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1byg

KINASE DOMAIN OF HUMAN C-TERMINAL SRC KINASE (CSK) IN COMPLEX WITH INHIBITOR STAUROSPORINE

Method: X-RAY DIFFRACTION D_max: 63.6 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	1byg
deposition_date	1998-10-14
title	KINASE DOMAIN OF HUMAN C-TERMINAL SRC KINASE (CSK) IN COMPLEX WITH INHIBITOR STAUROSPORINE
keywords	PROTEIN KINASE, C-TERMINAL SRC KINASE, PHOSPHORYLATION, STAUROSPORINE, TRANSFERASE; TRANSFERASE
method	X-RAY DIFFRACTION

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	19.71 Å
rg_electron	18.66 Å
i0	13339100.00
molecular_weight	28248.0 kDa
excluded_volume	35756 Å³
envelope_volume	41688 Å³
shell_volume	18792 Å³
envelope_diameter	65.4 Å
shell_rg	24.95 Å
envelope_rg	18.98 Å
shape_rg	18.62 Å
total_rg	19.73 Å
total_atoms	1988
n_residues	246
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	63.6 Å
rg_real	19.65 Å
rg_real_error	0.40 Å
i0_real	1.3340e+07
i0_real_error	1.6550e+05
rg_reciprocal	19.66 Å
i0_reciprocal	13340000.0000
total_estimate	0.8074
solution_quality	GOOD a GOOD solution
n_peaks	3
r_peak_primary	24.2 Å
skewness	0.291
kurtosis	-0.320
angular_range	— – 0.4050 Å⁻¹
current_alpha	0.0000
highest_alpha	3862000.0000
n_real_points	72
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.832; Stabil: 0.999; Sysdev: 1.000; Positv: 1.000; Valcen: 0.997; Smooth: 0.000

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4. Crystallography & Experiment

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5. Entities & Polymer Info (3)

Entity 1 polymer

description	PROTEIN (C-TERMINAL SRC KINASE)
formula_weight	31181.9 kDa
ec_number	2.7.1.112
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	2140

MGGSVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHELHL

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Escherichia coli

Entity 2 non-polymer

description	STAUROSPORINE
formula_weight	466.5 kDa
src_method	syn
entity_count	1

Entity 3 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	152

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6. Citations (1)

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length_a	44.490 Å
length_b	120.580 Å
length_c	48.290 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	4

space_group	P 21 21 2
int_tables_number	18
crystal_system	—

resolution	2.400 Å
resolution_low	20.000 Å
r_factor	—
r_work	0.1990
r_free	0.2870

fit	/app/data/saxs_computation/by/1byg/1byg.fit
pddf	/app/data/pr_computation/by/1byg/1byg.pr.out
profile	/app/data/saxs_computation/by/1byg/1byg.dat

KINASE DOMAIN OF HUMAN C-TERMINAL SRC KINASE (CSK) IN COMPLEX WITH INHIBITOR STAUROSPORINE

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction