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2rhb

Crystal structure of Nsp15-H234A mutant- Hexamer in asymmetric unit

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Uridylate-specific endoribonuclease

SARS coronavirus

UniProt P59641

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 6 water × 6 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1ysy 1z1i 2a5i 2fav 2fav 2fav 2fe8 2fe8 2fe8 2gdt 2gri 2gx4

21 assemblies; showing the first 12

Homodimer
1qz8 1uj1 1uk2 1uk3 1uw7 1wof 1z1j 2a5a 2a5i 2a5k 2alv 2amd

32 assemblies; showing the first 12

Homotetramer
1qz8 2fe8 2ozk

3 assemblies

Other homooligomers
2ahm 2fe8 2fe8 2rhb

4 assemblies

Heteromeric or nucleic-acid complex
2amq 2hob 2q6g 2z3c 2z3d 2z3e 2z3e

7 assemblies

View Construct and Data Evidence
UniProt name R1AB_CVHSA
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 8–353； UniProt 6430–6775 Author chain B； PDBConstruct 8–353； UniProt 6430–6775 Author chain C； PDBConstruct 8–353； UniProt 6430–6775 Author chain D； PDBConstruct 8–353； UniProt 6430–6775 Author chain E； PDBConstruct 8–353； UniProt 6430–6775 Author chain F； PDBConstruct 8–353； UniProt 6430–6775

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2rhb
Deposition date deposition_date2007-10-08
Structure title titleCrystal structure of Nsp15-H234A mutant- Hexamer in asymmetric unit
Keywords keywordsENDORIBONUCLEASE, SARS, HEXAMER, RNA, NSP, VIRAL PROTEIN; VIRAL PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2rhb__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2rhb__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2rhb__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）40.65 Å
Rg (electron density)39.98 Å
Total Rg40.40 Å
Atom count16054
Residues2072
Excluded volume287230 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2rhb__assembly_1__model_1 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 29 domains

SCOP 2.08 (17 domains)

Domain ID domain_idd2rhba1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.66 — S-adenosyl-L-methionine-dependent methyltransferases
Superfamily Superfamily superfamilyc.66.1 — S-adenosyl-L-methionine-dependent methyltransferases
Family Family familyc.66.1.48 — Nsp15 N-terminal domain-like
Domain ID domain_idd2rhba2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.294 — EndoU-like
Superfamily Superfamily superfamilyd.294.1 — EndoU-like
Family Family familyd.294.1.2 — Nsp15 C-terminal domain-like
Domain ID domain_idd2rhba3
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
Domain ID domain_idd2rhbb1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.66 — S-adenosyl-L-methionine-dependent methyltransferases
Superfamily Superfamily superfamilyc.66.1 — S-adenosyl-L-methionine-dependent methyltransferases
Family Family familyc.66.1.48 — Nsp15 N-terminal domain-like
Domain ID domain_idd2rhbb2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.294 — EndoU-like
Superfamily Superfamily superfamilyd.294.1 — EndoU-like
Family Family familyd.294.1.2 — Nsp15 C-terminal domain-like
Domain ID domain_idd2rhbb3
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
Domain ID domain_idd2rhbc1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.66 — S-adenosyl-L-methionine-dependent methyltransferases
Superfamily Superfamily superfamilyc.66.1 — S-adenosyl-L-methionine-dependent methyltransferases
Family Family familyc.66.1.48 — Nsp15 N-terminal domain-like
Domain ID domain_idd2rhbc2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.294 — EndoU-like
Superfamily Superfamily superfamilyd.294.1 — EndoU-like
Family Family familyd.294.1.2 — Nsp15 C-terminal domain-like
Domain ID domain_idd2rhbc3
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
Domain ID domain_idd2rhbd1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.66 — S-adenosyl-L-methionine-dependent methyltransferases
Superfamily Superfamily superfamilyc.66.1 — S-adenosyl-L-methionine-dependent methyltransferases
Family Family familyc.66.1.48 — Nsp15 N-terminal domain-like
Domain ID domain_idd2rhbd2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.294 — EndoU-like
Superfamily Superfamily superfamilyd.294.1 — EndoU-like
Family Family familyd.294.1.2 — Nsp15 C-terminal domain-like
Domain ID domain_idd2rhbd3
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
Domain ID domain_idd2rhbe1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.66 — S-adenosyl-L-methionine-dependent methyltransferases
Superfamily Superfamily superfamilyc.66.1 — S-adenosyl-L-methionine-dependent methyltransferases
Family Family familyc.66.1.48 — Nsp15 N-terminal domain-like
Domain ID domain_idd2rhbe2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.294 — EndoU-like
Superfamily Superfamily superfamilyd.294.1 — EndoU-like
Family Family familyd.294.1.2 — Nsp15 C-terminal domain-like
Domain ID domain_idd2rhbe3
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
Domain ID domain_idd2rhbf1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.66 — S-adenosyl-L-methionine-dependent methyltransferases
Superfamily Superfamily superfamilyc.66.1 — S-adenosyl-L-methionine-dependent methyltransferases
Family Family familyc.66.1.48 — Nsp15 N-terminal domain-like
Domain ID domain_idd2rhbf2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.294 — EndoU-like
Superfamily Superfamily superfamilyd.294.1 — EndoU-like
Family Family familyd.294.1.2 — Nsp15 C-terminal domain-like

CATH v4.4 (12 domains)

Domain ID domain_id2rhbA01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology160 — Double Stranded RNA Binding Domain
Homologous superfamily homologous superfamily820 — Nsp15 N-terminal domain-like
Domain ID domain_id2rhbA02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily11580 — nsp15 middle domain
Domain ID domain_id2rhbB01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology160 — Double Stranded RNA Binding Domain
Homologous superfamily homologous superfamily820 — Nsp15 N-terminal domain-like
Domain ID domain_id2rhbB02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily11580 — nsp15 middle domain
Domain ID domain_id2rhbC01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology160 — Double Stranded RNA Binding Domain
Homologous superfamily homologous superfamily820 — Nsp15 N-terminal domain-like
Domain ID domain_id2rhbC02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily11580 — nsp15 middle domain
Domain ID domain_id2rhbD01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology160 — Double Stranded RNA Binding Domain
Homologous superfamily homologous superfamily820 — Nsp15 N-terminal domain-like
Domain ID domain_id2rhbD02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily11580 — nsp15 middle domain
Domain ID domain_id2rhbE01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology160 — Double Stranded RNA Binding Domain
Homologous superfamily homologous superfamily820 — Nsp15 N-terminal domain-like
Domain ID domain_id2rhbE02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily11580 — nsp15 middle domain
Domain ID domain_id2rhbF01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology160 — Double Stranded RNA Binding Domain
Homologous superfamily homologous superfamily820 — Nsp15 N-terminal domain-like
Domain ID domain_id2rhbF02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily11580 — nsp15 middle domain
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7. Citations (1)