Fibronectin
Homo sapiens
State in the Current Structure
| Assembly | Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Associated Components | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|
| 1 | Protein heterocomplex Heteromer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count | Chain A； UniProt 93–182 | Fragment：UNP residues 93-182 | peptide from Fibronectin-binding protein A × 1 （P14738） SIN SUCCINIC ACID × 1 | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；pH 7；291 K；0.8M SUCCINIC ACID, pH7.0, VAPOR DIFFUSION, SITTING DROP, temperature 291K | Resolution 2.00 Å R-free 0.261 |
| 2 | Protein heterocomplex Heteromer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count | Chain B； UniProt 93–182 | Fragment：UNP residues 93-182 | peptide from Fibronectin-binding protein A × 1 （P14738） SIN SUCCINIC ACID × 1 | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；pH 7；291 K；0.8M SUCCINIC ACID, pH7.0, VAPOR DIFFUSION, SITTING DROP, temperature 291K | Resolution 2.00 Å R-free 0.261 |
| 3 | Protein heterocomplex Heteromer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count | Chain C； UniProt 93–182 | Fragment：UNP residues 93-182 | peptide from Fibronectin-binding protein A × 1 （P14738） SIN SUCCINIC ACID × 1 | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；pH 7；291 K；0.8M SUCCINIC ACID, pH7.0, VAPOR DIFFUSION, SITTING DROP, temperature 291K | Resolution 2.00 Å R-free 0.261 |
| 4 | Protein heterocomplex Heteromer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count | Chain D； UniProt 93–182 | Fragment：UNP residues 93-182 | peptide from Fibronectin-binding protein A × 1 （P14738） | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；pH 7；291 K；0.8M SUCCINIC ACID, pH7.0, VAPOR DIFFUSION, SITTING DROP, temperature 291K | Resolution 2.00 Å R-free 0.261 |
| 5 | Protein heterocomplex Heteromer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count | Chain E； UniProt 93–182 | Fragment：UNP residues 93-182 | peptide from Fibronectin-binding protein A × 1 （P14738） | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；pH 7；291 K；0.8M SUCCINIC ACID, pH7.0, VAPOR DIFFUSION, SITTING DROP, temperature 291K | Resolution 2.00 Å R-free 0.261 |
| 6 | Protein heterocomplex Heteromer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count | Chain F； UniProt 93–182 | Fragment：UNP residues 93-182 | peptide from Fibronectin-binding protein A × 1 （P14738） | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；pH 7；291 K；0.8M SUCCINIC ACID, pH7.0, VAPOR DIFFUSION, SITTING DROP, temperature 291K | Resolution 2.00 Å R-free 0.261 |
Other States of the Same Protein in the Database
Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.
| Other PDB | Difference from Current Entry 2RKZ | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1E88 Solution structure of 6F11F22F2, a compact three-module fragment of the gelatin-binding domain of human fibronectin Deposited 2000-09-18 | Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
305–464（160 aa）
Fragment：6F11F22F2, RESIDUES 305-464
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
SOLUTION NMR
NMR measurement conditions
pH 4.5；298 K
NMR sample composition
2MM 6F11F22F2, 20MM PHOSPHATE BUFFER
|
Resolution not provided |
| 1E8B Solution structure of 6F11F22F2, a compact three-module fragment of the gelatin-binding domain of human fibronectin Deposited 2000-09-18 | Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
305–464（160 aa）
Fragment：6F11F22F2, RESIDUES 305-464
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
SOLUTION NMR
NMR measurement conditions
pH 4.5；298 K
NMR sample composition
2MM 6F11F22F2, 20MM PHOSPHATE BUFFER
|
Resolution not provided |
| 1FBR FOURTH AND FIFTH FIBRONECTIN TYPE I MODULE PAIR Deposited 1995-08-08 | Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
183–275（93 aa）
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR mmCIF provides none of the parsed conditions | Resolution not provided |
| 1FNA CRYSTAL STRUCTURE OF THE TENTH TYPE III CELL ADHESION MODULE OF HUMAN FIBRONECTIN Deposited 1994-01-11 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1452–1542（91 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.80 Å |
| 1FNF FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10 Deposited 1995-09-30 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1173–1540（368 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5.8；pH 5.8
|
Resolution 2.00 Å R-free 0.308 |
| 1FNH CRYSTAL STRUCTURE OF HEPARIN AND INTEGRIN BINDING SEGMENT OF HUMAN FIBRONECTIN Deposited 1999-01-28 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1721–1991（271 aa）
Fragment：HEPARIN AND INTEGRIN BINDING
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；CRYSTALLIZATION CONDITIONS: 0.1M HEPES, PH7.5, 0.8M NA, K TARTRATE
|
Resolution 2.80 Å R-free 0.295 |
| 1J8K NMR STRUCTURE OF THE FIBRONECTIN EDA DOMAIN, NMR, 20 STRUCTURES Deposited 2001-05-22 | Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1631–1724（94 aa）
Fragment：EXTRA DOMAIN 2 (RESIDUES 1631-1724)
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 7；293 K；Ionic strength (raw mmCIF value) 400mM sodium sulfate；Pressure 1
NMR sample composition
2mM EDA U-15N,13C; 50mM phosphate buffer, 400mM sodium sulfate; 90% H2O, 10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 1O9A Solution structure of the complex of 1F12F1 from fibronectin with B3 from FnBB from S. dysgalactiae Deposited 2002-12-11 | Different construct Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
48–140（93 aa）
Fragment：N-TERMINAL F1 MODULE PAIR, RESIDUES 48-140
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 5；298 K
|
Resolution not provided |
