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1d7p

Crystal structure of the c2 domain of human factor viii at 1.5 a resolution at 1.5 A

Method: X-RAY DIFFRACTION Dmax: 54.7 Å Quality: GOOD
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1. Protein Identity and Related Structures Protein Identity & Related Structures

COAGULATION FACTOR VIII PRECURSOR

Homo sapiens

UniProt P00451

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count Chain M； UniProt 2190–2348 Fragment：C2-DOMAIN Mutation：S2296C SO4 SULFATE ION × 2 CYS CYSTEINE × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；pH 6.5；298 K；AMMONIUM SULFATE, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 298.0K Resolution 1.50 Å R-free 0.215

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 1D7P Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
12JP Structural determination of lipid-bound Factor VIII Deposited 2026-04-08 Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 20–2351（2332 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 3.46 Å
12JV Structural determination of lipid-bound Factor VIII Deposited 2026-04-08 Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 20–2351（2332 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 3.56 Å
1CFG MEMBRANE-BINDING PEPTIDE FROM THE C2 DOMAIN OF FACTOR VIII FORMS AN AMPHIPATHIC STRUCTURE AS DETERMINED BY NMR SPECTROSCOPY Deposited 1994-11-10 Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2322–2343（22 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR mmCIF provides none of the parsed conditions Resolution not provided
1FAC COAGULATION FACTOR VIII, NMR, 1 STRUCTURE Deposited 1996-06-30 Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2322–2342（21 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 4；308.3 K
Resolution not provided
1IQD Human Factor VIII C2 Domain complexed to human monoclonal BO2C11 Fab. Deposited 2001-07-21 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain C 2193–2348（156 aa） Fragment：C-TERMINAL DOMAIN
Mutation：S2296C No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；PEG8000, sodium chloride, HEPES, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.00 Å R-free 0.253
2R7E Crystal Structure Analysis of Coagulation Factor VIII Deposited 2007-09-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 19–760（742 aa） Fragment：residues 19-760
Chain B 1582–2351（770 aa） Fragment：residues 1582-2351
Mutation：F1838S CA CALCIUM ION × 3 CU COPPER (II) ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；8-10% PEG 8000, 0.1M Imidazole, 100-300 mM NaCl, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 3.70 Å R-free 0.347
3CDZ Crystal structure of human factor VIII Deposited 2008-02-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 20–759（740 aa） Fragment：B-domain deleted (UNP residues 20-764)
Chain B 1668–2351（684 aa） Fragment：B-domain deleted (UNP residues 1668-2351)
Not recorded CU COPPER (II) ION × 2 CA CALCIUM ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；298 K；100 mM Tris-HCl, 10% EtOH, 7% PEG 3350, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 3.98 Å R-free 0.327
3HNB Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor Deposited 2009-05-31 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain M 2189–2347（159 aa） Fragment：C2 domain of Factor VIIIa light chain, UNP residues 2189-2347
Not recorded 768 (2R)-1-(2,4-dichlorophenoxy)-3-[(2E)-2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]propan-2-ol × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；2.8M sodium chloride, 0.1M Tris-HCl, 3% glycol, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.15 Å R-free 0.220
3HNY Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor Deposited 2009-06-01 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain M 2189–2347（159 aa） Fragment：factor VIII c2 domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；2.8M sodium chloride, 0.1M Tris-HCl, 3% glycol, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.07 Å R-free 0.201
3HOB Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor Deposited 2009-06-01 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain M 2189–2347（159 aa） Fragment：factor VIII c2 domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；298 K；30.0% PEG 2000, MME 0.15M KBr, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 2.07 Å R-free 0.263
3HOB Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor Deposited 2009-06-01 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2189–2347（159 aa） Fragment：factor VIII c2 domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；298 K；30.0% PEG 2000, MME 0.15M KBr, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 2.07 Å R-free 0.263
3J2Q Model of membrane-bound factor VIII organized in 2D crystals Deposited 2012-12-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 20–764（745 aa） Fragment：UNP residues 20-764
Chain B 1668–2351（684 aa） Fragment：UNP residues 1668-2351
Not recorded CU COPPER (II) ION × 2 CA CALCIUM ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ELECTRON CRYSTALLOGRAPHY mmCIF provides none of the parsed conditions Resolution 15.00 Å
3J2S Membrane-bound factor VIII light chain Deposited 2012-12-21 Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 1710–2351（642 aa） Fragment：UNP residues 1710-2356
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer 20 mM Tris-HCl, 150 mM NaCl, 5mM CaCl2；pH 7.4；20 mM Tris-HCl, 150 mM NaCl, 5mM CaCl2
cryo-EM vitrification conditions Blot for 3.5 seconds before plunging；95 K；Cryogen ETHANE；Blot for 3.5 seconds before plunging into liquid ethane (Vitrobot Mark III)
Resolution 15.00 Å
4BDV CRYSTAL STRUCTURE OF A TRUNCATED B-DOMAIN HUMAN FACTOR VIII Deposited 2012-10-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 20–769（750 aa） Fragment：COAGULATION FACTOR VIII, RESIDUES 20-769,1657-1666
Chain A 1657–1666（10 aa） Fragment：COAGULATION FACTOR VIII, RESIDUES 20-769,1657-1666
Chain B 1667–2351（685 aa） Fragment：RESIDUES 1667-2351
Not recorded ZN ZINC ION × 1 CA CALCIUM ION × 1 EDO 1,2-ETHANEDIOL × 2 CU1 COPPER (I) ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.5；3% PEG550, 0.100 M NACL, 0.100 M TRIS-HCL PH 7.5, 10% ETHANOL
Resolution 3.98 Å R-free 0.246
