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{
"code": "SASD282",
"status": "Published",
"type_of_curve": "SEC-SAS",
"angular_unit": "1/A",
"project": {
"title": "Robust structural, kinetic and biophysical characterization of wild-type human ACOD1, selected mutants and their interaction with citraconate",
"publication": {
"title": "Robust structural, kinetic and biophysical characterization of wild-type human ACOD1, selected mutants and their interaction with citraconate",
"author_list": "Runge B, Oktay H, Fucci I, Merten E, Tarasov S, Fan L, Monteiro D",
"journal": "Journal of Structural Biology: X",
"doi": "10.1016/j.yjsbx.2026.100157",
"pmid": null,
"published_date": "2026 Aug"
},
"status": "released",
"submitted_date": "2026-06-24",
"released_date": "2026-08-10"
},
"pddf_data": null,
"intensities_data": "https://www.sasbdb.org/media/intensities_files/SASD282.dat",
"intensities_log_plot": "https://www.sasbdb.org/media/intensities_files/scattering_plots/SASD282_dat_img.png",
"intensities_kratky_plot": "https://www.sasbdb.org/media/intensities_files/scattering_plots/SASD282_kratky_img.png",
"pddf_plot": null,
"intensities_guinier_plot": "https://www.sasbdb.org/media/intensities_files/scattering_plots/SASD282_guinier_img.png",
"sascif_data": "https://www.sasbdb.org/media/sascif/sascif_files/SASD282.sascif",
"experiment": {
"instrument": {
"detector": {
"type": null,
"name": "Eiger2 S",
"resolution": null
},
"name": "Advanced Photon Source (APS), Argonne National Laboratory",
"city": "Lemont, IL",
"country": "USA",
"beamline_name": "12-ID-B",
"beam_geometry": null,
"type_of_source": "X-ray synchrotron",
"point_source": null,
"line_collimation": null,
"sample_path_length": null,
"line_collimation_slitlength": null,
"line_collimation_integrationwidth": null,
"xray_energy": null,
"beam_profile_ah": null,
"beam_profile_al": null
},
"sample": {
"molecule": [
{
"long_name": "cis-aconitate decarboxylase 1",
"short_name": "ACOD1",
"sequence": "GGGRKSITESFATAIHGLKVGHLTDRVIQRSKRMILDTLGAGFLGTTTEVFHIASQYSKIYSSNISSTVWGQPDIRLPPTYAAFVNGVAIHSMDFDDTWHPATHPSGAVLPVLTALAEALPRSPKFSGLDLLLAFNVGIEVQGRLLHFAKEANDMPKRFHPPSVVGTLGSAAAASKFLGLSSTKCREALAIAVSHAGAPMANAATQTKPLHIGNAAKHGIE",
"organism": "Homo sapiens",
"uniprot_code": "A6NK06",
"uniprot_range_first": null,
"uniprot_range_last": null,
"oligomerization": "dimer",
"molecular_type": "protein",
"uniprot_sequence": "MMLKSITESFATAIHGLKVGHLTDRVIQRSKRMILDTLGAGFLGTTTEVFHIASQYSKIY\nSSNISSTVWGQPDIRLPPTYAAFVNGVAIHSMDFDDTWHPATHPSGAVLPVLTALAEALP\nRSPKFSGLDLLLAFNVGIEVQGRLLHFAKEANDMPKRFHPPSVVGTLGSAAAASKFLGLS\nSTKCREALAIAVSHAGAPMANAATQTKPLHIGNAAKHGIEAAFLAMLGLQGNKQVLDLEA\nGFGAFYANYSPKVLPSIASYSWLLDQQDVAFKRFPAHLSTHWVADAAASVRKHLVAERAL\nLPTDYIKRIVLRIPNVQYVNRPFPVSEHEARHSFQYVACAMLLDGGITVPSFHECQINRP\nQVRELLSKVELEYPPDNLPSFNILYCEISVTLKDGATFTDRSDTFYGHWRKPLSQEDLEE\nKFRANASKMLSWDTVESLIKIVKNLEDLEDCSVLTTLLKGPSPPEVASNSPACNNSITNL\nS",
"mw": 50.596,
"total_mw": 101.192,
"number_molecules": 2,
"complex_state": false,
"deuteration": null,
"molecule_source": "biological",
"molecule_description": ""
}
],
"buffer": {
