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2agh

Structural basis for cooperative transcription factor binding to the CBP coactivator

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Myb proto-oncogene protein

Mus musculus

UniProt P06876

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 Crebbp protein × 1 （P45481） Zinc finger protein HRX × 1 （Q03164） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1guu 1gv2 1gv5 1gvd 1idy 1idz 1mbe 1mbf 1mbg 1mbh 1mbj 1mbk

12 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1h88 1mse 1msf 1sb0 2agh 6dmx 6dmx 6dnq

8 assemblies

View Construct and Data Evidence
UniProt name MYB_MOUSE
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–25； UniProt 291–315

Crebbp protein

Mus musculus

UniProt P45481

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 Myb proto-oncogene protein × 1 （P06876） Zinc finger protein HRX × 1 （Q03164） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1f81 1jjs 1tot 1u2n 2kkj 4i9o 5w0i

7 assemblies

Homodimer
4i9o

1 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1kbh 1kdx 1l8c 1sb0 2agh 2c52 2ka6 2l14 2lqh 2lqi 2lww 5hou

18 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name CBP_MOUSE
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–87； UniProt 586–672

Zinc finger protein HRX

Homo sapiens

UniProt Q03164

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 Myb proto-oncogene protein × 1 （P06876） Crebbp protein × 1 （P45481） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2j2s 2jyi 2kyu 2w5y 3lqh 5f5e

6 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2agh 2kkf 2ku7 2lxs 2lxt 2msr 2mtn 2w5z 3eg6 3lqi 3lqi 3lqi

57 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name HRX_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C； PDBConstruct 1–31； UniProt 2839–2869

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2agh
Deposition date deposition_date2005-07-26
Structure title titleStructural basis for cooperative transcription factor binding to the CBP coactivator
Keywords keywordsTranscription; TRANSCRIPTION
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2agh__assembly_1__model_19

Assembly 1 · Model 19 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2agh__assembly_1__model_19 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2agh__assembly_1__model_19 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）18.00 Å
Rg (electron density)16.49 Å
Total Rg17.59 Å
Atom count2339
Residues143
Excluded volume20664 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2agh__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 2agh__assembly_1__model_2 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 3 2agh__assembly_1__model_3 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 4 2agh__assembly_1__model_4 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 5 2agh__assembly_1__model_5 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 6 2agh__assembly_1__model_6 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 7 2agh__assembly_1__model_7 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 8 2agh__assembly_1__model_8 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 9 2agh__assembly_1__model_9 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 10 2agh__assembly_1__model_10 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 11 2agh__assembly_1__model_11 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 12 2agh__assembly_1__model_12 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 13 2agh__assembly_1__model_13 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 14 2agh__assembly_1__model_14 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 15 2agh__assembly_1__model_15 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 16 2agh__assembly_1__model_16 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 17 2agh__assembly_1__model_17 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 18 2agh__assembly_1__model_18 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 19 2agh__assembly_1__model_19 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 20 2agh__assembly_1__model_20 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd2aghb_
Class classa — All alpha proteins
Fold Fold folda.12 — Kix domain of CBP (creb binding protein)
Superfamily Superfamily superfamilya.12.1 — Kix domain of CBP (creb binding protein)
Family Family familya.12.1.1 — Kix domain of CBP (creb binding protein)

CATH v4.4 (1 domains)

Domain ID domain_id2aghB00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology246 — Serum Albumin; Chain A, Domain 1
Homologous superfamily homologous superfamily20 — Coactivator CBP, KIX domain
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7. Citations (1)