1fzd

STRUCTURE OF RECOMBINANT ALPHAEC DOMAIN FROM HUMAN FIBRINOGEN-420

Method: X-RAY DIFFRACTION

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1. 蛋白身份与相关结构 Protein Identity & Related Structures

FIBRINOGEN-420

Homo sapiens

当前结构中的状态

Assembly	物理组成	蛋白状态	分子拷贝数	共同组分	数据核对
1	其他组合	同源多聚体	蛋白 4 其他聚合物 4	;2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ; × 3 ;2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 CALCIUM ION × 4 water × 4	与蛋白数一致
2	其他组合	同源多聚体	蛋白 4 其他聚合物 2	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 2 CALCIUM ION × 4 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 water × 4	与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据

UniProt名称	FIBA_HUMAN
Isoform	—
PDB实体	1
链与序列区间	作者链 A； PDB构建体 1–201； UniProt 666–866 作者链 B； PDB构建体 1–201； UniProt 666–866 作者链 C； PDB构建体 1–201； UniProt 666–866 作者链 D； PDB构建体 1–201； UniProt 666–866 作者链 E； PDB构建体 1–201； UniProt 666–866 作者链 F； PDB构建体 1–201； UniProt 666–866 作者链 G； PDB构建体 1–201； UniProt 666–866 作者链 H； PDB构建体 1–201； UniProt 666–866

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id	1fzd
沉积日期 deposition_date	1998-06-22
结构标题 title	STRUCTURE OF RECOMBINANT ALPHAEC DOMAIN FROM HUMAN FIBRINOGEN-420
关键词 keywords	BLOOD COAGULATION, FIBRINOGEN-420, ALPHAEC DOMAIN, FIBRINOGEN RELATED DOMAIN, GLYCOSYLATED PROTEIN; BLOOD COAGULATION
实验方法 method	X-RAY DIFFRACTION

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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

1fzd__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

1fzd__assembly_2__model_1 | I(q)

100 个绘图点；横轴和纵轴均采用对数尺度。

1fzd__assembly_2__model_1 | P(r) · Pending

P(r) 将按相同 assembly/model 分别计算和展示。

Rg（Guinier）	30.88 Å
Rg（电子密度）	30.27 Å
总 Rg	30.91 Å
原子数	6456
残基数	788
排除体积	111580 Å³
最大 q	0.500 Å⁻¹

Assembly	Model	结构单元	聚集说明	状态	CRYSOL	操作
1	1	`1fzd__assembly_1__model_1`	tetrameric （4）	成功	4.1.3-1-20251215 (887e7ef)	查看下载
2	1	`1fzd__assembly_2__model_1`	tetrameric （4）	成功	4.1.3-1-20251215 (887e7ef)	查看下载

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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (7)

实体 1 Entity 1 polymer

描述 description	FIBRINOGEN-420
分子量 formula_weight	22840.7 kDa
来源方法 src_method	man
拷贝数 entity_count	8

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	A,B,C,D,E,F,G,H
原子数 atom_count	13595

ETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNDEGEGEFWLGNDYLHLLTQRGSVLRVELEDWAGNEAYAEYHFRVGSEAEGYALQVSSYEGTAGDALIEGSVEEGAEYTSHNNMQFSTFDRDADQWEENCAEVYGGGWWYNNCQAANLNGIYYPGGSYDPRNNSPYEIENGVVWVSFRGADYSLRAVRMKIRPLVTQ

来源 Source

来源生物 organism	Homo sapiens
通用名 common_name	human
NCBI 分类编号 ncbi_taxonomy_id	9606
宿主生物 host_organism	Pichia pastoris

实体 2 Entity 2 branched

描述 description	;2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ;
分子量 formula_weight	1114.0 kDa
来源方法 src_method	man
拷贝数 entity_count	3

实体 3 Entity 3 branched

描述 description	;2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ;
分子量 formula_weight	1114.0 kDa
来源方法 src_method	man
拷贝数 entity_count	1

实体 4 Entity 4 branched

描述 description	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
分子量 formula_weight	424.4 kDa
来源方法 src_method	man
拷贝数 entity_count	2

实体 5 Entity 5 non-polymer

描述 description	CALCIUM ION
分子量 formula_weight	40.1 kDa
来源方法 src_method	syn
拷贝数 entity_count	8

实体 6 Entity 6 non-polymer

描述 description	2-acetamido-2-deoxy-beta-D-glucopyranose
分子量 formula_weight	221.2 kDa
来源方法 src_method	man
拷贝数 entity_count	4

