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1g3n

STRUCTURE OF A P18(INK4C)-CDK6-K-CYCLIN TERNARY COMPLEX

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

CYCLIN-DEPENDENT KINASE 6

Homo sapiens

UniProt Q00534

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 CYCLIN-DEPENDENT KINASE 6 INHIBITOR × 1 （P42773） V-CYCLIN × 1 （O40946） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 3 CYCLIN-DEPENDENT KINASE 6 INHIBITOR × 1 （P42773） V-CYCLIN × 1 （O40946） Consistent with protein count
3 Protein heterocomplex Heteromer Protein 4 V-CYCLIN × 2 （O40946） Consistent with protein count
4 Protein heterocomplex Heteromer Protein 4 CYCLIN-DEPENDENT KINASE 6 INHIBITOR × 2 （P42773） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
3nup 3nux 4aua 4ez5 5l2i 5l2s 5l2t 6oql 6oqo 8i0m 9d8u 9pe7

13 assemblies; showing the first 12

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1bi7 1bi8 1blx 1g3n 1g3n 1g3n 1g3n 1jow 1xo2 2euf 2f2c 4tth

12 assemblies

View Construct and Data Evidence
UniProt name CDK6_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–326； UniProt 1–326 Author chain E； PDBConstruct 1–326； UniProt 1–326

CYCLIN-DEPENDENT KINASE 6 INHIBITOR

Homo sapiens

UniProt P42773

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 CYCLIN-DEPENDENT KINASE 6 × 1 （Q00534） V-CYCLIN × 1 （O40946） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 3 CYCLIN-DEPENDENT KINASE 6 × 1 （Q00534） V-CYCLIN × 1 （O40946） Consistent with protein count
4 Protein heterocomplex Heteromer Protein 4 CYCLIN-DEPENDENT KINASE 6 × 2 （Q00534） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1bu9 1mx2 1mx2 1mx4 1mx4 1mx6 1mx6

7 assemblies

Homodimer
1ihb

1 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1g3n 1g3n 1g3n

3 assemblies

View Construct and Data Evidence
UniProt name CDN2C_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–168； UniProt 1–168 Author chain F； PDBConstruct 1–168； UniProt 1–168

V-CYCLIN

Human herpesvirus 8

UniProt O40946

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 CYCLIN-DEPENDENT KINASE 6 × 1 （Q00534） CYCLIN-DEPENDENT KINASE 6 INHIBITOR × 1 （P42773） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 3 CYCLIN-DEPENDENT KINASE 6 × 1 （Q00534） CYCLIN-DEPENDENT KINASE 6 INHIBITOR × 1 （P42773） Consistent with protein count
3 Protein heterocomplex Heteromer Protein 4 CYCLIN-DEPENDENT KINASE 6 × 2 （Q00534） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1g3n 1g3n 1g3n

3 assemblies

View Construct and Data Evidence
UniProt name O40946_HHV8
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C； PDBConstruct 1–257； UniProt 1–257 Author chain G； PDBConstruct 1–257； UniProt 1–257

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1g3n
Deposition date deposition_date2000-10-24
Structure title titleSTRUCTURE OF A P18(INK4C)-CDK6-K-CYCLIN TERNARY COMPLEX
Keywords keywordsCyclin-dependent kinase, INK4 inhibitor, Viral cyclin, cell cycle, signaling protein; cell cycle, signaling protein
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1g3n__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1g3n__assembly_1__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1g3n__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）29.59 Å
Rg (electron density)28.56 Å
Total Rg29.30 Å
Atom count5322
Residues681
Excluded volume95184 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1g3n__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 1g3n__assembly_2__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 1g3n__assembly_3__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 1g3n__assembly_4__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 18 domains

SCOP 2.08 (8 domains)

Domain ID domain_idd1g3na_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.144 — Protein kinase-like (PK-like)
Superfamily Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
Family Family familyd.144.1.7 — Protein kinases, catalytic subunit
Domain ID domain_idd1g3nb_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.211 — beta-hairpin-alpha-hairpin repeat
Superfamily Superfamily superfamilyd.211.1 — Ankyrin repeat
Family Family familyd.211.1.1 — Ankyrin repeat
Domain ID domain_idd1g3nc1
Class classa — All alpha proteins
Fold Fold folda.74 — Cyclin-like
Superfamily Superfamily superfamilya.74.1 — Cyclin-like
Family Family familya.74.1.1 — Cyclin
Domain ID domain_idd1g3nc2
Class classa — All alpha proteins
Fold Fold folda.74 — Cyclin-like
Superfamily Superfamily superfamilya.74.1 — Cyclin-like
Family Family familya.74.1.1 — Cyclin
Domain ID domain_idd1g3ne_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.144 — Protein kinase-like (PK-like)
Superfamily Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
Family Family familyd.144.1.7 — Protein kinases, catalytic subunit
Domain ID domain_idd1g3nf_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.211 — beta-hairpin-alpha-hairpin repeat
Superfamily Superfamily superfamilyd.211.1 — Ankyrin repeat
Family Family familyd.211.1.1 — Ankyrin repeat
Domain ID domain_idd1g3ng1
Class classa — All alpha proteins
Fold Fold folda.74 — Cyclin-like
Superfamily Superfamily superfamilya.74.1 — Cyclin-like
Family Family familya.74.1.1 — Cyclin
Domain ID domain_idd1g3ng2
Class classa — All alpha proteins
Fold Fold folda.74 — Cyclin-like
Superfamily Superfamily superfamilya.74.1 — Cyclin-like
Family Family familya.74.1.1 — Cyclin

CATH v4.4 (10 domains)

Domain ID domain_id1g3nA01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology200 — Phosphorylase Kinase; domain 1
Homologous superfamily homologous superfamily20 — Phosphorylase Kinase; domain 1
Domain ID domain_id1g3nA02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology510 — Transferase(Phosphotransferase); domain 1
Homologous superfamily homologous superfamily10 — Transferase(Phosphotransferase) domain 1
Domain ID domain_id1g3nB00
Class class1 — Mainly Alpha
Architecture architecture25 — Alpha Horseshoe
Topology topology40 — Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homologous superfamily homologous superfamily20 — Ankyrin repeat-containing domain
Domain ID domain_id1g3nC01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology472 — Cyclin A; domain 1
Homologous superfamily homologous superfamily10 — Cyclin-like
Domain ID domain_id1g3nC02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology472 — Cyclin A; domain 1
Homologous superfamily homologous superfamily10 — Cyclin-like
Domain ID domain_id1g3nE01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology200 — Phosphorylase Kinase; domain 1
Homologous superfamily homologous superfamily20 — Phosphorylase Kinase; domain 1
Domain ID domain_id1g3nE02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology510 — Transferase(Phosphotransferase); domain 1
Homologous superfamily homologous superfamily10 — Transferase(Phosphotransferase) domain 1
Domain ID domain_id1g3nF00
Class class1 — Mainly Alpha
Architecture architecture25 — Alpha Horseshoe
Topology topology40 — Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homologous superfamily homologous superfamily20 — Ankyrin repeat-containing domain
Domain ID domain_id1g3nG01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology472 — Cyclin A; domain 1
Homologous superfamily homologous superfamily10 — Cyclin-like
Domain ID domain_id1g3nG02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology472 — Cyclin A; domain 1
Homologous superfamily homologous superfamily10 — Cyclin-like
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7. Citations (1)