| 1OWW Solution structure of the first type III module of human fibronectin determined by 1H, 15N NMR spectroscopy Deposited 2003-03-31 | Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
608–701（94 aa）
Fragment：Residues 608-701 of SWS P02751
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 6；313 K；Ionic strength (raw mmCIF value) unbuffered；Pressure ambient
NMR sample composition
1-2 mM [U-15N] protein, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 1Q38 Anastellin Deposited 2003-07-28 | Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
631–705（75 aa）
Fragment：Type 3 (FN3) domain
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 7；298 K；Ionic strength (raw mmCIF value) 150；Pressure ambient
NMR sample composition
1.5 mM anastellin U-15N, 10 mM Na2HPO4, 1.8 mM KH2PO4, 140 mM NaCl, 2.7 mM KCl, 2 mM CHAPS | 90% H2O/10% D2O
NMR sample composition
1.5 mM anastellin U-15N,13C, 10 mM Na2HPO4, 1.8 mM KH2PO4, 140 mM NaCl, 2.7 mM KCl, 2 mM CHAPS | 90% H2O/10% D2O
|
Resolution not provided |
| 1QGB SOLUTION STRUCTURE OF THE N-TERMINAL F1 MODULE PAIR FROM HUMAN FIBRONECTIN Deposited 1999-04-21 | Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
48–140（93 aa）
Fragment：N-TERMINAL F1 MODULE PAIR
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 4；310 K
NMR sample composition
2.2 mM [U-15N] 1F1-2F1, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 1QO6 Solution structure of a pair of modules from the gelatin-binding domain of fibronectin Deposited 1999-11-04 | Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
305–405（101 aa）
Fragment：FIBRONECTIN TYPE-I AND FIBRONECTIN TYPE-II MODULE PAIR FROM COLLAGEN-BINDING DOMAIN
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 4.5；310 K；Pressure 1
|
Resolution not provided |
| 1TTF THE THREE-DIMENSIONAL STRUCTURE OF THE TENTH TYPE III MODULE OF FIBRONECTIN: AN INSIGHT INTO RGD-MEDIATED INTERACTIONS Deposited 1993-07-14 | Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1447–1540（94 aa）
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR mmCIF provides none of the parsed conditions | Resolution not provided |
| 1TTG THE THREE-DIMENSIONAL STRUCTURE OF THE TENTH TYPE III MODULE OF FIBRONECTIN: AN INSIGHT INTO RGD-MEDIATED INTERACTIONS Deposited 1993-07-14 | Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1447–1540（94 aa）
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR mmCIF provides none of the parsed conditions | Resolution not provided |
| 2CG6 Second and third fibronectin type I module pair (crystal form I). Deposited 2006-02-27 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
93–182（90 aa）
Fragment：RESIDUES 93-182 (62-151 IN COORDINATES)
|
Not recorded | SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 4.5；0.2 M AMMONIUM SULPHATE, 0.1M NA ACETATE PH 4.5, 2% MPD, 5% PEG MME 550
|
Resolution 1.55 Å R-free 0.231 |
| 2CG7 SECOND AND THIRD FIBRONECTIN TYPE I MODULE PAIR (CRYSTAL FORM II). Deposited 2006-02-27 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
93–182（90 aa）
Fragment：RESIDUES 93-182 (62-151 IN COORDINATES)
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；WATER AND 0.02% SODIUM AZIDE, pH 7.00
|
Resolution 1.20 Å R-free 0.219 |
| 2CK2 Structure of core-swapped mutant of fibronectin Deposited 2006-04-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1447–1542（96 aa）
Fragment：RESIDUES 1447-1542
Chain B
1447–1542（96 aa）
Fragment：RESIDUES 1447-1542
|
Mutation：YES Mutation：YES | ACE ACETYL GROUP × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5.1；50% PEG-400, 0.1 M ACTEATE, 0.2 M LITHIUM SULPHATE, PH 5.1
|
Resolution 2.00 Å R-free 0.268 |
| 2CKU Solution structure of 2F13F1 from human fibronectin Deposited 2006-04-21 | Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
93–182（90 aa）
Fragment：2ND AND 3RD F1 MODULES, RESIDUES 93-182 (62-151 IN COORDINATES)
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
298 K
|
Resolution not provided |
| 2EC3 Solution structure of the 11th FN1 domain from human Fibronectin 1 Deposited 2007-02-09 | Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
2239–2299（61 aa）
Fragment：Fibronectin type-I
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 7；298 K；Ionic strength (raw mmCIF value) 120mM；Pressure ambient
NMR sample composition
1.14 mM 13C, 15N-labeled protein; 20mM d-Tris-HCl (pH7.0); 100mM NaCl; 1mM d-DTT; 0.02% NaN3; 90% H2O, 10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 2FN2 SOLUTION NMR STRUCTURE OF THE GLYCOSYLATED SECOND TYPE TWO MODULE OF FIBRONECTIN, 20 STRUCTURES Deposited 1997-08-06 | Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
375–433（59 aa）
Fragment：RESIDUES 375 - 433
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
SOLUTION NMR
NMR measurement conditions
pH 4.5；298 K；Ionic strength (raw mmCIF value) 0 mM；Pressure 10E+5 PA
NMR sample composition
H2O/D2O(9:1) OR D2O
|
Resolution not provided |
| 2FNB NMR STRUCTURE OF THE FIBRONECTIN ED-B DOMAIN, NMR, 20 STRUCTURES Deposited 1998-12-16 | Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1261–1355（95 aa）
Fragment：TYPE III DOMAIN
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 7；298 K；Ionic strength (raw mmCIF value) 63 mM；Pressure 1
|
Resolution not provided |
| 2H41 Solution structure of the second type III domain of human Fibronectin: minimized average structure Deposited 2006-05-23 | Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
721–809（89 aa）
Fragment：Fibronectin type-III 2(2F3)
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 7；303 K；Ionic strength (raw mmCIF value) 20mM NaCl, 20mM Na2HPO4；Pressure ambient
NMR sample composition
2.5mM 2F3 U-15N, 20mM NaPi pH 7.0, 20mM NaCl, 95% H2O, 5% D2O | 95% H2O/5% D2O
NMR sample composition
2mM 2F3 U-13C,15N, 20mM NaPi pH 7.0, 20mM NaCl, 95% H2O, 5% D2O | 95% H2O/5% D2O
NMR sample composition
2mM 2F3 U-13C,15N, 20mM NaPi pH 7.0, 20mM NaCl, 100% D2O | 100% D2O
