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2hd0

Structure of the catalytic domain of hepatitis C virus NS2

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Protease NS2-3 (p23)

Hepatitis C virus

UniProt P27958

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 octyl beta-D-glucopyranoside × 4 water × 2 Consistent with protein count
2 Protein homooligomer Homooligomer Protein 2 octyl beta-D-glucopyranoside × 1 water × 2 Consistent with protein count
3 Protein homooligomer Homooligomer Protein 2 octyl beta-D-glucopyranoside × 2 water × 2 Consistent with protein count
4 Protein homooligomer Homooligomer Protein 2 octyl beta-D-glucopyranoside × 1 water × 2 Consistent with protein count
5 Protein homooligomer Homooligomer Protein 2 octyl beta-D-glucopyranoside × 2 DECYL-BETA-D-MALTOPYRANOSIDE × 1 water × 2 Consistent with protein count
6 Protein homooligomer Homooligomer Protein 2 octyl beta-D-glucopyranoside × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1cwx 1jr6 1onb 1r7c 1r7d 1r7e 1r7f 1r7g 2jxf 2kdr 2n1p 2xi2

16 assemblies; showing the first 12

Homodimer
1a1r 1a1r 1hei 2hd0 2hd0 2hd0 2hd0 2hd0 2hd0

9 assemblies

Homotetramer
1a1r

1 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
1a1v 1n1l 1n1l 1n1l 1rgq 2o8m 2obq 4jzn 4jzo 4jzo 4jzo 4jzo

18 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name POLG_HCVH
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 2–128； UniProt 902–1025 Author chain B； PDBConstruct 2–128； UniProt 902–1025 Author chain C； PDBConstruct 2–128； UniProt 902–1025 Author chain D； PDBConstruct 2–128； UniProt 902–1025 Author chain E； PDBConstruct 2–128； UniProt 902–1025 Author chain F； PDBConstruct 2–128； UniProt 902–1025 Author chain G； PDBConstruct 2–128； UniProt 902–1025 Author chain H； PDBConstruct 2–128； UniProt 902–1025 Author chain I； PDBConstruct 2–128； UniProt 902–1025 Author chain J； PDBConstruct 2–128； UniProt 902–1025 Author chain K； PDBConstruct 2–128； UniProt 902–1025 Author chain L； PDBConstruct 2–128； UniProt 902–1025

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2hd0
Deposition date deposition_date2006-06-19
Structure title titleStructure of the catalytic domain of hepatitis C virus NS2
Keywords keywordsCysteine Protease, Dimer, Composite Active Site, Hydrolase; HYDROLASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2hd0__assembly_5__model_1

Assembly 5 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2hd0__assembly_5__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2hd0__assembly_5__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）23.00 Å
Rg (electron density)22.37 Å
Total Rg23.13 Å
Atom count1995
Residues254
Excluded volume36218 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2hd0__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 2hd0__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 2hd0__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 2hd0__assembly_4__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
5 1 2hd0__assembly_5__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
6 1 2hd0__assembly_6__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 24 domains

CATH v4.4 (24 domains)

Domain ID domain_id2hd0A01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1280 — Monooxygenase
Homologous superfamily homologous superfamily150 — Hepatitis C virus non-structural protein NS2, N-terminal domain
Domain ID domain_id2hd0A02
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology30 — SH3 type barrels.
Homologous superfamily homologous superfamily710 — Hepatitis C virus non-structural protein NS2, C-terminal domain
Domain ID domain_id2hd0B01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1280 — Monooxygenase
Homologous superfamily homologous superfamily150 — Hepatitis C virus non-structural protein NS2, N-terminal domain
Domain ID domain_id2hd0B02
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology30 — SH3 type barrels.
Homologous superfamily homologous superfamily710 — Hepatitis C virus non-structural protein NS2, C-terminal domain
Domain ID domain_id2hd0C01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1280 — Monooxygenase
Homologous superfamily homologous superfamily150 — Hepatitis C virus non-structural protein NS2, N-terminal domain
Domain ID domain_id2hd0C02
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology30 — SH3 type barrels.
Homologous superfamily homologous superfamily710 — Hepatitis C virus non-structural protein NS2, C-terminal domain
Domain ID domain_id2hd0D01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1280 — Monooxygenase
Homologous superfamily homologous superfamily150 — Hepatitis C virus non-structural protein NS2, N-terminal domain
Domain ID domain_id2hd0D02
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology30 — SH3 type barrels.
Homologous superfamily homologous superfamily710 — Hepatitis C virus non-structural protein NS2, C-terminal domain
Domain ID domain_id2hd0E01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1280 — Monooxygenase
Homologous superfamily homologous superfamily150 — Hepatitis C virus non-structural protein NS2, N-terminal domain
Domain ID domain_id2hd0E02
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology30 — SH3 type barrels.
Homologous superfamily homologous superfamily710 — Hepatitis C virus non-structural protein NS2, C-terminal domain
Domain ID domain_id2hd0F01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1280 — Monooxygenase
Homologous superfamily homologous superfamily150 — Hepatitis C virus non-structural protein NS2, N-terminal domain
Domain ID domain_id2hd0F02
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology30 — SH3 type barrels.
Homologous superfamily homologous superfamily710 — Hepatitis C virus non-structural protein NS2, C-terminal domain
Domain ID domain_id2hd0G01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1280 — Monooxygenase
Homologous superfamily homologous superfamily150 — Hepatitis C virus non-structural protein NS2, N-terminal domain
Domain ID domain_id2hd0G02
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology30 — SH3 type barrels.
Homologous superfamily homologous superfamily710 — Hepatitis C virus non-structural protein NS2, C-terminal domain
Domain ID domain_id2hd0H01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1280 — Monooxygenase
Homologous superfamily homologous superfamily150 — Hepatitis C virus non-structural protein NS2, N-terminal domain
Domain ID domain_id2hd0H02
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology30 — SH3 type barrels.
Homologous superfamily homologous superfamily710 — Hepatitis C virus non-structural protein NS2, C-terminal domain
Domain ID domain_id2hd0I01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1280 — Monooxygenase
Homologous superfamily homologous superfamily150 — Hepatitis C virus non-structural protein NS2, N-terminal domain
Domain ID domain_id2hd0I02
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology30 — SH3 type barrels.
Homologous superfamily homologous superfamily710 — Hepatitis C virus non-structural protein NS2, C-terminal domain
Domain ID domain_id2hd0J01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1280 — Monooxygenase
Homologous superfamily homologous superfamily150 — Hepatitis C virus non-structural protein NS2, N-terminal domain
Domain ID domain_id2hd0J02
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology30 — SH3 type barrels.
Homologous superfamily homologous superfamily710 — Hepatitis C virus non-structural protein NS2, C-terminal domain
Domain ID domain_id2hd0K01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1280 — Monooxygenase
Homologous superfamily homologous superfamily150 — Hepatitis C virus non-structural protein NS2, N-terminal domain
Domain ID domain_id2hd0K02
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology30 — SH3 type barrels.
Homologous superfamily homologous superfamily710 — Hepatitis C virus non-structural protein NS2, C-terminal domain
Domain ID domain_id2hd0L01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1280 — Monooxygenase
Homologous superfamily homologous superfamily150 — Hepatitis C virus non-structural protein NS2, N-terminal domain
Domain ID domain_id2hd0L02
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology30 — SH3 type barrels.
Homologous superfamily homologous superfamily710 — Hepatitis C virus non-structural protein NS2, C-terminal domain
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7. Citations (1)