Current Protein Identity：Q9Y6W6
New Search
Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1ZZW Crystal Structure of catalytic domain of Human MAP Kinase Phosphatase 5 Deposited 2005-06-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
320–467（148 aa）
Fragment：catalytic domain
|
Not recorded | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；291 K；PEG3350, Lithium sulfate, magnesium sulfate, DTT, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 1.60 Å R-free 0.217 |
| 1ZZW Crystal Structure of catalytic domain of Human MAP Kinase Phosphatase 5 Deposited 2005-06-14 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
320–467（148 aa）
Fragment：catalytic domain
|
Not recorded | SO4 SULFATE ION × 1 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；291 K；PEG3350, Lithium sulfate, magnesium sulfate, DTT, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 1.60 Å R-free 0.217 |
| 2OUC Crystal structure of the MAP kinase binding domain of MKP5 Deposited 2007-02-10 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
148–287（140 aa）
Fragment：Rhodanese domain (Residues 148-287)
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.5；277 K；100 mM sodium acetate (pH 4.5), and 2.3-2.5 M ammonium acetate, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 2.20 Å R-free 0.289 |
| 2OUC Crystal structure of the MAP kinase binding domain of MKP5 Deposited 2007-02-10 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
148–287（140 aa）
Fragment：Rhodanese domain (Residues 148-287)
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.5；277 K；100 mM sodium acetate (pH 4.5), and 2.3-2.5 M ammonium acetate, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 2.20 Å R-free 0.289 |
| 2OUD Crystal structure of the catalytic domain of human MKP5 Deposited 2007-02-10 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
315–482（168 aa）
Fragment：Tyrosine-protein phosphatase domain (Residues 315-482)
|
Not recorded | CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；277 K；100 mM Bis-tris (pH 6.0), and 2.7-3.0 M sodium chloride, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 2.80 Å R-free 0.248 |
| 3TG1 Crystal structure of p38alpha in complex with a MAPK docking partner Deposited 2011-08-17 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
139–288（150 aa）
Fragment：KBD (UNP RESIDUES 139-288)
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 7.5；293 K；100mM Tris pH7.5, 9% [w/v] polyethylene glycol 3350, 8% [w/v] sucrose, VAPOR DIFFUSION, temperature 293K
|
Resolution 2.71 Å R-free 0.260 |
| 6MC1 Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-(methylthio)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2018-08-30 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；25% PEG 3350, 200 mM ammonium acetate, 100 mM HEPES
|
Resolution 2.70 Å R-free 0.227 |
| 6MC1 Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-(methylthio)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2018-08-30 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 DTT 2,3-DIHYDROXY-1,4-DITHIOBUTANE × 1 ACT ACETATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；25% PEG 3350, 200 mM ammonium acetate, 100 mM HEPES
|
Resolution 2.70 Å R-free 0.227 |
| 6MC1 Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-(methylthio)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2018-08-30 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 DTT 2,3-DIHYDROXY-1,4-DITHIOBUTANE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；25% PEG 3350, 200 mM ammonium acetate, 100 mM HEPES
|
Resolution 2.70 Å R-free 0.227 |
| 6MC1 Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-(methylthio)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2018-08-30 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 DTT 2,3-DIHYDROXY-1,4-DITHIOBUTANE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；25% PEG 3350, 200 mM ammonium acetate, 100 mM HEPES
|
Resolution 2.70 Å R-free 0.227 |
| 6MC1 Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-(methylthio)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2018-08-30 | Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain E
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 DTT 2,3-DIHYDROXY-1,4-DITHIOBUTANE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；25% PEG 3350, 200 mM ammonium acetate, 100 mM HEPES
|
Resolution 2.70 Å R-free 0.227 |
| 6MC1 Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-(methylthio)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2018-08-30 | Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain F
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 DTT 2,3-DIHYDROXY-1,4-DITHIOBUTANE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；25% PEG 3350, 200 mM ammonium acetate, 100 mM HEPES
|
Resolution 2.70 Å R-free 0.227 |
