← Back to search
3kpe

Solution structure of the respiratory syncytial virus (RSV)six-helix bundle complexed with TMC353121, a small-moleucule inhibitor of RSV

Method: X-RAY DIFFRACTION
▼

1. Protein Identity and Related Structures Protein Identity & Related Structures

Fusion glycoprotein F0

OrganismNot specified

UniProt P03420

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 6 ;2-[[6-[[[2-(3-hydroxypropyl)-5-methylphenyl]amino]methyl]-2-[[3-(4-morpholinyl)propyl]amino]-1H-benzimidazol-1-yl]methyl]-6-methyl-3-pyridinol ; × 3 TETRAETHYLENE GLYCOL × 3 water × 6 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers
3kpe 5ea3 5ea4 5ea5 5ea6 5ea7 5ea8 5k6b 5k6c 5k6f 5k6g 5k6h

13 assemblies; showing the first 12

Heteromeric or nucleic-acid complex
29qj 3ixt 3ixt 3o41 3o41 3o45 3o45 3rki 4jhw 4mmq 4mmr 4mms

47 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name FUS_HRSVA
Isoform —
PDB entities 1, 2
Chains and sequence ranges Author chain A； PDBConstruct 1–51； UniProt 159–209 Author chain B； PDBConstruct 1–39； UniProt 482–520

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

▼

2. Structure Basics 2. Structure Basics

Entry ID entry_id3kpe
Deposition date deposition_date2009-11-16
Structure title titleSolution structure of the respiratory syncytial virus (RSV)six-helix bundle complexed with TMC353121, a small-moleucule inhibitor of RSV
Keywords keywords;peptide-small-molecule complex, alpha helix, coiled-coil, Envelope protein, Fusion protein, Glycoprotein, Host cell membrane, Host membrane, Lipoprotein, Membrane, Palmitate, Transmembrane, Virion, VIRAL PROTEIN ;; VIRAL PROTEIN, FUSION PROTEIN
Experimental Method methodX-RAY DIFFRACTION
▼

3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

3kpe__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

3kpe__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

3kpe__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）21.73 Å
Rg (electron density)21.29 Å
Total Rg22.11 Å
Atom count2091
Residues252
Excluded volume37930 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 3kpe__assembly_1__model_1 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
▶

4. Crystallography and Experiment 4. Crystallography & Experiment

▶

5. Entities and Polymers Entities & Polymers (5)

▼

6. Fold Classification (SCOP + CATH) 1 domains

CATH v4.4 (1 domains)

Domain ID domain_id3kpeA00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily300 —
▶

7. Citations (1)