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Structure of human annexin A2 in the presence of calcium ions

Method: X-RAY DIFFRACTION Dmax: 101.9 Å Quality: GOOD
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Annexin A2

Homo sapiens

UniProt P07355

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein homooligomer Homooligomer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count Chain A； UniProt 20–338 Chain B； UniProt 20–338 Mutation：A66E CA CALCIUM ION × 14 X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, calcium acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K Resolution 2.59 Å R-free 0.264

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 1XJL Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1W7B Annexin A2: Does it induce membrane aggregation by a new multimeric state of the protein. Deposited 2004-09-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 0–338（339 aa）
Mutation：YES No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；2.5 M NACL 0.1 M ACETATE PH 4.5 0.2 M LI2SO4
Resolution 1.52 Å R-free 0.240
2HYU Human Annexin A2 with heparin tetrasaccharide bound Deposited 2006-08-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric
Chain A 31–338（308 aa）
Not recorded CA CALCIUM ION × 5 X-RAY DIFFRACTION
X-ray crystallization conditions hanging drop；pH 5；290 K；1,6 hexanediol, pH 5.0, hanging drop, temperature 290K
Resolution 1.86 Å R-free 0.233
2HYV Human Annexin A2 with heparin hexasaccharide bound Deposited 2006-08-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric
Chain A 31–338（308 aa）
Not recorded CA CALCIUM ION × 5 X-RAY DIFFRACTION
X-ray crystallization conditions hanging drop；pH 5；290 K；1,6 hexanediol, pH 5.0, hanging drop, temperature 290K
Resolution 1.42 Å R-free 0.223
2HYW Human Annexin A2 with Calcium bound Deposited 2006-08-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 31–338（308 aa）
Not recorded CA CALCIUM ION × 7 X-RAY DIFFRACTION
X-ray crystallization conditions hanging drop；pH 8.5；290 K；PEG 8000, pH 8.5, hanging drop, temperature 290K
Resolution 2.10 Å R-free 0.257
2HYW Human Annexin A2 with Calcium bound Deposited 2006-08-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 31–338（308 aa）
Not recorded CA CALCIUM ION × 7 X-RAY DIFFRACTION
X-ray crystallization conditions hanging drop；pH 8.5；290 K；PEG 8000, pH 8.5, hanging drop, temperature 290K
Resolution 2.10 Å R-free 0.257
4DRW Crystal Structure of the Ternary Complex between S100A10, an Annexin A2 N-terminal Peptide and an AHNAK Peptide Deposited 2012-02-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 2–16（15 aa） Fragment：UNP P60903 residues 1-93 and UNP P07355 residues 2-16
Chain B 2–16（15 aa） Fragment：UNP P60903 residues 1-93 and UNP P07355 residues 2-16
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；100mM sodium chloride, 200mM magnesium chloride, 50mM sodium cacodylate, 20% PEG 1000, 0.15mM CYMAL-7, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 3.50 Å R-free 0.327
4DRW Crystal Structure of the Ternary Complex between S100A10, an Annexin A2 N-terminal Peptide and an AHNAK Peptide Deposited 2012-02-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric
Chain C 2–16（15 aa） Fragment：UNP P60903 residues 1-93 and UNP P07355 residues 2-16
Chain D 2–16（15 aa） Fragment：UNP P60903 residues 1-93 and UNP P07355 residues 2-16
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；100mM sodium chloride, 200mM magnesium chloride, 50mM sodium cacodylate, 20% PEG 1000, 0.15mM CYMAL-7, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 3.50 Å R-free 0.327
4FTG The crystal structure of an AHNAK peptide in complex with the S100A10/AnxA2 heterotetramer Deposited 2012-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric
Chain C 2–16（15 aa） Fragment：Annexin A2 N-terminal peptide (UNP residues 2-16)
Chain D 2–16（15 aa） Fragment：Annexin A2 N-terminal peptide (UNP residues 2-16)
Mutation：C9S Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：C9S Non-standard monomer：Yes (specific site not provided by mmCIF) IPA ISOPROPYL ALCOHOL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；290 K；20% PEG 8000 (w/v), 0.1 M Tris pH 8.5, 10% 2-propanol, VAPOR DIFFUSION, HANGING DROP, temperature 290K