| 7U4O Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-propyl-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-02-28 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | L8K 3,3-dimethyl-1-{[(9aM)-9-propyl-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；100 mM Tris, pH 7.5, 200 mM sodium acetate, 35% w/v PEG3350
|
Resolution 2.30 Å R-free 0.238 |
| 7U4O Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-propyl-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-02-28 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | L8K 3,3-dimethyl-1-{[(9aM)-9-propyl-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；100 mM Tris, pH 7.5, 200 mM sodium acetate, 35% w/v PEG3350
|
Resolution 2.30 Å R-free 0.238 |
| 7U4O Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-propyl-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-02-28 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | L8K 3,3-dimethyl-1-{[(9aM)-9-propyl-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；100 mM Tris, pH 7.5, 200 mM sodium acetate, 35% w/v PEG3350
|
Resolution 2.30 Å R-free 0.238 |
| 7U4O Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-propyl-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-02-28 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | L8K 3,3-dimethyl-1-{[(9aM)-9-propyl-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；100 mM Tris, pH 7.5, 200 mM sodium acetate, 35% w/v PEG3350
|
Resolution 2.30 Å R-free 0.238 |
| 7U4O Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-propyl-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-02-28 | Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain E
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | L8K 3,3-dimethyl-1-{[(9aM)-9-propyl-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；100 mM Tris, pH 7.5, 200 mM sodium acetate, 35% w/v PEG3350
|
Resolution 2.30 Å R-free 0.238 |
| 7U4O Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-propyl-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-02-28 | Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain F
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | L8K 3,3-dimethyl-1-{[(9aM)-9-propyl-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；100 mM Tris, pH 7.5, 200 mM sodium acetate, 35% w/v PEG3350
|
Resolution 2.30 Å R-free 0.238 |
| 7U4R Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-propyl-5,6-dihydrothieno[2,3-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-02-28 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | L8R 3,3-dimethyl-1-{[(9aM)-9-propyl-5,6-dihydrothieno[2,3-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；100 mM bis-Tris, pH 5.5, 200 mM ammonium acetate, 5% w/v PEG3350
|
Resolution 3.14 Å R-free 0.225 |
| 7U4R Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-propyl-5,6-dihydrothieno[2,3-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-02-28 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | L8R 3,3-dimethyl-1-{[(9aM)-9-propyl-5,6-dihydrothieno[2,3-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；100 mM bis-Tris, pH 5.5, 200 mM ammonium acetate, 5% w/v PEG3350
|
Resolution 3.14 Å R-free 0.225 |
| 7U4R Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-propyl-5,6-dihydrothieno[2,3-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-02-28 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | L8R 3,3-dimethyl-1-{[(9aM)-9-propyl-5,6-dihydrothieno[2,3-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；100 mM bis-Tris, pH 5.5, 200 mM ammonium acetate, 5% w/v PEG3350
|
Resolution 3.14 Å R-free 0.225 |
| 7U4R Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-propyl-5,6-dihydrothieno[2,3-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-02-28 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | L8R 3,3-dimethyl-1-{[(9aM)-9-propyl-5,6-dihydrothieno[2,3-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；100 mM bis-Tris, pH 5.5, 200 mM ammonium acetate, 5% w/v PEG3350
|
Resolution 3.14 Å R-free 0.225 |
| 7U4R Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-propyl-5,6-dihydrothieno[2,3-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-02-28 | Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain E
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | L8R 3,3-dimethyl-1-{[(9aM)-9-propyl-5,6-dihydrothieno[2,3-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；100 mM bis-Tris, pH 5.5, 200 mM ammonium acetate, 5% w/v PEG3350
|
Resolution 3.14 Å R-free 0.225 |
| 7U4R Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-propyl-5,6-dihydrothieno[2,3-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-02-28 | Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain F
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | L8R 3,3-dimethyl-1-{[(9aM)-9-propyl-5,6-dihydrothieno[2,3-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；100 mM bis-Tris, pH 5.5, 200 mM ammonium acetate, 5% w/v PEG3350
|
Resolution 3.14 Å R-free 0.225 |