4KI5 Cystal structure of human factor VIII C2 domain in a ternary complex with murine inhbitory antibodies 3E6 and G99 Deposited 2013-05-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric
Chain M 2190–2351（162 aa） Fragment：C2 domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；28% PEG-1000, 0.15 M sodium acetate, 0.025 M Tris-HCl, 0.05 M NaCl, 0.15 M ammonium nitrate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.47 Å R-free 0.238
4PT6 The discobody: an engineered discoidin domain from factor VIII that binds v 3 integrin with antibody-like affinities Deposited 2014-03-10 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2190–2351（162 aa） Fragment：unp residues 2190-2351
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.252
4PT6 The discobody: an engineered discoidin domain from factor VIII that binds v 3 integrin with antibody-like affinities Deposited 2014-03-10 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 2190–2351（162 aa） Fragment：unp residues 2190-2351
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.252
4XZU Crystal Structure of the Human Factor VIII C2 Domain in Complex with Murine 3E6 Inhibitory Antibody Deposited 2015-02-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain M 2193–2346（154 aa）
Not recorded MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；12-18% PEG 8000, MES, 0-200 mM magnesium chloride
Resolution 2.61 Å R-free 0.267
4XZU Crystal Structure of the Human Factor VIII C2 Domain in Complex with Murine 3E6 Inhibitory Antibody Deposited 2015-02-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain G 2193–2346（154 aa）
Not recorded MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；12-18% PEG 8000, MES, 0-200 mM magnesium chloride
Resolution 2.61 Å R-free 0.267
5K8D Crystal structure of rFVIIIFc Deposited 2016-05-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 20–759（740 aa）
Chain B 1713–2350（638 aa）
Not recorded CA CALCIUM ION × 3 CU COPPER (II) ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.3；297 K；5% Ethanol, 100mM TRIS pH 7.3
Resolution 4.19 Å R-free 0.362
6MF0 Crystal Structure Determination of Human/Porcine Chimera Coagulation Factor VIII Deposited 2018-09-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: monomeric
Chain A 387–761（375 aa） Fragment：UNP residues 1-386 (pig), 387-761 (human), 762-771,1438-1820 (pig), 2039-2351 (human)
Chain A 2039–2351（313 aa） Fragment：UNP residues 1-386 (pig), 387-761 (human), 762-771,1438-1820 (pig), 2039-2351 (human)
Chain B 387–761（375 aa） Fragment：UNP residues 1-386 (pig), 387-761 (human), 762-771,1438-1820 (pig), 2039-2351 (human)
Chain B 2039–2351（313 aa） Fragment：UNP residues 1-386 (pig), 387-761 (human), 762-771,1438-1820 (pig), 2039-2351 (human)
Not recorded CA CALCIUM ION × 2 ZN ZINC ION × 2 CU1 COPPER (I) ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；16% PEG3350, 0.025 M magnesium chloride, 0.025 M HEPES
Resolution 3.20 Å R-free 0.287
6MF0 Crystal Structure Determination of Human/Porcine Chimera Coagulation Factor VIII Deposited 2018-09-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric
Chain A 387–761（375 aa） Fragment：UNP residues 1-386 (pig), 387-761 (human), 762-771,1438-1820 (pig), 2039-2351 (human)
Chain A 2039–2351（313 aa） Fragment：UNP residues 1-386 (pig), 387-761 (human), 762-771,1438-1820 (pig), 2039-2351 (human)
Not recorded CA CALCIUM ION × 1 ZN ZINC ION × 1 CU1 COPPER (I) ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；16% PEG3350, 0.025 M magnesium chloride, 0.025 M HEPES
Resolution 3.20 Å R-free 0.287
6MF2 Improved Model of Human Coagulation Factor VIII Deposited 2018-09-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric
Chain A 19–760（742 aa） Fragment：UNP residues 19-760,1582-2351
Chain A 1582–2351（770 aa） Fragment：UNP residues 19-760,1582-2351
Not recorded CA CALCIUM ION × 1 ZN ZINC ION × 1 CU1 COPPER (I) ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；8-10% PEG8000, 0.1 M imidazole, 100-300 mM sodium chloride
Resolution 3.61 Å R-free 0.284
7K66 Structure of Blood Coagulation Factor VIII in Complex with an Anti-C1 Domain Pathogenic Antibody Inhibitor Deposited 2020-09-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 406–761（356 aa）
Chain A 2039–2351（313 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CU COPPER (II) ION × 1 CA CALCIUM ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.7；293 K；17.5 %(w/v) PEG 1500, 50 mM HEPES (pH 7.7)
Resolution 3.92 Å R-free 0.322
7KBT Factor VIII in complex with the anti-C2 domain antibody, G99 Deposited 2020-10-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 387–761（375 aa）
Chain A 2039–2351（313 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CU COPPER (II) ION × 1 ZN ZINC ION × 1 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；8 - 18% PEG 1500, PEG 6K, or PEG 10K and 50mM malic acid, pH 7.
Resolution 4.15 Å R-free 0.338
8G6I Coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor Deposited 2023-02-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 406–761（356 aa）
Chain A 2039–2351（313 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；150 mM NaCl, 20 mM HEPES pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.23 Å
8TY1 Cryo-EM structure of coagulation factor VIII bound to NB2E9 Deposited 2023-08-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 392–771（380 aa）
Chain A 2039–2351（313 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；20 mM HEPES (pH 7.4) and 150 mM NaCl
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.46 Å
9D5D Crystal Structure of Blood Coagulation Factor VIII C2 Domain Mutant L2251A/L2252A Deposited 2024-08-13 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain M 2191–2351（161 aa） Fragment：C2 domain (UNP residues 2191-2351)
Mutation：L2251A,L2252A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；4 M potassium formate, 0.1 M Bis-Tris propane, pH 9, 2% w/v PEG2000 MME
Resolution 1.83 Å R-free 0.223
9JBV Structure of Engineered Coagulation Factor VIII with Enhanced Secretion and Coagulation Potential Deposited 2024-08-27 Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1–764（764 aa）
Chain A 1659–2351（693 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.3
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.17 Å

