← Back to search
1agn

X-RAY STRUCTURE OF HUMAN SIGMA ALCOHOL DEHYDROGENASE

Method: X-RAY DIFFRACTION
▼

1. Protein Identity and Related Structures Protein Identity & Related Structures

HUMAN SIGMA ALCOHOL DEHYDROGENASE

Homo sapiens

UniProt P40394

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 ZINC ION × 8 ACETATE ION × 7 NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 2 water × 2 Consistent with protein count
2 Protein homooligomer Homooligomer Protein 2 ZINC ION × 8 ACETATE ION × 3 NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 2 water × 2 Consistent with protein count
3 Protein homooligomer Homooligomer Protein 4 ZINC ION × 16 ACETATE ION × 10 NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 water × 4 Consistent with protein count
4 Protein homooligomer Homooligomer Protein 4 ZINC ION × 16 ACETATE ION × 10 NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 water × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
1agn 1agn 1d1s 1d1s 1d1s 1d1t 1d1t 1d1t

8 assemblies

Homotetramer
1agn 1agn 1d1s 1d1t

4 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name ADH7_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–373； UniProt 2–374 Author chain B； PDBConstruct 1–373； UniProt 2–374 Author chain C； PDBConstruct 1–373； UniProt 2–374 Author chain D； PDBConstruct 1–373； UniProt 2–374

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

▼

2. Structure Basics 2. Structure Basics

Entry ID entry_id1agn
Deposition date deposition_date1996-06-04
Structure title titleX-RAY STRUCTURE OF HUMAN SIGMA ALCOHOL DEHYDROGENASE
Keywords keywordsOXIDOREDUCTASE; OXIDOREDUCTASE
Experimental Method methodX-RAY DIFFRACTION
▼

3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1agn__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1agn__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1agn__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）29.60 Å
Rg (electron density)29.63 Å
Total Rg30.11 Å
Atom count5702
Residues746
Excluded volume102700 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1agn__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 1agn__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 1agn__assembly_3__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 1agn__assembly_4__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
▶

4. Crystallography and Experiment 4. Crystallography & Experiment

▶

5. Entities and Polymers Entities & Polymers (5)

▼

6. Fold Classification (SCOP + CATH) 16 domains

SCOP 2.08 (8 domains)

Domain ID domain_idd1agna1
Class classb — All beta proteins
Fold Fold foldb.35 — GroES-like
Superfamily Superfamily superfamilyb.35.1 — GroES-like
Family Family familyb.35.1.2 — Alcohol dehydrogenase-like, N-terminal domain
Domain ID domain_idd1agna2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
Superfamily Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
Family Family familyc.2.1.1 — Alcohol dehydrogenase-like, C-terminal domain
Domain ID domain_idd1agnb1
Class classb — All beta proteins
Fold Fold foldb.35 — GroES-like
Superfamily Superfamily superfamilyb.35.1 — GroES-like
Family Family familyb.35.1.2 — Alcohol dehydrogenase-like, N-terminal domain
Domain ID domain_idd1agnb2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
Superfamily Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
Family Family familyc.2.1.1 — Alcohol dehydrogenase-like, C-terminal domain
Domain ID domain_idd1agnc1
Class classb — All beta proteins
Fold Fold foldb.35 — GroES-like
Superfamily Superfamily superfamilyb.35.1 — GroES-like
Family Family familyb.35.1.2 — Alcohol dehydrogenase-like, N-terminal domain
Domain ID domain_idd1agnc2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
Superfamily Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
Family Family familyc.2.1.1 — Alcohol dehydrogenase-like, C-terminal domain
Domain ID domain_idd1agnd1
Class classb — All beta proteins
Fold Fold foldb.35 — GroES-like
Superfamily Superfamily superfamilyb.35.1 — GroES-like
Family Family familyb.35.1.2 — Alcohol dehydrogenase-like, N-terminal domain
Domain ID domain_idd1agnd2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
Superfamily Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
Family Family familyc.2.1.1 — Alcohol dehydrogenase-like, C-terminal domain

CATH v4.4 (8 domains)

Domain ID domain_id1agnA01
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology180 — Quinone Oxidoreductase; Chain A, domain 1
Homologous superfamily homologous superfamily10 — Medium-chain alcohol dehydrogenases, catalytic domain
Domain ID domain_id1agnA02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
Domain ID domain_id1agnB01
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology180 — Quinone Oxidoreductase; Chain A, domain 1
Homologous superfamily homologous superfamily10 — Medium-chain alcohol dehydrogenases, catalytic domain
Domain ID domain_id1agnB02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
Domain ID domain_id1agnC01
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology180 — Quinone Oxidoreductase; Chain A, domain 1
Homologous superfamily homologous superfamily10 — Medium-chain alcohol dehydrogenases, catalytic domain
Domain ID domain_id1agnC02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
Domain ID domain_id1agnD01
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology180 — Quinone Oxidoreductase; Chain A, domain 1
Homologous superfamily homologous superfamily10 — Medium-chain alcohol dehydrogenases, catalytic domain
Domain ID domain_id1agnD02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
▶

7. Citations (1)