Resolution 2.51 Å R-free 0.251
4HRH Crystal Structure of p11-Annexin A2(N-terminal) Fusion Protein in Complex with SMARCA3 Peptide Deposited 2012-10-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–16（15 aa）
Chain B 2–16（15 aa）
Not recorded SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；293 K；0.1 M MES, 1.6 M (NH4)2SO4, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 293.0K
Resolution 3.00 Å R-free 0.263
4HRH Crystal Structure of p11-Annexin A2(N-terminal) Fusion Protein in Complex with SMARCA3 Peptide Deposited 2012-10-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 2–16（15 aa）
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；293 K；0.1 M MES, 1.6 M (NH4)2SO4, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 293.0K
Resolution 3.00 Å R-free 0.263
4HRH Crystal Structure of p11-Annexin A2(N-terminal) Fusion Protein in Complex with SMARCA3 Peptide Deposited 2012-10-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 2–16（15 aa）
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；293 K；0.1 M MES, 1.6 M (NH4)2SO4, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 293.0K
Resolution 3.00 Å R-free 0.263
4HRH Crystal Structure of p11-Annexin A2(N-terminal) Fusion Protein in Complex with SMARCA3 Peptide Deposited 2012-10-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Insufficient information Heteromer；Protein × 12 PDB declaration: dodecameric
Chain A 2–16（15 aa）
Chain B 2–16（15 aa）
Not recorded SO4 SULFATE ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；293 K；0.1 M MES, 1.6 M (NH4)2SO4, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 293.0K
Resolution 3.00 Å R-free 0.263
5LPU Crystal structure of Annexin A2 complexed with S100A4 Deposited 2016-08-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 2–339（338 aa）
Chain B 2–339（338 aa）
Mutation：A66E Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：A66E Non-standard monomer：Yes (specific site not provided by mmCIF) CA CALCIUM ION × 14 GOL GLYCEROL × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；296 K；0.1M Bis Tris pH 6.5, 0.2M ammonium acetate 4% PEG4000 and 1,5% glycerol
Resolution 2.10 Å R-free 0.207
5LPX Crystal structure of PKC phosphorylation-mimicking mutant (S26E) Annexin A2 Deposited 2016-08-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2–339（338 aa）
Mutation：S26E, A66E Non-standard monomer：Yes (specific site not provided by mmCIF) CA CALCIUM ION × 5 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；296 K；0.1 M Bis-Tris pH 6, 0.2 M ammonium acetate, 5% PEG 3350
Resolution 1.90 Å R-free 0.182
5LQ0 Crystal structure of Tyr24 phosphorylated Annexin A2 at 2.9 A resolution Deposited 2016-08-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2–339（338 aa）
Mutation：A66E Y24(PTR) Non-standard monomer：Yes (specific site not provided by mmCIF) CA CALCIUM ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；296 K；0.1 M MES pH 6, 0.1 M magnesium chloride, 4% PEG6000
Resolution 2.90 Å R-free 0.260
5LQ0 Crystal structure of Tyr24 phosphorylated Annexin A2 at 2.9 A resolution Deposited 2016-08-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 2–339（338 aa）
Mutation：A66E Y24(PTR) Non-standard monomer：Yes (specific site not provided by mmCIF) CA CALCIUM ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；296 K；0.1 M MES pH 6, 0.1 M magnesium chloride, 4% PEG6000
Resolution 2.90 Å R-free 0.260
5LQ2 Crystal structure of Tyr24 phosphorylated Annexin A2 at 3.4 A resolution Deposited 2016-08-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2–339（338 aa）
Mutation：A66E Y24(PTR) Non-standard monomer：Yes (specific site not provided by mmCIF) CA CALCIUM ION × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；296 K；0.1 M Tris pH 8.5, 10% ethanol
Resolution 3.40 Å R-free 0.234
5LQ2 Crystal structure of Tyr24 phosphorylated Annexin A2 at 3.4 A resolution Deposited 2016-08-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 2–339（338 aa）
Mutation：A66E Y24(PTR) Non-standard monomer：Yes (specific site not provided by mmCIF) CA CALCIUM ION × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；296 K；0.1 M Tris pH 8.5, 10% ethanol
Resolution 3.40 Å R-free 0.234