NMR sample composition
1mM 2F3 U-15N, 20mM NaPi pH 7.0, 20mM NaCl, 4% Radially compressed polyacrylamide gel, 95% H2O, 5% D2O | 95% H2O/5% D2O
|
Resolution not provided |
| 2H45 Solution structure of the second type III domain of human Fibronectin: ensemble of 25 structures Deposited 2006-05-23 | Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
721–809（89 aa）
Fragment：Fibronectin type-III 2(2F3)
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 7；303 K；Ionic strength (raw mmCIF value) 20mM NaCl, 20mM Na2HPO4；Pressure ambient
NMR sample composition
2.5mM 2F3 U-15N, 20mM NaPi pH 7.0, 20mM NaCl, 95% H2O, 5% D2O | 95% H2O/5% D2O
NMR sample composition
2mM 2F3 U-13C,15N, 20mM NaPi pH 7.0, 20mM NaCl, 95% H2O, 5% D2O | 95% H2O/5% D2O
NMR sample composition
2mM 2F3 U-13C,15N, 20mM NaPi pH 7.0, 20mM NaCl, 100% D2O | 100% D2O
NMR sample composition
1mM 2F3 U-15N, 20mM NaPi pH 7.0, 20mM NaCl, 4% Radially compressed polyacrylamide gel, 95% H2O, 5% D2O | 95% H2O/5% D2O
|
Resolution not provided |
| 2HA1 Complex of the first and second type III domains of human Fibronectin in solution Deposited 2006-06-12 | Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
609–809（201 aa）
Fragment：Fibronectin first and second type III domain pair (1F3-2F3)
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 7；303 K；Ionic strength (raw mmCIF value) 150mM NaCl, 20mM Na2HPO3；Pressure ambient
NMR sample composition
1.0mM 1F3-2F3 U-15N, 150mM NaCl, 20mM NaPi pH 7.0, 95% H2O, 5% D2O | 95% H2O/5% D2O
NMR sample composition
1.0mM 1F3-2F3 U-15N, 13C, 150mM NaCl, 20mM NaPi pH 7.0, 95% H2O, 5% D2O | 95% H2O/5% D2O
NMR sample composition
0.6mM 1F3-2F3 U-15N, 150mM NaCl, 20mM NaPi pH 7.0, 4% Radially compressed polyacrylamide gel, 95% H2O, 5% D2O | 95% H2O/5% D2O
|
Resolution not provided |
| 2N1K Structure of the Third Type III Domain from Human Fibronectin Deposited 2015-04-04 | Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
808–905（98 aa）
Fragment：third FN3 domain (UNP residues 808-905)
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 7.5；298.15 K；Ionic strength (raw mmCIF value) 0.17；Pressure ambient
NMR sample composition
0.6 mM [U-99% 13C; U-99% 15N] 3FN3, 10 mM sodium phosphate, 1.8 mM potassium phosphate, 140 mM sodium chloride, 2.7 mM potassium chloride, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition
0.6 mM [U-99% 15N] 3FN3, 10 mM sodium phosphate, 1.8 mM potassium phosphate, 140 mM sodium chloride, 2.7 mM potassium chloride, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition
0.6 mM 3FN3, 10 mM sodium phosphate, 1.8 mM potassium phosphate, 140 mM sodium chloride, 2.7 mM potassium chloride, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition
0.6 mM 3FN3, 10 mM sodium phosphate, 1.8 mM potassium phosphate, 140 mM sodium chloride, 2.7 mM potassium chloride, 100% D2O | 100% D2O
NMR sample composition
0.9 mM [U-99% 13C; U-99% 15N] 3FN3, 10 mM sodium phosphate, 1.8 mM potassium phosphate, 140 mM sodium chloride, 2.7 mM potassium chloride, 0.9 mM 3FN3, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 2OCF Human estrogen receptor alpha ligand-binding domain in complex with estradiol and the E2#23 FN3 monobody Deposited 2006-12-20 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain D
1447–1540（94 aa）
Fragment：E2#23 FN3 MONOBODY, Fibronectin type III Domain 10, Residues 1447-1540
|
Mutation：R1452T, D1453K, R1524L, G1525R, D1526L, S1527M, P1528L, S1530G | EST ESTRADIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；289 K；2.5M NaCl, 0.1M Imidazole, pH 8.0, 0.2M Zn(OAc)2, VAPOR DIFFUSION, SITTING DROP, temperature 289K
|
Resolution 2.95 Å R-free 0.251 |
| 2RKY Crystal structure of the fourth and fifth fibronectin F1 modules in complex with a fragment of staphylococcus aureus fnbpa-1 Deposited 2007-10-18 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
183–275（93 aa）
Fragment：UNP residues 183-275
|
Not recorded | SCN THIOCYANATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；100mM Tris-HCl, pH8.5, 0.15M Potassium thiocyanate, 20% PEG400, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 1.80 Å R-free 0.216 |
| 2RKY Crystal structure of the fourth and fifth fibronectin F1 modules in complex with a fragment of staphylococcus aureus fnbpa-1 Deposited 2007-10-18 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
183–275（93 aa）
Fragment：UNP residues 183-275
|
Not recorded | SCN THIOCYANATE ION × 3 K POTASSIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；100mM Tris-HCl, pH8.5, 0.15M Potassium thiocyanate, 20% PEG400, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 1.80 Å R-free 0.216 |
| 2RL0 Crystal structure of the fourth and fifth fibronectin F1 modules in complex with a fragment of staphylococcus aureus fnbpa-5 Deposited 2007-10-18 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
184–272（89 aa）
Fragment：UNP residues 184-272
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.2；291 K；0.2M NACL, 0.1M BIS TRIS, 14% PEG3350, pH6.2, VAPOR DIFFUSION, SITTING DROP, temperature 291K
|
Resolution 2.00 Å R-free 0.266 |
| 2RL0 Crystal structure of the fourth and fifth fibronectin F1 modules in complex with a fragment of staphylococcus aureus fnbpa-5 Deposited 2007-10-18 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
184–272（89 aa）
Fragment：UNP residues 184-272
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.2；291 K；0.2M NACL, 0.1M BIS TRIS, 14% PEG3350, pH6.2, VAPOR DIFFUSION, SITTING DROP, temperature 291K
|
Resolution 2.00 Å R-free 0.266 |
| 2RL0 Crystal structure of the fourth and fifth fibronectin F1 modules in complex with a fragment of staphylococcus aureus fnbpa-5 Deposited 2007-10-18 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain D
184–272（89 aa）
Fragment：UNP residues 184-272
