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2iyb

Structure of complex between the 3rd LIM domain of TES and the EVH1 domain of Mena

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

PROTEIN ENABLED HOMOLOG

HOMO SAPIENS

UniProt Q8N8S7

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 TESTIN × 1 （Q9UGI8） ZINC ION × 3 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 TESTIN × 1 （Q9UGI8） ZINC ION × 2 water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 TESTIN × 1 （Q9UGI8） ZINC ION × 2 water × 2 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 TESTIN × 1 （Q9UGI8） ZINC ION × 2 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
4my6 4my6 5naj 5naj 5naj 5naj 5nbf 5ncf 5ncf 5ncg 5ncg 5ncp

18 assemblies; showing the first 12

Homodimer
5neg

1 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2ho2 2iyb 2iyb 2iyb 2iyb 2xqn 5n91 5n91 5n9c 5n9p 5nbx 5nbx

27 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name ENAH_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 2–114； UniProt 1–113 Author chain B； PDBConstruct 2–114； UniProt 1–113 Author chain C； PDBConstruct 2–114； UniProt 1–113 Author chain D； PDBConstruct 2–114； UniProt 1–113

TESTIN

HOMO SAPIENS

UniProt Q9UGI8

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 PROTEIN ENABLED HOMOLOG × 1 （Q8N8S7） ZINC ION × 3 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 PROTEIN ENABLED HOMOLOG × 1 （Q8N8S7） ZINC ION × 2 water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 PROTEIN ENABLED HOMOLOG × 1 （Q8N8S7） ZINC ION × 2 water × 2 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 PROTEIN ENABLED HOMOLOG × 1 （Q8N8S7） ZINC ION × 2 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2iyb 2iyb 2iyb 2iyb 2xqn

5 assemblies

View Construct and Data Evidence
UniProt name TES_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain E； PDBConstruct 1–65； UniProt 357–421 Author chain F； PDBConstruct 1–65； UniProt 357–421 Author chain G； PDBConstruct 1–65； UniProt 357–421 Author chain H； PDBConstruct 1–65； UniProt 357–421

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2iyb
Deposition date deposition_date2006-07-14
Structure title titleStructure of complex between the 3rd LIM domain of TES and the EVH1 domain of Mena
Keywords keywords;LIM DOMAIN, SH3-BINDING, TUMOUR SUPRESSOR LIM DOMAIN EVH1 DOMAIN CELL MOTILITY, PHOSPHORYLATION, CYTOSKELETON, ACTIN-BINDING, METAL-BINDING ;; METAL-BINDING
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2iyb__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2iyb__assembly_1__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2iyb__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）17.47 Å
Rg (electron density)16.55 Å
Total Rg17.56 Å
Atom count1361
Residues178
Excluded volume24019 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2iyb__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 2iyb__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 2iyb__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 2iyb__assembly_4__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 13 domains

SCOP 2.08 (5 domains)

Domain ID domain_idd2iyba2
Class classb — All beta proteins
Fold Fold foldb.55 — PH domain-like barrel
Superfamily Superfamily superfamilyb.55.1 — PH domain-like
Family Family familyb.55.1.4 — Enabled/VASP homology 1 domain (EVH1 domain)
Domain ID domain_idd2iyba3
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
Domain ID domain_idd2iybb_
Class classb — All beta proteins
Fold Fold foldb.55 — PH domain-like barrel
Superfamily Superfamily superfamilyb.55.1 — PH domain-like
Family Family familyb.55.1.4 — Enabled/VASP homology 1 domain (EVH1 domain)
Domain ID domain_idd2iybc_
Class classb — All beta proteins
Fold Fold foldb.55 — PH domain-like barrel
Superfamily Superfamily superfamilyb.55.1 — PH domain-like
Family Family familyb.55.1.4 — Enabled/VASP homology 1 domain (EVH1 domain)
Domain ID domain_idd2iybd_
Class classb — All beta proteins
Fold Fold foldb.55 — PH domain-like barrel
Superfamily Superfamily superfamilyb.55.1 — PH domain-like
Family Family familyb.55.1.4 — Enabled/VASP homology 1 domain (EVH1 domain)

CATH v4.4 (8 domains)

Domain ID domain_id2iybA00
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology29 — PH-domain like
Homologous superfamily homologous superfamily30 — Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Domain ID domain_id2iybB00
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology29 — PH-domain like
Homologous superfamily homologous superfamily30 — Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Domain ID domain_id2iybC00
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology29 — PH-domain like
Homologous superfamily homologous superfamily30 — Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Domain ID domain_id2iybD00
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology29 — PH-domain like
Homologous superfamily homologous superfamily30 — Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Domain ID domain_id2iybE00
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology110 — Cysteine Rich Protein
Homologous superfamily homologous superfamily10 — Cysteine Rich Protein
Domain ID domain_id2iybF00
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology110 — Cysteine Rich Protein
Homologous superfamily homologous superfamily10 — Cysteine Rich Protein
Domain ID domain_id2iybG00
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology110 — Cysteine Rich Protein
Homologous superfamily homologous superfamily10 — Cysteine Rich Protein
Domain ID domain_id2iybH00
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology110 — Cysteine Rich Protein
Homologous superfamily homologous superfamily10 — Cysteine Rich Protein
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7. Citations (1)