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4iz5

Structure of the complex between ERK2 phosphomimetic mutant and PEA-15

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Mitogen-activated protein kinase 1

Homo sapiens

UniProt P28482

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Astrocytic phosphoprotein PEA-15 × 1 （Q15121） ADENOSINE-5'-DIPHOSPHATE × 1 SULFATE ION × 4 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Astrocytic phosphoprotein PEA-15 × 1 （Q15121） ADENOSINE-5'-DIPHOSPHATE × 1 SULFATE ION × 4 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 Astrocytic phosphoprotein PEA-15 × 1 （Q15121） ADENOSINE-5'-DIPHOSPHATE × 1 SULFATE ION × 4 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 Astrocytic phosphoprotein PEA-15 × 1 （Q15121） ADENOSINE-5'-DIPHOSPHATE × 1 SULFATE ION × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1pme 1tvo 1wzy 2ojg 2oji 2ojj 3i5z 3i60 3sa0 3w55 4fux 4fuy

151 assemblies; showing the first 12

Homodimer
4qte 8zjv

2 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2y9q 3d42 3d44 3tei 4fmq 4h3p 4h3p 4h3q 4iz5 4iz5 4iz5 4iz5

25 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name MK01_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 4–356； UniProt 8–360 Author chain B； PDBConstruct 4–356； UniProt 8–360 Author chain C； PDBConstruct 4–356； UniProt 8–360 Author chain D； PDBConstruct 4–356； UniProt 8–360

Astrocytic phosphoprotein PEA-15

Homo sapiens

UniProt Q15121

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Mitogen-activated protein kinase 1 × 1 （P28482） ADENOSINE-5'-DIPHOSPHATE × 1 SULFATE ION × 4 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Mitogen-activated protein kinase 1 × 1 （P28482） ADENOSINE-5'-DIPHOSPHATE × 1 SULFATE ION × 4 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 Mitogen-activated protein kinase 1 × 1 （P28482） ADENOSINE-5'-DIPHOSPHATE × 1 SULFATE ION × 4 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 Mitogen-activated protein kinase 1 × 1 （P28482） ADENOSINE-5'-DIPHOSPHATE × 1 SULFATE ION × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
6p6b 6p6c

2 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
4iz5 4iz5 4iz5 4iz5 4iza

5 assemblies

View Construct and Data Evidence
UniProt name PEA15_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain E； PDBConstruct 4–133； UniProt 1–130 Author chain F； PDBConstruct 4–133； UniProt 1–130 Author chain G； PDBConstruct 4–133； UniProt 1–130 Author chain H； PDBConstruct 4–133； UniProt 1–130

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id4iz5
Deposition date deposition_date2013-01-29
Structure title titleStructure of the complex between ERK2 phosphomimetic mutant and PEA-15
Keywords keywordsMAP Kinase, Death Effector Domain, Transferase; TRANSFERASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4iz5__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4iz5__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4iz5__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）24.03 Å
Rg (electron density)23.09 Å
Total Rg23.96 Å
Atom count3576
Residues433
Excluded volume63712 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4iz5__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 4iz5__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 4iz5__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 4iz5__assembly_4__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 16 domains

SCOP 2.08 (4 domains)

Domain ID domain_idd4iz5a_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.144 — Protein kinase-like (PK-like)
Superfamily Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
Family Family familyd.144.1.7 — Protein kinases, catalytic subunit
Domain ID domain_idd4iz5b_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.144 — Protein kinase-like (PK-like)
Superfamily Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
Family Family familyd.144.1.7 — Protein kinases, catalytic subunit
Domain ID domain_idd4iz5c_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.144 — Protein kinase-like (PK-like)
Superfamily Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
Family Family familyd.144.1.7 — Protein kinases, catalytic subunit
Domain ID domain_idd4iz5d_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.144 — Protein kinase-like (PK-like)
Superfamily Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
Family Family familyd.144.1.7 — Protein kinases, catalytic subunit

CATH v4.4 (12 domains)

Domain ID domain_id4iz5A01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology200 — Phosphorylase Kinase; domain 1
Homologous superfamily homologous superfamily20 — Phosphorylase Kinase; domain 1
Domain ID domain_id4iz5A02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology510 — Transferase(Phosphotransferase); domain 1
Homologous superfamily homologous superfamily10 — Transferase(Phosphotransferase) domain 1
Domain ID domain_id4iz5B01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology200 — Phosphorylase Kinase; domain 1
Homologous superfamily homologous superfamily20 — Phosphorylase Kinase; domain 1
Domain ID domain_id4iz5B02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology510 — Transferase(Phosphotransferase); domain 1
Homologous superfamily homologous superfamily10 — Transferase(Phosphotransferase) domain 1
Domain ID domain_id4iz5C01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology200 — Phosphorylase Kinase; domain 1
Homologous superfamily homologous superfamily20 — Phosphorylase Kinase; domain 1
Domain ID domain_id4iz5C02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology510 — Transferase(Phosphotransferase); domain 1
Homologous superfamily homologous superfamily10 — Transferase(Phosphotransferase) domain 1
Domain ID domain_id4iz5D01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology200 — Phosphorylase Kinase; domain 1
Homologous superfamily homologous superfamily20 — Phosphorylase Kinase; domain 1
Domain ID domain_id4iz5D02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology510 — Transferase(Phosphotransferase); domain 1
Homologous superfamily homologous superfamily10 — Transferase(Phosphotransferase) domain 1
Domain ID domain_id4iz5E00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id4iz5F00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id4iz5G00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id4iz5H00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
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7. Citations (1)