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.2；291 K；0.2M NACL, 0.1M BIS TRIS, 14% PEG3350, pH6.2, VAPOR DIFFUSION, SITTING DROP, temperature 291K
|
Resolution 2.00 Å R-free 0.266 |
| 2RL0 Crystal structure of the fourth and fifth fibronectin F1 modules in complex with a fragment of staphylococcus aureus fnbpa-5 Deposited 2007-10-18 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain F
184–272（89 aa）
Fragment：UNP residues 184-272
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.2；291 K；0.2M NACL, 0.1M BIS TRIS, 14% PEG3350, pH6.2, VAPOR DIFFUSION, SITTING DROP, temperature 291K
|
Resolution 2.00 Å R-free 0.266 |
| 2RL0 Crystal structure of the fourth and fifth fibronectin F1 modules in complex with a fragment of staphylococcus aureus fnbpa-5 Deposited 2007-10-18 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 5 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain I
184–272（89 aa）
Fragment：UNP residues 184-272
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.2；291 K；0.2M NACL, 0.1M BIS TRIS, 14% PEG3350, pH6.2, VAPOR DIFFUSION, SITTING DROP, temperature 291K
|
Resolution 2.00 Å R-free 0.266 |
| 2RL0 Crystal structure of the fourth and fifth fibronectin F1 modules in complex with a fragment of staphylococcus aureus fnbpa-5 Deposited 2007-10-18 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 6 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain K
184–272（89 aa）
Fragment：UNP residues 184-272
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.2；291 K；0.2M NACL, 0.1M BIS TRIS, 14% PEG3350, pH6.2, VAPOR DIFFUSION, SITTING DROP, temperature 291K
|
Resolution 2.00 Å R-free 0.266 |
| 3CAL Crystal structure of the second and third fibronectin F1 modules in complex with a fragment of staphylococcus aureus fnbpa-5 Deposited 2008-02-20 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
93–182（90 aa）
Fragment：UNP residues 93-182, Second and third F1 modules
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；291 K；0.95M succinic acid, pH7.0, VAPOR DIFFUSION, SITTING DROP, temperature 291K
|
Resolution 1.70 Å R-free 0.217 |
| 3CAL Crystal structure of the second and third fibronectin F1 modules in complex with a fragment of staphylococcus aureus fnbpa-5 Deposited 2008-02-20 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
93–182（90 aa）
Fragment：UNP residues 93-182, Second and third F1 modules
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；291 K；0.95M succinic acid, pH7.0, VAPOR DIFFUSION, SITTING DROP, temperature 291K
|
Resolution 1.70 Å R-free 0.217 |
| 3CH8 The crystal structure of PDZ-Fibronectin fusion protein Deposited 2008-03-08 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
1538–1631（94 aa）
|
Not recorded | MG MAGNESIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；31% isopropanol, 0.1M HEPES, 0.2M MgCl2, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 1.90 Å R-free 0.260 |
| 3EJH Crystal Structure of the Fibronectin 8-9FnI Domain Pair in Complex with a Type-I Collagen Peptide Deposited 2008-09-18 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
516–608（93 aa）
Fragment：8-9FnI
|
Mutation：N528Q, R534K | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；2.5 M NaCl, 0.1 M BisTris pH 6.5 , VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.10 Å R-free 0.242 |
| 3EJH Crystal Structure of the Fibronectin 8-9FnI Domain Pair in Complex with a Type-I Collagen Peptide Deposited 2008-09-18 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
516–608（93 aa）
Fragment：8-9FnI
|
Mutation：N528Q, R534K | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；2.5 M NaCl, 0.1 M BisTris pH 6.5 , VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.10 Å R-free 0.242 |
| 3GXE Complex of a Low Affinity Collagen Site with the Fibronectin 8-9FnI Domain Pair Deposited 2009-04-02 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
516–608（93 aa）
Fragment：8-9FnI, UNP residues 516-608
|
Mutation：N528Q, R534K | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.1 K；0.1M HEPES pH 7.5, 4.3M NaCl, VAPOR DIFFUSION, SITTING DROP, temperature 293.1K
|
Resolution 2.60 Å R-free 0.271 |
| 3GXE Complex of a Low Affinity Collagen Site with the Fibronectin 8-9FnI Domain Pair Deposited 2009-04-02 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
516–608（93 aa）
Fragment：8-9FnI, UNP residues 516-608
|
Mutation：N528Q, R534K | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.1 K；0.1M HEPES pH 7.5, 4.3M NaCl, VAPOR DIFFUSION, SITTING DROP, temperature 293.1K
|
Resolution 2.60 Å R-free 0.271 |
| 3R8Q Structure of Fibronectin domain 12-14 Deposited 2011-03-24 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1722–1992（271 aa）
Fragment：unp residues 1722-1992
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；291 K；0.1 M Na HEPES, 0.8 M sodium dihydrogen phosphate, 0.8 M potassium dihydrogen phosphate, supplemented with 35% glycerol for cryo-protection, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 291K
|
Resolution 2.40 Å R-free 0.236 |
| 3ZRZ Crystal structure of the second and third fibronectin F1 modules in complex with a fragment of Streptococcus pyogenes SfbI-5 Deposited 2011-06-21 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
93–182（90 aa）
Fragment：SECOND AND THIRD F1 MODULES, RESIDUES 93-182
|
Not recorded | SO4 SULFATE ION × 1 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；291 K；CRYSTALS OF THE PROTEIN/PEPTIDE COMPLEX (0.3 MM/3.5 MM, PH 7.7) WERE GROWN USING SITTING DROP VAPOUR DIFFUSION FROM A 1:1 DILUTION WITH WELL SOLUTION (0.1 M TRIS PH 7.0, 1.5 M (NH4)2SO4 AT 18 DEGREES CENTIGRADE
|
Resolution 1.70 Å R-free 0.222 |
| 3ZRZ Crystal structure of the second and third fibronectin F1 modules in complex with a fragment of Streptococcus pyogenes SfbI-5 Deposited 2011-06-21 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
