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10tl

Cryo-EM structure of human MOR bound with DAMGO and BMS986187

Method: ELECTRON MICROSCOPY D_max: 89.7 Å Quality: EXCELLENT

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	10tl
deposition_date	2026-02-08
last_revision	2026-05-27
title	Cryo-EM structure of human MOR bound with DAMGO and BMS986187
keywords	analgesics, GPCR, allosteric modulation, MEMBRANE PROTEIN; MEMBRANE PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	28.42 Å
rg_electron	27.24 Å
i0	123878000.00
molecular_weight	63571.0 kDa
excluded_volume	64245 Å³
envelope_volume	110470 Å³
shell_volume	33518 Å³
envelope_diameter	93.0 Å
shell_rg	34.86 Å
envelope_rg	27.32 Å
shape_rg	27.20 Å
total_rg	27.96 Å
total_atoms	4836
n_residues	568
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	89.7 Å
rg_real	28.31 Å
rg_real_error	0.55 Å
i0_real	1.2390e+08
i0_real_error	1.6750e+06
rg_reciprocal	28.35 Å
i0_reciprocal	123900000.0000
total_estimate	0.9074
solution_quality	EXCELLENT a EXCELLENT solution
n_peaks	2
r_peak_primary	32.0 Å
skewness	0.175
kurtosis	-0.575
angular_range	— – 0.2800 Å⁻¹
current_alpha	0.0000
highest_alpha	18250000.0000
n_real_points	57
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.940; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.999; Smooth: 0.972

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4. Crystallography & Experiment

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5. Entities & Polymer Info (4)

Entity 1 polymer

description	Mu-type opioid receptor
formula_weight	43577.8 kDa
mutation	F158W
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	R,F
atom_count	4836

MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIWTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQ

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Spodoptera frugiperda

Entity 2 polymer

description	TYR-DAL-GLY-MEA-ETA
formula_weight	513.6 kDa
src_method	syn
entity_count	2

Polymer

type	polypeptide(L)
strand_id	S,H

YAGFX

Entity 3 non-polymer

description	CHOLESTEROL
formula_weight	386.7 kDa
src_method	syn
entity_count	8

Entity 4 non-polymer

description	3,3,6,6-tetramethyl-9-[4-[(2-methylphenyl)methoxy]phenyl]-4,5,7,9-tetrahydro-2~{H}-xanthene-1,8-dione
formula_weight	470.6 kDa
src_method	syn
entity_count	2

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	3.500 Å
resolution_low	253.200 Å
r_factor	0.4083
r_work	0.4083
r_free	0.4016

resolution	3.50 Å
resolution_method	—
num_particles	101558

fit	/app/data/saxs_computation/0t/10tl/10tl.fit
pddf	/app/data/pr_computation/0t/10tl/10tl.pr.out
profile	/app/data/saxs_computation/0t/10tl/10tl.dat

Cryo-EM structure of human MOR bound with DAMGO and BMS986187

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

EM 3D

5. Entities & Polymer Info (4)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Entity 3 non-polymer

Entity 4 non-polymer

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)