SASDYY5

La-related protein 6 (LARP6) N-terminal region (NTR) apo

Data type: SASBDB experimental data Status: Published Curve type: Merged Last updated: 2026-02-21T16:07:53.696587+01:00

LARP6 N-terminal region (NTR), an intrinsically disordered tail spanning residues 1-84. Experimental molecular weight was estimated by SEC-MALLS.

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1. Samples, Components and Experimental Conditions Sample & Experiment

Sample 1 · La-related protein 6 (LARP6) N-terminal region (NTR) apo

Concentration4.0 – 5.0 Buffer / pH25 mM Tris-HCl, 100 mM KCl, 5 mM MgCl2, 1 mM DTT / 7.5
Experimental temperature15.0 Facility / beamlineDiamond Light Source / B21
Wavelength0.09537 nmExposure0.35 s × 600

Molecular Components

ComponentType / organismUniProt and ConstructOligomeric StateMolecular weight
La-related protein 6
View sequence
MAQSGGEARPGPKTAVQIRVAIQEAEDVDELEDEEEGAETRGAGDPARYLSPGWGSASEEEPSRGHSGTTASGGENEREDLEQ
proteinHomo sapiensQ9BRS81–83monomerMolecule count —8.727 kDa

Experimental Curves

CurvePoints / columnsq rangeUncertainty qualityNegative-intensity pointsSource file
12573[3]0.0045–0.34 1/AHas uncertainty columnMissing 028sasbdb/entries/y5/sasdyy5/source/SASDYY5.dat
▼

2. Measurements Reported by SASBDB Reported Results

MetricMethodValueUncertaintyUnit
dmaxP(r)9.4—Å
i0Guinier0.0127297—arbitrary
i0P(r)0.07635215—arbitrary
mwExperimental11.2—kDa
mwPorod13.0—kDa
porod_volumePorod21.0—ų
rgGuinier2.7090.056Å
rgP(r)2.73—Å

These values are reported by SASBDB; SAXSdb did not recalculate them from the experimental curve.

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3. Source Fits and Models Source Fits & Models

This entry has no source fit record.

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4. Source File Index Source Files

▶

5. Experiment Description and Publication Experiment & Publication

▼

6. Complete Source Record Complete Source Record

The following content comes directly from the SASBDB entry. Missing values are shown as “—”; SAXSdb does not infer undeclared units.

Open the original SASBDB entry

Buffer and Sample Properties

Buffer name25 mM Tris-HCl, 100 mM KCl, 5 mM MgCl2, 1 mM DTTBuffer concentration—
pH7.5Additives—
Buffer descriptionSEC-SAXS buffer
Purity measurement method—Extinction coefficient—
Absorbance—Scattering contrast—
Specific volume / dry volume— / —Mixture / deuteration— / —

Acquisition Conditions and Instrument

Measurement date2024-10-01Storage / measurement temperature4.0 / 15.0
Exposure time0.35Frames600
Wavelength0.09537Sample-to-detector distance3.6903
SourceX-ray synchrotronDetectorEiger 4M
Facility / beamlineDiamond Light Source / B21 · Didcot, UK
q range0.045 – 3.4Sample volume / flow rate— / —

Original SASBDB Plots

Experimental I(q)
Experimental I(q)
Experimental I(q), log-log
Experimental I(q), log-log
Guinier plot
Guinier plot
Kratky plot
Kratky plot
P(r) plot
P(r) plot

Downloadable Files

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full_entry_zip:source record and ZIP contents (2 items)
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pddf:source record
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sascif:source record
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summary:source record
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All source fields (unfiltered)

Every source field is expanded here, including empty values, list members and fields already shown above.

