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1gpw

Structural evidence for ammonia tunneling across the (beta/alpha)8 barrel of the imidazole glycerol phosphate synthase bienzyme complex.

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

HISF PROTEIN

THERMOTOGA MARITIMA

UniProt Q9X0C6

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 AMIDOTRANSFERASE HISH × 1 （Q9X0C8） PHOSPHATE ION × 2 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 AMIDOTRANSFERASE HISH × 1 （Q9X0C8） PHOSPHATE ION × 3 water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 AMIDOTRANSFERASE HISH × 1 （Q9X0C8） PHOSPHATE ION × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1vh7 2a0n 2w6r 3og3 4ewn 4fx7 4fx7 4fx7 4fx7 4j9j 5tql 5tql

23 assemblies; showing the first 12

Homodimer
1thf

1 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1gpw 1gpw 1gpw 2lle 2wjz 2wjz 2wjz 3zr4 3zr4 3zr4 6rtz 6ru0

17 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name Q9X0C6
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–253； UniProt 1–253 Author chain C； PDBConstruct 1–253； UniProt 1–253 Author chain E； PDBConstruct 1–253； UniProt 1–253

AMIDOTRANSFERASE HISH

THERMOTOGA MARITIMA

UniProt Q9X0C8

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 HISF PROTEIN × 1 （Q9X0C6） PHOSPHATE ION × 2 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 HISF PROTEIN × 1 （Q9X0C6） PHOSPHATE ION × 3 water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 HISF PROTEIN × 1 （Q9X0C6） PHOSPHATE ION × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1k9v 1kxj 1kxj 6ymu 6ymu 6ymu

6 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1gpw 1gpw 1gpw 2wjz 2wjz 2wjz 3zr4 3zr4 3zr4 6rtz 6ru0 6ru0

16 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name HIS5_THEMA
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–201； UniProt 1–201 Author chain D； PDBConstruct 1–201； UniProt 1–201 Author chain F； PDBConstruct 1–201； UniProt 1–201

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1gpw
Deposition date deposition_date2001-11-12
Structure title titleStructural evidence for ammonia tunneling across the (beta/alpha)8 barrel of the imidazole glycerol phosphate synthase bienzyme complex.
Keywords keywords;LYASE/TRANSFERASE, COMPLEX (LYASE-TRANSFERASE), HISTIDINE BIOSYNTHESIS, GLUTAMINASE, GLUTAMINE AMIDOTRANSFERASE, CYCLASE, AMMONIA CHANNEL, LYASE-TRANSFERASE complex ;; LYASE/TRANSFERASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1gpw__assembly_3__model_1

Assembly 3 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1gpw__assembly_3__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1gpw__assembly_3__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）23.49 Å
Rg (electron density)22.30 Å
Total Rg23.21 Å
Atom count3546
Residues452
Excluded volume63404 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1gpw__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 1gpw__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 1gpw__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 12 domains

SCOP 2.08 (6 domains)

Domain ID domain_idd1gpwa_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.1 — TIM beta/alpha-barrel
Superfamily Superfamily superfamilyc.1.2 — Ribulose-phoshate binding barrel
Family Family familyc.1.2.1 — Histidine biosynthesis enzymes
Domain ID domain_idd1gpwb_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.23 — Flavodoxin-like
Superfamily Superfamily superfamilyc.23.16 — Class I glutamine amidotransferase-like
Family Family familyc.23.16.1 — Class I glutamine amidotransferases (GAT)
Domain ID domain_idd1gpwc_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.1 — TIM beta/alpha-barrel
Superfamily Superfamily superfamilyc.1.2 — Ribulose-phoshate binding barrel
Family Family familyc.1.2.1 — Histidine biosynthesis enzymes
Domain ID domain_idd1gpwd_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.23 — Flavodoxin-like
Superfamily Superfamily superfamilyc.23.16 — Class I glutamine amidotransferase-like
Family Family familyc.23.16.1 — Class I glutamine amidotransferases (GAT)
Domain ID domain_idd1gpwe_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.1 — TIM beta/alpha-barrel
Superfamily Superfamily superfamilyc.1.2 — Ribulose-phoshate binding barrel
Family Family familyc.1.2.1 — Histidine biosynthesis enzymes
Domain ID domain_idd1gpwf_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.23 — Flavodoxin-like
Superfamily Superfamily superfamilyc.23.16 — Class I glutamine amidotransferase-like
Family Family familyc.23.16.1 — Class I glutamine amidotransferases (GAT)

CATH v4.4 (6 domains)

Domain ID domain_id1gpwA00
Class class3 — Alpha Beta
Architecture architecture20 — Alpha-Beta Barrel
Topology topology20 — TIM Barrel
Homologous superfamily homologous superfamily70 — Aldolase class I
Domain ID domain_id1gpwB00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily880 — Class I glutamine amidotransferase (GATase) domain
Domain ID domain_id1gpwC00
Class class3 — Alpha Beta
Architecture architecture20 — Alpha-Beta Barrel
Topology topology20 — TIM Barrel
Homologous superfamily homologous superfamily70 — Aldolase class I
Domain ID domain_id1gpwD00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily880 — Class I glutamine amidotransferase (GATase) domain
Domain ID domain_id1gpwE00
Class class3 — Alpha Beta
Architecture architecture20 — Alpha-Beta Barrel
Topology topology20 — TIM Barrel
Homologous superfamily homologous superfamily70 — Aldolase class I
Domain ID domain_id1gpwF00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily880 — Class I glutamine amidotransferase (GATase) domain
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7. Citations (2)