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10dj

Fyn Kinase Domain-Saracatinib Complex Structure

Method: X-RAY DIFFRACTION Dmax: 105.3 Å Quality: GOOD
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Tyrosine-protein kinase Fyn

Homo sapiens

UniProt P06241

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count Chain A； UniProt 263–537 Not recorded H8H N-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-7-[2-(4-METHYLPIPERAZIN-1-YL)ETHOXY]-5-(TETRAHYDRO-2H-PYRAN-4-YLOXY)QUINAZOLIN-4-AMINE × 1 X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；277 K；4.0 M ammonium acetate, 0.1 M sodium acetate trihydrate, pH 4.6 Resolution 2.22 Å R-free 0.268
2 Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count Chain B； UniProt 263–537 Not recorded H8H N-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-7-[2-(4-METHYLPIPERAZIN-1-YL)ETHOXY]-5-(TETRAHYDRO-2H-PYRAN-4-YLOXY)QUINAZOLIN-4-AMINE × 1 X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；277 K；4.0 M ammonium acetate, 0.1 M sodium acetate trihydrate, pH 4.6 Resolution 2.22 Å R-free 0.268

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 10DJ Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1A0N NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE COMPLEXED WITH THE SYNTHETIC PEPTIDE P2L CORRESPONDING TO RESIDUES 91-104 OF THE P85 SUBUNIT OF PI3-KINASE, FAMILY OF 25 STRUCTURES Deposited 1997-12-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 79–147（69 aa） Fragment：SH3 DOMAIN, RESIDUES 82 - 148
Mutation：N-TERMINAL GS FROM EXPRESSION SYSTEM No recorded non-water small molecule SOLUTION NMR mmCIF provides none of the parsed conditions Resolution not provided
1AOT NMR STRUCTURE OF THE FYN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PEPTIDE, MINIMIZED AVERAGE STRUCTURE Deposited 1997-07-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain F 142–247（106 aa） Fragment：SH2 DOMAIN
Mutation：C97S, C98S, C104S No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6；293 K
Resolution not provided
1AOU NMR STRUCTURE OF THE FYN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PEPTIDE, 22 STRUCTURES Deposited 1997-07-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain F 142–247（106 aa） Fragment：SH2 DOMAIN
Mutation：C97S, C98S, C104S No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6；293 K
Resolution not provided
1AVZ V-1 NEF PROTEIN IN COMPLEX WITH WILD TYPE FYN SH3 DOMAIN Deposited 1997-09-23 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain C 84–140（57 aa） Fragment：SRC-HOMOLOGY 3 DOMAIN
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 8.9；pH 8.9
Resolution 3.00 Å R-free 0.270
1AZG NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE KINASE COMPLEXED WITH THE SYNTHETIC PEPTIDE P2L CORRESPONDING TO RESIDUES 91-104 OF THE P85 SUBUNIT OF PI3-KINASE, MINIMIZED AVERAGE (PROBMAP) STRUCTURE Deposited 1997-11-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 81–147（67 aa） Fragment：SH3 DOMAIN, RESIDUES 82 - 148
Mutation：N-TERMINAL GS FROM EXPRESSION SYSTEM No recorded non-water small molecule SOLUTION NMR mmCIF provides none of the parsed conditions Resolution not provided
1EFN HIV-1 NEF PROTEIN IN COMPLEX WITH R96I MUTANT FYN SH3 DOMAIN Deposited 1996-06-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 85–142（58 aa） Fragment：SH3 DOMAIN, RESIDUES 85-141
Chain C 85–142（58 aa） Fragment：SH3 DOMAIN, RESIDUES 85-141
Mutation：R96I Mutation：R96I PBM TRIMETHYL LEAD ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å R-free 0.282
1FYN PHOSPHOTRANSFERASE Deposited 1995-05-17 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 80–141（62 aa） Fragment：SH3 DOMAIN
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.30 Å
1G83 CRYSTAL STRUCTURE OF FYN SH3-SH2 Deposited 2000-11-16 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 81–245（165 aa） Fragment：SH3 AND SH2 DOMAIN
Mutation：C238S, C239S, C245S No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 6；295 K；PEG 8000, sodium tartrate, TRIS , pH 6.0, VAPOR DIFFUSION, temperature 295.0K
Resolution 2.60 Å R-free 0.277
1G83 CRYSTAL STRUCTURE OF FYN SH3-SH2 Deposited 2000-11-16 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 81–245（165 aa） Fragment：SH3 AND SH2 DOMAIN
Mutation：C238S, C239S, C245S No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 6；295 K；PEG 8000, sodium tartrate, TRIS , pH 6.0, VAPOR DIFFUSION, temperature 295.0K
Resolution 2.60 Å R-free 0.277
