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2kxq

Solution Structure of Smurf2 WW2 and WW3 bound to Smad7 PY motif containing peptide

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

E3 ubiquitin-protein ligase SMURF2

Homo sapiens

UniProt Q9HAU4

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Smad7 PY motif containing peptide × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1zvd 2jqz 9fsh

3 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2djy 2kxq 2ltz 6fx4 6fx4 7m3q

6 assemblies

View Construct and Data Evidence
UniProt name SMUF2_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 7–90； UniProt 250–333

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2kxq
Deposition date deposition_date2010-05-11
Structure title titleSolution Structure of Smurf2 WW2 and WW3 bound to Smad7 PY motif containing peptide
Keywords keywordsWW, PY motif, Smurf2, TGF-beta, modular binding, PROTEIN BINDING; PROTEIN BINDING
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2kxq__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2kxq__assembly_1__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2kxq__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）15.06 Å
Rg (electron density)13.72 Å
Total Rg15.12 Å
Atom count1683
Residues110
Excluded volume15070 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2kxq__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 2kxq__assembly_1__model_2 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 3 2kxq__assembly_1__model_3 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 4 2kxq__assembly_1__model_4 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 5 2kxq__assembly_1__model_5 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 6 2kxq__assembly_1__model_6 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 7 2kxq__assembly_1__model_7 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 8 2kxq__assembly_1__model_8 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 9 2kxq__assembly_1__model_9 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 10 2kxq__assembly_1__model_10 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 2 domains

CATH v4.4 (2 domains)

Domain ID domain_id2kxqA01
Class class2 — Mainly Beta
Architecture architecture20 — Single Sheet
Topology topology70 — Ubiquitin Ligase Nedd4; Chain: W;
Homologous superfamily homologous superfamily10 —
Domain ID domain_id2kxqA02
Class class2 — Mainly Beta
Architecture architecture20 — Single Sheet
Topology topology70 — Ubiquitin Ligase Nedd4; Chain: W;
Homologous superfamily homologous superfamily10 —
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7. Citations (1)