| 7UMU Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((5,6-dihydrobenzo[h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-04-07 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | NUN 1-[(benzo[h]quinazolin-2-yl)sulfanyl]-3,3-dimethylbutan-2-one × 1 DTT 2,3-DIHYDROXY-1,4-DITHIOBUTANE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；100 mM HEPES (pH 7.5)
200 mM ammonium acetate
25% (w/v) PEG 3350
|
Resolution 2.51 Å R-free 0.228 |
| 7UMU Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((5,6-dihydrobenzo[h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-04-07 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | NUN 1-[(benzo[h]quinazolin-2-yl)sulfanyl]-3,3-dimethylbutan-2-one × 1 DTT 2,3-DIHYDROXY-1,4-DITHIOBUTANE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；100 mM HEPES (pH 7.5)
200 mM ammonium acetate
25% (w/v) PEG 3350
|
Resolution 2.51 Å R-free 0.228 |
| 7UMU Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((5,6-dihydrobenzo[h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-04-07 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | NUN 1-[(benzo[h]quinazolin-2-yl)sulfanyl]-3,3-dimethylbutan-2-one × 1 DTT 2,3-DIHYDROXY-1,4-DITHIOBUTANE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；100 mM HEPES (pH 7.5)
200 mM ammonium acetate
25% (w/v) PEG 3350
|
Resolution 2.51 Å R-free 0.228 |
| 7UMU Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((5,6-dihydrobenzo[h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-04-07 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | NUN 1-[(benzo[h]quinazolin-2-yl)sulfanyl]-3,3-dimethylbutan-2-one × 1 DTT 2,3-DIHYDROXY-1,4-DITHIOBUTANE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；100 mM HEPES (pH 7.5)
200 mM ammonium acetate
25% (w/v) PEG 3350
|
Resolution 2.51 Å R-free 0.228 |
| 7UMU Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((5,6-dihydrobenzo[h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-04-07 | Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain E
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | NUN 1-[(benzo[h]quinazolin-2-yl)sulfanyl]-3,3-dimethylbutan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；100 mM HEPES (pH 7.5)
200 mM ammonium acetate
25% (w/v) PEG 3350
|
Resolution 2.51 Å R-free 0.228 |
| 7UMU Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((5,6-dihydrobenzo[h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-04-07 | Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain F
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | NUN 1-[(benzo[h]quinazolin-2-yl)sulfanyl]-3,3-dimethylbutan-2-one × 1 DTT 2,3-DIHYDROXY-1,4-DITHIOBUTANE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；100 mM HEPES (pH 7.5)
200 mM ammonium acetate
25% (w/v) PEG 3350
|
Resolution 2.51 Å R-free 0.228 |
| 7UMV Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((5,6-dihydropyrido[2,3-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-04-07 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | NUU 1-{[(10aP)-5,6-dihydropyrido[2,3-h]quinazolin-2-yl]sulfanyl}-3,3-dimethylbutan-2-one × 1 ACT ACETATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；100 mM Tris, pH 7.5, 200 mM ammonium acetate, 40% w/v PEG3350
|
Resolution 1.80 Å R-free 0.172 |
| 7UN0 Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-chloro-5,6-dihydrobenzo[h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-04-08 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | NV3 1-[(9-chlorobenzo[h]quinazolin-2-yl)sulfanyl]-3,3-dimethylbutan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；100 mM HEPES, pH 7.0, 200 mM ammonium acetate, 25% w/v PEG3350
|
Resolution 3.00 Å R-free 0.214 |
| 7UN0 Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-chloro-5,6-dihydrobenzo[h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-04-08 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | NV3 1-[(9-chlorobenzo[h]quinazolin-2-yl)sulfanyl]-3,3-dimethylbutan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；100 mM HEPES, pH 7.0, 200 mM ammonium acetate, 25% w/v PEG3350
|
Resolution 3.00 Å R-free 0.214 |
| 7UN0 Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-chloro-5,6-dihydrobenzo[h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-04-08 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | NV3 1-[(9-chlorobenzo[h]quinazolin-2-yl)sulfanyl]-3,3-dimethylbutan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；100 mM HEPES, pH 7.0, 200 mM ammonium acetate, 25% w/v PEG3350
|
Resolution 3.00 Å R-free 0.214 |
| 7UN0 Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-chloro-5,6-dihydrobenzo[h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-04-08 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | NV3 1-[(9-chlorobenzo[h]quinazolin-2-yl)sulfanyl]-3,3-dimethylbutan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；100 mM HEPES, pH 7.0, 200 mM ammonium acetate, 25% w/v PEG3350
|
Resolution 3.00 Å R-free 0.214 |