1M27 Crystal structure of SAP/FynSH3/SLAM ternary complex Deposited 2002-06-21 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain C 83–143（61 aa） Fragment：SH3 domain (residues 82-143)
Not recorded FLC CITRATE ANION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.6；297 K；Tartrate, pH 5.6, VAPOR DIFFUSION, HANGING DROP, temperature 297K
Resolution 2.50 Å R-free 0.266
1NYF NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE, MINIMIZED AVERAGE (PROBMAP) STRUCTURE Deposited 1996-04-22 Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 81–147（67 aa） Fragment：SH3 DOMAIN, RESIDUES 82 - 148
Mutation：INS(GS-T82) No recorded non-water small molecule SOLUTION NMR mmCIF provides none of the parsed conditions Resolution not provided
1NYG NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE, FAMILY OF 20 STRUCTURES Deposited 1996-04-22 Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 81–147（67 aa） Fragment：SH3 DOMAIN, RESIDUES 82 - 148
Mutation：INS(GS-T82) No recorded non-water small molecule SOLUTION NMR mmCIF provides none of the parsed conditions Resolution not provided
1SHF CRYSTAL STRUCTURE OF THE SH3 DOMAIN IN HUMAN FYN; COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF SH3 DOMAINS IN TYROSINE KINASES AND SPECTRIN Deposited 1993-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 83–141（59 aa）
Chain B 83–141（59 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å
1ZBJ Inferential Structure Determination of the Fyn SH3 domain using NOESY data from a 15N,H2 enriched protein Deposited 2005-04-08 Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 83–141（59 aa） Fragment：SH3 domain, Residues 83-141
Not recorded No recorded non-water small molecule SOLUTION NMR mmCIF provides none of the parsed conditions Resolution not provided
2DQ7 Crystal Structure of Fyn kinase domain complexed with staurosporine Deposited 2006-05-23 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain X 261–537（277 aa） Fragment：Fyn, Protein kinase
Non-standard monomer：Yes (specific site not provided by mmCIF) STU STAUROSPORINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；277 K；1.15M ammonium sulfate, 0.2M NaCl, 0.1M imidazole, pH 8.0, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 2.80 Å R-free 0.281
2MQI human Fyn SH2 free state Deposited 2014-06-20 Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 148–248（101 aa） Fragment：UNP residues 149-248
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.5；298 K；Ionic strength (raw mmCIF value) 50；Pressure ambient
NMR sample composition 0.8-1.4 mM [U-13C; U-15N] FynSH2, 50 mM sodium phosphate, 5 mM DTT, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
2MRJ Structure of Fyn protein SH2 bound Deposited 2014-07-09 Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 148–248（101 aa） Fragment：UNP residues 149-248
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.5；298 K；Ionic strength (raw mmCIF value) 0；Pressure ambient
NMR sample composition 1 mM [U-99% 13C; U-99% 15N] FynSH2 bound, 93% H2O/7% D2O | 93% H2O/7% D2O
Resolution not provided
2MRK Fyn SH2 domain in complex with the natural inhibitory phosphotyrosine peptide Deposited 2014-07-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 149–248（100 aa） Fragment：UNP residues 149-248
Chain B 528–537（10 aa） Fragment：UNP residues 528-537
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.5；298 K；Ionic strength (raw mmCIF value) 0；Pressure ambient
NMR sample composition 0.93 mM [U-99% 13C; U-99% 15N] protein_1, 1.2 mM protein_2, 93% H2O/7% D2O | 93% H2O/7% D2O
Resolution not provided
3H0F Crystal structure of the human Fyn SH3 R96W mutant Deposited 2009-04-09 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 73–142（70 aa） Fragment：SH3 domain, UNP residues 73-142
Mutation：R96W PG5 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 9.1；277 K；2.0M ammonium sulphate, 2% PEG 400, 0.1M Tris, pH 9.1, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.61 Å R-free 0.282
3H0H human Fyn SH3 domain R96I mutant, crystal form I Deposited 2009-04-09 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 73–142（70 aa） Fragment：SH3 domain, UNP residues 73-142
Mutation：R96I PG4 TETRAETHYLENE GLYCOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.6；291 K；0.5M ammonium sulphate, 0.1M sodium citrate, 1.0M lithium sulphate, pH 5.6, VAPOR DIFFUSION, SITTING DROP, temperature 291K
Resolution 1.76 Å R-free 0.222
