DEOXYHYPUSINE SYNTHASE
Homo sapiens
State in the Current Structure
| Assembly | Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Associated Components | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|
| 1 | Protein homooligomer Homooligomer Protein × 4 PDB declaration: tetrameric（4） Consistent with protein copy count | Chain A； UniProt 9–369 | Not recorded | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 | X-RAY DIFFRACTION X-ray crystallization conditions：pH 4.5；9.0 MG/ML PROTEIN IN 1.7M PHOSPHATE FINAL PH 4.5 | Resolution 2.20 Å R-free 0.242 |
Other States of the Same Protein in the Database
Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.
| Other PDB | Difference from Current Entry 1DHS | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1RLZ Deoxyhypusine synthase holoenzyme in its high ionic strength, low pH crystal form Deposited 2003-11-26 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
|
Not recorded | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；298 K；1.7M sodium/potassium phosphate, 100mM Hepes (pH 7.5), NAD, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.15 Å R-free 0.245 |
| 1ROZ Deoxyhypusine synthase holoenzyme in its low ionic strength, high pH crystal form Deposited 2003-12-02 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Not recorded | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；Tris-HCl, KCl, NAD, 2-methyl-2,4-pentanediol, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.21 Å R-free 0.200 |
| 1RQD deoxyhypusine synthase holoenzyme in its low ionic strength, high pH crystal form with the inhibitor GC7 bound in the active site Deposited 2003-12-04 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Not recorded | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 GC7 1-GUANIDINIUM-7-AMINOHEPTANE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；Tris-HCl, KCl, NAD, 2-methyl-2,4-pentanediol,1-guanidinium-7-aminoheptane, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 3.00 Å R-free 0.232 |
| 6P4V 1.65 Angstrom ternary complex of Deoxyhypusine synthase with cofactor NAD and spermidine mimic inhibitor GC7 Deposited 2019-05-28 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Not recorded | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 GC7 1-GUANIDINIUM-7-AMINOHEPTANE × 4 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；0.1M TRIS (8.0) AND 65% MPD, VAPOR
DIFFUSION, HANGING DROP, TEMPERATURE 298K
|
Resolution 1.65 Å R-free 0.175 |
| 6PGR Cocomplex structure of Deoxyhypusine synthase with inhibitor 6-BROMO-N-(1H-INDOL-4-YL)-1-BENZOTHIOPHENE-2-CARBOXAMIDE Deposited 2019-06-24 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Not recorded | 8XY 6-bromo-N-(1H-indol-4-yl)-1-benzothiophene-2-carboxamide × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；1.6M SODIUM/POTASSIUM PHOSPHATE (PH
6.8), VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 298K
|
Resolution 1.95 Å R-free 0.194 |
| 6WKZ Cocomplex structure of Deoxyhypusine synthase with inhibitor 6-[(1R)-2-AMINO-1-PHENYLETHYL]-3-(PYRIDIN-3-YL)-4H,5H,6H,7H-THIENO[2,3-C]PYRIDIN-7-ONE Deposited 2020-04-17 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Not recorded | 8Y1 6-[(1R)-2-amino-1-phenylethyl]-3-(pyridin-3-yl)-5,6-dihydrothieno[2,3-c]pyridin-7(4H)-one × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；100mM Hepes (pH 7.0) and 2M sodium/potassium phosphate (pH 5.0)
|
Resolution 2.23 Å R-free 0.200 |
| 6WL6 Cocomplex structure of Deoxyhypusine synthase with inhibitor 6-[(2R)-1-AMINO-4-METHYLPENTAN-2-YL]-3-(PYRIDIN-3-YL)-4H,5H,6H,7H-THIENO[2,3-C]PYRIDIN-7-ONE Deposited 2020-04-18 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Not recorded | 91A 6-[(2R)-1-amino-4-methylpentan-2-yl]-3-(pyridin-3-yl)-5,6-dihydrothieno[2,3-c]pyridin-7(4H)-one × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；100mM Hepes, 2.0M Na/K Phosphate
|
Resolution 2.12 Å R-free 0.194 |
| 6XXH Crystal Structure of Human Deoxyhypusine Synthase in apo form Deposited 2020-01-27 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | BME BETA-MERCAPTOETHANOL × 2 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 ACT ACETATE ION × 2 OXM OXAMIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.52 Å R-free 0.176 |