| 7UN0 Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-chloro-5,6-dihydrobenzo[h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-04-08 | Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain E
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | NV3 1-[(9-chlorobenzo[h]quinazolin-2-yl)sulfanyl]-3,3-dimethylbutan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；100 mM HEPES, pH 7.0, 200 mM ammonium acetate, 25% w/v PEG3350
|
Resolution 3.00 Å R-free 0.214 |
| 7UN0 Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-chloro-5,6-dihydrobenzo[h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-04-08 | Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain F
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | NV3 1-[(9-chlorobenzo[h]quinazolin-2-yl)sulfanyl]-3,3-dimethylbutan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；100 mM HEPES, pH 7.0, 200 mM ammonium acetate, 25% w/v PEG3350
|
Resolution 3.00 Å R-free 0.214 |
| 7UN4 Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-propyl-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-04-08 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | NVF 1-{[(9aM)-5,6-dihydrothieno[2,3-h]quinazolin-2-yl]sulfanyl}-3,3-dimethylbutan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；100 mM Tris, pH 8.5, 200 mM ammonium acetate, 20% w/v PEG3350
|
Resolution 2.70 Å R-free 0.263 |
| 7UN4 Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-propyl-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-04-08 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | NVF 1-{[(9aM)-5,6-dihydrothieno[2,3-h]quinazolin-2-yl]sulfanyl}-3,3-dimethylbutan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；100 mM Tris, pH 8.5, 200 mM ammonium acetate, 20% w/v PEG3350
|
Resolution 2.70 Å R-free 0.263 |
| 7UN4 Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-propyl-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-04-08 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | NVF 1-{[(9aM)-5,6-dihydrothieno[2,3-h]quinazolin-2-yl]sulfanyl}-3,3-dimethylbutan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；100 mM Tris, pH 8.5, 200 mM ammonium acetate, 20% w/v PEG3350
|
Resolution 2.70 Å R-free 0.263 |
| 7UN4 Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-propyl-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-04-08 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | NVF 1-{[(9aM)-5,6-dihydrothieno[2,3-h]quinazolin-2-yl]sulfanyl}-3,3-dimethylbutan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；100 mM Tris, pH 8.5, 200 mM ammonium acetate, 20% w/v PEG3350
|
Resolution 2.70 Å R-free 0.263 |
| 7UN4 Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-propyl-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-04-08 | Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain E
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | NVF 1-{[(9aM)-5,6-dihydrothieno[2,3-h]quinazolin-2-yl]sulfanyl}-3,3-dimethylbutan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；100 mM Tris, pH 8.5, 200 mM ammonium acetate, 20% w/v PEG3350
|
Resolution 2.70 Å R-free 0.263 |
| 7UN4 Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-propyl-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor Deposited 2022-04-08 | Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain F
320–467（148 aa）
Fragment：UNP residues 320-467
|
Not recorded | NVF 1-{[(9aM)-5,6-dihydrothieno[2,3-h]quinazolin-2-yl]sulfanyl}-3,3-dimethylbutan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；100 mM Tris, pH 8.5, 200 mM ammonium acetate, 20% w/v PEG3350
|
Resolution 2.70 Å R-free 0.263 |
| 7Y4B Crystal structure of DUSP10 mutant_D59A Deposited 2022-06-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
320–467（148 aa）
|
Mutation：D59A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；283 K；22.5%(w/v) PEG 3000, 100mM Tris base/Hydrochloric acid, 200mM Calcium acetate
|
Resolution 1.86 Å R-free 0.230 |
| 7Y4B Crystal structure of DUSP10 mutant_D59A Deposited 2022-06-14 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
320–467（148 aa）
|
Mutation：D59A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；283 K；22.5%(w/v) PEG 3000, 100mM Tris base/Hydrochloric acid, 200mM Calcium acetate
|
Resolution 1.86 Å R-free 0.230 |
| 7Y4C Crystal structure of DUSP10 Deposited 2022-06-14 | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
320–467（148 aa）
Chain B
320–467（148 aa）
Chain C
320–467（148 aa）
Chain D
320–467（148 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；283 K；25% (w/v) PEG 3000, 100 mM Tris base /Hydrochloric acid,
175 mM Calcium acetate
|
Resolution 1.87 Å R-free 0.268 |
| 7Y4D Crystal structure of DUSP10 mutant_S95A Deposited 2022-06-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
320–467（148 aa）
|
Mutation：S95A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；283 K；22.5% (w/v) PEG 3000, 100 mM Tris base /Hydrochloric acid,