5N7D MAGI-1 complexed with a RSK1 peptide Deposited 2017-02-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 40–357（318 aa）
Not recorded GOL GLYCEROL × 3 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5；296 K；8% PEG 400, 100 mM acetate buffer
Resolution 2.30 Å R-free 0.227
5N7D MAGI-1 complexed with a RSK1 peptide Deposited 2017-02-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric
Chain B 40–357（318 aa）
Not recorded GOL GLYCEROL × 2 CA CALCIUM ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5；296 K；8% PEG 400, 100 mM acetate buffer
Resolution 2.30 Å R-free 0.227
5N7F MAGI-1 complexed with a pRSK1 peptide Deposited 2017-02-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 40–357（318 aa）
Not recorded GOL GLYCEROL × 3 CA CALCIUM ION × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；296 K；14% PEG 8000, 200 mM MgCl2, 100 mM TRIS
Resolution 2.30 Å R-free 0.240
5N7F MAGI-1 complexed with a pRSK1 peptide Deposited 2017-02-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric
Chain B 40–357（318 aa）
Not recorded GOL GLYCEROL × 3 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；296 K；14% PEG 8000, 200 mM MgCl2, 100 mM TRIS
Resolution 2.30 Å R-free 0.240
5N7G MAGI-1 complexed with a synthetic pRSK1 peptide Deposited 2017-02-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 22–339（318 aa）
Not recorded GOL GLYCEROL × 3 CA CALCIUM ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；296 K；14% PEG 8000, 200 mM MgCl2, 100 mM TRIS
Resolution 2.95 Å R-free 0.264
5N7G MAGI-1 complexed with a synthetic pRSK1 peptide Deposited 2017-02-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric
Chain B 22–339（318 aa）
Not recorded GOL GLYCEROL × 2 CA CALCIUM ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；296 K；14% PEG 8000, 200 mM MgCl2, 100 mM TRIS
Resolution 2.95 Å R-free 0.264
6T58 Structure determination of the transactivation domain of p53 in complex with S100A4 using annexin A2 as a crystallization chaperone Deposited 2019-10-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric
Chain A 29–339（311 aa）
Mutation：A280E,A280E,A280E,A280E GOL GLYCEROL × 2 CA CALCIUM ION × 10 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；0.12 M Alcohols 0.1 M Sodium HEPES; MOPS (acid) pH7.5 20% v/v Ethylene glycol; 10 % w/v PEG 8000 Morpheus D6
Resolution 3.10 Å R-free 0.272
6T58 Structure determination of the transactivation domain of p53 in complex with S100A4 using annexin A2 as a crystallization chaperone Deposited 2019-10-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric
Chain B 29–339（311 aa）
Mutation：A280E,A280E,A280E,A280E GOL GLYCEROL × 2 CA CALCIUM ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；0.12 M Alcohols 0.1 M Sodium HEPES; MOPS (acid) pH7.5 20% v/v Ethylene glycol; 10 % w/v PEG 8000 Morpheus D6
Resolution 3.10 Å R-free 0.272
6TWQ MAGI1_2 complexed with a 16E6 peptide Deposited 2020-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 22–339（318 aa）
Not recorded CIT CITRIC ACID × 2 GOL GLYCEROL × 1 CA CALCIUM ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；296 K；22% PEG3000, 100 mM Na-citrate (pH 5.5), 100 mM Na-citrate
Resolution 2.65 Å R-free 0.262
6TWQ MAGI1_2 complexed with a 16E6 peptide Deposited 2020-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 22–339（318 aa）
Not recorded CIT CITRIC ACID × 1 GOL GLYCEROL × 1 CA CALCIUM ION × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；296 K；22% PEG3000, 100 mM Na-citrate (pH 5.5), 100 mM Na-citrate
Resolution 2.65 Å R-free 0.262
6TWU MAGI1_2 complexed with a phosphomimetic 16E6 peptide Deposited 2020-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric
Chain A 40–357（318 aa）
Not recorded GOL GLYCEROL × 2 CIT CITRIC ACID × 1 CA CALCIUM ION × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；296 K；22% PEG3000, 100mM Na-citrate (pH5.5), 100mM Na-citrate
Resolution 2.40 Å R-free 0.255
6TWU MAGI1_2 complexed with a phosphomimetic 16E6 peptide Deposited 2020-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 40–357（318 aa）
Not recorded GOL GLYCEROL × 1 CIT CITRIC ACID × 2 CA CALCIUM ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；296 K；22% PEG3000, 100mM Na-citrate (pH5.5), 100mM Na-citrate