summary.json:134 field values
Field pathRaw value
codeSASDYY5
statusPublished
type_of_curveMerged
angular_unit1/A
project.titleAn intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6.
project.publication.titleAn intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6.
project.publication.author_listCapraro F, Abis G, Incocciati A, Simpson PJ, Karimzadeh M, Masino L, Barley A, Bui TTT, Kelly G, Goodarzi H, Conte MR, Mardakheh FK
project.publication.journalNat Commun
project.publication.doi10.1038/s41467-026-69789-z
project.publication.pmid41714637
project.publication.published_date2026 Feb 19
project.statusreleased
project.submitted_date2026-01-20
project.released_date2026-02-21
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experiment.instrument.detector.typenull
experiment.instrument.detector.nameEiger 4M
experiment.instrument.detector.resolution75.0
experiment.instrument.nameDiamond Light Source
experiment.instrument.cityDidcot
experiment.instrument.countryUK
experiment.instrument.beamline_nameB21
experiment.instrument.beam_geometrynull
experiment.instrument.type_of_sourceX-ray synchrotron
experiment.instrument.point_sourcenull
experiment.instrument.line_collimationnull
experiment.instrument.sample_path_lengthnull
experiment.instrument.line_collimation_slitlengthnull
experiment.instrument.line_collimation_integrationwidthnull
experiment.instrument.xray_energynull
experiment.instrument.beam_profile_ahnull
experiment.instrument.beam_profile_alnull
experiment.sample.molecule[0].long_nameLa-related protein 6
experiment.sample.molecule[0].short_nameLARP6
experiment.sample.molecule[0].sequenceMAQSGGEARPGPKTAVQIRVAIQEAEDVDELEDEEEGAETRGAGDPARYLSPGWGSASEEEPSRGHSGTTASGGENEREDLEQ
experiment.sample.molecule[0].organismHomo sapiens
experiment.sample.molecule[0].uniprot_codeQ9BRS8
experiment.sample.molecule[0].uniprot_range_first1
experiment.sample.molecule[0].uniprot_range_last83
experiment.sample.molecule[0].oligomerizationmonomer
experiment.sample.molecule[0].molecular_typeprotein
experiment.sample.molecule[0].uniprot_sequenceMAQSGGEARPGPKTAVQIRVAIQEAEDVDELEDEEEGAETRGAGDPARYLSPGWGSASEE EPSRGHSGTTASGGENEREDLEQEWKPPDEELIKKLVDQIEFYFSDENLEKDAFLLKHVR RNKLGYVSVKLLTSFKKVKHLTRDWRTTAHALKYSVVLELNEDHRKVRRTTPVPLFPNEN LPSKMLLVYDLYLSPKLWALATPQKNGRVQEKVMEHLLKLFGTFGVISSVRILKPGRELP PDIRRISSRYSQVGTQECAIVEFEEVEAAIKAHEFMITESQGKENMKAVLIGMKPPKKKP AKDKNHDEEPTASIHLNKSLNKRVEELQYMGDESSANSSSDPESNPTSPMAGRRHAATNK LSPSGHQNLFLSPNASPCTSPWSSPLAQRKGVSRKSPLAEEGRLNCSTSPEIFRKCMDYS SDSSVTPSGSPWVRRRRQAEMGTQEKSPGTSPLLSRKMQTADGLPVGVLRLPRGPDNTRG FHGHERSRACV
experiment.sample.molecule[0].mw8.727
experiment.sample.molecule[0].total_mw8.727
experiment.sample.molecule[0].number_molecules0
experiment.sample.molecule[0].complex_stateFalse
experiment.sample.molecule[0].deuterationnull
experiment.sample.molecule[0].molecule_sourcebiological
experiment.sample.molecule[0].molecule_descriptionLARP6 N-terminal region (NTR) intrinsically disordered tail
experiment.sample.buffer.name25 mM Tris-HCl, 100 mM KCl, 5 mM MgCl2, 1 mM DTT
experiment.sample.buffer.concentration_unitnull
experiment.sample.buffer.commentSEC-SAXS buffer
experiment.sample.buffer.additivenull
experiment.sample.buffer.concentrationnull
experiment.sample.buffer.pkanull
experiment.sample.buffer.ph7.5
experiment.sample.buffer.deuterationnull
experiment.sample.purity_methodnull
experiment.sample.nameLa-related protein 6 (LARP6) N-terminal region (NTR) apo
experiment.sample.ext_coefficientnull
experiment.sample.contrastnull
experiment.sample.specific_volnull
experiment.sample.dry_volnull