25 other PDB entries and 29 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name FA8_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain M； PDBConstruct 1–159； UniProt 2190–2348

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

SAXS profile for 1d7p

P(r) Distance Distribution P(r) Distribution

P(r) distribution for 1d7p
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2. Structure Basics 2. Structure Basics

Entry ID entry_id1d7p
Deposition date deposition_date1999-10-19
Structure title titleCrystal structure of the c2 domain of human factor viii at 1.5 a resolution at 1.5 A
Keywords keywordsBETA SANDWICH, BLOOD CLOTTING; BLOOD CLOTTING
Experimental Method methodX-RAY DIFFRACTION
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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier16.27 Å
Radius of gyration Rg (electron density) rg_electron15.09 Å
Forward intensity I(0) i06685220.00
Molecular weight molecular_weight18450.0 kDa
Excluded volume excluded_volume22948 ų
Envelope volume envelope_volume25312 ų
Hydration-shell volume shell_volume14104 ų
Envelope diameter envelope_diameter53.8 Å
Shell Rg shell_rg21.14 Å
Envelope Rg envelope_rg15.58 Å
Shape Rg shape_rg15.03 Å
Total Rg total_rg16.34 Å
Total atoms total_atoms1291
Residues n_residues159
Spherical-harmonic order n_harmonics20
q range q_range— – 0.5000 Å−1
Data points n_points101
Shell type shell_typedirectional
Solvent electron density solvent_density0.3340 e/ų
Shell contrast contrast_shell0.0300 e/ų
CRYSOL version crysol_version4.1.3
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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax54.7 Å
Rg (real space) rg_real16.16 Å
Rg uncertainty (real space) rg_real_error0.34 Å
I(0) (real space) i0_real6.6850e+06
I(0) uncertainty (real space) i0_real_error7.9720e+04
Rg (reciprocal space) rg_reciprocal16.17 Å
I(0) (reciprocal space) i0_reciprocal6685000.0000
Solution quality estimate total_estimate0.8690
Solution quality rating solution_quality GOOD a GOOD solution
P(r) peaks n_peaks2
Primary peak position r_peak_primary21.0 Å
Skewness Skewness skewness0.177
Kurtosis Kurtosis kurtosis-0.285
Angular range angular_range— – 0.4900 Å−1
Current regularization parameter α current_alpha0.0000
Highest regularization parameter α highest_alpha1254000.0000
Real-space data points n_real_points79
GNOM version gnom_version4.1.3
Quality Criteria quality_criteria AN1: 0.000; Oscil: 0.768; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.998; Smooth: 0.991
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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (5)

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7. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd1d7pm_
Class classb — All beta proteins
Fold Fold foldb.18 — Galactose-binding domain-like
Superfamily Superfamily superfamilyb.18.1 — Galactose-binding domain-like
Family Family familyb.18.1.2 — Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain)

CATH v4.4 (1 domains)

Domain ID domain_id1d7pM00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily260 — Galactose-binding domain-like
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8. Citations (1)

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9. Files and Curves (10)