200 mM Calcium acetate
|
Resolution 2.18 Å R-free 0.230 |
| 7Y4D Crystal structure of DUSP10 mutant_S95A Deposited 2022-06-14 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
320–467（148 aa）
|
Mutation：S95A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；283 K；22.5% (w/v) PEG 3000, 100 mM Tris base /Hydrochloric acid,
200 mM Calcium acetate
|
Resolution 2.18 Å R-free 0.230 |
| 7Y4E Crystal structure of DUSP10 mutant_N130A Deposited 2022-06-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
320–467（148 aa）
|
Mutation：N130A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；283 K；27.5% (w/v) PEG 3000, 100 mM Tris base /Hydrochloric acid,
175mM Calcium acetate
|
Resolution 1.93 Å R-free 0.233 |
| 7Y4E Crystal structure of DUSP10 mutant_N130A Deposited 2022-06-14 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
320–467（148 aa）
|
Mutation：N130A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；283 K；27.5% (w/v) PEG 3000, 100 mM Tris base /Hydrochloric acid,
175mM Calcium acetate
|
Resolution 1.93 Å R-free 0.233 |
| 9BPN Crystal structure of the allosteric MKP5 mutant Y435W Deposited 2024-05-07 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
320–466（147 aa）
|
Mutation：Y435W | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；295 K；0.1 M Tris, pH 8.5, 3 M sodium chloride
|
Resolution 2.40 Å R-free 0.288 |
| 9BPN Crystal structure of the allosteric MKP5 mutant Y435W Deposited 2024-05-07 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
320–466（147 aa）
|
Mutation：Y435W | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；295 K；0.1 M Tris, pH 8.5, 3 M sodium chloride
|
Resolution 2.40 Å R-free 0.288 |
| 9BU4 Crystal structure of an MKP5 mutant, Y435W, in complex with an allosteric inhibitor Deposited 2024-05-16 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
320–466（147 aa）
|
Mutation：Y435W | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；295 K；0.1 M Tris, pH 8.5, 3 M sodium chloride
|
Resolution 2.90 Å R-free 0.266 |
| 9BU4 Crystal structure of an MKP5 mutant, Y435W, in complex with an allosteric inhibitor Deposited 2024-05-16 | Assembly 10 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain J
320–466（147 aa）
|
Mutation：Y435W | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；295 K；0.1 M Tris, pH 8.5, 3 M sodium chloride
|
Resolution 2.90 Å R-free 0.266 |
| 9BU4 Crystal structure of an MKP5 mutant, Y435W, in complex with an allosteric inhibitor Deposited 2024-05-16 | Assembly 11 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain K
320–466（147 aa）
|
Mutation：Y435W | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；295 K；0.1 M Tris, pH 8.5, 3 M sodium chloride
|
Resolution 2.90 Å R-free 0.266 |
| 9BU4 Crystal structure of an MKP5 mutant, Y435W, in complex with an allosteric inhibitor Deposited 2024-05-16 | Assembly 12 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain L
320–466（147 aa）
|
Mutation：Y435W | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；295 K；0.1 M Tris, pH 8.5, 3 M sodium chloride
|
Resolution 2.90 Å R-free 0.266 |
| 9BU4 Crystal structure of an MKP5 mutant, Y435W, in complex with an allosteric inhibitor Deposited 2024-05-16 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
320–466（147 aa）
|
Mutation：Y435W | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；295 K；0.1 M Tris, pH 8.5, 3 M sodium chloride
|
Resolution 2.90 Å R-free 0.266 |
| 9BU4 Crystal structure of an MKP5 mutant, Y435W, in complex with an allosteric inhibitor Deposited 2024-05-16 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
320–466（147 aa）
|
Mutation：Y435W | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；295 K；0.1 M Tris, pH 8.5, 3 M sodium chloride
|
Resolution 2.90 Å R-free 0.266 |
| 9BU4 Crystal structure of an MKP5 mutant, Y435W, in complex with an allosteric inhibitor Deposited 2024-05-16 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
320–466（147 aa）
|
Mutation：Y435W | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；295 K；0.1 M Tris, pH 8.5, 3 M sodium chloride
|
Resolution 2.90 Å R-free 0.266 |
| 9BU4 Crystal structure of an MKP5 mutant, Y435W, in complex with an allosteric inhibitor Deposited 2024-05-16 | Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain E
320–466（147 aa）
|
Mutation：Y435W | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；295 K；0.1 M Tris, pH 8.5, 3 M sodium chloride
|
Resolution 2.90 Å R-free 0.266 |
| 9BU4 Crystal structure of an MKP5 mutant, Y435W, in complex with an allosteric inhibitor Deposited 2024-05-16 | Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain F
320–466（147 aa）
|
Mutation：Y435W | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；295 K；0.1 M Tris, pH 8.5, 3 M sodium chloride
|
Resolution 2.90 Å R-free 0.266 |
| 9BU4 Crystal structure of an MKP5 mutant, Y435W, in complex with an allosteric inhibitor Deposited 2024-05-16 | Assembly 7 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain G