3H0I human Fyn SH3 domain R96I mutant, crystal form II Deposited 2009-04-09 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 73–142（70 aa） Fragment：SH3 domain, UNP residues 73-142
Mutation：R96I No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.6；291 K；0.2M ammonium acetate, 0.1M TRIS, 30% v/v MPD, pH 5.6, VAPOR DIFFUSION, SITTING DROP, temperature 291K
Resolution 2.20 Å R-free 0.243
3H0I human Fyn SH3 domain R96I mutant, crystal form II Deposited 2009-04-09 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 73–142（70 aa） Fragment：SH3 domain, UNP residues 73-142
Mutation：R96I No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.6；291 K；0.2M ammonium acetate, 0.1M TRIS, 30% v/v MPD, pH 5.6, VAPOR DIFFUSION, SITTING DROP, temperature 291K
Resolution 2.20 Å R-free 0.243
3UA6 Crystal Structure of the Human Fyn SH3 domain Deposited 2011-10-21 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 81–143（63 aa） Fragment：SH3 domain (UNP residues 81-143)
Not recorded GOL GLYCEROL × 2 FMT FORMIC ACID × 5 NA SODIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；5.5 M sodium formate, 0.1 M MES, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.85 Å R-free 0.246
3UA6 Crystal Structure of the Human Fyn SH3 domain Deposited 2011-10-21 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 81–143（63 aa） Fragment：SH3 domain (UNP residues 81-143)
Not recorded FMT FORMIC ACID × 1 NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；5.5 M sodium formate, 0.1 M MES, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.85 Å R-free 0.246
3UA7 Crystal Structure of the Human Fyn SH3 domain in complex with a peptide from the Hepatitis C virus NS5A-protein Deposited 2011-10-21 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 81–143（63 aa） Fragment：SH3 domain (UNP residues 81-143)
Not recorded GOL GLYCEROL × 1 CL CHLORIDE ION × 1 NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；4 M sodium formate, 10 mM zinc chloride, 0.1 M Tris, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.50 Å R-free 0.231
3UA7 Crystal Structure of the Human Fyn SH3 domain in complex with a peptide from the Hepatitis C virus NS5A-protein Deposited 2011-10-21 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 81–143（63 aa） Fragment：SH3 domain (UNP residues 81-143)
Not recorded ZN ZINC ION × 1 FMT FORMIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；4 M sodium formate, 10 mM zinc chloride, 0.1 M Tris, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.50 Å R-free 0.231
3UA7 Crystal Structure of the Human Fyn SH3 domain in complex with a peptide from the Hepatitis C virus NS5A-protein Deposited 2011-10-21 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 81–143（63 aa） Fragment：SH3 domain (UNP residues 81-143)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；4 M sodium formate, 10 mM zinc chloride, 0.1 M Tris, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.50 Å R-free 0.231
3UA7 Crystal Structure of the Human Fyn SH3 domain in complex with a peptide from the Hepatitis C virus NS5A-protein Deposited 2011-10-21 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain C 81–143（63 aa） Fragment：SH3 domain (UNP residues 81-143)
Not recorded ZN ZINC ION × 1 FMT FORMIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；4 M sodium formate, 10 mM zinc chloride, 0.1 M Tris, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.50 Å R-free 0.231
4D8D Crystal structure of HIV-1 NEF Fyn-SH3 R96W variant Deposited 2012-01-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 84–141（58 aa） Fragment：SRC-HOMOLOGY 3 DOMAIN (UNP Residues 84-141)
Mutation：R96W No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.4；293 K；0.3 M sodium potassium tartrate, 0.5 M bicine buffer , 1cmc D-octylglucopyranoside, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.52 Å R-free 0.238
4D8D Crystal structure of HIV-1 NEF Fyn-SH3 R96W variant Deposited 2012-01-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 84–141（58 aa） Fragment：SRC-HOMOLOGY 3 DOMAIN (UNP Residues 84-141)
Mutation：R96W GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.4；293 K；0.3 M sodium potassium tartrate, 0.5 M bicine buffer , 1cmc D-octylglucopyranoside, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.52 Å R-free 0.238
4EIK Crystal Structure of the Human Fyn SH3 domain in complex with the synthetic peptide VSL12 Deposited 2012-04-05 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 81–143（63 aa） Fragment：SH3 domain (UNP residues 81-143)
