2hg4

Structure of the ketosynthase-acyltransferase didomain of module 5 from DEBS.

Method: X-RAY DIFFRACTION

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1. Protein Identity and Related Structures Protein Identity & Related Structures

6-Deoxyerythronolide B Synthase

Saccharopolyspora erythraea

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein homooligomer	Homooligomer	Protein 2	ACETATE ION × 2 SULFATE ION × 2 CHLORIDE ION × 1 water × 2	Consistent with protein count
2	Protein homooligomer	Homooligomer	Protein 2	ACETATE ION × 2 SULFATE ION × 1 CHLORIDE ION × 2 water × 2	Consistent with protein count
3	Protein homooligomer	Homooligomer	Protein 2	ACETATE ION × 2 SULFATE ION × 2 CHLORIDE ION × 2 water × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	Q5UNP4_SACER
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–917； UniProt 1–917 Author chain B； PDBConstruct 1–917； UniProt 1–917 Author chain C； PDBConstruct 1–917； UniProt 1–917 Author chain D； PDBConstruct 1–917； UniProt 1–917 Author chain E； PDBConstruct 1–917； UniProt 1–917 Author chain F； PDBConstruct 1–917； UniProt 1–917

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	2hg4
Deposition date deposition_date	2006-06-26
Structure title title	Structure of the ketosynthase-acyltransferase didomain of module 5 from DEBS.
Keywords keywords	ketosynthase, acyltransferase, module 5, DEBS, TRANSFERASE; TRANSFERASE
Experimental Method method	X-RAY DIFFRACTION

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2hg4__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2hg4__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

2hg4__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	47.87 Å
Rg (electron density)	49.09 Å
Total Rg	48.82 Å
Atom count	13073
Residues	1734
Excluded volume	229630 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`2hg4__assembly_1__model_1`	dimeric （2）	Success	4.1.3-1-20251215 (887e7ef)	View Download
2	1	`2hg4__assembly_2__model_1`	dimeric （2）	Success	4.1.3-1-20251215 (887e7ef)	View Download
3	1	`2hg4__assembly_3__model_1`	dimeric （2）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

Entity 1 Entity 1 polymer

Description description	6-Deoxyerythronolide B Synthase
Molecular weight formula_weight	97980.9 kDa
EC 编号 ec_number	2.3.1.94
Source method src_method	man
Copy count entity_count	6

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,B,C,D,E,F
Atom count atom_count	39402

MSGDNGMTEEKLRRYLKRTVTELDSVTARLREVEHRAGEPIAIVGMACRFPGDVDSPESFWEFVSGGGDAIAEAPADRGWEPDPDARLGGMLAAAGDFDAGFFGISPREALAMDPQQRIMLEISWEALERAGHDPVSLRGSATGVFTGVGTVDYGPRPDEAPDEVLGYVGTGTASSVASGRVAYCLGLEGPAMTVDTACSSGLTALHLAMESLRRDECGLALAGGVTVMSSPGAFTEFRSQGGLAADGRCKPFSKAADGFGLAEGAGVLVLQRLSAARREGRPVLAVLRGSAVNQDGASNGLTAPSGPAQQRVIRRALENAGVRAGDVDYVEAHGTGTRLGDPIEVHALLSTYGAERDPDDPLWIGSVKSNIGHTQAAAGVAGVMKAVLALRHGEMPRTLHFDEPSPQIEWDLGAVSVVSQARSWPAGERPRRAGVSSFGISGTNAHVIVEEAPEADEPEPAPDSGPVPLVLSGRDEQAMRAQAGRLADHLAREPRNSLRDTGFTLATRRSAWEHRAVVVGDRDEALAGLRAVADGRIADRTATGQARTRRGVAMVFPGQGAQWQGMARDLLRESQVFADSIRDCERALAPHVDWSLTDLLSGARPLDRVDVVQPALFAVMVSLAALWRSHGVEPAAVVGHSQGEIAAAHVAGALTLEDAAKLVAVRSRVLRRLGGQGGMASFGLGTEQAAERIGRFAGALSIASVNGPRSVVVAGESGPLDELIAECEAEAHKARRIPVDYASHSPQVESLREELLTELAGISPVSADVALYSTTTGQPIDTATMDTAYWYANLREQVRFQDATRQLAEAGFDAFVEVSPHPVLTVGIEATLDSALPADAGACVVGTLRRDRGGLADFHTALGEAYAQGVEVDWSPAFADARPVELPVYPFQRQRYWLPIPTGGRARDEDDDWRYQ