实体 7 Entity 7 water

描述 description	water
分子量 formula_weight	18.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	496

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6. 折叠分类 (SCOP + CATH) 24 domains

SCOP 2.08 (8 domains)

结构域编号 domain_id	d1fzda_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.171 — Fibrinogen C-terminal domain-like
超家族 Superfamily superfamily	d.171.1 — Fibrinogen C-terminal domain-like
家族 Family family	d.171.1.1 — Fibrinogen C-terminal domain-like

结构域编号 domain_id	d1fzdb_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.171 — Fibrinogen C-terminal domain-like
超家族 Superfamily superfamily	d.171.1 — Fibrinogen C-terminal domain-like
家族 Family family	d.171.1.1 — Fibrinogen C-terminal domain-like

结构域编号 domain_id	d1fzdc_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.171 — Fibrinogen C-terminal domain-like
超家族 Superfamily superfamily	d.171.1 — Fibrinogen C-terminal domain-like
家族 Family family	d.171.1.1 — Fibrinogen C-terminal domain-like

结构域编号 domain_id	d1fzdd_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.171 — Fibrinogen C-terminal domain-like
超家族 Superfamily superfamily	d.171.1 — Fibrinogen C-terminal domain-like
家族 Family family	d.171.1.1 — Fibrinogen C-terminal domain-like

结构域编号 domain_id	d1fzde_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.171 — Fibrinogen C-terminal domain-like
超家族 Superfamily superfamily	d.171.1 — Fibrinogen C-terminal domain-like
家族 Family family	d.171.1.1 — Fibrinogen C-terminal domain-like

结构域编号 domain_id	d1fzdf_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.171 — Fibrinogen C-terminal domain-like
超家族 Superfamily superfamily	d.171.1 — Fibrinogen C-terminal domain-like
家族 Family family	d.171.1.1 — Fibrinogen C-terminal domain-like

结构域编号 domain_id	d1fzdg_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.171 — Fibrinogen C-terminal domain-like
超家族 Superfamily superfamily	d.171.1 — Fibrinogen C-terminal domain-like
家族 Family family	d.171.1.1 — Fibrinogen C-terminal domain-like

结构域编号 domain_id	d1fzdh_
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.171 — Fibrinogen C-terminal domain-like
超家族 Superfamily superfamily	d.171.1 — Fibrinogen C-terminal domain-like
家族 Family family	d.171.1.1 — Fibrinogen C-terminal domain-like

CATH v4.4 (16 domains)

结构域编号 domain_id	1fzdA01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	90 — Alpha-Beta Complex
拓扑 Topology topology	215 — Gamma Fibrinogen; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Gamma Fibrinogen, chain A, domain 1

结构域编号 domain_id	1fzdA02
类 Class class	4 — Few Secondary Structures
架构 Architecture architecture	10 — Irregular
拓扑 Topology topology	530 — Gamma-fibrinogen Carboxyl Terminal Fragment; domain 2
同源超家族 H-superfamily homologous superfamily	10 — Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2

结构域编号 domain_id	1fzdB01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	90 — Alpha-Beta Complex
拓扑 Topology topology	215 — Gamma Fibrinogen; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Gamma Fibrinogen, chain A, domain 1

结构域编号 domain_id	1fzdB02
类 Class class	4 — Few Secondary Structures
架构 Architecture architecture	10 — Irregular
拓扑 Topology topology	530 — Gamma-fibrinogen Carboxyl Terminal Fragment; domain 2
同源超家族 H-superfamily homologous superfamily	10 — Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2

结构域编号 domain_id	1fzdC01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	90 — Alpha-Beta Complex
拓扑 Topology topology	215 — Gamma Fibrinogen; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Gamma Fibrinogen, chain A, domain 1

结构域编号 domain_id	1fzdC02
类 Class class	4 — Few Secondary Structures
架构 Architecture architecture	10 — Irregular
拓扑 Topology topology	530 — Gamma-fibrinogen Carboxyl Terminal Fragment; domain 2
同源超家族 H-superfamily homologous superfamily	10 — Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2

结构域编号 domain_id	1fzdD01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	90 — Alpha-Beta Complex
拓扑 Topology topology	215 — Gamma Fibrinogen; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Gamma Fibrinogen, chain A, domain 1

结构域编号 domain_id	1fzdD02
类 Class class	4 — Few Secondary Structures
架构 Architecture architecture	10 — Irregular
拓扑 Topology topology	530 — Gamma-fibrinogen Carboxyl Terminal Fragment; domain 2
同源超家族 H-superfamily homologous superfamily	10 — Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2