Not recorded NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；5.5 M sodium formate, 0.1 M MES, pH 6, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.60 Å R-free 0.195
4U17 Swapped dimer of the human Fyn-SH2 domain Deposited 2014-07-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: Dimeric
Chain A 148–248（101 aa） Fragment：Fyn-SH2 domain (UNP residues 148-248)
Chain C 148–248（101 aa） Fragment：Fyn-SH2 domain (UNP residues 148-248)
Not recorded PO4 PHOSPHATE ION × 5 EDO 1,2-ETHANEDIOL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；50 mM sodium phosphate pH 6.5
Resolution 1.99 Å R-free 0.255
4U17 Swapped dimer of the human Fyn-SH2 domain Deposited 2014-07-15 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: Dimeric
Chain B 148–248（101 aa） Fragment：Fyn-SH2 domain (UNP residues 148-248)
Not recorded PO4 PHOSPHATE ION × 4 EDO 1,2-ETHANEDIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；50 mM sodium phosphate pH 6.5
Resolution 1.99 Å R-free 0.255
4U1P Human Fyn-SH2 domain in complex with a synthetic high-affinity phospho-peptide Deposited 2014-07-16 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: DIMERIC
Chain A 148–248（101 aa） Fragment：Human Fyn-SH2 domain, RESIDUES 148-248
Not recorded 15P POLYETHYLENE GLYCOL (N=34) × 1 NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M MOPS/Na HEPES pH 7.5, 0.12 M monosaccharide mixture, PEG 1000, 12.5%(w/v) PEG 3350 and 12.5%(v/v) MPD
Resolution 1.40 Å R-free 0.188
4ZNX Crystal structure of the Fyn-SH3 domain in complex with the high affinity peptide APP12 Deposited 2015-05-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 84–141（58 aa） Fragment：SH3 DOMAIN, UNP residues 84-141
Chain B 84–141（58 aa） Fragment：SH3 DOMAIN, UNP residues 84-141
Chain C 84–141（58 aa） Fragment：SH3 DOMAIN, UNP residues 84-141
Chain D 84–141（58 aa） Fragment：SH3 DOMAIN, UNP residues 84-141
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；4 M sodium formate, 0.1 M Hepes
Resolution 2.10 Å R-free 0.222
5ZAU Complex of the human FYN SH3 and monobody binder Deposited 2018-02-09 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 85–141（57 aa） Fragment：UNP residues 85-141
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 8；298 K；Ionic strength (raw mmCIF value) 300；Pressure 1
NMR sample composition 1 mM [U-99% 13C; U-99% 15N] FYN SH3 domain, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 1 mM [U-99% 13C; U-99% 15N] Monobody Binder, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 1 mM [U-99% 15N; U-98% 2H] FYN SH3 domain, 1.5 mM Unlabeled Monobody Binder, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 0.2 mM [U-99% 15N] FYN SH3 domain, 1 mM Unlabeled Monobody Binder, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 0.2 mM [U-99% 15N] Monobody Binder, 1 mM Unlabeled FYN SH3 domain, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
6IPY His-tagged Fyn SH3 domain R96I mutant Deposited 2018-11-05 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 82–144（63 aa） Fragment：UNP residues 82-144
Mutation：R96I No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 3.5；295 K；0.1M Citric acid pH 3.5 and 25%(w/v) Polyethylene glycol 3,350
Resolution 1.34 Å R-free 0.201
6IPZ Fyn SH3 domain R96W mutant, crystallized with 18-crown-6 Deposited 2018-11-05 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain Z 82–144（63 aa） Fragment：UNP residues 82-144
Mutation：R96W O4B 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.6；295 K；0.08M Sodium acetate trihydrate pH 4.6, 1.6M Ammonium sulfate, 20%(v/v) Glycerol
Resolution 1.58 Å R-free 0.209
7A2J Crystal structure of the Fyn SH3 domain in space group C21 at pH 7.5 Deposited 2020-08-18 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 83–142（60 aa）
Not recorded NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；4.5M sodium formate, 0.1M Hepes
Resolution 1.50 Å R-free 0.247
7A2J Crystal structure of the Fyn SH3 domain in space group C21 at pH 7.5 Deposited 2020-08-18 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 83–142（60 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；4.5M sodium formate, 0.1M Hepes
Resolution 1.50 Å R-free 0.247
7A2K Crystal structure of the Fyn SH3 domain in space group P1 at pH 7.5 Deposited 2020-08-18 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 83–142（60 aa）
Not recorded NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；4.5M sodium formate, 0.1M Hepes
Resolution 1.50 Å R-free 0.236