Source Source

Source organism organism	Saccharopolyspora erythraea
NCBI taxonomy ID ncbi_taxonomy_id	1836
Host organism host_organism	Escherichia coli BL21

Entity 2 Entity 2 non-polymer

Description description	ACETATE ION
Molecular weight formula_weight	59.0 kDa
Source method src_method	syn
Copy count entity_count	6

Entity 3 Entity 3 non-polymer

Description description	SULFATE ION
Molecular weight formula_weight	96.1 kDa
Source method src_method	syn
Copy count entity_count	5

Entity 4 Entity 4 non-polymer

Description description	CHLORIDE ION
Molecular weight formula_weight	35.5 kDa
Source method src_method	syn
Copy count entity_count	5

Entity 5 Entity 5 water

Description description	water
Molecular weight formula_weight	18.0 kDa
Source method src_method	nat
Copy count entity_count	310

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6. Fold Classification (SCOP + CATH) 60 domains

SCOP 2.08 (42 domains)

Domain ID domain_id	d2hg4a1
Class class	h — Coiled coil proteins
Fold Fold fold	h.1 — Parallel coiled-coil
Superfamily Superfamily superfamily	h.1.38 — N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)
Family Family family	h.1.38.1 — N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)

Domain ID domain_id	d2hg4a2
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.95 — Thiolase-like
Superfamily Superfamily superfamily	c.95.1 — Thiolase-like
Family Family family	c.95.1.1 — Thiolase-related

Domain ID domain_id	d2hg4a3
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.95 — Thiolase-like
Superfamily Superfamily superfamily	c.95.1 — Thiolase-like
Family Family family	c.95.1.1 — Thiolase-related

Domain ID domain_id	d2hg4a4
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.390 — KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like
Superfamily Superfamily superfamily	d.390.1 — KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like
Family Family family	d.390.1.1 — KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like

Domain ID domain_id	d2hg4a5
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.58 — Ferredoxin-like
Superfamily Superfamily superfamily	d.58.23 — Probable ACP-binding domain of malonyl-CoA ACP transacylase
Family Family family	d.58.23.1 — Probable ACP-binding domain of malonyl-CoA ACP transacylase

Domain ID domain_id	d2hg4a6
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.19 — FabD/lysophospholipase-like
Superfamily Superfamily superfamily	c.19.1 — FabD/lysophospholipase-like
Family Family family	c.19.1.1 — FabD-like

Domain ID domain_id	d2hg4a7
Class class	j — Peptides
Fold Fold fold	j.134 — C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like
Superfamily Superfamily superfamily	j.134.1 — C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like
Family Family family	j.134.1.1 — C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like

Domain ID domain_id	d2hg4b1
Class class	h — Coiled coil proteins
Fold Fold fold	h.1 — Parallel coiled-coil
Superfamily Superfamily superfamily	h.1.38 — N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)
Family Family family	h.1.38.1 — N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)

Domain ID domain_id	d2hg4b2
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.95 — Thiolase-like
Superfamily Superfamily superfamily	c.95.1 — Thiolase-like
Family Family family	c.95.1.1 — Thiolase-related

Domain ID domain_id	d2hg4b3
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.95 — Thiolase-like
Superfamily Superfamily superfamily	c.95.1 — Thiolase-like
Family Family family	c.95.1.1 — Thiolase-related

Domain ID domain_id	d2hg4b4
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.390 — KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like
Superfamily Superfamily superfamily	d.390.1 — KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like
Family Family family	d.390.1.1 — KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like

Domain ID domain_id	d2hg4b5
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.58 — Ferredoxin-like
Superfamily Superfamily superfamily	d.58.23 — Probable ACP-binding domain of malonyl-CoA ACP transacylase
Family Family family	d.58.23.1 — Probable ACP-binding domain of malonyl-CoA ACP transacylase

Domain ID domain_id	d2hg4b6
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.19 — FabD/lysophospholipase-like
Superfamily Superfamily superfamily	c.19.1 — FabD/lysophospholipase-like
Family Family family	c.19.1.1 — FabD-like

Domain ID domain_id	d2hg4b7
Class class	j — Peptides
Fold Fold fold	j.134 — C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like
Superfamily Superfamily superfamily	j.134.1 — C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like
Family Family family	j.134.1.1 — C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like

Domain ID domain_id	d2hg4c1
Class class	h — Coiled coil proteins
Fold Fold fold	h.1 — Parallel coiled-coil
Superfamily Superfamily superfamily	h.1.38 — N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)
Family Family family	h.1.38.1 — N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)

Domain ID domain_id	d2hg4c2
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.95 — Thiolase-like
Superfamily Superfamily superfamily	c.95.1 — Thiolase-like
Family Family family	c.95.1.1 — Thiolase-related

Domain ID domain_id	d2hg4c3
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.95 — Thiolase-like
Superfamily Superfamily superfamily	c.95.1 — Thiolase-like
Family Family family	c.95.1.1 — Thiolase-related

Domain ID domain_id	d2hg4c4
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.390 — KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like
Superfamily Superfamily superfamily	d.390.1 — KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like
Family Family family	d.390.1.1 — KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like

Domain ID domain_id	d2hg4c5
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.58 — Ferredoxin-like
Superfamily Superfamily superfamily	d.58.23 — Probable ACP-binding domain of malonyl-CoA ACP transacylase
Family Family family	d.58.23.1 — Probable ACP-binding domain of malonyl-CoA ACP transacylase

Domain ID domain_id	d2hg4c6
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.19 — FabD/lysophospholipase-like
Superfamily Superfamily superfamily	c.19.1 — FabD/lysophospholipase-like
Family Family family	c.19.1.1 — FabD-like

Domain ID domain_id	d2hg4c7
Class class	j — Peptides
Fold Fold fold	j.134 — C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like
Superfamily Superfamily superfamily	j.134.1 — C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like
Family Family family	j.134.1.1 — C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like

Domain ID domain_id	d2hg4d1
Class class	h — Coiled coil proteins
Fold Fold fold	h.1 — Parallel coiled-coil
Superfamily Superfamily superfamily	h.1.38 — N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)
Family Family family	h.1.38.1 — N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)

Domain ID domain_id	d2hg4d2
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.95 — Thiolase-like
Superfamily Superfamily superfamily	c.95.1 — Thiolase-like
Family Family family	c.95.1.1 — Thiolase-related

Domain ID domain_id	d2hg4d3
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.95 — Thiolase-like
Superfamily Superfamily superfamily	c.95.1 — Thiolase-like
Family Family family	c.95.1.1 — Thiolase-related

Domain ID domain_id	d2hg4d4
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.390 — KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like
Superfamily Superfamily superfamily	d.390.1 — KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like
Family Family family	d.390.1.1 — KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like

Domain ID domain_id	d2hg4d5
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.58 — Ferredoxin-like
Superfamily Superfamily superfamily	d.58.23 — Probable ACP-binding domain of malonyl-CoA ACP transacylase
Family Family family	d.58.23.1 — Probable ACP-binding domain of malonyl-CoA ACP transacylase

Domain ID domain_id	d2hg4d6
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.19 — FabD/lysophospholipase-like
Superfamily Superfamily superfamily	c.19.1 — FabD/lysophospholipase-like
Family Family family	c.19.1.1 — FabD-like

Domain ID domain_id	d2hg4d7
Class class	j — Peptides
Fold Fold fold	j.134 — C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like
Superfamily Superfamily superfamily	j.134.1 — C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like
Family Family family	j.134.1.1 — C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like