93–182（90 aa）
Fragment：SECOND AND THIRD F1 MODULES, RESIDUES 93-182
|
Not recorded | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；291 K；CRYSTALS OF THE PROTEIN/PEPTIDE COMPLEX (0.3 MM/3.5 MM, PH 7.7) WERE GROWN USING SITTING DROP VAPOUR DIFFUSION FROM A 1:1 DILUTION WITH WELL SOLUTION (0.1 M TRIS PH 7.0, 1.5 M (NH4)2SO4 AT 18 DEGREES CENTIGRADE
|
Resolution 1.70 Å R-free 0.222 |
| 4GH7 Crystal structure of Anticalin N7A in complex with oncofetal fibronectin fragment Fn7B8 Deposited 2012-08-07 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
1173–1448（276 aa）
Fragment：Fn7B8, UNP residues 1173-1448
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；17-19%(w/v) PEG3350, 0.1M Na-citrate, pH 5.5-6.0, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 2.60 Å R-free 0.259 |
| 4GH7 Crystal structure of Anticalin N7A in complex with oncofetal fibronectin fragment Fn7B8 Deposited 2012-08-07 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain D
1173–1448（276 aa）
Fragment：Fn7B8, UNP residues 1173-1448
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；17-19%(w/v) PEG3350, 0.1M Na-citrate, pH 5.5-6.0, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 2.60 Å R-free 0.259 |
| 4LXO Crystal structure of 9,10Fn3-elegantin chimera Deposited 2013-07-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1357–1540（184 aa）
|
Mutation：L1408P, V1490C, T1491R, G1492A, S1496N, A1498D, S1499C | CA CALCIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；293 K；0.2M calcium acetate, 7%(w/v) PEG10000, pH 7.6, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 1.42 Å R-free 0.193 |
| 4LXO Crystal structure of 9,10Fn3-elegantin chimera Deposited 2013-07-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
1357–1540（184 aa）
|
Mutation：L1408P, V1490C, T1491R, G1492A, S1496N, A1498D, S1499C | CA CALCIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；293 K；0.2M calcium acetate, 7%(w/v) PEG10000, pH 7.6, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 1.42 Å R-free 0.193 |
| 4MMX Integrin AlphaVBeta3 ectodomain bound to the tenth domain of Fibronectin Deposited 2013-09-09 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
1539–1631（93 aa）
Fragment：Fibronectin type-III domain 10 (UNP residues 1448-1540)
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 MN MANGANESE (II) ION × 8 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；277.15 K；12% PEG3350, 0.8 M sodium chloride, 0.1 M sodium acetate, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 277.15K
|
Resolution 3.32 Å R-free 0.269 |
| 4MMY Integrin AlphaVBeta3 ectodomain bound to the tenth domain of Fibronectin with the IAKGDWND motif Deposited 2013-09-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
1448–1540（93 aa）
Fragment：Fibronectin type-III domain 10 (UNP residues 1448-1540)
|
Mutation：TGRGDSPASS to IARGDWNDG | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 MN MANGANESE (II) ION × 8 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；277.15 K；12% PEG3350, 0.8 M sodium chloride, 0.1 M sodium acetate, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 277.15K
|
Resolution 3.18 Å R-free 0.252 |
| 4MMZ Integrin AlphaVBeta3 ectodomain bound to an antagonistic tenth domain of Fibronectin Deposited 2013-09-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
1539–1631（93 aa）
Fragment：Fibronectin type-III domain 10 (UNP residues 1448-1540)
|
Mutation：GRGDSPAS to PRGDWNEG | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 MN MANGANESE (II) ION × 8 NA SODIUM ION × 1 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；277.15 K；12% PEG3350, 0.8 M sodium chloride, 0.1 M sodium acetate, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 277.15K
|
Resolution 3.10 Å R-free 0.255 |
| 4PZ5 Crystal structure of the second and third fibronectin F1 modules in complex with a fragment of BBK32 from Borrelia burgdorferi Deposited 2014-03-28 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
93–182（90 aa）
Fragment：2FN1-3FN1, UNP RESIDUES 93-182
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.9；291 K；1.4 M Na/K phosphate, pH 6.9, VAPOR DIFFUSION, SITTING DROP, temperature 291K
|
Resolution 1.96 Å R-free 0.199 |
| 5DFT Structure of the Eleventh Type III Domain from Human Fibronectin Deposited 2015-08-27 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1539–1635（97 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；1.1M sodium citrate, 0.1M citric acid and 0.1M sodium iodine
|
Resolution 2.50 Å R-free 0.248 |
| 5DFT Structure of the Eleventh Type III Domain from Human Fibronectin Deposited 2015-08-27 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 10 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain J
1539–1635（97 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；1.1M sodium citrate, 0.1M citric acid and 0.1M sodium iodine
|
Resolution 2.50 Å R-free 0.248 |
| 5DFT Structure of the Eleventh Type III Domain from Human Fibronectin Deposited 2015-08-27 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
1539–1635（97 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；1.1M sodium citrate, 0.1M citric acid and 0.1M sodium iodine
|
Resolution 2.50 Å R-free 0.248 |
| 5DFT Structure of the Eleventh Type III Domain from Human Fibronectin Deposited 2015-08-27 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
1539–1635（97 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；1.1M sodium citrate, 0.1M citric acid and 0.1M sodium iodine
|
Resolution 2.50 Å R-free 0.248 |
| 5DFT Structure of the Eleventh Type III Domain from Human Fibronectin Deposited 2015-08-27 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
1539–1635（97 aa）
|
