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10op

Cryo-EM structure of Sudan Ebolavirus GP bound by three neutralizing antibodies 545S, 523S and 294S

Method: ELECTRON MICROSCOPY D_max: 149.1 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	10op
deposition_date	2026-01-29
title	Cryo-EM structure of Sudan Ebolavirus GP bound by three neutralizing antibodies 545S, 523S and 294S
keywords	SUDV, neutralizing mAbs, VIRAL PROTEIN-IMMUNE SYSTEM complex; VIRAL PROTEIN/IMMUNE SYSTEM
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	50.60 Å
rg_electron	50.39 Å
i0	1637380000.00
molecular_weight	331180.0 kDa
excluded_volume	411490 Å³
envelope_volume	586700 Å³
shell_volume	96280 Å³
envelope_diameter	159.7 Å
shell_rg	54.68 Å
envelope_rg	49.30 Å
shape_rg	50.35 Å
total_rg	50.67 Å
total_atoms	23337
n_residues	2886
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	149.1 Å
rg_real	50.51 Å
rg_real_error	0.80 Å
i0_real	1.6370e+09
i0_real_error	2.7780e+07
rg_reciprocal	50.67 Å
i0_reciprocal	1638000000.0000
total_estimate	0.8409
solution_quality	GOOD a GOOD solution
n_peaks	1
r_peak_primary	62.5 Å
skewness	0.264
kurtosis	-0.396
angular_range	— – 0.1550 Å⁻¹
current_alpha	0.0000
highest_alpha	80180000.0000
n_real_points	32
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.967; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.983; Smooth: 0.044

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4. Crystallography & Experiment

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5. Entities & Polymer Info (9)

Entity 1 polymer

description	Envelope glycoprotein 1
formula_weight	22494.2 kDa
src_method	man
entity_count	3

Polymer

type	polypeptide(L)
strand_id	A,C,E
atom_count	23337

SMPLGVVTNSTLEVTEIDQLVCKDHLASTDQLKSVGLNLEGSGVSTDIPSATKRWGFRSGVPPKVVSYEAGEWAENCYNLEIKKPDGSECLPPPPDGVRGFPRCRYVHKAQGTGPCPGDYAFHKDGAFFLYDRLASTVIYRGVNFAEGVIAFLILAKPKETFLQSPPIREAVNYTENTSSYYATSYLEYEIENFGAQHSTTLFK

Source

organism	Sudan ebolavirus
ncbi_taxonomy_id	186540
host_organism	Homo sapiens

Entity 2 polymer

description	Envelope glycoprotein 2
formula_weight	13982.9 kDa
src_method	man
entity_count	3

Polymer

type	polypeptide(L)
strand_id	B,D,F

KCNPNLHYWTAQEQHNAAGIAWIPYFGPGAEGIYTEGLMHNQNALVCGLRQLANETTQALQLFLRATTELRTYTILNRKAIDFLLRRWGGTCRILGPDCCIEPHDWTKNITDKINQIIHDFI

Source

organism	Sudan ebolavirus
ncbi_taxonomy_id	186540
host_organism	Homo sapiens

Entity 3 polymer

description	545S Heavy Chain
formula_weight	13118.5 kDa
src_method	man
entity_count	3

Polymer

type	polypeptide(L)
strand_id	G,I,K

QVQLQESGPGLVKPSQTLSLTCTVSGGSISRAGSYWSWIRQHPGKGLEWIGYISYSGSTYYNPSLESRVTMSLDTSKSQFSLKLSSVTAADTAVYYCAREDRSGFYGLDVWGQGTTVTVSS

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 4 polymer

description	545S Light Chain
formula_weight	12349.7 kDa
src_method	man
entity_count	3

Polymer

type	polypeptide(L)
strand_id	H,J,L

QSVLTQPSSLSASPGATASLTCTLRSGINVDTYRIYWYQQKPGSPPQYLLRYKSDSDKHQGSGVPSRFSGSKDASANAGILLISGLQSADEADYYCMIWHSGAWVFGGGTKLTVQ

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 5 polymer

description	523S Heavy Chain
formula_weight	13711.2 kDa
src_method	man
entity_count	3

Polymer

type	polypeptide(L)
strand_id	M,O,Q

QVQLVQSGAELKKPGASVKVSCKASGYTFSDHYVHWVRQAPGQGLEWMGRINPNSGGTNYAQRFLGRVTMTRDASISTAYLDLSSLRSDDTAVYYCARSSSSWSGHYYYYMDVWGKGTTVTVSS

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 6 polymer

description	523S Light Chain
formula_weight	11366.5 kDa
src_method	man
entity_count	3

Polymer

type	polypeptide(L)
strand_id	N,P,R

QSVLTQPPSVSAAPGQRVTISCSGSTSNIASNFVSWYQQLPGTAPKLLIYDNHKRPSGIPDRFSGSKSGTSATLGITGLQTGDEADYYCGTWDSSLSAGVFGGGTKVTVL

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 7 polymer

description	294S Heavy Chain
formula_weight	13835.4 kDa
src_method	man
entity_count	3

Polymer

type	polypeptide(L)
strand_id	S,U,W

QVQLQESGPGLVKPSQTLSLTCTVSGGSISSGGYHWSWIRQHPGKGLEWIGNIYYNGRTYYNPSLKSRVTISVDTSENEFSLKLSSVTAADTAVYYCARDRRRPRIGHDYGMDVWGQGTKVIVSS

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 8 polymer

description	294S Light Chain
formula_weight	11787.0 kDa
src_method	man
entity_count	3

Polymer

type	polypeptide(L)
strand_id	T,V,X

DIQMTQSPSSLSASVGDRVTISCRASQSISNFLNWYQQKPGQAPKLLIYTASNLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQIYNTGMYSFGQGTKLEIK

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 9 branched

description	;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ;
formula_weight	910.8 kDa
src_method	man
entity_count	3

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	2.63 Å
resolution_method	—
num_particles	724000

fit	/app/data/saxs_computation/0o/10op/10op.fit
pddf	/app/data/pr_computation/0o/10op/10op.pr.out
profile	/app/data/saxs_computation/0o/10op/10op.dat

Cryo-EM structure of Sudan Ebolavirus GP bound by three neutralizing antibodies 545S, 523S and 294S

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

EM 3D

5. Entities & Polymer Info (9)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

Entity 3 polymer

Polymer

Source

Entity 4 polymer

Polymer

Source

Entity 5 polymer

Polymer

Source

Entity 6 polymer

Polymer

Source

Entity 7 polymer

Polymer

Source

Entity 8 polymer

Polymer

Source

Entity 9 branched

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)