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"title": "The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4.",
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"title": "The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4.",
"author_list": "Watson AA, Mahajan P, Mertens HD, Deery MJ, Zhang W, Pham P, Du X, Bartke T, Zhang W, Edlich C, Berridge G, Chen Y, Burgess-Brown NA, Kouzarides T, Wiechens N, Owen-Hughes T, Svergun DI, Gileadi O, Laue ED",
"journal": "J Mol Biol",
"doi": "10.1016/j.jmb.2012.04.031",
"pmid": "22575888",
"published_date": "2012 Sep 7"
},
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"address": "Notkestraße 85, Geb. 25A, 22607 Hamburg, Deutschland, Germany",
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"description": "The ATPase CHD4 mediates nucleosome remodeling by the NuRD (nucleosome remodeling and deacetylase) complex. The NuRD complex serves as a crucial epigenetic regulator of cell differentiation, proliferation, and hematopoietic development by coupling the deacetylation and demethylation of histones, nucleosome mobilization, and the recruitment of transcription factors. The three dimensional small-angle X-ray scattering model of CHD4 helps to define its interdomain interactions, with cross linking and limited proteolysis studies used to validate the model. Functional and binding assays suggest a regulatory role for the PHD and chromo domains.",
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