7A2K Crystal structure of the Fyn SH3 domain in space group P1 at pH 7.5 Deposited 2020-08-18 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 83–142（60 aa）
Not recorded NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；4.5M sodium formate, 0.1M Hepes
Resolution 1.50 Å R-free 0.236
7A2K Crystal structure of the Fyn SH3 domain in space group P1 at pH 7.5 Deposited 2020-08-18 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain C 83–142（60 aa）
Not recorded NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；4.5M sodium formate, 0.1M Hepes
Resolution 1.50 Å R-free 0.236
7A2K Crystal structure of the Fyn SH3 domain in space group P1 at pH 7.5 Deposited 2020-08-18 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain D 83–142（60 aa）
Not recorded NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；4.5M sodium formate, 0.1M Hepes
Resolution 1.50 Å R-free 0.236
7A2L Crystal structure of the Fyn SH3 domain mutant E129Q in space group C21 at pH 4.0 Deposited 2020-08-18 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 83–142（60 aa）
Mutation：E129Q FMT FORMIC ACID × 2 NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4；298 K；3.5M sodium formate, 0.1M sodium acetate
Resolution 1.90 Å R-free 0.261
7A2L Crystal structure of the Fyn SH3 domain mutant E129Q in space group C21 at pH 4.0 Deposited 2020-08-18 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 83–142（60 aa）
Mutation：E129Q No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4；298 K；3.5M sodium formate, 0.1M sodium acetate
Resolution 1.90 Å R-free 0.261
7A2M Crystal structure of the Fyn SH3 domain A95S-D99T mutant in C21 space group Deposited 2020-08-18 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 83–142（60 aa）
Mutation：A95S D99T NA SODIUM ION × 2 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4；298 K；4.5 M sodium formate, 0.1 sodium acetate
Resolution 1.50 Å R-free 0.255
7A2M Crystal structure of the Fyn SH3 domain A95S-D99T mutant in C21 space group Deposited 2020-08-18 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 83–142（60 aa）
Mutation：A95S D99T NA SODIUM ION × 1 FMT FORMIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4；298 K；4.5 M sodium formate, 0.1 sodium acetate
Resolution 1.50 Å R-free 0.255
7A2N Crystal structure of the Fyn SH3 domain A95S-D99T mutant in space group P21 Deposited 2020-08-18 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 83–142（60 aa）
Mutation：A95S D99T FMT FORMIC ACID × 1 NA SODIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4；298 K；4.5 M sodium formate, 0.1 sodium acetate
Resolution 1.40 Å R-free 0.203
7A2N Crystal structure of the Fyn SH3 domain A95S-D99T mutant in space group P21 Deposited 2020-08-18 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 83–142（60 aa）
Mutation：A95S D99T FMT FORMIC ACID × 2 NA SODIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4；298 K；4.5 M sodium formate, 0.1 sodium acetate
Resolution 1.40 Å R-free 0.203
7A2N Crystal structure of the Fyn SH3 domain A95S-D99T mutant in space group P21 Deposited 2020-08-18 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain C 83–142（60 aa）
Mutation：A95S D99T FMT FORMIC ACID × 3 NA SODIUM ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4；298 K；4.5 M sodium formate, 0.1 sodium acetate
Resolution 1.40 Å R-free 0.203
7A2N Crystal structure of the Fyn SH3 domain A95S-D99T mutant in space group P21 Deposited 2020-08-18 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain D 83–142（60 aa）
Mutation：A95S D99T FMT FORMIC ACID × 3 NA SODIUM ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4；298 K；4.5 M sodium formate, 0.1 sodium acetate
Resolution 1.40 Å R-free 0.203
7A2O Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant at pH 4.5 Deposited 2020-08-18 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 83–142（60 aa）
Mutation：L112V S114N S115T E121L R123H PGE TRIETHYLENE GLYCOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.5；298 K；5% PEG 300, 1.5 ammonium sulfate, 0.1M sodium acetate
Resolution 0.94 Å R-free 0.175
7A2P Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant at pH 5.0 with PEG Deposited 2020-08-18 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 83–143（61 aa）
Mutation：L112V S114N S115T E121L R123H PGE TRIETHYLENE GLYCOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；5% PEG 300, 2.0 ammonium sulfate, 0.1M sodium acetate
Resolution 0.90 Å R-free 0.150
7A2Q Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant at pH 3.0 with PEG Deposited 2020-08-18 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 83–143（61 aa）