Not recorded | CIT CITRIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；1.1M sodium citrate, 0.1M citric acid and 0.1M sodium iodine
|
Resolution 2.50 Å R-free 0.248 |
| 5DFT Structure of the Eleventh Type III Domain from Human Fibronectin Deposited 2015-08-27 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain E
1539–1635（97 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；1.1M sodium citrate, 0.1M citric acid and 0.1M sodium iodine
|
Resolution 2.50 Å R-free 0.248 |
| 5DFT Structure of the Eleventh Type III Domain from Human Fibronectin Deposited 2015-08-27 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain F
1539–1635（97 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；1.1M sodium citrate, 0.1M citric acid and 0.1M sodium iodine
|
Resolution 2.50 Å R-free 0.248 |
| 5DFT Structure of the Eleventh Type III Domain from Human Fibronectin Deposited 2015-08-27 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 7 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain G
1539–1635（97 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；1.1M sodium citrate, 0.1M citric acid and 0.1M sodium iodine
|
Resolution 2.50 Å R-free 0.248 |
| 5DFT Structure of the Eleventh Type III Domain from Human Fibronectin Deposited 2015-08-27 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 8 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain H
1539–1635（97 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；1.1M sodium citrate, 0.1M citric acid and 0.1M sodium iodine
|
Resolution 2.50 Å R-free 0.248 |
| 5DFT Structure of the Eleventh Type III Domain from Human Fibronectin Deposited 2015-08-27 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 9 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain I
1539–1635（97 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；1.1M sodium citrate, 0.1M citric acid and 0.1M sodium iodine
|
Resolution 2.50 Å R-free 0.248 |
| 5J6Z Structure of anastellin bound to beta-strands A and B from the third type III domain of fibronectin Deposited 2016-04-05 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
806–834（29 aa）
Fragment：residues 806-834
Chain B
631–705（75 aa）
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 7.5；298 K；Ionic strength (raw mmCIF value) 166；Pressure 100000
NMR sample composition
0.6 mM [U-99% 13C; U-99% 15N] AB, 0.6 mM anastellin, 10 mM sodium phosphate, 1.8 mM potassium phosphate, 140 mM sodium chloride, 2.7 mM potassium chloride, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition
0.6 mM AB, 0.6 mM [U-99% 13C; U-99% 15N] anastellin, 10 mM sodium phosphate, 1.8 mM potassium phosphate, 140 mM sodium chloride, 2.7 mM potassium chloride, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition
0.6 mM [U-99% 15N] AB, 0.6 mM anastellin, 10 mM sodium phosphate, 1.8 mM potassium phosphate, 140 mM sodium chloride, 2.7 mM potassium chloride, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition
0.6 mM AB, 0.6 mM [U-99% 15N] anastellin, 10 mM sodium phosphate, 1.8 mM potassium phosphate, 140 mM sodium chloride, 2.7 mM potassium chloride, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 5M0A Solution structure of isolated 15th Fibronectin III domain from human fibronectin Deposited 2016-10-04 | Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
2108–2193（86 aa）
Fragment：15th Fibronectin III domain, UNP residues 2108-2193
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 6.5；298 K；Ionic strength (raw mmCIF value) 161；Pressure 1
NMR measurement conditions
pH 6.5；298 K；Ionic strength (raw mmCIF value) 161；Pressure 1
NMR sample composition
10 mM TRIS, 150 mM sodium chloride, 0.02 ug/mL TSP, 1 mM sodium azide, 0.35 mM [U-13C; U-15N] 15th Fibronectin III domain from human fibronectin, 0.5 mM EDTA, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition
10 mM [U-2H] TRIS, 0.35 mM [U-13C; U-15N] 15th Fibronectin III domain from human fibronectin, 150 mM sodium chloride, 1 mM sodium azide, 0.02 ug/mL TSP, 0.5 mM EDTA, 100% D2O | 100% D2O
|
Resolution not provided |
| 5N47 Structure of Anticalin N7E in complex with the three-domain fragment Fn7B8 of human oncofetal fibronectin Deposited 2017-02-10 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
1173–1448（276 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；17 % (w/v) PEG3350, 0.2 M NaCl, 0.1 M Na-malonate
|
Resolution 3.00 Å R-free 0.241 |
| 5N47 Structure of Anticalin N7E in complex with the three-domain fragment Fn7B8 of human oncofetal fibronectin Deposited 2017-02-10 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain D
1173–1448（276 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；17 % (w/v) PEG3350, 0.2 M NaCl, 0.1 M Na-malonate
|
Resolution 3.00 Å R-free 0.241 |
| 5N47 Structure of Anticalin N7E in complex with the three-domain fragment Fn7B8 of human oncofetal fibronectin Deposited 2017-02-10 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain F
1173–1448（276 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；17 % (w/v) PEG3350, 0.2 M NaCl, 0.1 M Na-malonate
|
Resolution 3.00 Å R-free 0.241 |
| 5N48 Structure of Anticalin N9B in complex with extra-domain B of human oncofetal fibronectin Deposited 2017-02-10 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
1266–1357（92 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；29 % (w/v) PEG4000, 0.1 M Na-malonate
|
Resolution 1.60 Å R-free 0.208 |
| 5N48 Structure of Anticalin N9B in complex with extra-domain B of human oncofetal fibronectin Deposited 2017-02-10 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain D
1266–1357（92 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；29 % (w/v) PEG4000, 0.1 M Na-malonate
|
Resolution 1.60 Å R-free 0.208 |
| 6HNF Structure in solution of human fibronectin type III-domain 14 Deposited 2018-09-14 | Different construct Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1904–1991（88 aa）
