1rwx
;Crystal structure of human caspase-1 in complex with 4-oxo-3-{6-[4-(quinoxalin-2-yloxy)-benzoylamino]-2-thiophen-2-yl-hexanoylamino}-butyric acid ;
SAXS 散射曲线 SAXS Profile
P(r) 距离分布 P(r) Distribution
1. 结构基本信息 1. Structure Basics
| 条目编号 entry_id | 1rwx |
| 沉积日期 deposition_date | 2003-12-17 |
| 结构标题 title | ;Crystal structure of human caspase-1 in complex with 4-oxo-3-{6-[4-(quinoxalin-2-yloxy)-benzoylamino]-2-thiophen-2-yl-hexanoylamino}-butyric acid ; |
| 关键词 keywords | protein-small molecule inhibitor complex, HYDROLASE; HYDROLASE |
| 实验方法 method | X-RAY DIFFRACTION |
2. SAXS 参数 (CRYSOL 理论计算) 2. SAXS Parameters (CRYSOL)
| 回转半径 Rg (Guinier) rg_guinier | 20.11 Å |
| 回转半径 Rg (电子) rg_electron | 18.97 Å |
| 零角强度 I(0) i0 | 17033900.00 |
| 分子量 molecular_weight | 30604.0 kDa |
| 排除体积 excluded_volume | 38131 ų |
| 包络体积 envelope_volume | 46681 ų |
| 水化壳体积 shell_volume | 20252 ų |
| 包络直径 envelope_diameter | 73.1 Å |
| 壳层 Rg shell_rg | 25.94 Å |
| 包络 Rg envelope_rg | 19.89 Å |
| 形状 Rg shape_rg | 18.96 Å |
| 总 Rg total_rg | 20.01 Å |
| 总原子数 total_atoms | 2142 |
| 残基数 n_residues | 266 |
| 球谐函数阶数 n_harmonics | 20 |
| q 范围 q_range | — – 0.5000 Å−1 |
| 数据点数 n_points | 101 |
| 壳层类型 shell_type | directional |
| 溶剂电子密度 solvent_density | 0.3340 e/ų |
| 壳层衬度 contrast_shell | 0.0300 e/ų |
| CRYSOL 版本 crysol_version | 4.1.3 |
3. P(r) 距离分布 (GNOM 反演) 3. P(r) Analysis (GNOM)
| 最大尺寸 Dmax dmax | 66.8 Å |
| Rg (实空间) rg_real | 20.04 Å |
| Rg 误差 (实空间) rg_real_error | 0.51 Å |
| I(0) (实空间) i0_real | 1.7030e+07 |
| I(0) 误差 (实空间) i0_real_error | 2.3300e+05 |
| Rg (倒空间) rg_reciprocal | 20.05 Å |
| I(0) (倒空间) i0_reciprocal | 17030000.0000 |
| 解质量估计 total_estimate | 0.8009 |
| 解质量评级 solution_quality | GOOD a GOOD solution |
| P(r) 峰数 n_peaks | 3 |
| 主峰位置 r_peak_primary | 25.8 Å |
| 偏度 Skewness skewness | 0.259 |
| 峰度 Kurtosis kurtosis | -0.262 |
| 角度范围 angular_range | — – 0.3950 Å−1 |
| 当前正则化参数 α current_alpha | 0.0000 |
| 最高正则化参数 α highest_alpha | 3352000.0000 |
| 实空间数据点数 n_real_points | 71 |
| GNOM 版本 gnom_version | 4.1.3 |
| 质量判据 quality_criteria | AN1: 0.000; Oscil: 0.803; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 1.000; Smooth: 0.000 |
4. 晶体学与实验 4. Crystallography & Experiment
5. 实体与聚合体信息 (4)
6. 折叠分类 (SCOP + CATH) 3 domains
SCOP 2.08 (1 domains)
| 结构域编号 domain_id | d1rwx.1 |
| 类 Class class | c — Alpha and beta proteins (a/b) |
| 折叠类型 Fold fold | c.17 — Caspase-like |
| 超家族 Superfamily superfamily | c.17.1 — Caspase-like |
| 家族 Family family | c.17.1.1 — Caspase catalytic domain |
CATH v4.4 (2 domains)
| 结构域编号 domain_id | 1rwxA00 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 40 — 3-Layer(aba) Sandwich |
| 拓扑 Topology topology | 50 — Rossmann fold |
| 同源超家族 H-superfamily homologous superfamily | 1460 — |
| 结构域编号 domain_id | 1rwxB00 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 30 — 2-Layer Sandwich |
| 拓扑 Topology topology | 70 — Alpha-Beta Plaits |
| 同源超家族 H-superfamily homologous superfamily | 1470 — Caspase-like |