Resolution 2.40 Å R-free 0.255
6TWX MAGI1_2 complexed with a phosphorylated 16E6 peptide Deposited 2020-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 22–339（318 aa）
Not recorded GOL GLYCEROL × 1 CIT CITRIC ACID × 1 CA CALCIUM ION × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；296 K；22% PEG3000, 100mM Na-citrate (5.5), 100mM Na-citrate
Resolution 2.30 Å R-free 0.259
6TWX MAGI1_2 complexed with a phosphorylated 16E6 peptide Deposited 2020-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 22–339（318 aa）
Not recorded GOL GLYCEROL × 1 CIT CITRIC ACID × 2 CA CALCIUM ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；296 K；22% PEG3000, 100mM Na-citrate (5.5), 100mM Na-citrate
Resolution 2.30 Å R-free 0.259
6TWY MAGI1_2 complexed with a phosphomimetic RSK1 peptide Deposited 2020-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric
Chain A 40–357（318 aa）
Not recorded GOL GLYCEROL × 2 CIT CITRIC ACID × 1 CA CALCIUM ION × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；296 K；22% PEG3000, 100mM Na-citrate (pH 5.5), 100mM Na-citrate
Resolution 2.30 Å R-free 0.250
6TWY MAGI1_2 complexed with a phosphomimetic RSK1 peptide Deposited 2020-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 40–357（318 aa）
Not recorded GOL GLYCEROL × 1 CIT CITRIC ACID × 2 CA CALCIUM ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；296 K；22% PEG3000, 100mM Na-citrate (pH 5.5), 100mM Na-citrate
Resolution 2.30 Å R-free 0.250
7DTO Human Annexin A2 with C132-C261 intramolecular disulfide bond Deposited 2021-01-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 31–339（309 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 6.5；289 K；13% PEG 550 MME, 0.1 M Bis-Tris pH 6.5, 50 mM NaCl
Resolution 2.80 Å R-free 0.223
7EQ7 Co-Crystal Structure Analysis of Annexin A2 and 5alpha-EAL Deposited 2021-04-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1–339（339 aa）
Not recorded CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 7；293 K；100 mM Tris, 20% PEG3350, 0.2 M sodium acetate
Resolution 2.11 Å R-free 0.251
7NMI Transactivation domain of p53 in complex with S100P, using annexin A2 as crystallization chaperone Deposited 2021-02-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 29–339（311 aa）
Mutation：A238E GOL GLYCEROL × 1 CA CALCIUM ION × 9 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；Morpheus screen (MD) H6 0.1 M Amino acids, 0.1 M Buffer System 2, pH 7.5, 30 % v/v Precipitant Mix 2
Resolution 2.10 Å R-free 0.228
7P70 The PDZ-domain of SNTB1 complexed with the PDZ-binding motif of HPV35-E6 Deposited 2021-07-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 22–339（318 aa）
Not recorded CA CALCIUM ION × 5 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；20% polyethylene glycol 3350, 200 mM sodium malonate buffered at pH 7.0
Resolution 2.00 Å R-free 0.209
7P71 The PDZ domain of MAGI1_2 complexed with the PDZ-binding motif of HPV35-E6 Deposited 2021-07-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 22–339（318 aa）
Not recorded CA CALCIUM ION × 4 GOL GLYCEROL × 3 CIT CITRIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；20-25% polyethylene glycol 3000, 100 mM sodium citrate buffered at pH 5.5 and 100 mM trisodium-citrate
Resolution 2.60 Å R-free 0.281
7P71 The PDZ domain of MAGI1_2 complexed with the PDZ-binding motif of HPV35-E6 Deposited 2021-07-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 22–339（318 aa）
Not recorded CA CALCIUM ION × 4 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；20-25% polyethylene glycol 3000, 100 mM sodium citrate buffered at pH 5.5 and 100 mM trisodium-citrate
Resolution 2.60 Å R-free 0.281
7P72 The PDZ domain of SNX27 complexed with the PDZ-binding motif of MERS-E Deposited 2021-07-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 22–339（318 aa）
Not recorded CA CALCIUM ION × 5 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；10% polyethylene glycol 8000, 100 mM imidazole buffered at pH 8.0
Resolution 2.15 Å R-free 0.240
7P73 The PDZ domain of SYNJ2BP complexed with the PDZ-binding motif of HTLV1-TAX1 Deposited 2021-07-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 23–339（317 aa）