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 7.4；298 K；Ionic strength (raw mmCIF value) 162.7；Pressure 1030
NMR sample composition
1.0 mM [U-13C; U-15N] FNIII14, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 6MFA Fragment of human fibronectin containing the 4th-7th type III domains Deposited 2018-09-10 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
903–1268（366 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；0.1 M MES pH 5.5, 7% PEG 6000
|
Resolution 1.75 Å R-free 0.238 |
| 6MSV Structure of the 6th type III domain from human fibronectin Deposited 2018-10-18 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1085–1173（89 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2.0 M Ammonium Sulfate
|
Resolution 2.40 Å R-free 0.295 |
| 6MSV Structure of the 6th type III domain from human fibronectin Deposited 2018-10-18 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 10 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain J
1085–1173（89 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2.0 M Ammonium Sulfate
|
Resolution 2.40 Å R-free 0.295 |
| 6MSV Structure of the 6th type III domain from human fibronectin Deposited 2018-10-18 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 11 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain K
1085–1173（89 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2.0 M Ammonium Sulfate
|
Resolution 2.40 Å R-free 0.295 |
| 6MSV Structure of the 6th type III domain from human fibronectin Deposited 2018-10-18 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 12 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain L
1085–1173（89 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2.0 M Ammonium Sulfate
|
Resolution 2.40 Å R-free 0.295 |
| 6MSV Structure of the 6th type III domain from human fibronectin Deposited 2018-10-18 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 13 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1085–1173（89 aa）
Chain G
1085–1173（89 aa）
Chain H
1085–1173（89 aa）
Chain J
1085–1173（89 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2.0 M Ammonium Sulfate
|
Resolution 2.40 Å R-free 0.295 |
| 6MSV Structure of the 6th type III domain from human fibronectin Deposited 2018-10-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 14 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain B
1085–1173（89 aa）
Chain D
1085–1173（89 aa）
Chain F
1085–1173（89 aa）
Chain L
1085–1173（89 aa）
|
Not recorded | GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2.0 M Ammonium Sulfate
|
Resolution 2.40 Å R-free 0.295 |
| 6MSV Structure of the 6th type III domain from human fibronectin Deposited 2018-10-18 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 15 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain C
1085–1173（89 aa）
Chain E
1085–1173（89 aa）
Chain I
1085–1173（89 aa）
Chain K
1085–1173（89 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2.0 M Ammonium Sulfate
|
Resolution 2.40 Å R-free 0.295 |
| 6MSV Structure of the 6th type III domain from human fibronectin Deposited 2018-10-18 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
1085–1173（89 aa）
|
Not recorded | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2.0 M Ammonium Sulfate
|
Resolution 2.40 Å R-free 0.295 |
| 6MSV Structure of the 6th type III domain from human fibronectin Deposited 2018-10-18 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
1085–1173（89 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2.0 M Ammonium Sulfate
|
Resolution 2.40 Å R-free 0.295 |
| 6MSV Structure of the 6th type III domain from human fibronectin Deposited 2018-10-18 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
1085–1173（89 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2.0 M Ammonium Sulfate
|
Resolution 2.40 Å R-free 0.295 |
| 6MSV Structure of the 6th type III domain from human fibronectin Deposited 2018-10-18 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain E
1085–1173（89 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2.0 M Ammonium Sulfate
|
Resolution 2.40 Å R-free 0.295 |
| 6MSV Structure of the 6th type III domain from human fibronectin Deposited 2018-10-18 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain F
1085–1173（89 aa）
|
Not recorded | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2.0 M Ammonium Sulfate
|
Resolution 2.40 Å R-free 0.295 |
| 6MSV Structure of the 6th type III domain from human fibronectin Deposited 2018-10-18 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 7 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain G
1085–1173（89 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2.0 M Ammonium Sulfate
|
Resolution 2.40 Å R-free 0.295 |
| 6MSV Structure of the 6th type III domain from human fibronectin Deposited 2018-10-18 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 8 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain H
1085–1173（89 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2.0 M Ammonium Sulfate
|
Resolution 2.40 Å R-free 0.295 |
| 6MSV Structure of the 6th type III domain from human fibronectin Deposited 2018-10-18 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 9 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain I
1085–1173（89 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2.0 M Ammonium Sulfate
|
Resolution 2.40 Å R-free 0.295 |
| 6NAJ Integrin AlphaVBeta3 ectodomain bound to Hr10 variant of the 10th domain of Fibronectin. Deposited 2018-12-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
1539–1629（91 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 7 MN MANGANESE (II) ION × 8 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；277 K；100 M Sodium Acetate, PEG4000, 800 mM Sodium Chloride.
