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3e1y

Crystal structure of human eRF1/eRF3 complex

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Eukaryotic peptide chain release factor subunit 1

Homo sapiens

UniProt P62495

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A × 1 （P15170） ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A × 1 （P15170） ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A × 1 （P15170） Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A × 1 （P15170） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1dt9 2hst 2ktu 2ktv 2lgt 2llx 2mq6 2mq9

8 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3e1y 3e1y 3e1y 3e1y 3j5y 3jag 3jah 3jai 4d5n 4d61 5a8l 5lzt

28 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name ERF1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 15–451； UniProt 1–437 Author chain B； PDBConstruct 15–451； UniProt 1–437 Author chain C； PDBConstruct 15–451； UniProt 1–437 Author chain D； PDBConstruct 15–451； UniProt 1–437

Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

Homo sapiens

UniProt P15170

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Eukaryotic peptide chain release factor subunit 1 × 1 （P62495） ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Eukaryotic peptide chain release factor subunit 1 × 1 （P62495） ADENOSINE-5'-TRIPHOSPHATE × 1 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 Eukaryotic peptide chain release factor subunit 1 × 1 （P62495） Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 Eukaryotic peptide chain release factor subunit 1 × 1 （P62495） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3e1y 3e1y 3e1y 3e1y 3j5y 4d61 5hxb 5hxb 5lzt 6xk9 6xk9 9hne

13 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name ERF3A_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain E； PDBConstruct 6–204； UniProt 301–499 Author chain F； PDBConstruct 6–204； UniProt 301–499 Author chain G； PDBConstruct 6–204； UniProt 301–499 Author chain H； PDBConstruct 6–204； UniProt 301–499

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id3e1y
Deposition date deposition_date2008-08-05
Structure title titleCrystal structure of human eRF1/eRF3 complex
Keywords keywordsTranslation termination, eRF1, eRF3, peptide release, PTC, Protein biosynthesis, GTP-binding, Nucleotide-binding, Translation; TRANSLATION
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

3e1y__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

3e1y__assembly_1__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

3e1y__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）33.22 Å
Rg (electron density)32.39 Å
Total Rg33.07 Å
Atom count4531
Residues575
Excluded volume81521 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 3e1y__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 3e1y__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 3e1y__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 3e1y__assembly_4__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 16 domains

CATH v4.4 (16 domains)

Domain ID domain_id3e1yA01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology960 — Translation, Eukaryotic Peptide Chain Release Factor Subunit 1; Chain A
Homologous superfamily homologous superfamily10 — eRF1 domain 1
Domain ID domain_id3e1yA02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology420 — Nucleotidyltransferase; domain 5
Homologous superfamily homologous superfamily60 — eRF1 domain 2
Domain ID domain_id3e1yA03
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology1330 — 60s Ribosomal Protein L30; Chain: A;
Homologous superfamily homologous superfamily30 — Ribosomal protein L30/S12
Domain ID domain_id3e1yB01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology960 — Translation, Eukaryotic Peptide Chain Release Factor Subunit 1; Chain A
Homologous superfamily homologous superfamily10 — eRF1 domain 1
Domain ID domain_id3e1yB02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology420 — Nucleotidyltransferase; domain 5
Homologous superfamily homologous superfamily60 — eRF1 domain 2
Domain ID domain_id3e1yB03
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology1330 — 60s Ribosomal Protein L30; Chain: A;
Homologous superfamily homologous superfamily30 — Ribosomal protein L30/S12
Domain ID domain_id3e1yC02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology420 — Nucleotidyltransferase; domain 5
Homologous superfamily homologous superfamily60 — eRF1 domain 2
Domain ID domain_id3e1yD02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology420 — Nucleotidyltransferase; domain 5
Homologous superfamily homologous superfamily60 — eRF1 domain 2
Domain ID domain_id3e1yE01
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology30 — Elongation Factor Tu (Ef-tu); domain 3
Homologous superfamily homologous superfamily10 — Translation factors
Domain ID domain_id3e1yE02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology30 — Elongation Factor Tu (Ef-tu); domain 3
Homologous superfamily homologous superfamily10 — Translation factors
Domain ID domain_id3e1yF01
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology30 — Elongation Factor Tu (Ef-tu); domain 3
Homologous superfamily homologous superfamily10 — Translation factors
Domain ID domain_id3e1yF02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology30 — Elongation Factor Tu (Ef-tu); domain 3
Homologous superfamily homologous superfamily10 — Translation factors
Domain ID domain_id3e1yG01
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology30 — Elongation Factor Tu (Ef-tu); domain 3
Homologous superfamily homologous superfamily10 — Translation factors
Domain ID domain_id3e1yG02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology30 — Elongation Factor Tu (Ef-tu); domain 3
Homologous superfamily homologous superfamily10 — Translation factors
Domain ID domain_id3e1yH01
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology30 — Elongation Factor Tu (Ef-tu); domain 3
Homologous superfamily homologous superfamily10 — Translation factors
Domain ID domain_id3e1yH02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology30 — Elongation Factor Tu (Ef-tu); domain 3
Homologous superfamily homologous superfamily10 — Translation factors
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7. Citations (1)