Domain ID domain_id	d2hg4e1
Class class	h — Coiled coil proteins
Fold Fold fold	h.1 — Parallel coiled-coil
Superfamily Superfamily superfamily	h.1.38 — N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)
Family Family family	h.1.38.1 — N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)

Domain ID domain_id	d2hg4e2
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.95 — Thiolase-like
Superfamily Superfamily superfamily	c.95.1 — Thiolase-like
Family Family family	c.95.1.1 — Thiolase-related

Domain ID domain_id	d2hg4e3
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.95 — Thiolase-like
Superfamily Superfamily superfamily	c.95.1 — Thiolase-like
Family Family family	c.95.1.1 — Thiolase-related

Domain ID domain_id	d2hg4e4
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.390 — KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like
Superfamily Superfamily superfamily	d.390.1 — KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like
Family Family family	d.390.1.1 — KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like

Domain ID domain_id	d2hg4e5
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.58 — Ferredoxin-like
Superfamily Superfamily superfamily	d.58.23 — Probable ACP-binding domain of malonyl-CoA ACP transacylase
Family Family family	d.58.23.1 — Probable ACP-binding domain of malonyl-CoA ACP transacylase

Domain ID domain_id	d2hg4e6
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.19 — FabD/lysophospholipase-like
Superfamily Superfamily superfamily	c.19.1 — FabD/lysophospholipase-like
Family Family family	c.19.1.1 — FabD-like

Domain ID domain_id	d2hg4e7
Class class	j — Peptides
Fold Fold fold	j.134 — C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like
Superfamily Superfamily superfamily	j.134.1 — C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like
Family Family family	j.134.1.1 — C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like

Domain ID domain_id	d2hg4f1
Class class	h — Coiled coil proteins
Fold Fold fold	h.1 — Parallel coiled-coil
Superfamily Superfamily superfamily	h.1.38 — N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)
Family Family family	h.1.38.1 — N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)

Domain ID domain_id	d2hg4f2
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.95 — Thiolase-like
Superfamily Superfamily superfamily	c.95.1 — Thiolase-like
Family Family family	c.95.1.1 — Thiolase-related

Domain ID domain_id	d2hg4f3
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.95 — Thiolase-like
Superfamily Superfamily superfamily	c.95.1 — Thiolase-like
Family Family family	c.95.1.1 — Thiolase-related

Domain ID domain_id	d2hg4f4
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.390 — KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like
Superfamily Superfamily superfamily	d.390.1 — KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like
Family Family family	d.390.1.1 — KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like

Domain ID domain_id	d2hg4f5
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.58 — Ferredoxin-like
Superfamily Superfamily superfamily	d.58.23 — Probable ACP-binding domain of malonyl-CoA ACP transacylase
Family Family family	d.58.23.1 — Probable ACP-binding domain of malonyl-CoA ACP transacylase

Domain ID domain_id	d2hg4f6
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.19 — FabD/lysophospholipase-like
Superfamily Superfamily superfamily	c.19.1 — FabD/lysophospholipase-like
Family Family family	c.19.1.1 — FabD-like

Domain ID domain_id	d2hg4f7
Class class	j — Peptides
Fold Fold fold	j.134 — C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like
Superfamily Superfamily superfamily	j.134.1 — C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like
Family Family family	j.134.1.1 — C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like

CATH v4.4 (18 domains)

Domain ID domain_id	2hg4A01
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	47 — Peroxisomal Thiolase; Chain A, domain 1
Homologous superfamily homologous superfamily	10 — Thiolase/Chalcone synthase

Domain ID domain_id	2hg4A02
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily	3290 —

Domain ID domain_id	2hg4A03
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	366 — Malonyl-Coenzyme A Acyl Carrier Protein; domain 2
Homologous superfamily homologous superfamily	10 — Malonyl-Coenzyme A Acyl Carrier Protein, domain 2

Domain ID domain_id	2hg4B01
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	47 — Peroxisomal Thiolase; Chain A, domain 1
Homologous superfamily homologous superfamily	10 — Thiolase/Chalcone synthase

Domain ID domain_id	2hg4B02
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily	3290 —

