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3cii

Structure of NKG2A/CD94 bound to HLA-E

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

HLA class I histocompatibility antigen, alpha chain E

Homo sapiens

UniProt P13747

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 5 Beta-2-microglobulin × 1 （P61769） HLA class I histocompatibility antigen peptide × 1 （P17693） Natural killer cells antigen CD94 × 1 （Q13241） NKG2-A/NKG2-B type II integral membrane protein × 1 （P26715） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 5 Beta-2-microglobulin × 1 （P61769） HLA class I histocompatibility antigen peptide × 1 （P17693） Natural killer cells antigen CD94 × 1 （Q13241） NKG2-A/NKG2-B type II integral membrane protein × 1 （P26715） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1kpr 1kpr 1kpr 1kpr 1ktl 1ktl 1ktl 1mhe 2esv 3am8 3am8 3bze

58 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name HLAE_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–273； UniProt 23–295 Author chain D； PDBConstruct 1–273； UniProt 23–295

Beta-2-microglobulin

Homo sapiens

UniProt P61769

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 5 HLA class I histocompatibility antigen, alpha chain E × 1 （P13747） HLA class I histocompatibility antigen peptide × 1 （P17693） Natural killer cells antigen CD94 × 1 （Q13241） NKG2-A/NKG2-B type II integral membrane protein × 1 （P26715） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 5 HLA class I histocompatibility antigen, alpha chain E × 1 （P13747） HLA class I histocompatibility antigen peptide × 1 （P17693） Natural killer cells antigen CD94 × 1 （Q13241） NKG2-A/NKG2-B type II integral membrane protein × 1 （P26715） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1jnj 1lds 1py4 1py4 1py4 1py4 2d4d 2d4f 2vb5 2xks 2xku 2yxf

61 assemblies; showing the first 12

Homodimer
2x89 2x89 2z9t 3low 4r9h 4r9h 4ra3 4ra3 4rah 6m1b

10 assemblies

Homotetramer
2e8d 2f8o 3tlr 3tm6 3tm6 7afv

6 assemblies

Other homooligomers
3ciq 3ciq 3loz 6gk3 8a7o 8a7p 8a7q 8a7t

8 assemblies

Heteromeric or nucleic-acid complex
1a1m 1a1n 1a1o 1a6z 1a6z 1a9b 1a9b 1a9e 1agb 1agc 1agd 1age

1914 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name B2MG_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 2–100； UniProt 21–119 Author chain E； PDBConstruct 2–100； UniProt 21–119

HLA class I histocompatibility antigen peptide

OrganismNot specified

UniProt P17693

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 5 HLA class I histocompatibility antigen, alpha chain E × 1 （P13747） Beta-2-microglobulin × 1 （P61769） Natural killer cells antigen CD94 × 1 （Q13241） NKG2-A/NKG2-B type II integral membrane protein × 1 （P26715） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 5 HLA class I histocompatibility antigen, alpha chain E × 1 （P13747） Beta-2-microglobulin × 1 （P61769） Natural killer cells antigen CD94 × 1 （Q13241） NKG2-A/NKG2-B type II integral membrane protein × 1 （P26715） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1ydp 1ydp 2d31 2d31 2dyp 3bze 3bze 3bze 3bze 3cdg 3cdg 3cii

17 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name HLAG_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C； PDBConstruct 1–9； UniProt 3–11 Author chain F； PDBConstruct 1–9； UniProt 3–11

Natural killer cells antigen CD94

Homo sapiens

UniProt Q13241

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 5 HLA class I histocompatibility antigen, alpha chain E × 1 （P13747） Beta-2-microglobulin × 1 （P61769） HLA class I histocompatibility antigen peptide × 1 （P17693） NKG2-A/NKG2-B type II integral membrane protein × 1 （P26715） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 5 HLA class I histocompatibility antigen, alpha chain E × 1 （P13747） Beta-2-microglobulin × 1 （P61769） HLA class I histocompatibility antigen peptide × 1 （P17693） NKG2-A/NKG2-B type II integral membrane protein × 1 （P26715） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1b6e

1 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3bdw 3bdw 3cdg 3cdg 3cii 3cii

