1ym7
G Protein-Coupled Receptor Kinase 2 (GRK2)
SAXS 散射曲线 SAXS Profile
P(r) 距离分布 P(r) Distribution
1. 结构基本信息 1. Structure Basics
| 条目编号 entry_id | 1ym7 |
| 沉积日期 deposition_date | 2005-01-20 |
| 结构标题 title | G Protein-Coupled Receptor Kinase 2 (GRK2) |
| 关键词 keywords | G protein, kinase, GPCR, GRK2, Beta-ARK1, TRANSFERASE; TRANSFERASE |
| 实验方法 method | X-RAY DIFFRACTION |
2. SAXS 参数 (CRYSOL 理论计算) 2. SAXS Parameters (CRYSOL)
| 回转半径 Rg (Guinier) rg_guinier | 79.33 Å |
| 回转半径 Rg (电子) rg_electron | 80.22 Å |
| 零角强度 I(0) i0 | 1101630000.00 |
| 分子量 molecular_weight | 282390.0 kDa |
| 排除体积 excluded_volume | 354520 ų |
| 包络体积 envelope_volume | 667730 ų |
| 水化壳体积 shell_volume | 76761 ų |
| 包络直径 envelope_diameter | 267.5 Å |
| 壳层 Rg shell_rg | 65.97 Å |
| 包络 Rg envelope_rg | 76.56 Å |
| 形状 Rg shape_rg | 80.18 Å |
| 总 Rg total_rg | 80.10 Å |
| 总原子数 total_atoms | 19846 |
| 残基数 n_residues | 2422 |
| 球谐函数阶数 n_harmonics | 20 |
| q 范围 q_range | — – 0.5000 Å−1 |
| 数据点数 n_points | 101 |
| 壳层类型 shell_type | directional |
| 溶剂电子密度 solvent_density | 0.3340 e/ų |
| 壳层衬度 contrast_shell | 0.0300 e/ų |
| CRYSOL 版本 crysol_version | 4.1.3 |
3. P(r) 距离分布 (GNOM 反演) 3. P(r) Analysis (GNOM)
| 最大尺寸 Dmax dmax | 239.9 Å |
| Rg (实空间) rg_real | 79.76 Å |
| Rg 误差 (实空间) rg_real_error | 1.97 Å |
| I(0) (实空间) i0_real | 1.1000e+09 |
| I(0) 误差 (实空间) i0_real_error | 2.1580e+07 |
| Rg (倒空间) rg_reciprocal | 76.31 Å |
| I(0) (倒空间) i0_reciprocal | 1093000000.0000 |
| 解质量估计 total_estimate | 0.7863 |
| 解质量评级 solution_quality | GOOD a GOOD solution |
| P(r) 峰数 n_peaks | 2 |
| 主峰位置 r_peak_primary | 48.0 Å |
| 偏度 Skewness skewness | 0.370 |
| 峰度 Kurtosis kurtosis | -0.750 |
| 角度范围 angular_range | — – 0.1000 Å−1 |
| 当前正则化参数 α current_alpha | 0.0199 |
| 最高正则化参数 α highest_alpha | 29390000.0000 |
| 实空间数据点数 n_real_points | 21 |
| GNOM 版本 gnom_version | 4.1.3 |
| 质量判据 quality_criteria | AN1: 0.000; Oscil: 0.816; Stabil: 0.999; Sysdev: 1.000; Positv: 1.000; Valcen: 0.766; Smooth: 0.004 |
4. 晶体学与实验 4. Crystallography & Experiment
5. 实体与聚合体信息 (1)
6. 折叠分类 (SCOP + CATH) 12 domains
SCOP 2.08 (12 domains)
| 结构域编号 domain_id | d1ym7a1 |
| 类 Class class | a — All alpha proteins |
| 折叠类型 Fold fold | a.91 — Regulator of G-protein signaling, RGS |
| 超家族 Superfamily superfamily | a.91.1 — Regulator of G-protein signaling, RGS |
| 家族 Family family | a.91.1.1 — Regulator of G-protein signaling, RGS |
| 结构域编号 domain_id | d1ym7a2 |
| 类 Class class | b — All beta proteins |
| 折叠类型 Fold fold | b.55 — PH domain-like barrel |
| 超家族 Superfamily superfamily | b.55.1 — PH domain-like |
| 家族 Family family | b.55.1.1 — Pleckstrin-homology domain (PH domain) |
| 结构域编号 domain_id | d1ym7a3 |
| 类 Class class | d — Alpha and beta proteins (a+b) |