Not recorded CA CALCIUM ION × 7 GOL GLYCEROL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；120mM Monosaccharides, 100mM Buffer System 3 pH 8.5, 50 % Precipitant Mix 2 (F10 Morpheus)
Resolution 1.85 Å R-free 0.192
7P74 The PDZ domain of SYNJ2BP complexed with the phosphorylated PDZ-binding motif of RSK1 Deposited 2021-07-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 22–339（318 aa）
Not recorded CA CALCIUM ION × 4 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；100mM ammonium sulfate, 100mM sodium formate, 25% PEG smear broad
Resolution 1.90 Å R-free 0.211
7PC3 The second PDZ domain of DLG1 complexed with the PDZ-binding motif of HTLV1-TAX1 Deposited 2021-08-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 29–339（311 aa）
Not recorded CA CALCIUM ION × 4 GOL GLYCEROL × 4 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M Lithium sulfate, 0.1 M bis-Tris pH 5.5, 25% w/v PEG 3350
Resolution 1.95 Å R-free 0.201
7PC4 The PDZ domain of SNTB1 complexed with the PDZ-binding motif of HTLV1-TAX1 Deposited 2021-08-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 22–339（318 aa）
Not recorded CA CALCIUM ION × 5 EDO 1,2-ETHANEDIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M HEPES pH 7.5, 10% w/v PEG 8000, 8% v/v Ethylene glycol
Resolution 2.30 Å R-free 0.260
7PC5 The third PDZ domain of PDZD7 complexed with the PDZ-binding motif of EXOC4 Deposited 2021-08-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 22–339（318 aa）
Not recorded CA CALCIUM ION × 5 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.2M ammonium sulfate, 15% PEG 4000, 0.1M TRIS pH8.5
Resolution 1.70 Å R-free 0.188
7PC7 The PDZ domain of SNTG1 complexed with the acetylated PDZ-binding motif of PTEN Deposited 2021-08-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 22–339（318 aa）
Not recorded CA CALCIUM ION × 6 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M Tris 8.5, 22 % v/v PEG Smear Broad
Resolution 2.10 Å R-free 0.218
7PC7 The PDZ domain of SNTG1 complexed with the acetylated PDZ-binding motif of PTEN Deposited 2021-08-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 22–339（318 aa）
Not recorded CA CALCIUM ION × 6 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M Tris 8.5, 22 % v/v PEG Smear Broad
Resolution 2.10 Å R-free 0.218
7PC8 The PDZ domain of SNTG1 complexed with the phosphomimetic mutant PDZ-binding motif of RSK1 Deposited 2021-08-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 22–339（318 aa）
Not recorded CA CALCIUM ION × 5 GOL GLYCEROL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.15 M Lithium sulfate, 0.05 M Magnesium chloride hexahydrate ,0.1 M HEPES 7.8, 20 % v/v PEG Smear High
Resolution 2.50 Å R-free 0.232
7PC8 The PDZ domain of SNTG1 complexed with the phosphomimetic mutant PDZ-binding motif of RSK1 Deposited 2021-08-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 22–339（318 aa）
Not recorded CA CALCIUM ION × 4 GOL GLYCEROL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.15 M Lithium sulfate, 0.05 M Magnesium chloride hexahydrate ,0.1 M HEPES 7.8, 20 % v/v PEG Smear High
Resolution 2.50 Å R-free 0.232
7PC9 The PDZ domain of SYNJ2BP complexed with the PDZ-binding motif of HTLV1-TAX1 Deposited 2021-08-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric
Chain B 29–339（311 aa）
Not recorded CA CALCIUM ION × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M HEPES pH 7.5, 10% w/v PEG 8000, 8% v/v Ethylene glycol
Resolution 2.40 Å R-free 0.243
7PC9 The PDZ domain of SYNJ2BP complexed with the PDZ-binding motif of HTLV1-TAX1 Deposited 2021-08-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 29–339（311 aa）
Not recorded CA CALCIUM ION × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M HEPES pH 7.5, 10% w/v PEG 8000, 8% v/v Ethylene glycol
Resolution 2.40 Å R-free 0.243
7PCB The PDZ domain of SNX27 fused with ANXA2 Deposited 2021-08-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric
Chain A 29–339（311 aa）
Not recorded CA CALCIUM ION × 5 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M Potassium thiocyanate 0.1 M Sodium bromide 0.1 M MES 6.5 12 % v/v PEG Smear High
Resolution 2.00 Å R-free 0.205
7QQL The PDZ domain of SNTG2 complexed with the phosphorylated PDZ-binding motif of RSK1 Deposited 2022-01-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 29–339（311 aa）
Not recorded CA CALCIUM ION × 5 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；298 K；0.1 M Succinic acid pH 7.0 15% w/v PEG 3350
Resolution 2.44 Å R-free 0.230
7QQL The PDZ domain of SNTG2 complexed with the phosphorylated PDZ-binding motif of RSK1 Deposited 2022-01-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 29–339（311 aa）
Not recorded CA CALCIUM ION × 4 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；298 K；0.1 M Succinic acid pH 7.0 15% w/v PEG 3350
Resolution 2.44 Å R-free 0.230
7QQL The PDZ domain of SNTG2 complexed with the phosphorylated PDZ-binding motif of RSK1 Deposited 2022-01-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 29–339（311 aa）
Not recorded CA CALCIUM ION × 5 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；298 K；0.1 M Succinic acid pH 7.0 15% w/v PEG 3350
Resolution 2.44 Å R-free 0.230
7QQM The PDZ domain of LRRC7 fused with ANXA2 Deposited 2022-01-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric
Chain A 23–339（317 aa）
Not recorded CA CALCIUM ION × 4 GOL GLYCEROL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；298 K；0.1 M Potassium thiocyanate 0.1 M Sodium bromide 0.1 M MES 6.5 12 % v/v PEG Smear High
Resolution 1.60 Å R-free 0.198
7QQN The PDZ domain of SNTG1 complexed with the acetylated PDZ-binding motif of TRPV3 Deposited 2022-01-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 22–339（318 aa）
Not recorded CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；298 K；0.15 M Lithium sulfate 0.05 M Magnesium chloride hexahydrate 0.1 M HEPES 7.8 20 % v/v PEG Smear High
Resolution 2.45 Å R-free 0.263
7QQN The PDZ domain of SNTG1 complexed with the acetylated PDZ-binding motif of TRPV3 Deposited 2022-01-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 22–339（318 aa）
Not recorded CA CALCIUM ION × 5 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；298 K；0.15 M Lithium sulfate 0.05 M Magnesium chloride hexahydrate 0.1 M HEPES 7.8 20 % v/v PEG Smear High
Resolution 2.45 Å R-free 0.263
7ZVN Crystal structure of human Annexin A2 in complex with full phosphorothioate 5-10 2'-methoxyethyl DNA gapmer antisense oligonucleotide solved at 1.87 A resolution Deposited 2022-05-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric
Chain A 34–339（306 aa）
Not recorded GOL GLYCEROL × 8 CA CALCIUM ION × 7 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.3；290 K；4% w/v PEG 4000, 14% v/v glycerol, 0.03 M MgCl2/CaCl2, 0.1 M bicine/Trizma base pH 8.3
Resolution 1.87 Å R-free 0.198
7ZVX Crystal structure of human Annexin A2 in complex with full phosphorothioate 5-10 2'-methoxyethyl DNA gapmer antisense oligonucleotide solved at 2.4 A resolution Deposited 2022-05-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: dimeric
Chain A 34–339（306 aa）
Not recorded CA CALCIUM ION × 5 EDO 1,2-ETHANEDIOL × 7 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.1；290 K；12% w/v PEG 8000, 24% v/v ethylene glycol, 0.02 M sodium formate/ammonium acetate/trisodium citrate/sodium potassium L-tartrate/sodium oxamate, 0.1 M MES/imidazole pH 6.1
Resolution 2.40 Å R-free 0.242
7ZVX Crystal structure of human Annexin A2 in complex with full phosphorothioate 5-10 2'-methoxyethyl DNA gapmer antisense oligonucleotide solved at 2.4 A resolution Deposited 2022-05-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein–DNA Monomer；Protein × 1 PDB declaration: dimeric
Chain B 34–339（306 aa）
Not recorded CA CALCIUM ION × 6 EDO 1,2-ETHANEDIOL × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.1；290 K；12% w/v PEG 8000, 24% v/v ethylene glycol, 0.02 M sodium formate/ammonium acetate/trisodium citrate/sodium potassium L-tartrate/sodium oxamate, 0.1 M MES/imidazole pH 6.1
Resolution 2.40 Å R-free 0.242
8AEL SYNJ2BP complex with a synthetic Vangl2 peptide (3mer). Deposited 2022-07-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 22–339（318 aa）
Not recorded CA CALCIUM ION × 4 GOL GLYCEROL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M Ammonium Sulfate, 0.1 M Sodium formate, 0.1 M HEPES 7.0, 25% v/v PEG Smear Broad
Resolution 2.20 Å R-free 0.264