Domain ID domain_id	2hg4B03
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	366 — Malonyl-Coenzyme A Acyl Carrier Protein; domain 2
Homologous superfamily homologous superfamily	10 — Malonyl-Coenzyme A Acyl Carrier Protein, domain 2

Domain ID domain_id	2hg4C01
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	47 — Peroxisomal Thiolase; Chain A, domain 1
Homologous superfamily homologous superfamily	10 — Thiolase/Chalcone synthase

Domain ID domain_id	2hg4C02
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily	3290 —

Domain ID domain_id	2hg4C03
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	366 — Malonyl-Coenzyme A Acyl Carrier Protein; domain 2
Homologous superfamily homologous superfamily	10 — Malonyl-Coenzyme A Acyl Carrier Protein, domain 2

Domain ID domain_id	2hg4D01
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	47 — Peroxisomal Thiolase; Chain A, domain 1
Homologous superfamily homologous superfamily	10 — Thiolase/Chalcone synthase

Domain ID domain_id	2hg4D02
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily	3290 —

Domain ID domain_id	2hg4D03
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	366 — Malonyl-Coenzyme A Acyl Carrier Protein; domain 2
Homologous superfamily homologous superfamily	10 — Malonyl-Coenzyme A Acyl Carrier Protein, domain 2

Domain ID domain_id	2hg4E01
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	47 — Peroxisomal Thiolase; Chain A, domain 1
Homologous superfamily homologous superfamily	10 — Thiolase/Chalcone synthase

Domain ID domain_id	2hg4E02
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily	3290 —

Domain ID domain_id	2hg4E03
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	366 — Malonyl-Coenzyme A Acyl Carrier Protein; domain 2
Homologous superfamily homologous superfamily	10 — Malonyl-Coenzyme A Acyl Carrier Protein, domain 2

Domain ID domain_id	2hg4F01
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	47 — Peroxisomal Thiolase; Chain A, domain 1
Homologous superfamily homologous superfamily	10 — Thiolase/Chalcone synthase

Domain ID domain_id	2hg4F02
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily	3290 —

Domain ID domain_id	2hg4F03
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	366 — Malonyl-Coenzyme A Acyl Carrier Protein; domain 2
Homologous superfamily homologous superfamily	10 — Malonyl-Coenzyme A Acyl Carrier Protein, domain 2

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Unit-cell length a length_a	305.258 Å
Unit-cell length b length_b	150.149 Å
Unit-cell length c length_c	184.378 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	110.03 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	24

Space group space_group	C 1 2 1
Space-group number int_tables_number	5
Crystal system crystal_system	—

Resolution resolution	2.730 Å
Low-resolution limit resolution_low	48.030 Å
R factor r_factor	0.2181
R_work r_work	0.2161
R_free r_free	0.2550

Structure of the ketosynthase-acyltransferase didomain of module 5 from DEBS.

1. Protein Identity and Related Structures Protein Identity & Related Structures

6-Deoxyerythronolide B Synthase

State in the Current Structure

Other States of the Same Protein in the Database

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

2hg4__assembly_1__model_1

2hg4__assembly_1__model_1 | I(q)

2hg4__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (5)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 non-polymer

Entity 3 Entity 3 non-polymer

Entity 4 Entity 4 non-polymer

Entity 5 Entity 5 water

6. Fold Classification (SCOP + CATH) 60 domains

SCOP 2.08 (42 domains)

CATH v4.4 (18 domains)

7. Citations (3)

Structure of the ketosynthase-acyltransferase didomain of module 5 from DEBS.

1. Protein Identity and Related Structures Protein Identity & Related Structures

6-Deoxyerythronolide B Synthase

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

2hg4__assembly_1__model_1

2hg4__assembly_1__model_1 | I(q)

2hg4__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (5)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 non-polymer

Entity 3 Entity 3 non-polymer

Entity 4 Entity 4 non-polymer

Entity 5 Entity 5 water

6. Fold Classification (SCOP + CATH) 60 domains

SCOP 2.08 (42 domains)

CATH v4.4 (18 domains)

7. Citations (3)