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2jjc

Hsp90 alpha ATPase domain with bound small molecule fragment

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

HEAT SHOCK PROTEIN HSP 90-ALPHA

HOMO SAPIENS

UniProt P07900

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 DIMETHYL SULFOXIDE × 2 PYRIMIDIN-2-AMINE × 2 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1byq 1osf 1uy6 1uy7 1uy8 1uy9 1uyc 1uyd 1uye 1uyf 1uyg 1uyh

406 assemblies; showing the first 12

Homodimer
1yer 2bsm 2bt0 2bt0 2jjc 2qg0 2uwd 2vci 2vcj 2xdl 2ye2 2ye3

101 assemblies; showing the first 12

Homotetramer
3k99

1 assemblies

Other homooligomers
3q6m 3q6n

2 assemblies

Heteromeric or nucleic-acid complex
2k5b 4aif 4aif 4cgq 4cgu 4cgv 4cgv 4cgw 4cgw 6fdp 7krj 7kw7

21 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name HS90A_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 5–11； UniProt 9–15 Author chain A； PDBConstruct 12–218； UniProt 17–223

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2jjc
Deposition date deposition_date2008-03-31
Structure title titleHsp90 alpha ATPase domain with bound small molecule fragment
Keywords keywords;HSP90, ATPASE, CHAPERONE, CYTOPLASM, HEAT SHOCK, NUCLEOTIDE-BINDING, ALTERNATIVE SPLICING, ATP-BINDING, PHOSPHOPROTEIN, STRESS RESPONSE ;; CHAPERONE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2jjc__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2jjc__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2jjc__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）23.05 Å
Rg (electron density)21.96 Å
Total Rg22.89 Å
Atom count3286
Residues414
Excluded volume58590 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2jjc__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd2jjca_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.122 — ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily Superfamily superfamilyd.122.1 — ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family Family familyd.122.1.1 — Heat shock protein 90, HSP90, N-terminal domain

CATH v4.4 (1 domains)

Domain ID domain_id2jjcA00
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology565 — Heat Shock Protein 90
Homologous superfamily homologous superfamily10 — Histidine kinase-like ATPase, C-terminal domain
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7. Citations (1)