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2hst

Solution structure of the middle domain of human eukaryotic translation termination factor eRF1

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Eukaryotic peptide chain release factor subunit 1

Homo sapiens

UniProt P62495

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 No other associated polymer Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1dt9 2hst 2ktu 2ktv 2lgt 2llx 2mq6 2mq9

8 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3e1y 3e1y 3e1y 3e1y 3j5y 3jag 3jah 3jai 4d5n 4d61 5a8l 5lzt

28 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name ERF1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–136； UniProt 139–274

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2hst
Deposition date deposition_date2006-07-23
Structure title titleSolution structure of the middle domain of human eukaryotic translation termination factor eRF1
Keywords keywordsTermination of protein synthesis, peptidyl-tRNA hydrolysis, NMR solution structure, TRANSLATION; TRANSLATION
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2hst__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2hst__assembly_1__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2hst__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）17.27 Å
Rg (electron density)16.05 Å
Total Rg17.14 Å
Atom count2121
Residues136
Excluded volume18750 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2hst__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 2hst__assembly_1__model_2 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 3 2hst__assembly_1__model_3 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 4 2hst__assembly_1__model_4 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 5 2hst__assembly_1__model_5 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 6 2hst__assembly_1__model_6 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 7 2hst__assembly_1__model_7 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 8 2hst__assembly_1__model_8 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 9 2hst__assembly_1__model_9 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 10 2hst__assembly_1__model_10 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 11 2hst__assembly_1__model_11 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 12 2hst__assembly_1__model_12 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 13 2hst__assembly_1__model_13 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 14 2hst__assembly_1__model_14 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 15 2hst__assembly_1__model_15 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 16 2hst__assembly_1__model_16 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 17 2hst__assembly_1__model_17 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 18 2hst__assembly_1__model_18 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 19 2hst__assembly_1__model_19 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 20 2hst__assembly_1__model_20 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 21 2hst__assembly_1__model_21 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 22 2hst__assembly_1__model_22 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 23 2hst__assembly_1__model_23 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 24 2hst__assembly_1__model_24 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 25 2hst__assembly_1__model_25 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (1)

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd2hsta_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.55 — Ribonuclease H-like motif
Superfamily Superfamily superfamilyc.55.4 — Translational machinery components
Family Family familyc.55.4.2 — ERF1/Dom34 middle domain-like

CATH v4.4 (1 domains)

Domain ID domain_id2hstA00
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology420 — Nucleotidyltransferase; domain 5
Homologous superfamily homologous superfamily60 — eRF1 domain 2
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7. Citations (1)