| 6XXI Crystal Structure of Human Deoxyhypusine Synthase in complex with NAD Deposited 2020-01-27 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | ACT ACETATE ION × 28 EDO 1,2-ETHANEDIOL × 36 NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 BME BETA-MERCAPTOETHANOL × 8 FMT FORMIC ACID × 2 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.68 Å R-free 0.166 |
| 6XXJ Crystal Structure of Human Deoxyhypusine Synthase in complex with spermidine and NAD Deposited 2020-01-27 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | SPD SPERMIDINE × 4 NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 EDO 1,2-ETHANEDIOL × 18 ACT ACETATE ION × 8 BME BETA-MERCAPTOETHANOL × 8 FMT FORMIC ACID × 10 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 OXM OXAMIC ACID × 2 PGE TRIETHYLENE GLYCOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.41 Å R-free 0.160 |
| 6XXK Crystal Structure of Human Deoxyhypusine Synthase in complex with spermidine Deposited 2020-01-27 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | SPD SPERMIDINE × 4 EDO 1,2-ETHANEDIOL × 28 ACT ACETATE ION × 18 BME BETA-MERCAPTOETHANOL × 8 FMT FORMIC ACID × 22 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix, 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.65 Å R-free 0.162 |
| 6XXL Crystal Structure of Human Deoxyhypusine Synthase in complex with spermine Deposited 2020-01-27 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | FMT FORMIC ACID × 2 SPM SPERMINE × 4 EDO 1,2-ETHANEDIOL × 8 OXM OXAMIC ACID × 4 ACT ACETATE ION × 18 BME BETA-MERCAPTOETHANOL × 2 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 3350, PEG 1000), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.69 Å R-free 0.179 |
| 6XXM Crystal Structure of Human Deoxyhypusine Synthase in complex with putrescine Deposited 2020-01-27 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | PUT 1,4-DIAMINOBUTANE × 4 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 3350, PEG 1000), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.67 Å R-free 0.175 |
| 7A6S Crystal Structure of Asn173Ser variant of Human Deoxyhypusine Synthase Deposited 2020-08-26 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Mutation：N173S Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：N173S Non-standard monomer：Yes (specific site not provided by mmCIF) | EDO 1,2-ETHANEDIOL × 14 ACT ACETATE ION × 4 OXM OXAMIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 3350, PEG 1000), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.75 Å R-free 0.199 |
| 7A6T Crystal Structure of Asn173Ser variant of Human Deoxyhypusine Synthase in complex with NAD and spermidine Deposited 2020-08-26 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Mutation：N173S Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：N173S Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 SPD SPERMIDINE × 4 EDO 1,2-ETHANEDIOL × 12 BME BETA-MERCAPTOETHANOL × 2 OXM OXAMIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 3350, PEG 1000), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.66 Å R-free 0.193 |
| 8A0E CryoEM structure of DHS-eIF5A1 complex Deposited 2022-05-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
Chain C
1–369（369 aa）
Chain D
1–369（369 aa）
|
Mutation：K329A Mutation：K329A Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 SPD SPERMIDINE × 3 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 9.3
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.80 Å |
| 8A0F Crystal structure of human deoxyhypusine synthase variant K329A in complex with NAD and SPD Deposited 2022-05-27 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Mutation：K329A Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：K329A Non-standard monomer：Yes (specific site not provided by mmCIF) | SPD SPERMIDINE × 4 EDO 1,2-ETHANEDIOL × 2 NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；Protein (20 mg/ml) mixed with with equal volume of mother liquor:
0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350) and 100mM Tris-Bicine pH 8.5.
conditions based on Morpheus screen.
|
Resolution 1.64 Å R-free 0.178 |
| 8A0G Human deoxyhypusine synthase with trapped transition state Deposited 2022-05-27 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | 13D 1,3-DIAMINOPROPANE × 2 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 SPD SPERMIDINE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；20 mg/ml protein solution was mixed with equal volume of mother liquor consisting of 0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix, PEG 1000, PEG 3350 and 100 mM Tris-Bicine pH 8.5.
