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1h2n

Factor Inhibiting HIF-1 alpha

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR

HOMO SAPIENS

UniProt Q9NWT6

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 FE (II) ION × 2 2-OXOGLUTARIC ACID × 2 SULFATE ION × 6 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2cgn 2cgo 5op6 7a1l 8ihz 8ii0 9iif 9jtx 9m23

9 assemblies

Homodimer
1h2n 1iz3 1mze 1mze 1mzf 1mzf 1yci 2w0x 2wa3 2wa4 2yc0 2yde

31 assemblies; showing the first 12

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2ilm 2xum 2xum 2y0i 3d8c 3d8c 3p3n 3p3p 4b7e 4b7k 4jaa 4nr1

25 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name HIF1N_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–349； UniProt 1–349

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1h2n
Deposition date deposition_date2002-08-12
Structure title titleFactor Inhibiting HIF-1 alpha
Keywords keywordsTRANSCRIPTION ACTIVATOR, OXIDOREDUCTASE, OXYGENASE, HYPOXIA, HYDROXYLASE; OXIDOREDUCTASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1h2n__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1h2n__assembly_1__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1h2n__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）34.49 Å
Rg (electron density)34.49 Å
Total Rg34.77 Å
Atom count5430
Residues664
Excluded volume95679 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1h2n__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 3 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd1h2na_
Class classb — All beta proteins
Fold Fold foldb.82 — Double-stranded beta-helix
Superfamily Superfamily superfamilyb.82.2 — Clavaminate synthase-like
Family Family familyb.82.2.6 — Hypoxia-inducible factor HIF ihhibitor (FIH1)

CATH v4.4 (2 domains)

Domain ID domain_id1h2nA01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily10 — Jelly Rolls
Domain ID domain_id1h2nA02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology287 — Helix Hairpins
Homologous superfamily homologous superfamily1010 — Clavaminate synthase-like
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7. Citations (1)