6 assemblies

View Construct and Data Evidence
UniProt name KLRD1_HUMAN
Isoform —
PDB entities 4
Chains and sequence ranges Author chain G； PDBConstruct 1–121； UniProt 59–179 Author chain I； PDBConstruct 1–121； UniProt 59–179

NKG2-A/NKG2-B type II integral membrane protein

Homo sapiens

UniProt P26715

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 5 HLA class I histocompatibility antigen, alpha chain E × 1 （P13747） Beta-2-microglobulin × 1 （P61769） HLA class I histocompatibility antigen peptide × 1 （P17693） Natural killer cells antigen CD94 × 1 （Q13241） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 5 HLA class I histocompatibility antigen, alpha chain E × 1 （P13747） Beta-2-microglobulin × 1 （P61769） HLA class I histocompatibility antigen peptide × 1 （P17693） Natural killer cells antigen CD94 × 1 （Q13241） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2rmx 2yu7 3bdw 3bdw 3cdg 3cdg 3cii 3cii

8 assemblies

View Construct and Data Evidence
UniProt name NKG2A_HUMAN
Isoform —
PDB entities 5
Chains and sequence ranges Author chain H； PDBConstruct 1–120； UniProt 113–232 Author chain J； PDBConstruct 1–120； UniProt 113–232

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id3cii
Deposition date deposition_date2008-03-11
Structure title titleStructure of NKG2A/CD94 bound to HLA-E
Keywords keywords;C-type lectin-like, Glycoprotein, Immune response, Membrane, MHC I, Transmembrane, Disease mutation, Glycation, Immunoglobulin domain, Pyrrolidone carboxylic acid, Secreted, Lectin, Receptor, Signal-anchor, IMMUNE SYSTEM ;; IMMUNE SYSTEM
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

3cii__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

3cii__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

3cii__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）29.83 Å
Rg (electron density)29.06 Å
Total Rg29.73 Å
Atom count5073
Residues619
Excluded volume88787 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 3cii__assembly_1__model_1 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 3cii__assembly_2__model_1 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 10 domains

SCOP 2.08 (10 domains)

Domain ID domain_idd3ciia1
Class classb — All beta proteins
Fold Fold foldb.1 — Immunoglobulin-like beta-sandwich
Superfamily Superfamily superfamilyb.1.1 — Immunoglobulin
Family Family familyb.1.1.2 — C1 set domains (antibody constant domain-like)
Domain ID domain_idd3ciia2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.19 — MHC antigen-recognition domain
Superfamily Superfamily superfamilyd.19.1 — MHC antigen-recognition domain
Family Family familyd.19.1.1 — MHC antigen-recognition domain
Domain ID domain_idd3ciib1
Class classb — All beta proteins
Fold Fold foldb.1 — Immunoglobulin-like beta-sandwich
Superfamily Superfamily superfamilyb.1.1 — Immunoglobulin
Family Family familyb.1.1.2 — C1 set domains (antibody constant domain-like)
Domain ID domain_idd3ciib2
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
Domain ID domain_idd3ciid1
Class classb — All beta proteins
Fold Fold foldb.1 — Immunoglobulin-like beta-sandwich
Superfamily Superfamily superfamilyb.1.1 — Immunoglobulin
Family Family familyb.1.1.2 — C1 set domains (antibody constant domain-like)
Domain ID domain_idd3ciid2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.19 — MHC antigen-recognition domain
Superfamily Superfamily superfamilyd.19.1 — MHC antigen-recognition domain
Family Family familyd.19.1.1 — MHC antigen-recognition domain
Domain ID domain_idd3ciie1
Class classb — All beta proteins
Fold Fold foldb.1 — Immunoglobulin-like beta-sandwich
Superfamily Superfamily superfamilyb.1.1 — Immunoglobulin
Family Family familyb.1.1.2 — C1 set domains (antibody constant domain-like)
Domain ID domain_idd3ciie2
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
Domain ID domain_idd3ciig1
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.169 — C-type lectin-like
Superfamily Superfamily superfamilyd.169.1 — C-type lectin-like
Family Family familyd.169.1.1 — C-type lectin domain
Domain ID domain_idd3ciii1
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.169 — C-type lectin-like
Superfamily Superfamily superfamilyd.169.1 — C-type lectin-like
Family Family familyd.169.1.1 — C-type lectin domain
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7. Citations (1)