|
Resolution 3.10 Å R-free 0.268 |
| 6XAX Structure of a fragment of human fibronectin containing the 11th type III domain, extra domain A, and the 12th type III domain Deposited 2020-06-04 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
1630–1903（274 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.2M Ca(CH3COO)2, 0.1M imidazole pH 8.0, 10%(w/v) PEG 8000
|
Resolution 2.40 Å R-free 0.312 |
| 6XAX Structure of a fragment of human fibronectin containing the 11th type III domain, extra domain A, and the 12th type III domain Deposited 2020-06-04 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1630–1903（274 aa）
|
Not recorded | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.2M Ca(CH3COO)2, 0.1M imidazole pH 8.0, 10%(w/v) PEG 8000
|
Resolution 2.40 Å R-free 0.312 |
| 6XAY Structure of a fragment of human fibronectin containing the 10th, 11th and 12th type III domains Deposited 2020-06-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1447–1722（276 aa）
|
Mutation：V1643G | GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.5M (NH4)2SO4, 0.1M Citric acid pH 4.0, 30%(v/v)PEG 600, 10%(v/v) glycerol
|
Resolution 2.48 Å R-free 0.296 |
| 6XAY Structure of a fragment of human fibronectin containing the 10th, 11th and 12th type III domains Deposited 2020-06-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
1447–1722（276 aa）
|
Mutation：V1643G | GOL GLYCEROL × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.5M (NH4)2SO4, 0.1M Citric acid pH 4.0, 30%(v/v)PEG 600, 10%(v/v) glycerol
|
Resolution 2.48 Å R-free 0.296 |
| 6XAY Structure of a fragment of human fibronectin containing the 10th, 11th and 12th type III domains Deposited 2020-06-05 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
1447–1722（276 aa）
|
Mutation：V1643G | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.5M (NH4)2SO4, 0.1M Citric acid pH 4.0, 30%(v/v)PEG 600, 10%(v/v) glycerol
|
Resolution 2.48 Å R-free 0.296 |
| 6XAY Structure of a fragment of human fibronectin containing the 10th, 11th and 12th type III domains Deposited 2020-06-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
1447–1722（276 aa）
|
Mutation：V1643G | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.5M (NH4)2SO4, 0.1M Citric acid pH 4.0, 30%(v/v)PEG 600, 10%(v/v) glycerol
|
Resolution 2.48 Å R-free 0.296 |
| 7NWL Cryo-EM structure of human integrin alpha5beta1 (open form) in complex with fibronectin and TS2/16 Fv-clasp Deposited 2021-03-17 | Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 5 PDB declaration: pentameric |
Chain C
1173–1540（368 aa）
|
Not recorded | MN MANGANESE (II) ION × 7 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE-PROPANE
|
Resolution 3.10 Å |
| 8PEQ Complex of diubiquitin-derived artificial binding protein (Affilin) variant Af2 with its target oncofetal fibronectin (fragment 7B8) Deposited 2023-06-14 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
1174–1447（274 aa）
|
Not recorded | SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 7.3；298 K；500 mM lithium sulfate, 15% PEG 8000 (w/v)
|
Resolution 2.32 Å R-free 0.251 |
| 8PEQ Complex of diubiquitin-derived artificial binding protein (Affilin) variant Af2 with its target oncofetal fibronectin (fragment 7B8) Deposited 2023-06-14 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
1174–1447（274 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 7.3；298 K；500 mM lithium sulfate, 15% PEG 8000 (w/v)
|
Resolution 2.32 Å R-free 0.251 |
| 8PEQ Complex of diubiquitin-derived artificial binding protein (Affilin) variant Af2 with its target oncofetal fibronectin (fragment 7B8) Deposited 2023-06-14 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
1174–1447（274 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 7.3；298 K；500 mM lithium sulfate, 15% PEG 8000 (w/v)
|
Resolution 2.32 Å R-free 0.251 |
| 9P6S Cryo-EM structure of human integrin alpha5beta1 in complex with fibronectin (FN 7-10) Deposited 2025-06-19 | Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
1449–1631（183 aa）
|
Not recorded | MN MANGANESE (II) ION × 7 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE-PROPANE
|
Resolution 2.61 Å |
54 other PDB entries and 98 assemblies. Open the comparison page and filter oligomeric states
View Construct and Data Evidence
| UniProt name | FINC_HUMAN |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain A； PDBConstruct 1–90； UniProt 93–182 Author chain B； PDBConstruct 1–90； UniProt 93–182 Author chain C； PDBConstruct 1–90； UniProt 93–182 Author chain D； PDBConstruct 1–90； UniProt 93–182 Author chain E； PDBConstruct 1–90； UniProt 93–182 Author chain F； PDBConstruct 1–90； UniProt 93–182 |