40 other PDB entries and 63 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name ANXA2_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–319； UniProt 20–338 Author chain B； PDBConstruct 1–319； UniProt 20–338

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

SAXS profile for 1xjl

P(r) Distance Distribution P(r) Distribution

P(r) distribution for 1xjl
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2. Structure Basics 2. Structure Basics

Entry ID entry_id1xjl
Deposition date deposition_date2004-09-23
Structure title titleStructure of human annexin A2 in the presence of calcium ions
Keywords keywordsannexins, calcium-binding protein, lipid-binding protein, LIPID BINDING PROTEIN; LIPID BINDING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier32.35 Å
Radius of gyration Rg (electron density) rg_electron32.18 Å
Forward intensity I(0) i085399300.00
Molecular weight molecular_weight73530.0 kDa
Excluded volume excluded_volume92156 ų
Envelope volume envelope_volume119410 ų
Hydration-shell volume shell_volume32172 ų
Envelope diameter envelope_diameter110.4 Å
Shell Rg shell_rg37.64 Å
Envelope Rg envelope_rg31.72 Å
Shape Rg shape_rg32.17 Å
Total Rg total_rg32.68 Å
Total atoms total_atoms5138
Residues n_residues638
Spherical-harmonic order n_harmonics20
q range q_range— – 0.5000 Å−1
Data points n_points101
Shell type shell_typedirectional
Solvent electron density solvent_density0.3340 e/ų
Shell contrast contrast_shell0.0300 e/ų
CRYSOL version crysol_version4.1.3
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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax101.9 Å
Rg (real space) rg_real32.52 Å
Rg uncertainty (real space) rg_real_error0.77 Å
I(0) (real space) i0_real8.5400e+07
I(0) uncertainty (real space) i0_real_error1.3140e+06
Rg (reciprocal space) rg_reciprocal32.46 Å
I(0) (reciprocal space) i0_reciprocal85390000.0000
Solution quality estimate total_estimate0.8153
Solution quality rating solution_quality GOOD a GOOD solution
P(r) peaks n_peaks1
Primary peak position r_peak_primary99.8 Å
Skewness Skewness skewness0.367
Kurtosis Kurtosis kurtosis-0.636
Angular range angular_range— – 0.2450 Å−1
Current regularization parameter α current_alpha0.0000
Highest regularization parameter α highest_alpha13330000.0000
Real-space data points n_real_points50
GNOM version gnom_version4.1.3
Quality Criteria quality_criteria AN1: 0.000; Oscil: 0.902; Stabil: 0.994; Sysdev: 1.000; Positv: 1.000; Valcen: 0.908; Smooth: 0.000
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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (3)

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7. Fold Classification (SCOP + CATH) 10 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd1xjla_
Class classa — All alpha proteins
Fold Fold folda.65 — Annexin
Superfamily Superfamily superfamilya.65.1 — Annexin
Family Family familya.65.1.1 — Annexin
Domain ID domain_idd1xjlb_
Class classa — All alpha proteins
Fold Fold folda.65 — Annexin
Superfamily Superfamily superfamilya.65.1 — Annexin
Family Family familya.65.1.1 — Annexin

CATH v4.4 (8 domains)

Domain ID domain_id1xjlA01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology220 — Annexin V; domain 1
Homologous superfamily homologous superfamily10 — Annexin
Domain ID domain_id1xjlA02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology220 — Annexin V; domain 1
Homologous superfamily homologous superfamily10 — Annexin
Domain ID domain_id1xjlA03
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology220 — Annexin V; domain 1
Homologous superfamily homologous superfamily10 — Annexin
Domain ID domain_id1xjlA04
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology220 — Annexin V; domain 1
Homologous superfamily homologous superfamily10 — Annexin
Domain ID domain_id1xjlB01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology220 — Annexin V; domain 1
Homologous superfamily homologous superfamily10 — Annexin
Domain ID domain_id1xjlB02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology220 — Annexin V; domain 1
Homologous superfamily homologous superfamily10 — Annexin
Domain ID domain_id1xjlB03
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology220 — Annexin V; domain 1
Homologous superfamily homologous superfamily10 — Annexin
Domain ID domain_id1xjlB04
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology220 — Annexin V; domain 1
Homologous superfamily homologous superfamily10 — Annexin
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8. Citations (1)

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9. Files and Curves (10)