Mutation：L112V S114N S115T E121L R123H PG4 TETRAETHYLENE GLYCOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；5% PEG 300, 5 mM beta-cyclodextrin, 2.0 ammonium sulfate, 0.1M sodium citrate
Resolution 0.94 Å R-free 0.161
7A2R Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant at pH 6.0 Deposited 2020-08-18 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 83–143（61 aa）
Mutation：L112V S114N S115T E121L R123H No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；298 K；1.5 ammonium sulfate, 0.1M MES
Resolution 1.05 Å R-free 0.173
7A2S Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant at pH 5.0 Deposited 2020-08-18 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 83–143（61 aa）
Mutation：L112V S114N S115T E121L R123H No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；2.0 ammonium sulfate, 0.1M sodium acetate
Resolution 1.02 Å R-free 0.175
7A2T Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant at pH 4.0 Deposited 2020-08-18 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 83–143（61 aa）
Mutation：L112V S114N S115T E121L R123H ACT ACETATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4；298 K；1 ammonium sulfate, 0.1M sodium acetate
Resolution 1.22 Å R-free 0.203
7A2U Crystal structure of the Fyn SH3 domain L112V-S114N-S115T at pH 4.5 Deposited 2020-08-18 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 83–142（60 aa）
Mutation：L112V S114N S115T ACT ACETATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.5；298 K；1.5 M ammonium sulfate, 0.1 sodium acetate
Resolution 1.70 Å R-free 0.200
7A2V Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E129Q at pH 4.0 Deposited 2020-08-18 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 83–142（60 aa）
Mutation：L112V S114N S115T E129Q No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4；298 K；1.5 M ammonium sulfate, 0.1 sodium acetate
Resolution 1.81 Å R-free 0.220
7A2W Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant in complex with VSL12 at pH 3.0 Deposited 2020-08-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 83–142（60 aa） Fragment：SH3 domain
Mutation：L112V S114N S115T E121L R123H CIT CITRIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 3；298 K；0.5 M ammonium sulfate, 0.1 sodium citrate
Resolution 0.99 Å R-free 0.151
7A2X Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant in complex with VSL12 at pH 5.0 Deposited 2020-08-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 83–142（60 aa） Fragment：SH3 domain
Mutation：L112V S114N S115T E121L R123H No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；0.5 M ammonium sulfate, 0.1 sodium acetate
Resolution 0.92 Å R-free 0.148
7A2Y Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant in complex with VSL12 at pH 4.0 Deposited 2020-08-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 83–142（60 aa） Fragment：SH3 domain
Mutation：L112V S114N S115T E121L R123H No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4；298 K；0.5 M ammonium sulfate, 0.1 sodium acetate
Resolution 0.97 Å R-free 0.146
7A2Z Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant in complex with VSL12 at pH 6.0 Deposited 2020-08-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 83–142（60 aa） Fragment：SH3 domain
Mutation：L112V S114N S115T E121L R123H No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；298 K；1 M ammonium sulfate, 0.1 sodium acetate
Resolution 1.14 Å R-free 0.195
8KDX Tau-S214 Phosphorylation Inhibits Fyn Kinase Interaction and Increases the Decay Time of NMDAR-mediated Current Deposited 2023-08-10 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 85–142（58 aa） Fragment：FynSH3 domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293.15 K；1.2 M Sodium citrate tribasic dehydrated, 0.1 M Tris buffer pH8.5
Resolution 1.01 Å R-free 0.185
9GHK Crystal structure of Fyn SH3 domain/tau 214-220 peptide complex Deposited 2024-08-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 80–143（64 aa）
Chain B 80–143（64 aa）
Not recorded NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M NaCl, 0.4 M NaH2PO4, 1.5 M K2HPO4, 0.1 M imidazole pH 7.5
Resolution 1.42 Å R-free 0.218
9PGZ X-ray crystal structure of SRD42 Deposited 2025-07-08 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric
Chain A 87–141（55 aa）
Not recorded ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；279 K；0.5 M Sodium chloride, 0.01 M Hexadecyltrimethylammonium bromide
Resolution 2.60 Å R-free 0.247

