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2lf1

Solution structure of L. casei dihydrofolate reductase complexed with NADPH, 30 structures

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Dihydrofolate reductase

Lactobacillus casei

UniProt P00381

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1ao8 1bzf 1dis 1diu 1lud 2hm9 2hqp 2l28 2lf1 3dfr

10 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name DYR_LACCA
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–162； UniProt 2–163

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2lf1
Deposition date deposition_date2011-06-28
Structure title titleSolution structure of L. casei dihydrofolate reductase complexed with NADPH, 30 structures
Keywords keywordsOXIDOREDUCTASE, DHFR, positive cooperativity, protein-ligand interactions; OXIDOREDUCTASE
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2lf1__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2lf1__assembly_1__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2lf1__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）16.87 Å
Rg (electron density)15.48 Å
Total Rg16.56 Å
Atom count2638
Residues162
Excluded volume23625 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2lf1__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 2lf1__assembly_1__model_2 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 3 2lf1__assembly_1__model_3 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 4 2lf1__assembly_1__model_4 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 5 2lf1__assembly_1__model_5 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 6 2lf1__assembly_1__model_6 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 7 2lf1__assembly_1__model_7 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 8 2lf1__assembly_1__model_8 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 9 2lf1__assembly_1__model_9 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 10 2lf1__assembly_1__model_10 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 11 2lf1__assembly_1__model_11 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 12 2lf1__assembly_1__model_12 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 13 2lf1__assembly_1__model_13 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 14 2lf1__assembly_1__model_14 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 15 2lf1__assembly_1__model_15 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 16 2lf1__assembly_1__model_16 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 17 2lf1__assembly_1__model_17 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 18 2lf1__assembly_1__model_18 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 19 2lf1__assembly_1__model_19 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 20 2lf1__assembly_1__model_20 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 21 2lf1__assembly_1__model_21 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 22 2lf1__assembly_1__model_22 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 23 2lf1__assembly_1__model_23 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 24 2lf1__assembly_1__model_24 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 25 2lf1__assembly_1__model_25 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 26 2lf1__assembly_1__model_26 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 27 2lf1__assembly_1__model_27 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 28 2lf1__assembly_1__model_28 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 29 2lf1__assembly_1__model_29 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 30 2lf1__assembly_1__model_30 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd2lf1a_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.71 — Dihydrofolate reductase-like
Superfamily Superfamily superfamilyc.71.1 — Dihydrofolate reductase-like
Family Family familyc.71.1.1 — Dihydrofolate reductases

CATH v4.4 (1 domains)

Domain ID domain_id2lf1A00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology430 — Dihydrofolate Reductase, subunit A
Homologous superfamily homologous superfamily10 — Dihydrofolate Reductase, subunit A
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7. Citations (1)