| 折叠类型 Fold fold | d.144 — Protein kinase-like (PK-like) |
| 超家族 Superfamily superfamily | d.144.1 — Protein kinase-like (PK-like) |
| 家族 Family family | d.144.1.7 — Protein kinases, catalytic subunit |
| 结构域编号 domain_id | d1ym7b1 |
| 类 Class class | a — All alpha proteins |
| 折叠类型 Fold fold | a.91 — Regulator of G-protein signaling, RGS |
| 超家族 Superfamily superfamily | a.91.1 — Regulator of G-protein signaling, RGS |
| 家族 Family family | a.91.1.1 — Regulator of G-protein signaling, RGS |
| 结构域编号 domain_id | d1ym7b2 |
| 类 Class class | b — All beta proteins |
| 折叠类型 Fold fold | b.55 — PH domain-like barrel |
| 超家族 Superfamily superfamily | b.55.1 — PH domain-like |
| 家族 Family family | b.55.1.1 — Pleckstrin-homology domain (PH domain) |
| 结构域编号 domain_id | d1ym7b3 |
| 类 Class class | d — Alpha and beta proteins (a+b) |
| 折叠类型 Fold fold | d.144 — Protein kinase-like (PK-like) |
| 超家族 Superfamily superfamily | d.144.1 — Protein kinase-like (PK-like) |
| 家族 Family family | d.144.1.7 — Protein kinases, catalytic subunit |
| 结构域编号 domain_id | d1ym7c1 |
| 类 Class class | a — All alpha proteins |
| 折叠类型 Fold fold | a.91 — Regulator of G-protein signaling, RGS |
| 超家族 Superfamily superfamily | a.91.1 — Regulator of G-protein signaling, RGS |
| 家族 Family family | a.91.1.1 — Regulator of G-protein signaling, RGS |
| 结构域编号 domain_id | d1ym7c2 |
| 类 Class class | b — All beta proteins |
| 折叠类型 Fold fold | b.55 — PH domain-like barrel |
| 超家族 Superfamily superfamily | b.55.1 — PH domain-like |
| 家族 Family family | b.55.1.1 — Pleckstrin-homology domain (PH domain) |
| 结构域编号 domain_id | d1ym7c3 |
| 类 Class class | d — Alpha and beta proteins (a+b) |
| 折叠类型 Fold fold | d.144 — Protein kinase-like (PK-like) |
| 超家族 Superfamily superfamily | d.144.1 — Protein kinase-like (PK-like) |
| 家族 Family family | d.144.1.7 — Protein kinases, catalytic subunit |
| 结构域编号 domain_id | d1ym7d1 |
| 类 Class class | a — All alpha proteins |
| 折叠类型 Fold fold | a.91 — Regulator of G-protein signaling, RGS |
| 超家族 Superfamily superfamily | a.91.1 — Regulator of G-protein signaling, RGS |
| 家族 Family family | a.91.1.1 — Regulator of G-protein signaling, RGS |
| 结构域编号 domain_id | d1ym7d2 |
| 类 Class class | b — All beta proteins |
| 折叠类型 Fold fold | b.55 — PH domain-like barrel |
| 超家族 Superfamily superfamily | b.55.1 — PH domain-like |
| 家族 Family family | b.55.1.1 — Pleckstrin-homology domain (PH domain) |
| 结构域编号 domain_id | d1ym7d3 |
| 类 Class class | d — Alpha and beta proteins (a+b) |
| 折叠类型 Fold fold | d.144 — Protein kinase-like (PK-like) |
| 超家族 Superfamily superfamily | d.144.1 — Protein kinase-like (PK-like) |
| 家族 Family family | d.144.1.7 — Protein kinases, catalytic subunit |