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2lnh

Enterohaemorrhagic E. coli (EHEC) exploits a tryptophan switch to hijack host F-actin assembly

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Neural Wiskott-Aldrich syndrome protein

Homo sapiens

UniProt O00401

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 × 1 （Q9UHR4） Secreted effector protein EspF(U) × 1 （P0DJ89） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2ff3 2lnh 2vcp 2vcp 4cc2 4cc2 4cc7 4cc7 4cc7 4cc7 4cc7 4cc7

16 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name WASL_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 2–65； UniProt 207–270

Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1

Homo sapiens

UniProt Q9UHR4

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 Neural Wiskott-Aldrich syndrome protein × 1 （O00401） Secreted effector protein EspF(U) × 1 （P0DJ89） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2kxc 2lnh

2 assemblies

View Construct and Data Evidence
UniProt name BI2L1_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 4–67； UniProt 339–402

Secreted effector protein EspF(U)

Escherichia coli O157:H7

UniProt P0DJ89

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 Neural Wiskott-Aldrich syndrome protein × 1 （O00401） Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 × 1 （Q9UHR4） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2lnh

1 assemblies

View Construct and Data Evidence
UniProt name ESFU3_ECO57
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C； PDBConstruct 2–48； UniProt 221–267

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2lnh
Deposition date deposition_date2011-12-28
Structure title titleEnterohaemorrhagic E. coli (EHEC) exploits a tryptophan switch to hijack host F-actin assembly
Keywords keywordsProtein complex, Signaling Protein-Protein Binding complex; Signaling Protein/Protein Binding
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2lnh__assembly_1__model_15

Assembly 1 · Model 15 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2lnh__assembly_1__model_15 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2lnh__assembly_1__model_15 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）21.63 Å
Rg (electron density)20.94 Å
Total Rg21.63 Å
Atom count2782
Residues179
Excluded volume24926 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2lnh__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 2lnh__assembly_1__model_2 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 3 2lnh__assembly_1__model_3 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 4 2lnh__assembly_1__model_4 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 5 2lnh__assembly_1__model_5 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 6 2lnh__assembly_1__model_6 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 7 2lnh__assembly_1__model_7 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 8 2lnh__assembly_1__model_8 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 9 2lnh__assembly_1__model_9 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 10 2lnh__assembly_1__model_10 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 11 2lnh__assembly_1__model_11 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 12 2lnh__assembly_1__model_12 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 13 2lnh__assembly_1__model_13 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 14 2lnh__assembly_1__model_14 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 15 2lnh__assembly_1__model_15 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 16 2lnh__assembly_1__model_16 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 17 2lnh__assembly_1__model_17 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 18 2lnh__assembly_1__model_18 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 19 2lnh__assembly_1__model_19 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 20 2lnh__assembly_1__model_20 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 5 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd2lnhb1
Class classb — All beta proteins
Fold Fold foldb.34 — SH3-like barrel
Superfamily Superfamily superfamilyb.34.2 — SH3-domain
Family Family familyb.34.2.1 — SH3-domain
Domain ID domain_idd2lnhb2
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags

CATH v4.4 (3 domains)

Domain ID domain_id2lnhA00
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology810 — SerineThreonine-protein kinase PAK-alpha; Chain A
Homologous superfamily homologous superfamily10 — CRIB domain
Domain ID domain_id2lnhB00
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology30 — SH3 type barrels.
Homologous superfamily homologous superfamily40 — SH3 Domains
Domain ID domain_id2lnhC00
Class class6 — Special
Architecture architecture10 — Helix non-globular
Topology topology250 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily3330 — TccP2/EspF(U)-like
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7. Citations (1)