320–466（147 aa）
|
Mutation：Y435W | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；295 K；0.1 M Tris, pH 8.5, 3 M sodium chloride
|
Resolution 2.90 Å R-free 0.266 |
| 9BU4 Crystal structure of an MKP5 mutant, Y435W, in complex with an allosteric inhibitor Deposited 2024-05-16 | Assembly 8 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain H
320–466（147 aa）
|
Mutation：Y435W | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；295 K；0.1 M Tris, pH 8.5, 3 M sodium chloride
|
Resolution 2.90 Å R-free 0.266 |
| 9BU4 Crystal structure of an MKP5 mutant, Y435W, in complex with an allosteric inhibitor Deposited 2024-05-16 | Assembly 9 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain I
320–466（147 aa）
|
Mutation：Y435W | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；295 K；0.1 M Tris, pH 8.5, 3 M sodium chloride
|
Resolution 2.90 Å R-free 0.266 |
| 9NSB Crystal structure of an MKP5 allosteric loop mutant, S446G, in complex with an allosteric inhibitor Deposited 2025-03-16 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
320–466（147 aa）
Fragment：UNP residues 320-466
|
Mutation：S446G | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.2 M Tricine, pH 7.4, sodium hydroxide, PEG4000
|
Resolution 2.50 Å R-free 0.264 |
| 9NSB Crystal structure of an MKP5 allosteric loop mutant, S446G, in complex with an allosteric inhibitor Deposited 2025-03-16 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
320–466（147 aa）
Fragment：UNP residues 320-466
|
Mutation：S446G | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.2 M Tricine, pH 7.4, sodium hydroxide, PEG4000
|
Resolution 2.50 Å R-free 0.264 |
| 9NSB Crystal structure of an MKP5 allosteric loop mutant, S446G, in complex with an allosteric inhibitor Deposited 2025-03-16 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
320–466（147 aa）
Fragment：UNP residues 320-466
|
Mutation：S446G | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.2 M Tricine, pH 7.4, sodium hydroxide, PEG4000
|
Resolution 2.50 Å R-free 0.264 |
| 9NSB Crystal structure of an MKP5 allosteric loop mutant, S446G, in complex with an allosteric inhibitor Deposited 2025-03-16 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
320–466（147 aa）
Fragment：UNP residues 320-466
|
Mutation：S446G | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.2 M Tricine, pH 7.4, sodium hydroxide, PEG4000
|
Resolution 2.50 Å R-free 0.264 |
| 9NSB Crystal structure of an MKP5 allosteric loop mutant, S446G, in complex with an allosteric inhibitor Deposited 2025-03-16 | Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain E
320–466（147 aa）
Fragment：UNP residues 320-466
|
Mutation：S446G | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.2 M Tricine, pH 7.4, sodium hydroxide, PEG4000
|
Resolution 2.50 Å R-free 0.264 |
| 9NSB Crystal structure of an MKP5 allosteric loop mutant, S446G, in complex with an allosteric inhibitor Deposited 2025-03-16 | Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain F
320–466（147 aa）
Fragment：UNP residues 320-466
|
Mutation：S446G | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.2 M Tricine, pH 7.4, sodium hydroxide, PEG4000
|
Resolution 2.50 Å R-free 0.264 |
| 9NYM Crystal structure of an MKP5 allosteric loop mutant, N448A Deposited 2025-03-27 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
320–466（147 aa）
|
Not recorded | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；297 K；0.1 M Tris, pH 6.5, 2.0 M ammonium sulfate
|
Resolution 2.00 Å R-free 0.241 |
| 9NYM Crystal structure of an MKP5 allosteric loop mutant, N448A Deposited 2025-03-27 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
320–466（147 aa）
|
Not recorded | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；297 K；0.1 M Tris, pH 6.5, 2.0 M ammonium sulfate
|
Resolution 2.00 Å R-free 0.241 |
| 9O8W Crystal structure of an MKP5 mutant, Y435F, in complex with an allosteric inhibitor Deposited 2025-04-16 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
320–467（148 aa）
|
Mutation：Y435F | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；2 M ammonium sulfate (precipitant), 0.1 M HEPES, pH 7.5 (buffer)
|
Resolution 2.39 Å R-free 0.251 |
| 9O8W Crystal structure of an MKP5 mutant, Y435F, in complex with an allosteric inhibitor Deposited 2025-04-16 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
320–467（148 aa）
|
Mutation：Y435F | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；2 M ammonium sulfate (precipitant), 0.1 M HEPES, pH 7.5 (buffer)
|
Resolution 2.39 Å R-free 0.251 |
| 9O8W Crystal structure of an MKP5 mutant, Y435F, in complex with an allosteric inhibitor Deposited 2025-04-16 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
320–467（148 aa）
|
Mutation：Y435F | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；2 M ammonium sulfate (precipitant), 0.1 M HEPES, pH 7.5 (buffer)
|
