← Back to search

1e1v

HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR NU2058

Method: X-RAY DIFFRACTION D_max: 66.4 Å Quality: GOOD

SAXS Profile

P(r) Distribution

▼

1. Structure Basics

entry_id	1e1v
deposition_date	2000-05-11
title	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR NU2058
keywords	PROTEIN KINASE, CELL CYCLE, PHOSPHORYLATION, CELL DIVISION, MITOSIS, INHIBITION; PROTEIN KINASE
method	X-RAY DIFFRACTION

▼

Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

▼

2. SAXS Parameters (CRYSOL)

rg_guinier	20.29 Å
rg_electron	19.20 Å
i0	17096800.00
molecular_weight	33324.0 kDa
excluded_volume	42621 Å³
envelope_volume	47709 Å³
shell_volume	20663 Å³
envelope_diameter	68.2 Å
shell_rg	25.67 Å
envelope_rg	19.52 Å
shape_rg	19.19 Å
total_rg	20.16 Å
total_atoms	2356
n_residues	290
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

▼

3. P(r) Analysis (GNOM)

dmax	66.4 Å
rg_real	20.21 Å
rg_real_error	0.45 Å
i0_real	1.7100e+07
i0_real_error	2.3590e+05
rg_reciprocal	20.23 Å
i0_reciprocal	17100000.0000
total_estimate	0.8041
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	24.7 Å
skewness	0.270
kurtosis	-0.275
angular_range	— – 0.3900 Å⁻¹
current_alpha	0.0000
highest_alpha	4360000.0000
n_real_points	71
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.818; Stabil: 0.999; Sysdev: 1.000; Positv: 1.000; Valcen: 0.998; Smooth: 0.000

▶

4. Crystallography & Experiment

▶

5. Entities & Polymer Info (3)

Entity 1 polymer

description	CYCLIN-DEPENDENT PROTEIN KINASE 2
formula_weight	34002.5 kDa
ec_number	2.7.1.37
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	2529

XMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL

Source

organism	HOMO SAPIENS
common_name	HUMAN
ncbi_taxonomy_id	9606
host_organism	SPODOPTERA FRUGIPERDA

Entity 2 non-polymer

description	6-O-CYCLOHEXYLMETHYL GUANINE
formula_weight	247.3 kDa
src_method	syn
entity_count	1

Entity 3 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	173

▶

6. Citations (1)

▶

length_a	52.620 Å
length_b	71.050 Å
length_c	71.500 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	4

space_group	P 21 21 21
int_tables_number	19
crystal_system	—

resolution	1.950 Å
resolution_low	25.000 Å
r_factor	—
r_work	0.1950
r_free	0.2690

fit	/app/data/saxs_computation/e1/1e1v/1e1v.fit
pddf	/app/data/pr_computation/e1/1e1v/1e1v.pr.out
profile	/app/data/saxs_computation/e1/1e1v/1e1v.dat

HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR NU2058

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction