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1bi7

MECHANISM OF G1 CYCLIN DEPENDENT KINASE INHIBITION FROM THE STRUCTURE OF THE CDK6-P16INK4A TUMOR SUPPRESSOR COMPLEX

Method: X-RAY DIFFRACTION D_max: 74.9 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	1bi7
deposition_date	1998-06-22
title	MECHANISM OF G1 CYCLIN DEPENDENT KINASE INHIBITION FROM THE STRUCTURE OF THE CDK6-P16INK4A TUMOR SUPPRESSOR COMPLEX
keywords	;CYCLIN DEPENDENT KINASE, CYCLIN DEPENDENT KINASE INHIBITORY PROTEIN, CDK, INK4, CELL CYCLE, MULTIPLE TUMOR SUPPRESSOR, MTS1, COMPLEX (KINASE-ANTI-ONCOGENE), COMPLEX (KINASE-ANTI-ONCOGENE) complex ;; COMPLEX (KINASE/ANTI-ONCOGENE)
method	X-RAY DIFFRACTION

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	22.88 Å
rg_electron	21.80 Å
i0	32192000.00
molecular_weight	43777.0 kDa
excluded_volume	54901 Å³
envelope_volume	62940 Å³
shell_volume	24112 Å³
envelope_diameter	75.0 Å
shell_rg	28.63 Å
envelope_rg	22.07 Å
shape_rg	21.81 Å
total_rg	22.62 Å
total_atoms	3087
n_residues	394
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	74.9 Å
rg_real	22.82 Å
rg_real_error	0.40 Å
i0_real	3.2190e+07
i0_real_error	4.3050e+05
rg_reciprocal	22.84 Å
i0_reciprocal	32190000.0000
total_estimate	0.8943
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	26.5 Å
skewness	0.277
kurtosis	-0.384
angular_range	— – 0.3450 Å⁻¹
current_alpha	0.0000
highest_alpha	7732000.0000
n_real_points	66
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.876; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.999; Smooth: 0.995

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4. Crystallography & Experiment

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5. Entities & Polymer Info (2)

Entity 1 polymer

description	CYCLIN-DEPENDENT KINASE 6
formula_weight	36987.3 kDa
ec_number	2.7.1.-
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	3087

MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Spodoptera frugiperda

Entity 2 polymer

description	MULTIPLE TUMOR SUPPRESSOR
formula_weight	16555.6 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	B

MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGANPNAPNSYGRRPIQVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAAAGGTRGSNHARIDAAEGPSDIPD

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Escherichia coli

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6. Citations (1)

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length_a	123.100 Å
length_b	123.100 Å
length_c	112.500 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	8

space_group	P 41 2 2
int_tables_number	91
crystal_system	—

resolution	3.400 Å
resolution_low	10.000 Å
r_factor	0.2270
r_work	0.2270
r_free	0.3300

fit	/app/data/saxs_computation/bi/1bi7/1bi7.fit
pddf	/app/data/pr_computation/bi/1bi7/1bi7.pr.out
profile	/app/data/saxs_computation/bi/1bi7/1bi7.dat

MECHANISM OF G1 CYCLIN DEPENDENT KINASE INHIBITION FROM THE STRUCTURE OF THE CDK6-P16INK4A TUMOR SUPPRESSOR COMPLEX

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction

5. Entities & Polymer Info (2)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)