experiment.sample.absorbptionnull
experiment.sample.deuterationnull
experiment.sample.mixturenull
experiment.contributor[0].affiliation[0].short_namenull
experiment.contributor[0].affiliation[0].addressLondon, UK
experiment.contributor[0].affiliation[0].full_nameKing's College London
experiment.contributor[0].affiliation[0].webpagehttps://www.kcl.ac.uk
experiment.contributor[0].contributor_nameGiancarlo
experiment.contributor[0].contributor_surnameAbis
experiment.contributor[0].orcid
experiment.concentration_methodnull
experiment.concentration_unitnull
experiment.date2024-10-01
experiment.storage_temperature4.0
experiment.cell_temperature15.0
experiment.exposure_time0.35
experiment.number_of_frames600
experiment.wavelength0.09537
experiment.sample_detector_distance3.6903
experiment.concentration_min4.0
experiment.concentration_max5.0
experiment.sample_volumenull
experiment.flow_ratenull
experiment.s_min0.045
experiment.s_max3.4
experiment.total_exposure_timenull
experiment.seccolumnnull
fits[]
estimated_volume_methodnull
pddf_softwareScÅtter
pddf_software_versionnull
i0_calibration_standardnull
descriptionLARP6 N-terminal region (NTR), an intrinsically disordered tail spanning residues 1-84. Experimental molecular weight was estimated by SEC-MALLS.
experiment_descriptionnull
tags[]
intensity_unitarbitrary
experimental_mw11.2
experimental_mw_errornull
guinier_i0_mwnull
guinier_i0_mw_errornull
porod_mw13.0
porod_mw_errornull
pddf_i00.07635215
pddf_i0_errornull
guinier_i00.0127297
guinier_i0_errornull
pddf_rg2.73
pddf_rg_errornull
guinier_rg2.709
guinier_rg_error0.056
pddf_dmax9.4
pddf_dmax_errornull
porod_volume21.0
porod_volume_errornull
estimated_volumenull
estimated_volume_errornull
guinier_point_first40
guinier_point_last375
pddf_point_firstnull
pddf_point_lastnull
i0_calibration_standard_datanull
intensities_log_log_plotSASDYY5_datloglog_img.png
symmetrynull
last_modified2026-02-21T16:07:53.696587+01:00
bragg_peak[]
manifest.json:34 field values
Field pathRaw value
codeSASDYY5
statussuccess
started_at2026-08-11T14:59:26.656351+00:00
finished_at2026-08-11T14:59:33.749351+00:00
source_last_modified2026-02-21T16:07:53.696587+01:00
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View the complete summary.json source
{
  "code": "SASDYY5",
  "status": "Published",
  "type_of_curve": "Merged",
  "angular_unit": "1/A",
  "project": {
    "title": "An intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6.",
    "publication": {
      "title": "An intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6.",
      "author_list": "Capraro F, Abis G, Incocciati A, Simpson PJ, Karimzadeh M, Masino L, Barley A, Bui TTT, Kelly G, Goodarzi H, Conte MR, Mardakheh FK",
      "journal": "Nat Commun",
      "doi": "10.1038/s41467-026-69789-z",
      "pmid": "41714637",
      "published_date": "2026 Feb 19"
    },
    "status": "released",
    "submitted_date": "2026-01-20",
    "released_date": "2026-02-21"
  },
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          "short_name": "LARP6",
          "sequence": "MAQSGGEARPGPKTAVQIRVAIQEAEDVDELEDEEEGAETRGAGDPARYLSPGWGSASEEEPSRGHSGTTASGGENEREDLEQ",
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          "uniprot_range_first": 1,
          "uniprot_range_last": 83,
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  "symmetry": null,
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  "bragg_peak": []
}
View the complete manifest.json source
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  "status": "success",
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