|
Resolution 1.84 Å R-free 0.164 |
| 8PVU Cryo-EM structure of DHS-ERK2 complex with 1:1 stoichiometry refined in C1 symmetry Deposited 2023-07-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
Chain C
1–369（369 aa）
Chain D
1–369（369 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.8；50mM Tris-HCl, 200mM NaCl, 3mM 2-mercaptoethanol
cryo-EM vitrification conditions
Cryogen ETHANE；blot time: 2 s, blot force: 0
|
Resolution 3.50 Å |
| 8R3U Crystal structure of DHPS in complex with an inhibitor Deposited 2023-11-10 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain AAA
2–369（368 aa）
Chain BBB
2–369（368 aa）
Chain CCC
2–369（368 aa）
Chain DDD
2–369（368 aa）
|
Not recorded | XTQ 2-[(2~{R})-1-azanyl-4-methyl-pentan-2-yl]-5-pyridin-3-yl-isoquinolin-1-one × 4 EDO 1,2-ETHANEDIOL × 18 DMS DIMETHYL SULFOXIDE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；291 K；20 % w/v PEG 3350, 0.2 M Ammonium chloride
|
Resolution 1.63 Å R-free 0.210 |
| 9ID1 Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00015 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I28 piperazin-1-yl(pyridin-4-yl)methanone × 6 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.62 Å R-free 0.195 |
| 9ID2 Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00019 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1IGQ (4R)-4-phenyl-1,2-thiazolidine 1,1-dioxide × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 EDO 1,2-ETHANEDIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.45 Å R-free 0.207 |
| 9ID3 Human Deoxyhypusine Synthase Fragment Screening Campaign - ligandT00025 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 EDO 1,2-ETHANEDIOL × 8 A1IGP (3-oxidanylazetidin-1-yl)-phenyl-methanone × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.39 Å R-free 0.203 |
| 9ID4 Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00038 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I2A 5-pyrrolidin-1-ylsulfonyl-1~{H}-pyridin-2-one × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.45 Å R-free 0.205 |
| 9ID5 Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00048 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I14 6-chloranyl-3~{H}-1,3-benzoxazol-2-one × 8 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.46 Å R-free 0.205 |
| 9ID6 Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00049 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I20 2-(pyridin-4-ylmethyl)pyrazol-3-amine × 6 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.44 Å R-free 0.218 |
| 9ID7 Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00058 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I13 4-methoxypyridine-2-carboxamide × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.50 Å R-free 0.202 |
| 9ID8 Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00065 covalently linked to the catalytic lysine (K329) Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I3P 2-methyl-1,3-thiazole × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.52 Å R-free 0.204 |
| 9ID9 Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00068 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I2Z 2-methyl-4-(trifluoromethyl)-1~{H}-imidazole × 2 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.60 Å R-free 0.206 |
| 9IDA Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00079 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 UYY 2-methoxybenzamide × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.41 Å R-free 0.218 |
| 9IDB Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00082 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 A1I3D 2-oxidanylidene-1,3-dihydroindole-5-carboxylic acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.46 Å R-free 0.196 |
| 9IDC Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00086 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I17 (2~{R})-1,2,3,4-tetrahydroquinoline-2-carboxamide × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.56 Å R-free 0.215 |
| 9IDD Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00089 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 4 A1I2D 2~{H}-indazole-6-carboxamide × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.45 Å R-free 0.210 |
| 9IDE Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00096 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 A1I2F 3-cyclopropyl-1,2-oxazol-5-amine × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.47 Å R-free 0.200 |
| 9IDF Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00127 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I2O 4-phenyl-1~{H}-1,2,4-triazol-5-one × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.43 Å R-free 0.206 |
| 9IDG Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00128 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 A1I22 2-(trifluoromethyl)-3~{H}-pyridin-6-one × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.46 Å R-free 0.213 |
| 9IDH Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00143 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 9NN 4-(aminomethyl)pyridin-2-amine × 2 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.56 Å R-free 0.207 |
| 9IDI Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00154 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I2S imidazo[1,2-a]pyridin-2-ylmethanamine × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.47 Å R-free 0.222 |
| 9IDJ Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00155 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 PYQ PYROQUILON × 8 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.50 Å R-free 0.225 |
| 9IDK Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00165 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I29 5,6-dihydro-4~{H}-cyclopenta[b]thiophen-2-ylmethanamine × 6 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.60 Å R-free 0.207 |
| 9IDL Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00173 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I2M pyridine-3-sulfonamide × 2 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.50 Å R-free 0.204 |