Resolution 2.39 Å R-free 0.251 |
| 9O8W Crystal structure of an MKP5 mutant, Y435F, in complex with an allosteric inhibitor Deposited 2025-04-16 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
320–467（148 aa）
|
Mutation：Y435F | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；2 M ammonium sulfate (precipitant), 0.1 M HEPES, pH 7.5 (buffer)
|
Resolution 2.39 Å R-free 0.251 |
| 9O8W Crystal structure of an MKP5 mutant, Y435F, in complex with an allosteric inhibitor Deposited 2025-04-16 | Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain E
320–467（148 aa）
|
Mutation：Y435F | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；2 M ammonium sulfate (precipitant), 0.1 M HEPES, pH 7.5 (buffer)
|
Resolution 2.39 Å R-free 0.251 |
| 9O8W Crystal structure of an MKP5 mutant, Y435F, in complex with an allosteric inhibitor Deposited 2025-04-16 | Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain F
320–467（148 aa）
|
Mutation：Y435F | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；2 M ammonium sulfate (precipitant), 0.1 M HEPES, pH 7.5 (buffer)
|
Resolution 2.39 Å R-free 0.251 |
| 9OK9 Crystal structure of an MKP5 allosteric loop mutant, P447V, in complex with an allosteric inhibitor Deposited 2025-05-09 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
320–467（148 aa）
Fragment：UNP residues 320-467
|
Mutation：P447V | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；297 K；0.2 M ADA, pH 6.7 (buffer), 20% w/v PEG4000 (precipitant)
|
Resolution 3.00 Å R-free 0.239 |
| 9OK9 Crystal structure of an MKP5 allosteric loop mutant, P447V, in complex with an allosteric inhibitor Deposited 2025-05-09 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
320–467（148 aa）
Fragment：UNP residues 320-467
|
Mutation：P447V | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；297 K；0.2 M ADA, pH 6.7 (buffer), 20% w/v PEG4000 (precipitant)
|
Resolution 3.00 Å R-free 0.239 |
| 9OK9 Crystal structure of an MKP5 allosteric loop mutant, P447V, in complex with an allosteric inhibitor Deposited 2025-05-09 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
320–467（148 aa）
Fragment：UNP residues 320-467
|
Mutation：P447V | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；297 K；0.2 M ADA, pH 6.7 (buffer), 20% w/v PEG4000 (precipitant)
|
Resolution 3.00 Å R-free 0.239 |
| 9OK9 Crystal structure of an MKP5 allosteric loop mutant, P447V, in complex with an allosteric inhibitor Deposited 2025-05-09 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
320–467（148 aa）
Fragment：UNP residues 320-467
|
Mutation：P447V | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；297 K；0.2 M ADA, pH 6.7 (buffer), 20% w/v PEG4000 (precipitant)
|
Resolution 3.00 Å R-free 0.239 |
| 9OK9 Crystal structure of an MKP5 allosteric loop mutant, P447V, in complex with an allosteric inhibitor Deposited 2025-05-09 | Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain E
320–467（148 aa）
Fragment：UNP residues 320-467
|
Mutation：P447V | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；297 K；0.2 M ADA, pH 6.7 (buffer), 20% w/v PEG4000 (precipitant)
|
Resolution 3.00 Å R-free 0.239 |
| 9OK9 Crystal structure of an MKP5 allosteric loop mutant, P447V, in complex with an allosteric inhibitor Deposited 2025-05-09 | Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain F
320–467（148 aa）
Fragment：UNP residues 320-467
|
Mutation：P447V | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；297 K；0.2 M ADA, pH 6.7 (buffer), 20% w/v PEG4000 (precipitant)
|
Resolution 3.00 Å R-free 0.239 |
| 9Q7X Crystal structure of the MKP5 loop mutant N448A in complex with the allosteric inhibitor Deposited 2025-08-25 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
320–466（147 aa）
|
Not recorded | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.1 M HEPES, pH 7.5, 1.4 M sodium citrate tribasic dihydrate
|
Resolution 2.95 Å R-free 0.241 |
| 9Q7X Crystal structure of the MKP5 loop mutant N448A in complex with the allosteric inhibitor Deposited 2025-08-25 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
320–466（147 aa）
|
Not recorded | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.1 M HEPES, pH 7.5, 1.4 M sodium citrate tribasic dihydrate
|
Resolution 2.95 Å R-free 0.241 |
| 9Q7X Crystal structure of the MKP5 loop mutant N448A in complex with the allosteric inhibitor Deposited 2025-08-25 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
320–466（147 aa）
|
Not recorded | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.1 M HEPES, pH 7.5, 1.4 M sodium citrate tribasic dihydrate
|
Resolution 2.95 Å R-free 0.241 |
| 9Q7X Crystal structure of the MKP5 loop mutant N448A in complex with the allosteric inhibitor Deposited 2025-08-25 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
320–466（147 aa）
|
Not recorded | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.1 M HEPES, pH 7.5, 1.4 M sodium citrate tribasic dihydrate
|