结构域编号 domain_id	1fzdE01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	90 — Alpha-Beta Complex
拓扑 Topology topology	215 — Gamma Fibrinogen; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Gamma Fibrinogen, chain A, domain 1

结构域编号 domain_id	1fzdE02
类 Class class	4 — Few Secondary Structures
架构 Architecture architecture	10 — Irregular
拓扑 Topology topology	530 — Gamma-fibrinogen Carboxyl Terminal Fragment; domain 2
同源超家族 H-superfamily homologous superfamily	10 — Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2

结构域编号 domain_id	1fzdF01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	90 — Alpha-Beta Complex
拓扑 Topology topology	215 — Gamma Fibrinogen; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Gamma Fibrinogen, chain A, domain 1

结构域编号 domain_id	1fzdF02
类 Class class	4 — Few Secondary Structures
架构 Architecture architecture	10 — Irregular
拓扑 Topology topology	530 — Gamma-fibrinogen Carboxyl Terminal Fragment; domain 2
同源超家族 H-superfamily homologous superfamily	10 — Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2

结构域编号 domain_id	1fzdG01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	90 — Alpha-Beta Complex
拓扑 Topology topology	215 — Gamma Fibrinogen; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Gamma Fibrinogen, chain A, domain 1

结构域编号 domain_id	1fzdG02
类 Class class	4 — Few Secondary Structures
架构 Architecture architecture	10 — Irregular
拓扑 Topology topology	530 — Gamma-fibrinogen Carboxyl Terminal Fragment; domain 2
同源超家族 H-superfamily homologous superfamily	10 — Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2

结构域编号 domain_id	1fzdH01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	90 — Alpha-Beta Complex
拓扑 Topology topology	215 — Gamma Fibrinogen; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Gamma Fibrinogen, chain A, domain 1

结构域编号 domain_id	1fzdH02
类 Class class	4 — Few Secondary Structures
架构 Architecture architecture	10 — Irregular
拓扑 Topology topology	530 — Gamma-fibrinogen Carboxyl Terminal Fragment; domain 2
同源超家族 H-superfamily homologous superfamily	10 — Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2

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晶胞边长 a length_a	71.250 Å
晶胞边长 b length_b	105.180 Å
晶胞边长 c length_c	71.140 Å
晶胞夹角 α angle_alpha	104.60 °
晶胞夹角 β angle_beta	108.95 °
晶胞夹角 γ angle_gamma	71.47 °
晶胞分子数 Z z_pdb	8

空间群 space_group	P 1
空间群编号 int_tables_number	1
晶系 crystal_system	—

分辨率 resolution	2.100 Å
最低分辨率 resolution_low	20.000 Å
R 因子 r_factor	0.1990
R_work r_work	0.1950
R_free r_free	0.2550

STRUCTURE OF RECOMBINANT ALPHAEC DOMAIN FROM HUMAN FIBRINOGEN-420

1. 蛋白身份与相关结构 Protein Identity & Related Structures

FIBRINOGEN-420

当前结构中的状态

数据库中的同蛋白其他状态

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

1fzd__assembly_2__model_1

1fzd__assembly_2__model_1 | I(q)

1fzd__assembly_2__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (7)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

实体 2 Entity 2 branched

实体 3 Entity 3 branched

实体 4 Entity 4 branched

实体 5 Entity 5 non-polymer

实体 6 Entity 6 non-polymer

实体 7 Entity 7 water

6. 折叠分类 (SCOP + CATH) 24 domains

SCOP 2.08 (8 domains)

CATH v4.4 (16 domains)

7. 引用文献 (1)

STRUCTURE OF RECOMBINANT ALPHAEC DOMAIN FROM HUMAN FIBRINOGEN-420

1. 蛋白身份与相关结构 Protein Identity & Related Structures

FIBRINOGEN-420

当前结构中的状态

数据库中的同蛋白其他状态

单体

同源二聚体

同源四聚体

其他同源多聚体

异源或核酸复合物

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

1fzd__assembly_2__model_1

1fzd__assembly_2__model_1 | I(q)

1fzd__assembly_2__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (7)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

实体 2 Entity 2 branched

实体 3 Entity 3 branched

实体 4 Entity 4 branched

实体 5 Entity 5 non-polymer

实体 6 Entity 6 non-polymer

实体 7 Entity 7 water

6. 折叠分类 (SCOP + CATH) 24 domains

SCOP 2.08 (8 domains)

CATH v4.4 (16 domains)

7. 引用文献 (1)