| 9IDM Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00175 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 OCH QUINOLIN-2(1H)-ONE × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.43 Å R-free 0.201 |
| 9IDN Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00178 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I3A (3~{S})-3-azanyl-1-phenyl-pyrrolidin-2-one × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.43 Å R-free 0.193 |
| 9IDO Human Deoxyhypusine Synthase Fragment Screening Campaign - UNLand VT00188 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I2R 4-(trifluoromethyl)-3~{H}-pyridin-6-one × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.39 Å R-free 0.215 |
| 9IDP Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00190 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I11 2-(2-methylbenzimidazol-1-yl)ethanol × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.54 Å R-free 0.196 |
| 9IDQ Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00193 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I2L 4-methylsulfonylmorpholine × 8 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.39 Å R-free 0.212 |
| 9IDR Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00204 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I19 methyl (3~{R})-1-methyl-5-oxidanylidene-pyrrolidine-3-carboxylate × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.44 Å R-free 0.206 |
| 9IDS Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00210 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I3M 2-methyl-1,2-thiazinane 1,1-dioxide × 2 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.66 Å R-free 0.185 |
| 9IDT Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00213 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I2W (3~{R},5~{S})-3-ethyl-1,2-oxazolidine-5-carboxylic acid × 2 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.33 Å R-free 0.195 |
| 9IDU Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00215 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I2T methyl 3,5-dimethyl-1~{H}-pyrazole-4-carboxylate × 6 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5'
|
Resolution 1.34 Å R-free 0.213 |
| 9IDV Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00216 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 A1IGM 1-methylpyrrole-2-carboxamide × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5'
|
Resolution 1.33 Å R-free 0.205 |
| 9IDW Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00217 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I3E 3,4-dihydroisochromen-1-one × 8 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.34 Å R-free 0.214 |
| 9IDX Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00218 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1IGJ 5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.47 Å R-free 0.218 |
| 9IDY Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00219 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1IGN 1-methyl-1-(phenylmethyl)urea × 2 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.37 Å R-free 0.206 |
| 9IDZ Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00221 Deposited 2025-02-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 2 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 1 2AQ QUINOLIN-2-AMINE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.44 Å R-free 0.214 |
| 9IE0 Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00222 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I3C ~{N}-methyl-~{N}-pyridin-2-yl-ethanamide × 2 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.50 Å R-free 0.196 |
| 9IE1 Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00223 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I2G 2-fluoranyl-~{N},~{N}-dimethyl-benzenesulfonamide × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.35 Å R-free 0.209 |
| 9IE2 Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00224 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 X4P 2-chloropyridine-4-carboxamide × 6 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.39 Å R-free 0.217 |
| 9IE3 Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00228 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I3K 2-methoxypyridine-3-carboxylic acid × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.30 Å R-free 0.203 |
| 9IE4 Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00229 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I3J [1-(phenylmethyl)-1,2,3-triazol-4-yl]methanol × 12 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.34 Å R-free 0.221 |
| 9IE5 Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00230 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I10 4-(4-fluorophenyl)-1~{H}-pyrazol-3-amine × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.43 Å R-free 0.222 |
| 9IE6 Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00234 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I23 (2-phenyl-1~{H}-imidazol-4-yl)methanol × 6 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.66 Å R-free 0.192 |
| 9IE7 Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00236 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I27 methyl pyridazine-4-carboxylate × 6 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.42 Å R-free 0.199 |
| 9IE8 Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00253 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 A1I3R 7-methyl-1-azaspiro[3.5]nonan-2-one × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.56 Å R-free 0.198 |
| 9IE9 Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00254 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I3L 4-pyridin-3-yl-3~{H}-1,3-thiazol-2-one × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.39 Å R-free 0.206 |
