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2phe

Model for VP16 binding to PC4

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

TRANSCRIPTIONAL COACTIVATOR PC4

Homo sapiens

UniProt P53999

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 Alpha trans-inducing protein × 1 （P06492） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
1pcf 1pcf 1pcf 1pcf 7e4w 7e4w 7e4w 7e4w 7e4w 7e4w 7e4w 7e4w

12 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2c62 2phe 4usg

3 assemblies

View Construct and Data Evidence
UniProt name TCP4_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 2–66； UniProt 63–127 Author chain B； PDBConstruct 2–66； UniProt 63–127

Alpha trans-inducing protein

Herpes simplex virus (type 1 / strain 17)

UniProt P06492

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 TRANSCRIPTIONAL COACTIVATOR PC4 × 2 （P53999） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
16vp

1 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2phe 2phg

2 assemblies

View Construct and Data Evidence
UniProt name ATIN_HHV11
Isoform —
PDB entities 2
Chains and sequence ranges Author chain C； PDBConstruct 1–26； UniProt 465–490

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2phe
Deposition date deposition_date2007-04-11
Structure title titleModel for VP16 binding to PC4
Keywords keywordsPC4, VP16, transcription, cofactor, activator; TRANSCRIPTION
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2phe__assembly_1__model_8

Assembly 1 · Model 8 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2phe__assembly_1__model_8 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2phe__assembly_1__model_8 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）16.90 Å
Rg (electron density)15.78 Å
Total Rg16.85 Å
Atom count1294
Residues158
Excluded volume23099 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2phe__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 2phe__assembly_1__model_2 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 3 2phe__assembly_1__model_3 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 4 2phe__assembly_1__model_4 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 5 2phe__assembly_1__model_5 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 6 2phe__assembly_1__model_6 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 7 2phe__assembly_1__model_7 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 8 2phe__assembly_1__model_8 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 9 2phe__assembly_1__model_9 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 10 2phe__assembly_1__model_10 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 6 domains

SCOP 2.08 (4 domains)

Domain ID domain_idd2phea1
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.18 — ssDNA-binding transcriptional regulator domain
Superfamily Superfamily superfamilyd.18.1 — ssDNA-binding transcriptional regulator domain
Family Family familyd.18.1.1 — Transcriptional coactivator PC4 C-terminal domain
Domain ID domain_idd2phea2
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
Domain ID domain_idd2pheb1
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.18 — ssDNA-binding transcriptional regulator domain
Superfamily Superfamily superfamilyd.18.1 — ssDNA-binding transcriptional regulator domain
Family Family familyd.18.1.1 — Transcriptional coactivator PC4 C-terminal domain
Domain ID domain_idd2pheb2
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags

CATH v4.4 (2 domains)

Domain ID domain_id2pheA00
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology31 — Transcriptional Co-activator pc4; Chain A
Homologous superfamily homologous superfamily10 — Transcriptional Coactivator Pc4; Chain A
Domain ID domain_id2pheB00
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology31 — Transcriptional Co-activator pc4; Chain A
Homologous superfamily homologous superfamily10 — Transcriptional Coactivator Pc4; Chain A
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7. Citations (1)