"name": "20 mM HEPES , 150 mM NaCl, 0.5 mM TCEP, and 2% (v/v) glycerol",
"concentration_unit": null,
"comment": null,
"additive": null,
"concentration": null,
"pka": null,
"ph": 7.5,
"deuteration": null
},
"purity_method": null,
"name": "Citraconate-bound Cis-aconitate decarboxylase (ACOD1)",
"ext_coefficient": null,
"contrast": null,
"specific_vol": null,
"dry_vol": null,
"absorbption": null,
"deuteration": null,
"mixture": null
},
"contributor": [
{
"affiliation": [
{
"short_name": null,
"address": null,
"full_name": "Frederick Nationla Lab for Cancer Research",
"webpage": null
}
],
"contributor_name": "Lixin",
"contributor_surname": "Fan",
"orcid": ""
}
],
"concentration_method": null,
"concentration_unit": null,
"date": "2026-03-06",
"storage_temperature": -20.0,
"cell_temperature": 20.0,
"exposure_time": 0.3,
"number_of_frames": 769,
"wavelength": 0.0932,
"sample_detector_distance": 2.0,
"concentration_min": null,
"concentration_max": 6.0,
"sample_volume": 100.0,
"flow_rate": 0.3,
"s_min": 0.05,
"s_max": 5.0,
"total_exposure_time": null,
"seccolumn": 2
},
"fits": [
{
"models": [
{
"model_plot": "https://www.sasbdb.org/media/pdb_file/images/SASD282_fit1_model1_img.png",
"software": "Other",
"pdb_link": [],
"model_title": null,
"type_of_model": "other",
"software_version": "N/A",
"model_data": "https://www.sasbdb.org/media/pdb_file/SASD282_fit1_model1.pdb",
"model_mw": null,
"bead_radius": null,
"log": "https://www.sasbdb.org/media/log_files/9O5N_citrabonded.log",
"symmetry": null,
"comment": "Model derived from unpublished crystal structure, assigned PDB ID: 9O5N",
"user": 480
}
],
"fit_unit": "1/A",
"fit_plot": "https://www.sasbdb.org/media/fitting_files/scattering_plots/SASD282_fit1_fixed_fit_img.png",
"software": "CRYSOL",
"chi_square_value": 0.231,
"p_value": 0.0005,
"fit_residual_plot": "SASD282_fit1_fitresiduals_img.png",
"fit_data": "https://www.sasbdb.org/media/fitting_files/SASD282_fit1.fit",
"fit_log": "https://www.sasbdb.org/media/fitting_files/log_files/9O5N_citrabonded.log",
"software_version": "2.8.3",
"description": ""
}
],
"estimated_volume_method": null,
"pddf_software": null,
"pddf_software_version": null,
"i0_calibration_standard": null,
"description": null,
"experiment_description": null,
"tags": [],
"intensity_unit": "1/cm",
"experimental_mw": 97.2,
"experimental_mw_error": null,
"guinier_i0_mw": null,
"guinier_i0_mw_error": null,
"porod_mw": null,
"porod_mw_error": null,
"pddf_i0": null,
"pddf_i0_error": null,
"guinier_i0": 0.0881514,
"guinier_i0_error": null,
"pddf_rg": null,
"pddf_rg_error": null,
"guinier_rg": 3.176,
"guinier_rg_error": 0.006,
"pddf_dmax": null,
"pddf_dmax_error": null,
"porod_volume": null,
"porod_volume_error": null,
"estimated_volume": null,
"estimated_volume_error": null,
"guinier_point_first": 7,
"guinier_point_last": 145,
"pddf_point_first": null,
"pddf_point_last": null,
"i0_calibration_standard_data": null,
"intensities_log_log_plot": "SASD282_datloglog_img.png",
"symmetry": null,
"last_modified": "2026-08-10T15:33:56.279344+02:00",
"bragg_peak": []
}