50 other PDB entries and 67 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name FYN_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–275； UniProt 263–537 Author chain B； PDBConstruct 1–275； UniProt 263–537

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

SAXS profile for 10dj

P(r) Distance Distribution P(r) Distribution

P(r) distribution for 10dj
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2. Structure Basics 2. Structure Basics

Entry ID entry_id10dj
Deposition date deposition_date2026-01-13
Structure title titleFyn Kinase Domain-Saracatinib Complex Structure
Keywords keywordsTyrosine-protein kinase Fyn, SIGNALING PROTEIN; SIGNALING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier30.09 Å
Radius of gyration Rg (electron density) rg_electron29.79 Å
Forward intensity I(0) i059690500.00
Molecular weight molecular_weight62615.0 kDa
Excluded volume excluded_volume79104 ų
Envelope volume envelope_volume99015 ų
Hydration-shell volume shell_volume28710 ų
Envelope diameter envelope_diameter109.6 Å
Shell Rg shell_rg35.71 Å
Envelope Rg envelope_rg29.87 Å
Shape Rg shape_rg29.78 Å
Total Rg total_rg30.39 Å
Total atoms total_atoms8756
Residues n_residues546
Spherical-harmonic order n_harmonics20
q range q_range— – 0.5000 Å−1
Data points n_points101
Shell type shell_typedirectional
Solvent electron density solvent_density0.3340 e/ų
Shell contrast contrast_shell0.0300 e/ų
CRYSOL version crysol_version4.1.3
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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax105.3 Å
Rg (real space) rg_real30.24 Å
Rg uncertainty (real space) rg_real_error0.89 Å
I(0) (real space) i0_real5.9690e+07
I(0) uncertainty (real space) i0_real_error9.4310e+05
Rg (reciprocal space) rg_reciprocal30.18 Å
I(0) (reciprocal space) i0_reciprocal59690000.0000
Solution quality estimate total_estimate0.8464
Solution quality rating solution_quality GOOD a GOOD solution
P(r) peaks n_peaks2
Primary peak position r_peak_primary27.8 Å
Skewness Skewness skewness0.408
Kurtosis Kurtosis kurtosis-0.522
Angular range angular_range— – 0.2650 Å−1
Current regularization parameter α current_alpha0.0000
Highest regularization parameter α highest_alpha18590000.0000
Real-space data points n_real_points54
GNOM version gnom_version4.1.3
Quality Criteria quality_criteria AN1: 0.000; Oscil: 0.748; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.778; Smooth: 0.977
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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (3)

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8. Citations (1)

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9. Files and Curves (10)