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8pvu

Cryo-EM structure of DHS-ERK2 complex with 1:1 stoichiometry refined in C1 symmetry

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Mitogen-activated protein kinase 1

Homo sapiens

UniProt P28482

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 5 Deoxyhypusine synthase × 4 （P49366） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1pme 1tvo 1wzy 2ojg 2oji 2ojj 3i5z 3i60 3sa0 3w55 4fux 4fuy

151 assemblies; showing the first 12

Homodimer
4qte 8zjv

2 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2y9q 3d42 3d44 3tei 4fmq 4h3p 4h3p 4h3q 4iz5 4iz5 4iz5 4iz5

25 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name MK01_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain E； PDBConstruct 2–361； UniProt 1–360

Deoxyhypusine synthase

Homo sapiens

UniProt P49366

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 5 Mitogen-activated protein kinase 1 × 1 （P28482） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
9idz 9ieh

2 assemblies

Homotetramer
1dhs 1rlz 1roz 1rqd 6p4v 6pgr 6wkz 6wl6 6xxh 6xxi 6xxj 6xxk

85 assemblies; showing the first 12

Other homooligomers

None

Heteromeric or nucleic-acid complex
8a0e 8pvu

2 assemblies

View Construct and Data Evidence
UniProt name DHYS_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain A； PDBConstruct 2–370； UniProt 1–369 Author chain B； PDBConstruct 2–370； UniProt 1–369 Author chain C； PDBConstruct 2–370； UniProt 1–369 Author chain D； PDBConstruct 2–370； UniProt 1–369

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8pvu
Deposition date deposition_date2023-07-18
Structure title titleCryo-EM structure of DHS-ERK2 complex with 1:1 stoichiometry refined in C1 symmetry
Keywords keywordshypusination, transferase, protein-protein interaction, ERK1/2 kinase-independent function, TRANSLATION; TRANSLATION
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8pvu__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8pvu__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8pvu__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）38.16 Å
Rg (electron density)37.49 Å
Total Rg38.04 Å
Atom count12336
Residues1558
Excluded volume220710 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8pvu__assembly_1__model_1 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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7. Citations (1)