.
Resolution 2.15 Å R-free 0.241
9YDM Targeting PTPN22 at non-orthosteric binding sites - a fragment approach Deposited 2025-09-22 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–303（303 aa）
Not recorded EOH ETHANOL × 1 GOL GLYCEROL × 3 SO4 SULFATE ION × 1 A1CU3 N-(3-methyl-1H-pyrazol-5-yl)-3-phenylpropanamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；292.15 K；0.1 M HEPES pH 7.5, 0.2 M MgCl2, and 25% PEG 3350
Resolution 1.99 Å R-free 0.276
9YDM Targeting PTPN22 at non-orthosteric binding sites - a fragment approach Deposited 2025-09-22 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1–303（303 aa）
Not recorded EOH ETHANOL × 1 GOL GLYCEROL × 2 A1CU3 N-(3-methyl-1H-pyrazol-5-yl)-3-phenylpropanamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；292.15 K；0.1 M HEPES pH 7.5, 0.2 M MgCl2, and 25% PEG 3350
Resolution 1.99 Å R-free 0.276
9YG0 Targeting PTPN22 at non-orthosteric binding sites - a fragment approach Deposited 2025-09-27 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–303（303 aa）
Not recorded GOL GLYCEROL × 1 EOH ETHANOL × 1 MG MAGNESIUM ION × 1 A1CWM 1-[(3S)-3-amino-2,3-dihydro-1H-indol-1-yl]-3-phenylpropan-1-one × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；292.15 K；PEGII C9: 0.1 M TRIS pH 8.5, 0.2 M magnesium chloride, & 16 % PEG 4000
Resolution 1.76 Å R-free 0.240
9YG0 Targeting PTPN22 at non-orthosteric binding sites - a fragment approach Deposited 2025-09-27 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1–303（303 aa）
Not recorded EOH ETHANOL × 2 MG MAGNESIUM ION × 3 A1CWM 1-[(3S)-3-amino-2,3-dihydro-1H-indol-1-yl]-3-phenylpropan-1-one × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；292.15 K；PEGII C9: 0.1 M TRIS pH 8.5, 0.2 M magnesium chloride, & 16 % PEG 4000
Resolution 1.76 Å R-free 0.240
9YG0 Targeting PTPN22 at non-orthosteric binding sites - a fragment approach Deposited 2025-09-27 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain C 1–303（303 aa）
Not recorded EOH ETHANOL × 1 MG MAGNESIUM ION × 1 A1CWM 1-[(3S)-3-amino-2,3-dihydro-1H-indol-1-yl]-3-phenylpropan-1-one × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；292.15 K；PEGII C9: 0.1 M TRIS pH 8.5, 0.2 M magnesium chloride, & 16 % PEG 4000
Resolution 1.76 Å R-free 0.240
9YG0 Targeting PTPN22 at non-orthosteric binding sites - a fragment approach Deposited 2025-09-27 Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain D 1–303（303 aa）
Not recorded EOH ETHANOL × 2 A1CWM 1-[(3S)-3-amino-2,3-dihydro-1H-indol-1-yl]-3-phenylpropan-1-one × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；292.15 K；PEGII C9: 0.1 M TRIS pH 8.5, 0.2 M magnesium chloride, & 16 % PEG 4000
Resolution 1.76 Å R-free 0.240
9YG1 Targeting PTPN22 at non-orthosteric binding sites - a fragment approach Deposited 2025-09-27 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–303（303 aa）
Not recorded EOH ETHANOL × 3 A1CWL 1-phenyl-1H-pyrazol-4-ol × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；292.15 K；PEGII C9: 0.1 M TRIS pH 8.5, 0.2 M magnesium chloride, & 16% PEG 4000
Resolution 1.97 Å R-free 0.224
9YG1 Targeting PTPN22 at non-orthosteric binding sites - a fragment approach Deposited 2025-09-27 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1–303（303 aa）
Not recorded EOH ETHANOL × 4 SO4 SULFATE ION × 1 GOL GLYCEROL × 1 MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；292.15 K；PEGII C9: 0.1 M TRIS pH 8.5, 0.2 M magnesium chloride, & 16% PEG 4000
Resolution 1.97 Å R-free 0.224
9YG2 Targeting PTPN22 at non-orthosteric binding sites - a fragment approach Deposited 2025-09-27 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–303（303 aa）
Not recorded CL CHLORIDE ION × 3 EDO 1,2-ETHANEDIOL × 4 GOL GLYCEROL × 1 A1CWK 5-chloro-3-methyl-1-[(3R)-pyrrolidin-3-yl]-1H-indole × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；292.15 K；PTPN22-PD303 (20mg/ml), PEGII C9: 0.1 M TRIS pH 8.5, 0.2 M MgCl2, & 16 % PEG 4000
Resolution 2.26 Å R-free 0.242
9YG2 Targeting PTPN22 at non-orthosteric binding sites - a fragment approach Deposited 2025-09-27 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1–303（303 aa）
Not recorded EDO 1,2-ETHANEDIOL × 1 GOL GLYCEROL × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；292.15 K；PTPN22-PD303 (20mg/ml), PEGII C9: 0.1 M TRIS pH 8.5, 0.2 M MgCl2, & 16 % PEG 4000
Resolution 2.26 Å R-free 0.242
9YG3 Targeting PTPN22 at non-orthosteric binding sites - a fragment approach Deposited 2025-09-27 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–303（303 aa）
Not recorded EDO 1,2-ETHANEDIOL × 1 NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；292.15 K；0.2M MgCl2, 25.00%w/v PEG 3350, 0.10M HEPES, pH 7.5
Resolution 1.96 Å R-free 0.241
9YG3 Targeting PTPN22 at non-orthosteric binding sites - a fragment approach Deposited 2025-09-27 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1–303（303 aa）
Not recorded EDO 1,2-ETHANEDIOL × 1 NA SODIUM ION × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；292.15 K；0.2M MgCl2, 25.00%w/v PEG 3350, 0.10M HEPES, pH 7.5
Resolution 1.96 Å R-free 0.241

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.