Resolution 2.95 Å R-free 0.241 |
| 9Q7X Crystal structure of the MKP5 loop mutant N448A in complex with the allosteric inhibitor Deposited 2025-08-25 | Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain E
320–466（147 aa）
|
Not recorded | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.1 M HEPES, pH 7.5, 1.4 M sodium citrate tribasic dihydrate
|
Resolution 2.95 Å R-free 0.241 |
| 9Q7X Crystal structure of the MKP5 loop mutant N448A in complex with the allosteric inhibitor Deposited 2025-08-25 | Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain F
320–466（147 aa）
|
Not recorded | CJA 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.1 M HEPES, pH 7.5, 1.4 M sodium citrate tribasic dihydrate
|
Resolution 2.95 Å R-free 0.241 |
| 9Y55 A crystal structure of DUSP10 loop mutant I445A Deposited 2025-09-04 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
320–466（147 aa）
Fragment：CD domain (UNP residues 320-466)
|
Mutation：I445A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M imidazole, pH 8.0, 2.5 M sodium chloride
|
Resolution 3.50 Å R-free 0.245 |
| 9Y55 A crystal structure of DUSP10 loop mutant I445A Deposited 2025-09-04 | Assembly 10 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain J
320–466（147 aa）
Fragment：CD domain (UNP residues 320-466)
|
Mutation：I445A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M imidazole, pH 8.0, 2.5 M sodium chloride
|
Resolution 3.50 Å R-free 0.245 |
| 9Y55 A crystal structure of DUSP10 loop mutant I445A Deposited 2025-09-04 | Assembly 11 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain K
320–466（147 aa）
Fragment：CD domain (UNP residues 320-466)
|
Mutation：I445A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M imidazole, pH 8.0, 2.5 M sodium chloride
|
Resolution 3.50 Å R-free 0.245 |
| 9Y55 A crystal structure of DUSP10 loop mutant I445A Deposited 2025-09-04 | Assembly 12 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain L
320–466（147 aa）
Fragment：CD domain (UNP residues 320-466)
|
Mutation：I445A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M imidazole, pH 8.0, 2.5 M sodium chloride
|
Resolution 3.50 Å R-free 0.245 |
| 9Y55 A crystal structure of DUSP10 loop mutant I445A Deposited 2025-09-04 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
320–466（147 aa）
Fragment：CD domain (UNP residues 320-466)
|
Mutation：I445A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M imidazole, pH 8.0, 2.5 M sodium chloride
|
Resolution 3.50 Å R-free 0.245 |
| 9Y55 A crystal structure of DUSP10 loop mutant I445A Deposited 2025-09-04 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
320–466（147 aa）
Fragment：CD domain (UNP residues 320-466)
|
Mutation：I445A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M imidazole, pH 8.0, 2.5 M sodium chloride
|
Resolution 3.50 Å R-free 0.245 |
| 9Y55 A crystal structure of DUSP10 loop mutant I445A Deposited 2025-09-04 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
320–466（147 aa）
Fragment：CD domain (UNP residues 320-466)
|
Mutation：I445A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M imidazole, pH 8.0, 2.5 M sodium chloride
|
Resolution 3.50 Å R-free 0.245 |
| 9Y55 A crystal structure of DUSP10 loop mutant I445A Deposited 2025-09-04 | Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain E
320–466（147 aa）
Fragment：CD domain (UNP residues 320-466)
|
Mutation：I445A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M imidazole, pH 8.0, 2.5 M sodium chloride
|
Resolution 3.50 Å R-free 0.245 |
| 9Y55 A crystal structure of DUSP10 loop mutant I445A Deposited 2025-09-04 | Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain F
320–466（147 aa）
Fragment：CD domain (UNP residues 320-466)
|
Mutation：I445A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M imidazole, pH 8.0, 2.5 M sodium chloride
|
Resolution 3.50 Å R-free 0.245 |
| 9Y55 A crystal structure of DUSP10 loop mutant I445A Deposited 2025-09-04 | Assembly 7 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain G
320–466（147 aa）
Fragment：CD domain (UNP residues 320-466)
|
Mutation：I445A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M imidazole, pH 8.0, 2.5 M sodium chloride
|
Resolution 3.50 Å R-free 0.245 |
| 9Y55 A crystal structure of DUSP10 loop mutant I445A Deposited 2025-09-04 | Assembly 8 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain H
320–466（147 aa）
Fragment：CD domain (UNP residues 320-466)
|
Mutation：I445A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M imidazole, pH 8.0, 2.5 M sodium chloride
|
Resolution 3.50 Å R-free 0.245 |
| 9Y55 A crystal structure of DUSP10 loop mutant I445A Deposited 2025-09-04 | Assembly 9 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain I
320–466（147 aa）
Fragment：CD domain (UNP residues 320-466)
|
Mutation：I445A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M imidazole, pH 8.0, 2.5 M sodium chloride
|
Resolution 3.50 Å R-free 0.245 |