| 9IEA Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00257 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I2P ~{N},3,5-trimethyl-1,2-oxazole-4-sulfonamide × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.30 Å R-free 0.253 |
| 9IEB Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00259 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 VSL methyl 4,5,6,7-tetrahydro-2H-indazole-3-carboxylate × 8 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.58 Å R-free 0.221 |
| 9IEC Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00261 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I2N 2-morpholin-4-ylpyridine-3-carbonitrile × 2 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.46 Å R-free 0.213 |
| 9IED Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00268 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I25 4-phenyl-1,3-thiazol-2-amine × 2 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.40 Å R-free 0.204 |
| 9IEE Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00403 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I24 3-azanyl-1-methyl-2,5-dihydropyridin-6-one × 2 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.66 Å R-free 0.187 |
| 9IEF Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00405 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 L3N 1~{H}-quinazoline-2,4-dione × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.46 Å R-free 0.200 |
| 9IEG Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00407 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I3G 8-chloranyl-1,2,3,4-tetrahydroisoquinoline × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.27 Å R-free 0.255 |
| 9IEH Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00409 Deposited 2025-02-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 2 A1I3F (5-chloranylpyrimidin-2-yl)methanamine × 2 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.46 Å R-free 0.218 |
| 9IEI Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00416 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I3H 4,4-dimethyloxane-2,6-dione × 2 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.58 Å R-free 0.193 |
| 9IEJ Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00417 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I2X 3,4-dimethylpyridine × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.90 Å R-free 0.200 |
| 9IEK Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00423 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 A1I3N 4-(1~{H}-imidazol-2-yl)phenol × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.70 Å R-free 0.197 |
| 9IEL Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00424 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I21 isoquinoline-6-carboxylic acid × 2 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.72 Å R-free 0.195 |
| 9IEM Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00427 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1ED2 1-methylpyridin-2-one × 6 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.39 Å R-free 0.204 |
| 9IEN Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00428 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I2E 2-methyl-1,8-naphthyridine-3-carboxylic acid × 2 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.37 Å R-free 0.200 |
| 9IEO Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00438 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I3I 1-[(2~{R})-oxan-2-yl]pyrazole × 6 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.68 Å R-free 0.211 |
| 9IEP Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00440 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 DH6 CINNAMIDE × 2 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.68 Å R-free 0.196 |
| 9IEQ Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00441 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I3O [3-(piperidin-1-ylmethyl)phenyl]methanimine × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.41 Å R-free 0.207 |
| 9IER Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00442 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 A1I3T furo[3,4-c]pyridine-1,3-dione × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.47 Å R-free 0.203 |
| 9IES Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00445 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I12 [4-(aminomethyl)phenyl]-pyrrolidin-1-yl-methanone × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.45 Å R-free 0.211 |
| 9IET Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00446 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I3S 4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.44 Å R-free 0.201 |
| 9IEU Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00447 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I3B (4~{R})-2,2,4-trimethylpyrrolidine × 4 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.45 Å R-free 0.214 |
| 9IEV Human Deoxyhypusine Synthase Fragment Screening Campaign - ligand VT00451 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 A1I2U (2~{S})-~{N}-methylpiperidine-2-carboxamide × 6 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.44 Å R-free 0.204 |
| 9IEX Human Deoxyhypusine Synthase Fragment Screening Campaign - VT0155 follow-up ligand DMP7 Deposited 2025-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–369（369 aa）
Chain B
1–369（369 aa）
Chain C
1–369（369 aa）
Chain D
1–369（369 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | A1I7E 6-[2-oxidanylidene-2-(11-oxidanylidene-1-azatricyclo[6.3.1.0^{4,12}]dodeca-4(12),5,7-trien-6-yl)ethyl]-1-azatricyclo[6.3.1.0^{4,12}]dodeca-4,6,8(12)-trien-11-one × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.025-0.125 mM carboxylic acid mix, 30-60% precipitant mix (MPD, PEG 1000, PEG 3350), 100 mM Tris-Bicine pH = 8.5
|
Resolution 1.95 Å R-free 0.197 |
88 other PDB entries and 88 assemblies. Open the comparison page and filter oligomeric states
View Construct and Data Evidence
| UniProt name | DHYS_HUMAN |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain A； PDBConstruct 1–361； UniProt 9–369 |
