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1osf

Human Hsp90 in complex with 17-desmethoxy-17-N,N-Dimethylaminoethylamino-Geldanamycin

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

heat shock 90kDa protein 1, alpha; heat shock 90kD protein 1, alpha

Homo sapiens

UniProt P07900

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 17-DESMETHOXY-17-N,N-DIMETHYLAMINOETHYLAMINO-GELDANAMYCIN × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 2 ACETIC ACID × 2 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1byq 1osf 1uy6 1uy7 1uy8 1uy9 1uyc 1uyd 1uye 1uyf 1uyg 1uyh

406 assemblies; showing the first 12

Homodimer
1yer 2bsm 2bt0 2bt0 2jjc 2qg0 2uwd 2vci 2vcj 2xdl 2ye2 2ye3

101 assemblies; showing the first 12

Homotetramer
3k99

1 assemblies

Other homooligomers
3q6m 3q6n

2 assemblies

Heteromeric or nucleic-acid complex
2k5b 4aif 4aif 4cgq 4cgu 4cgv 4cgv 4cgw 4cgw 6fdp 7krj 7kw7

21 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name HS90A_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–215； UniProt 9–223

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1osf
Deposition date deposition_date2003-03-19
Structure title titleHuman Hsp90 in complex with 17-desmethoxy-17-N,N-Dimethylaminoethylamino-Geldanamycin
Keywords keywordsCELL CYCLE; CELL CYCLE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1osf__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1osf__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1osf__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）18.73 Å
Rg (electron density)17.32 Å
Total Rg18.45 Å
Atom count1763
Residues215
Excluded volume31608 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1osf__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd1osfa_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.122 — ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily Superfamily superfamilyd.122.1 — ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family Family familyd.122.1.1 — Heat shock protein 90, HSP90, N-terminal domain

CATH v4.4 (1 domains)

Domain ID domain_id1osfA00
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology565 — Heat Shock Protein 90
Homologous superfamily homologous superfamily10 — Histidine kinase-like ATPase, C-terminal domain
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7. Citations (1)