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1r8q

FULL-LENGTH ARF1-GDP-MG IN COMPLEX WITH BREFELDIN A AND A SEC7 DOMAIN

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

ADP-ribosylation factor 1

Bos taurus

UniProt P84080

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Arno × 1 （Q99418） MAGNESIUM ION × 1 GUANOSINE-3'-MONOPHOSPHATE-5'-DIPHOSPHATE × 1 1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE × 1 ZINC ION × 1 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Arno × 1 （Q99418） MAGNESIUM ION × 1 GUANOSINE-3'-MONOPHOSPHATE-5'-DIPHOSPHATE × 1 1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE × 1 water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 4 Arno × 2 （Q99418） MAGNESIUM ION × 2 GUANOSINE-3'-MONOPHOSPHATE-5'-DIPHOSPHATE × 2 1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE × 2 ZINC ION × 1 water × 4 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 4 Arno × 2 （Q99418） MAGNESIUM ION × 2 GUANOSINE-3'-MONOPHOSPHATE-5'-DIPHOSPHATE × 2 1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE × 2 ZINC ION × 1 water × 4 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 4 Arno × 2 （Q99418） MAGNESIUM ION × 2 GUANOSINE-3'-MONOPHOSPHATE-5'-DIPHOSPHATE × 2 1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE × 2 ZINC ION × 1 water × 4 Consistent with protein count
6 Protein heterocomplex Heteromer Protein 4 Arno × 2 （Q99418） MAGNESIUM ION × 2 GUANOSINE-3'-MONOPHOSPHATE-5'-DIPHOSPHATE × 2 1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE × 2 ZINC ION × 1 water × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1r8q 1r8q 1r8q 1r8q 1r8q 1r8q 1r8s 1r8s 1s9d 4c0a 4c0a 4c0a

13 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name ARF1_BOVIN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–181； UniProt 1–180 Author chain B； PDBConstruct 1–181； UniProt 1–180

Arno

Homo sapiens

UniProt Q99418

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 ADP-ribosylation factor 1 × 1 （P84080） MAGNESIUM ION × 1 GUANOSINE-3'-MONOPHOSPHATE-5'-DIPHOSPHATE × 1 1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE × 1 ZINC ION × 1 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 ADP-ribosylation factor 1 × 1 （P84080） MAGNESIUM ION × 1 GUANOSINE-3'-MONOPHOSPHATE-5'-DIPHOSPHATE × 1 1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE × 1 water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 4 ADP-ribosylation factor 1 × 2 （P84080） MAGNESIUM ION × 2 GUANOSINE-3'-MONOPHOSPHATE-5'-DIPHOSPHATE × 2 1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE × 2 ZINC ION × 1 water × 4 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 4 ADP-ribosylation factor 1 × 2 （P84080） MAGNESIUM ION × 2 GUANOSINE-3'-MONOPHOSPHATE-5'-DIPHOSPHATE × 2 1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE × 2 ZINC ION × 1 water × 4 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 4 ADP-ribosylation factor 1 × 2 （P84080） MAGNESIUM ION × 2 GUANOSINE-3'-MONOPHOSPHATE-5'-DIPHOSPHATE × 2 1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE × 2 ZINC ION × 1 water × 4 Consistent with protein count
6 Protein heterocomplex Heteromer Protein 4 ADP-ribosylation factor 1 × 2 （P84080） MAGNESIUM ION × 2 GUANOSINE-3'-MONOPHOSPHATE-5'-DIPHOSPHATE × 2 1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE × 2 ZINC ION × 1 water × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1pbv 1r8m 4jmi 4jmo 4jwl 4jxh 4l5m 4z21

8 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1r8q 1r8q 1r8q 1r8q 1r8q 1r8q 1r8s 1r8s 1s9d

9 assemblies

View Construct and Data Evidence
UniProt name CYH2_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain E； PDBConstruct 1–203； UniProt 50–252 Author chain F； PDBConstruct 1–203； UniProt 50–252

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1r8q
Deposition date deposition_date2003-10-28
Structure title titleFULL-LENGTH ARF1-GDP-MG IN COMPLEX WITH BREFELDIN A AND A SEC7 DOMAIN
Keywords keywordsPROTEIN TRANSPORT/EXCHANGE FACTOR, PROTEIN TRANSPORT-EXCHANGE FACTOR complex; PROTEIN TRANSPORT/EXCHANGE FACTOR
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1r8q__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1r8q__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1r8q__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）23.94 Å
Rg (electron density)22.99 Å
Total Rg23.82 Å
Atom count3047
Residues370
Excluded volume54225 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1r8q__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 1r8q__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 1r8q__assembly_3__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 1r8q__assembly_4__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
5 1 1r8q__assembly_5__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
6 1 1r8q__assembly_6__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (7)

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6. Fold Classification (SCOP + CATH) 10 domains

SCOP 2.08 (4 domains)

Domain ID domain_idd1r8qa_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.8 — G proteins
Domain ID domain_idd1r8qb_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.8 — G proteins
Domain ID domain_idd1r8qe_
Class classa — All alpha proteins
Fold Fold folda.118 — alpha-alpha superhelix
Superfamily Superfamily superfamilya.118.3 — Sec7 domain
Family Family familya.118.3.1 — Sec7 domain
Domain ID domain_idd1r8qf_
Class classa — All alpha proteins
Fold Fold folda.118 — alpha-alpha superhelix
Superfamily Superfamily superfamilya.118.3 — Sec7 domain
Family Family familya.118.3.1 — Sec7 domain

CATH v4.4 (6 domains)

Domain ID domain_id1r8qA00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id1r8qB00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id1r8qE01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology220 — Annexin V; domain 1
Homologous superfamily homologous superfamily20 —
Domain ID domain_id1r8qE02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology1000 — Arf Nucleotide-binding Site Opener; domain 2
Homologous superfamily homologous superfamily11 — Arf Nucleotide-binding Site Opener,domain 2
Domain ID domain_id1r8qF01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology220 — Annexin V; domain 1
Homologous superfamily homologous superfamily20 —
Domain ID domain_id1r8qF02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology1000 — Arf Nucleotide-binding Site Opener; domain 2
Homologous superfamily homologous superfamily11 — Arf Nucleotide-binding Site Opener,domain 2
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7. Citations (1)