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10dj

Fyn Kinase Domain-Saracatinib Complex Structure

Method: X-RAY DIFFRACTION D_max: 105.3 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	10dj
deposition_date	2026-01-13
title	Fyn Kinase Domain-Saracatinib Complex Structure
keywords	Tyrosine-protein kinase Fyn, SIGNALING PROTEIN; SIGNALING PROTEIN
method	X-RAY DIFFRACTION

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	30.09 Å
rg_electron	29.79 Å
i0	59690500.00
molecular_weight	62615.0 kDa
excluded_volume	79104 Å³
envelope_volume	99015 Å³
shell_volume	28710 Å³
envelope_diameter	109.6 Å
shell_rg	35.71 Å
envelope_rg	29.87 Å
shape_rg	29.78 Å
total_rg	30.39 Å
total_atoms	8756
n_residues	546
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	105.3 Å
rg_real	30.24 Å
rg_real_error	0.89 Å
i0_real	5.9690e+07
i0_real_error	9.4310e+05
rg_reciprocal	30.18 Å
i0_reciprocal	59690000.0000
total_estimate	0.8464
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	27.8 Å
skewness	0.408
kurtosis	-0.522
angular_range	— – 0.2650 Å⁻¹
current_alpha	0.0000
highest_alpha	18590000.0000
n_real_points	54
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.748; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.778; Smooth: 0.977

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4. Crystallography & Experiment

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5. Entities & Polymer Info (3)

Entity 1 polymer

description	Tyrosine-protein kinase Fyn
formula_weight	32373.2 kDa
ec_number	2.7.10.2
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	A,B
atom_count	9214

VWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENLVDENLYF

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Spodoptera frugiperda

Entity 2 non-polymer

description	N-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-7-[2-(4-METHYLPIPERAZIN-1-YL)ETHOXY]-5-(TETRAHYDRO-2H-PYRAN-4-YLOXY)QUINAZOLIN-4-AMINE
formula_weight	542.0 kDa
src_method	syn
entity_count	2

Entity 3 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	458

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6. Citations (1)

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length_a	79.687 Å
length_b	89.601 Å
length_c	92.010 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	8

space_group	P 21 21 2
int_tables_number	18
crystal_system	—

resolution	2.220 Å
resolution_low	33.850 Å
r_factor	0.2459
r_work	0.2447
r_free	0.2681

fit	/app/data/saxs_computation/0d/10dj/10dj.fit
pddf	/app/data/pr_computation/0d/10dj/10dj.pr.out
profile	/app/data/saxs_computation/0d/10dj/10dj.dat

Fyn Kinase Domain-Saracatinib Complex Structure

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction