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4mmq

Crystal Structure of Prefusion-stabilized RSV F Variant DS

Method: X-RAY DIFFRACTION Dmax: 107.8 Å Quality: GOOD
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Fusion glycoprotein F2

Human respiratory syncytial virus A2

UniProt P03420

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Insufficient information Heteromer Protein × 6 PDB declaration: hexameric（6） Consistent with protein copy count Chain A； UniProt 26–107 Chain B； UniProt 137–513 Mutation：P102A Mutation：S155C, S290C, I379V, M447V SO4 SULFATE ION × 18 X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 9.5；298 K；1.4 M K/Na tartrate, 0.1M CHES pH 9.5, 0.2 M LiSO4, VAPOR DIFFUSION, HANGING DROP, temperature 298K Resolution 3.25 Å R-free 0.274

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 4MMQ Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
29QJ Respiratory syncytial virus fusion protein N-terminal heptad repeat domain in complex with Double stapled peptide 4/4g Deposited 2026-03-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 159–209（51 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.32 Å R-free 0.232
3IXT Crystal Structure of Motavizumab Fab Bound to Peptide Epitope Deposited 2009-09-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain P 254–277（24 aa） Fragment：sequence database residues 254-277
Non-standard monomer：Yes (specific site not provided by mmCIF) EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；17.5% PEG 8000, 0.2 M zinc acetate, 0.1 M cacodylate pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.75 Å R-free 0.274
3IXT Crystal Structure of Motavizumab Fab Bound to Peptide Epitope Deposited 2009-09-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain C 254–277（24 aa） Fragment：sequence database residues 254-277
Non-standard monomer：Yes (specific site not provided by mmCIF) EDO 1,2-ETHANEDIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；17.5% PEG 8000, 0.2 M zinc acetate, 0.1 M cacodylate pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.75 Å R-free 0.274
3KPE Solution structure of the respiratory syncytial virus (RSV)six-helix bundle complexed with TMC353121, a small-moleucule inhibitor of RSV Deposited 2009-11-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 159–209（51 aa） Fragment：proteinase K-resistant core of heptad repeat 1
Chain B 482–520（39 aa） Fragment：proteinase K-resistant core of heptad repeat 2
Not recorded TM3 2-[[6-[[[2-(3-hydroxypropyl)-5-methylphenyl]amino]methyl]-2-[[3-(4-morpholinyl)propyl]amino]-1H-benzimidazol-1-yl]methyl]-6-methyl-3-pyridinol × 3 PG4 TETRAETHYLENE GLYCOL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；30% (v/v) PEG-400 + 100 mM HEPES, pH 7.5 + 200 mM NaCl, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 1.47 Å R-free 0.196
3O41 Crystal Structure of 101F Fab Bound to 15-mer Peptide Epitope Deposited 2010-07-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain P 422–436（15 aa） Fragment：Residues 422-436
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 8 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；20.5% (w/v) PEG 4000, 0.2 M lithium sulfate monohydrate, 0.1 M Tris-HCl pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.95 Å R-free 0.217
3O41 Crystal Structure of 101F Fab Bound to 15-mer Peptide Epitope Deposited 2010-07-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain C 422–436（15 aa） Fragment：Residues 422-436
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；20.5% (w/v) PEG 4000, 0.2 M lithium sulfate monohydrate, 0.1 M Tris-HCl pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.95 Å R-free 0.217
3O45 Crystal Structure of 101F Fab Bound to 17-mer Peptide Epitope Deposited 2010-07-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain P 422–438（17 aa） Fragment：UNP residues 422-438
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；20.5% (w/v) PEG 4000, 0.2 M lithium sulfate monohydrate, 0.1 M Tris-HCl pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.87 Å R-free 0.254
3O45 Crystal Structure of 101F Fab Bound to 17-mer Peptide Epitope Deposited 2010-07-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain C 422–438（17 aa） Fragment：UNP residues 422-438
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；20.5% (w/v) PEG 4000, 0.2 M lithium sulfate monohydrate, 0.1 M Tris-HCl pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.87 Å R-free 0.254
3RKI Structural basis for immunization with post-fusion RSV F to elicit high neutralizing antibody titers Deposited 2011-04-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 1–524（524 aa） Fragment：Respiratory Syncytial Virus F, residues 1-524
Chain B 1–524（524 aa） Fragment：Respiratory Syncytial Virus F, residues 1-524
Chain C 1–524（524 aa） Fragment：Respiratory Syncytial Virus F, residues 1-524
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；298 K；4.2 M Sodium Formate, 100 mM Sodium Acetate, pH 5.1, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 3.20 Å R-free 0.264
4JHW Crystal Structure of Respiratory Syncytial Virus Fusion Glycoprotein Stabilized in the Prefusion Conformation by Human Antibody D25 Deposited 2013-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 9 PDB declaration: nonameric
Chain F 26–109（84 aa）
Chain F 137–513（377 aa）
Mutation：P102A, I379V, M447V Mutation：P102A, I379V, M447V No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；30% (w/v) PEG 400, 3.75% (w/v) PEG 3350, 0.1 M HEPES pH 7.5, and 1% (v/v) 1,2-butanediol, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 3.60 Å R-free 0.267
4MMR Crystal Structure of Prefusion-stabilized RSV F Variant Cav1 at pH 9.5 Deposited 2013-09-09 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 26–107（82 aa）
Chain B 137–513（377 aa）
Mutation：P102A Mutation：S190F, V207L, I379V, M447V No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 9.5；293 K；1.4M sodium potassium tartarate, 0.1M CHES, pH 9.5, 0.2M Li2SO4, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 3.10 Å R-free 0.264
4MMS Crystal Structure of Prefusion-stabilized RSV F Variant Cav1 at pH 5.5 Deposited 2013-09-09 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 26–107（82 aa）
Chain B 137–513（377 aa）
Chain C 26–107（82 aa）
Chain D 137–513（377 aa）
Chain E 26–107（82 aa）
Chain F 137–513（377 aa）
Mutation：P102A Mutation：S190F, V207L, I379V, M447V Mutation：P102A Mutation：S190F, V207L, I379V, M447V Mutation：P102A Mutation：S190F, V207L, I379V, M447V SO4 SULFATE ION × 14 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；1.7 M ammonium sulfate, 0.1 M citrate pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.40 Å R-free 0.214
4MMT Crystal Structure of Prefusion-stabilized RSV F Variant DS-Cav1 at pH 9.5 Deposited 2013-09-09 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 26–107（82 aa）
Chain B 137–513（377 aa）
Mutation：P102A Mutation：S155C, S190F, V207L, S290C, I379V, M447V No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 9.5；1.8 M Na/K tartrate, 0.2 M LiSO4, 0.1 M CHES pH9.5, VAPOR DIFFUSION, HANGING DROP
Resolution 3.05 Å R-free 0.243
4MMU Crystal Structure of Prefusion-stabilized RSV F Variant DS-Cav1 at pH 5.5 Deposited 2013-09-09 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 26–107（82 aa）
Chain B 137–513（377 aa）
Mutation：P102A Mutation：S155C, S190F, V207L, S290C, I379V, M447V SO4 SULFATE ION × 12 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 PO4 PHOSPHATE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；1.8 M Ammonium sulphate 0.1 M citrate pH5.5, VAPOR DIFFUSION, HANGING DROP
Resolution 3.00 Å R-free 0.228
4MMV Crystal Structure of Prefusion-stabilized RSV F Variant DS-Cav1-TriC at pH 9.5 Deposited 2013-09-09 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 26–107（82 aa）
Chain B 137–513（377 aa）
Mutation：P102A Mutation：S155C, S190F, V207L, S290C, I379V, M447, VD486H, E487Q, F488W, D489H No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 9.5；293 K；1.4M sodium potassium tartarate, 0.1M CHES, pH 9.5, 0.2M Li2SO4, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.81 Å R-free 0.279
4ZYP Crystal Structure of Motavizumab and Quaternary-Specific RSV-Neutralizing Human Antibody AM14 in Complex with Prefusion RSV F Glycoprotein Deposited 2015-05-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain A 26–513（488 aa）
Chain B 26–513（488 aa）
Chain C 26–513（488 aa）
Mutation：S155C, S190F, V207L, S290C, I379V, M447V Mutation：S155C, S190F, V207L, S290C, I379V, M447V Mutation：S155C, S190F, V207L, S290C, I379V, M447V No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；5.645mg/mL EndoH digested DS-Cav1 + AM14 Fab + Motavizumab Fab, 11.4% PEG8000, 1.71% MPD, 0.1M Imidazole pH 6.5
Resolution 5.50 Å R-free 0.277
5C69 Crystal Structure of Prefusion-stabilized RSV F variant PR-DM Deposited 2015-06-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 26–518（493 aa） Fragment：F2 subunit, F1 subunit ectodomain
Mutation：N67I, S215P, I379V, M447V SO4 SULFATE ION × 42 NHE 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID × 12 CL CHLORIDE ION × 30 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 9.5；293 K；1.24M K/Na tartrate, 0.2M LiSO4, 0.1M CHES pH 9.5
Resolution 2.30 Å R-free 0.217
5C6B Crystal Structure of Prefusion-stabilized RSV F variant SC-TM Deposited 2015-06-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 6 PDB declaration: hexameric
Chain F 26–513（488 aa） Fragment：ectodomain
Mutation：N67I, S215P, E487Q, I379V, M447V,N67I, S215P, E487Q, I379V, M447V NHE 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID × 6 SO4 SULFATE ION × 24 CL CHLORIDE ION × 12 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 9.5；293 K；1.34M K/Na tartrate, 0.2M LiSO4, 0.1M CHES pH 9.5
Resolution 2.40 Å R-free 0.211
5EA3 Crystal Structure of Inhibitor JNJ-2408068 in Complex with Prefusion RSV F Glycoprotein Deposited 2015-10-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain F 1–513（513 aa） Fragment：RSV F ectodomain (UNP residues 1-513)
Mutation：V207L, S190F, S155C, S290C NHE 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID × 3 SO4 SULFATE ION × 18 5NK 2-[[2-[[1-(2-azanylethyl)piperidin-4-yl]amino]-4-methyl-benzimidazol-1-yl]methyl]-6-methyl-pyridin-3-ol × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 9.5；293 K；1.54 M potassium/sodium tartrate, 0.2 M lithium sulfate, 0.1 M CHES, pH 9.5
Resolution 2.75 Å R-free 0.229
5EA4 Crystal Structure of Inhibitor JNJ-49153390 in Complex with Prefusion RSV F Glycoprotein Deposited 2015-10-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain F 1–513（513 aa） Fragment：RSV F ectodomain (UNP residues 1-513)
Mutation：S190F, V207L, S155C, S290C NHE 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID × 3 SO4 SULFATE ION × 15 5NM 3-[[5-bromanyl-1-(3-methylsulfonylpropyl)benzimidazol-2-yl]methyl]-1-cyclopropyl-imidazo[4,5-c]pyridin-2-one × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 9.5；293 K；1.54 M potassium/sodium tartrate, 0.2 M lithium sulfate, 0.1 M CHES, pH 9.5
Resolution 2.30 Å R-free 0.214
5EA5 Crystal Structure of Inhibitor TMC-353121 in Complex with Prefusion RSV F Glycoprotein Deposited 2015-10-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain F 1–513（513 aa） Fragment：RSV F ectodomain (UNP residues 1-513)
Mutation：S190F, V207L, S155C, S290C NHE 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID × 3 TM3 2-[[6-[[[2-(3-hydroxypropyl)-5-methylphenyl]amino]methyl]-2-[[3-(4-morpholinyl)propyl]amino]-1H-benzimidazol-1-yl]methyl]-6-methyl-3-pyridinol × 3 SO4 SULFATE ION × 3 TAR D(-)-TARTARIC ACID × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 9.5；293 K；1.54 M potassium/sodium tartrate, 0.2 M lithium sulfate, 0.1 M CHES, pH 9.5
Resolution 3.05 Å R-free 0.248
5EA6 Crystal Structure of Inhibitor BTA-9881 in Complex with Prefusion RSV F Glycoprotein Deposited 2015-10-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain F 1–513（513 aa） Fragment：RSV F ectodomain (UNP residues 1-513)
Mutation：S190F, V207L, S155C, S290C NHE 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID × 3 SO4 SULFATE ION × 12 5NP (9~{b}~{R})-9~{b}-(4-chlorophenyl)-1-pyridin-3-ylcarbonyl-2,3-dihydroimidazo[5,6]pyrrolo[1,2-~{a}]pyridin-5-one × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 9.5；293 K；1.54 M potassium/sodium tartrate, 0.2 M lithium sulfate, 0.1 M CHES, pH 9.5
Resolution 2.75 Å R-free 0.235
5EA7 Crystal Structure of Inhibitor BMS-433771 in Complex with Prefusion RSV F Glycoprotein Deposited 2015-10-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain F 1–513（513 aa） Fragment：RSV F ectodomain (UNP residues 1-513)
Mutation：S190F, V207L, S155C, S290C SO4 SULFATE ION × 15 NHE 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID × 3 5NO 1-cyclopropyl-3-[[1-(4-oxidanylbutyl)benzimidazol-2-yl]methyl]imidazo[4,5-c]pyridin-2-one × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 9.5；293 K；1.54 M potassium/sodium tartrate, 0.2 M lithium sulfate, 0.1 M CHES, pH 9.5
Resolution 2.85 Å R-free 0.241
5EA8 Crystal Structure of Prefusion RSV F Glycoprotein Fusion Inhibitor Resistance Mutant D489Y Deposited 2015-10-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain F 1–513（513 aa） Fragment：RSV F ectodomain (UNP residues 1-513)
Mutation：S190F, V207L, S155C, S290C, D489Y SO4 SULFATE ION × 15 NHE 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID × 3 TAR D(-)-TARTARIC ACID × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 9.5；293 K；1.54 M potassium/sodium tartrate, 0.2 M lithium sulfate, 0.1 M CHES, pH 9.5
Resolution 2.60 Å R-free 0.237
5J3D Crystal structure of human Fab 14N4 in complex with post-fusion RSV F Deposited 2016-03-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain E 26–98（73 aa） Fragment：UNP residues 26-98
Chain F 147–513（367 aa） Fragment：UNP residues 147-513
Chain G 26–98（73 aa） Fragment：UNP residues 26-98
Chain I 147–513（367 aa） Fragment：UNP residues 147-513
Chain J 26–98（73 aa） Fragment：UNP residues 26-98
Chain K 147–513（367 aa） Fragment：UNP residues 147-513
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；293 K；2 M ammonium sulfate, 5% 2-propanol
Resolution 4.08 Å R-free 0.282
5K6B Crystal structure of prefusion-stabilized RSV F single-chain 9 DS-Cav1 variant. Deposited 2016-05-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain F 26–105（80 aa） Fragment：UNP residues 26-105 linked to residues 145-509 via LINKER residues GS
Chain F 145–509（365 aa） Fragment：UNP residues 26-105 linked to residues 145-509 via LINKER residues GS
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 SO4 SULFATE ION × 12 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；293 K；0.1 M NaOAc-Acetic Acid pH 5.5, 1.09 M Li2SO4, 0.12 M MgSO4, 3.33 % (w/v) PEG 400
Resolution 2.98 Å R-free 0.260
5K6C Crystal structure of prefusion-stabilized RSV F single-chain 9-10 DS-Cav1 variant. Deposited 2016-05-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain F 26–103（78 aa） Fragment：UNP residues 26-101 linked to residues 145-509 via LINKER residues ATGS
Chain F 145–509（365 aa） Fragment：UNP residues 26-101 linked to residues 145-509 via LINKER residues ATGS
Not recorded SO4 SULFATE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.1 M HEPES pH 7.5, 0.19 M (NH4)2SO4, 11 % iso-propanol, 17 % PEG 8,000
Resolution 3.58 Å R-free 0.262
5K6F Crystal structure of prefusion-stabilized RSV F single-chain 9-19 DS-Cav1 variant. Deposited 2016-05-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain F 26–103（78 aa） Fragment：UNP residues 26-103 linked to residues 145-509 via LINKER residues GGSGGSG
Chain F 145–509（365 aa） Fragment：UNP residues 26-103 linked to residues 145-509 via LINKER residues GGSGGSG
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M Na citrate pH 5.6, 15 % iso-propanol, 17 % PEG 4,000
Resolution 2.59 Å R-free 0.237
5K6G Crystal structure of prefusion-stabilized RSV F single-chain 9-24 DS-Cav1 variant. Deposited 2016-05-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain F 26–96（71 aa） Fragment：UNP residues 26-79 and UNP residues 145-509 linked via LINKER residues GS
Chain F 145–509（365 aa） Fragment：UNP residues 26-79 and UNP residues 145-509 linked via LINKER residues GS
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M NaOAc-Acetic Acid pH 5.5, 1.82 M Li2SO4, 0.1 M MgSO4, 5 % (w/v) PEG 400
Resolution 2.90 Å R-free 0.287
5K6H Crystal structure of prefusion-stabilized RSV F single-chain 9-10 DS-Cav1 A149C-Y458C variant. Deposited 2016-05-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain F 26–103（78 aa） Fragment：UNP residues 26-103 linked to residues 145-509 via LINKER residues GS
Chain F 145–509（365 aa） Fragment：UNP residues 26-103 linked to residues 145-509 via LINKER residues GS
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M phosphate-citrate, pH4.2, 0.12 M NaCl, 9.5% (w/v) PEG 8,000
Resolution 2.65 Å R-free 0.252
5K6I Crystal structure of prefusion-stabilized RSV F single-chain 9-10 DS-Cav1 A149C-Y458C, S46G-E92D-S215P-K465Q variant. Deposited 2016-05-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain F 26–103（78 aa） Fragment：UNP residues 26-103 and residues 145-509 linked via LINKER residues GS
Chain F 145–509（365 aa） Fragment：UNP residues 26-103 and residues 145-509 linked via LINKER residues GS
Not recorded ZN ZINC ION × 6 EDO 1,2-ETHANEDIOL × 6 PO4 PHOSPHATE ION × 3 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1M Na Cacodylate, pH 6.5, 0.2M ZnAC, 17% (w/v) PEG 8,000
Resolution 2.92 Å R-free 0.253
5TOJ Crystal structure of the RSV F glycoprotein in complex with the neutralizing single-domain antibody F-VHH-4 Deposited 2016-10-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 1–513（513 aa）
Chain B 1–513（513 aa）
Chain C 1–513（513 aa）
Mutation：S155C, S190F, V207L, S290C, I379V, M447V Mutation：S155C, S190F, V207L, S290C, I379V, M447V Mutation：S155C, S190F, V207L, S290C, I379V, M447V NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.5；293 K；2.45 mg/mL EndoH-digested DS-Cav1 + F-VHH-4, 14.75% w/v PEG3350, 8.8% v/v isopropanol, 0.2 M ammonium citrate
Resolution 3.30 Å R-free 0.234
5TOK Crystal structure of the RSV F glycoprotein in complex with the neutralizing single-domain antibody F-VHH-L66 Deposited 2016-10-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 1–513（513 aa）
Chain B 1–513（513 aa）
Chain C 1–513（513 aa）
Mutation：S155C, S190F, V207L, S290C, I379V, M447V Mutation：S155C, S190F, V207L, S290C, I379V, M447V Mutation：S155C, S190F, V207L, S290C, I379V, M447V NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；293 K；4.79 mg/mL EndoH-digested DS-Cav1 + F-VHH-L66, 0.05 M potassium phosphate, 20% w/v PEG4000
Resolution 3.80 Å R-free 0.286
5TPN Crystal structure of RSV F in complex with human antibody hRSV90 Deposited 2016-10-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 27–513（487 aa）
Mutation：N67I, S215P, I379V, M447V No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；30% PEG, 400/200 mM MgCl2, 6H2O/100 mM HEPES pH 7.5
Resolution 3.14 Å R-free 0.262
5U68 Structural basis for antibody cross-neutralization of respiratory syncytial virus and human metapneumovirus Deposited 2016-12-07 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 1–513（513 aa） Fragment：UNP P03420 residues 1-513,UNP M1E1E4 residues 1-28
Chain B 1–513（513 aa） Fragment：UNP P03420 residues 1-513,UNP M1E1E4 residues 1-28
Chain C 1–513（513 aa） Fragment：UNP P03420 residues 1-513,UNP M1E1E4 residues 1-28
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；295 K；0.1M Potassium Nitrate, 0.1M Citrate Phosphate pH 4.2, 1 % Tacsimate pH 7.0, 14 (w/v) % PEG 6000
Resolution 3.08 Å R-free 0.239
5UDC Crystal Structure of RSV F A2 Bound to MEDI8897 Deposited 2016-12-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric
Chain A 1–513（513 aa）
Chain D 1–513（513 aa）
Chain F 1–513（513 aa）
Mutation：S155C, S290C, S190F, V207L Mutation：S155C, S290C, S190F, V207L Mutation：S155C, S290C, S190F, V207L CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；10% w/v PEG8000, 20% v/v ethylene glycol, 0.1 M Tris/BICINE pH 8.5, 0.02 M carboxylic acids, 0.3 M NDSB-195
Resolution 3.45 Å R-free 0.232
5W23 Crystal Structure of RSV F in complex with 5C4 Fab Deposited 2017-06-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 9 PDB declaration: nonameric
Chain A 1–513（513 aa） Fragment：UNP residues 1-513
Chain B 1–513（513 aa） Fragment：UNP residues 1-513
Chain C 1–513（513 aa） Fragment：UNP residues 1-513
Not recorded ZN ZINC ION × 8 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；Seed stock: 0.01 M zinc sulfate heptahydrate, 0.1 M MES hydrate pH 6.5, 22.5% v/v PEG MME 550 and 0.5% w/v polyvinylpyrrolidone K15 Reservoir solution: 0.2 M ammonium acetate, 0.1 M BIS-TRIS pH 6.5 and 25% PEG 3350
Resolution 3.40 Å R-free 0.239
6CXC 3.9A Cryo-EM structure of murine antibody bound at a novel epitope of respiratory syncytial virus fusion protein Deposited 2018-04-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 12 PDB declaration: dodecameric
Chain A 26–526（501 aa）
Chain B 26–526（501 aa）
Chain C 26–526（501 aa）
Chain D 26–526（501 aa）
Chain E 26–526（501 aa）
Chain F 26–526（501 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen NITROGEN
Resolution 3.90 Å
6DC3 RSV prefusion F bound to RSD5 Fab Deposited 2018-05-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric
Chain F 1–513（513 aa）
Not recorded SO4 SULFATE ION × 13 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；1.8 M Lithium sulfate, 0.1 M Tris pH 8.0
Resolution 3.50 Å R-free 0.205
6DC5 RSV prefusion F in complex with AM22 Fab Deposited 2018-05-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 1–513（513 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CD CADMIUM ION × 1 PEG DI(HYDROXYETHYL)ETHER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；32% PEG 400, 4% PEG 3350, 0.01 M cadmium chloride, 0.1 M sodium acetate pH 5.5
Resolution 3.50 Å R-free 0.280
6DC5 RSV prefusion F in complex with AM22 Fab Deposited 2018-05-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric
Chain D 1–513（513 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CD CADMIUM ION × 1 PEG DI(HYDROXYETHYL)ETHER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；32% PEG 400, 4% PEG 3350, 0.01 M cadmium chloride, 0.1 M sodium acetate pH 5.5
Resolution 3.50 Å R-free 0.280
6DC5 RSV prefusion F in complex with AM22 Fab Deposited 2018-05-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric
Chain G 1–513（513 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CD CADMIUM ION × 1 PEG DI(HYDROXYETHYL)ETHER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；32% PEG 400, 4% PEG 3350, 0.01 M cadmium chloride, 0.1 M sodium acetate pH 5.5
Resolution 3.50 Å R-free 0.280
6OE4 Prefusion RSV F monomer bound by neutralizing antibody CR9501 Deposited 2019-03-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 1–513（513 aa）
Mutation：S155C, S290C EDO 1,2-ETHANEDIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；4.2mg/mL monomeric prefusion F (DS-Cav1) + CR9501 Fab, 14.3% (w/v) PEG8000, 2.4% (v/v) 2-methyl-2,4-pentanediol (MPD), 0.1 M sodium citrate pH 5.5, 0.1 M sodium malonate pH 7.0
Resolution 3.30 Å R-free 0.259
6OE4 Prefusion RSV F monomer bound by neutralizing antibody CR9501 Deposited 2019-03-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain D 1–513（513 aa）
Mutation：S155C, S290C EDO 1,2-ETHANEDIOL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；4.2mg/mL monomeric prefusion F (DS-Cav1) + CR9501 Fab, 14.3% (w/v) PEG8000, 2.4% (v/v) 2-methyl-2,4-pentanediol (MPD), 0.1 M sodium citrate pH 5.5, 0.1 M sodium malonate pH 7.0
Resolution 3.30 Å R-free 0.259
6OE5 Splayed open prefusion RSV F captured by CR9501 and motavizumab Fabs Deposited 2019-03-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric
Chain A 1–513（513 aa）
Mutation：N67I, S215P No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；4.69 mg/mL prefusion F (PR-DM) + motavizumab Fab + CR9501 Fab, 30% (v/v) PEG400, 0.19 M ammonium sulfate, 3.1% (w/v) PEG8000, 0.1 M Tris pH 8.5
Resolution 4.10 Å R-free 0.306
6OUS Structure of fusion glycoprotein from human respiratory syncytial virus Deposited 2019-05-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 12 PDB declaration: dodecameric
Chain A 26–109（84 aa）
Chain B 137–513（377 aa）
Chain C 26–109（84 aa）
Chain D 137–513（377 aa）
Chain E 26–109（84 aa）
Chain F 137–513（377 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；100 mM Tris 8.5, 10% PEG 8000, 200 mM ammonium sulfate
Resolution 3.40 Å R-free 0.275
6OUS Structure of fusion glycoprotein from human respiratory syncytial virus Deposited 2019-05-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Heteromer；Protein × 12 PDB declaration: dodecameric
Chain G 26–109（84 aa）
Chain H 137–513（377 aa）
Chain I 26–109（84 aa）
Chain J 137–513（377 aa）
Chain K 26–109（84 aa）
Chain L 137–513（377 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；100 mM Tris 8.5, 10% PEG 8000, 200 mM ammonium sulfate
Resolution 3.40 Å R-free 0.275
6W52 Prefusion RSV F bound by neutralizing antibody RSB1 Deposited 2020-03-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 26–107（82 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；0.1 M Hepes pH 7.5, 25% PEG 2000 MME, 0.01 M spermidine
Resolution 3.74 Å R-free 0.286
7MMN Crystal Structure of the Prefusion RSV F Glycoprotein bound by human antibody AM14 Deposited 2021-04-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain A 26–97（72 aa）
Chain B 137–513（377 aa）
Chain C 26–97（72 aa）
Chain I 137–513（377 aa）
Chain J 26–97（72 aa）
Chain K 137–513（377 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；0.2M NaCl, 0.1M MES pH 6.0, 20% w/v PEG 2000 MME
Resolution 3.57 Å R-free 0.245
8KG5 Prefusion RSV F Bound to Lonafarnib and D25 Fab Deposited 2023-08-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric
Chain A 1–513（513 aa）
Chain B 1–513（513 aa）
Chain C 1–513（513 aa）
Not recorded 336 4-{2-[4-(3,10-DIBROMO-8-CHLORO-6,11-DIHYDRO-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YL)PIPERIDIN-1-YL]-2-OXOETHYL}PIPERIDINE-1-CARBOXAMIDE × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.17 Å
8ULJ Prefusion RSV F bound by neutralizing antibody 2E08 Deposited 2023-10-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 12 PDB declaration: dodecameric
Chain A 26–104（79 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；23.64%w/v PEG 1500, 0.1 M MMT buffer (DL-malic acid:MES:Tris base at a molar ratio of 1:2:2) with pH 4.36
Resolution 3.00 Å R-free 0.264
8ULK Prefusion RSV F bound by neutralizing antibody 1G12 Deposited 2023-10-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 12 PDB declaration: dodecameric
Chain A 26–97（72 aa）
Chain B 26–97（72 aa）
Chain C 26–97（72 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；0.2 M Sodium sulfate, 20 % w/v PEG 3350
Resolution 4.28 Å R-free 0.279
9HVW Respiratory Syncytial Virus Fusion protein in the postfusion conformation in complex with monoclonal antibody 131-2a Fab Deposited 2025-01-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric
Chain A 26–105（80 aa）
Chain B 26–105（80 aa）
Chain C 26–105（80 aa）
Chain D 137–515（379 aa）
Chain E 137–515（379 aa）
Chain F 137–515（379 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9LM5 Cryo-EM structure of prefusion-stabilized RSV F (DS-Cav1 strain: A2) in complex with nanobody 1G9 Deposited 2025-01-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 1–513（513 aa）
Chain B 1–513（513 aa）
Chain C 1–513（513 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.77 Å
9LM6 Cryo-EM structure of prefusion-stabilized RSV F (DS-Cav1 strain: A2) in complex with nanobody 1D8 Deposited 2025-01-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 1–513（513 aa）
Chain B 1–513（513 aa）
Chain C 1–513（513 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.26 Å
9MKN Structure of the Respiratory Syncytial Virus Fusion Protein Bound to Human Antibodies RSV_2245 and RSV_3301 Deposited 2024-12-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric
Chain A 27–96（70 aa）
Chain B 137–506（370 aa）
Chain C 27–96（70 aa）
Chain D 137–506（370 aa）
Chain E 27–96（70 aa）
Chain F 137–506（370 aa）
Mutation：I379V, M447V variant Mutation：I379V, M447V variant Mutation：I379V, M447V variant No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
9RA5 Respiratory syncytial virus fusion protein N-terminal heptad repeat domain in complex with Double stapled peptide 3/4i Deposited 2025-05-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 159–209（51 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.62 Å R-free 0.207
9U74 Respiratory Syncytial Virus pre-F trimer bound by neutralizing antibody PR306007 Deposited 2025-03-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 26–103（78 aa）
Chain B 137–513（377 aa）
Chain C 26–103（78 aa）
Chain D 137–513（377 aa）
Chain E 26–103（78 aa）
Chain F 137–513（377 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.08 Å
9WDP Cyro-EM structure of prefusion RSV fusion glycoprotein in complex with Ziresovir and motavizumab Fab Deposited 2025-08-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 9 PDB declaration: nonameric
Chain A 1–513（513 aa）
Chain B 1–513（513 aa）
Chain C 1–513（513 aa）
Not recorded A1EV1 ~{N}-[(3-azanyloxetan-3-yl)methyl]-2-[1,1-bis(oxidanylidene)-3,5-dihydro-2~{H}-1$l^{6},4-benzothiazepin-4-yl]-6-methyl-quinazolin-4-amine × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.27 Å

52 other PDB entries and 59 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name FUS_HRSVA
Isoform —
PDB entities 1, 2
Chains and sequence ranges Author chain A； PDBConstruct 1–82； UniProt 26–107 Author chain B； PDBConstruct 1–377； UniProt 137–513

Fusion glycoprotein F1 fused with Fibritin trimerization domain

Enterobacteria phage T4

UniProt P10104

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Insufficient information Heteromer Protein × 6 PDB declaration: hexameric（6） Consistent with protein copy count Chain B； UniProt 458–484 Mutation：S155C, S290C, I379V, M447V Fusion glycoprotein F2 × 3 （P03420） SO4 SULFATE ION × 18 X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 9.5；298 K；1.4 M K/Na tartrate, 0.1M CHES pH 9.5, 0.2 M LiSO4, VAPOR DIFFUSION, HANGING DROP, temperature 298K Resolution 3.25 Å R-free 0.274

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 4MMQ Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1AA0 FIBRITIN DELETION MUTANT E (BACTERIOPHAGE T4) Deposited 1997-01-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 371–483（113 aa） Fragment：DELETION MUTANT E, DEL(368-486)
Not recorded CL CHLORIDE ION × 3 ZN ZINC ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；PROTEIN WAS CRYSTALLIZED AT 22OC USING 34% PEG400, 0.1M ZN ACETATE IN 0.1M MES BUFFER AT PH6.0 AS WELL SOLUTION BY MIXING EQUAL AMOUNT OF WELL SOLUTION AND PROTEIN SOLUTION AT 29MG/ML IN A HANGING DROP, vapor diffusion - hanging drop
Resolution 2.20 Å R-free 0.259
1AVY FIBRITIN DELETION MUTANT M (BACTERIOPHAGE T4) Deposited 1997-09-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 413–486（74 aa） Fragment：DELETION MUTANT M, RESIDUES 413 - 486 OF THE WILD TYPE
Mutation：R416S, S421K, N425I, N428D, T433R No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；HANGING DROPS WITH 20MG/ML PROTEIN AND 1.75M LI2SO4, 0.1M TRIS-HCL, PH7.5, AS PRECIPITANT, vapor diffusion - hanging drop
Resolution 1.85 Å R-free 0.253
1AVY FIBRITIN DELETION MUTANT M (BACTERIOPHAGE T4) Deposited 1997-09-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain B 413–486（74 aa） Fragment：DELETION MUTANT M, RESIDUES 413 - 486 OF THE WILD TYPE
Mutation：R416S, S421K, N425I, N428D, T433R No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；HANGING DROPS WITH 20MG/ML PROTEIN AND 1.75M LI2SO4, 0.1M TRIS-HCL, PH7.5, AS PRECIPITANT, vapor diffusion - hanging drop
Resolution 1.85 Å R-free 0.253
1AVY FIBRITIN DELETION MUTANT M (BACTERIOPHAGE T4) Deposited 1997-09-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain C 413–486（74 aa） Fragment：DELETION MUTANT M, RESIDUES 413 - 486 OF THE WILD TYPE
Mutation：R416S, S421K, N425I, N428D, T433R No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；HANGING DROPS WITH 20MG/ML PROTEIN AND 1.75M LI2SO4, 0.1M TRIS-HCL, PH7.5, AS PRECIPITANT, vapor diffusion - hanging drop
Resolution 1.85 Å R-free 0.253
1OX3 crystal structure of mini-fibritin Deposited 2003-04-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 2–81（80 aa） Fragment：UNP residues 2-81 and 456-484
Chain A 456–484（29 aa） Fragment：UNP residues 2-81 and 456-484
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；303 K；PEG 6000, pH 7, VAPOR DIFFUSION, HANGING DROP, temperature 303K
Resolution 2.00 Å R-free 0.221
1RFO Trimeric Foldon of the T4 phagehead fibritin Deposited 2003-11-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa） Fragment：trimerization domain (residues 457-483)
Chain B 458–484（27 aa） Fragment：trimerization domain (residues 457-483)
Chain C 458–484（27 aa） Fragment：trimerization domain (residues 457-483)
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7.1；298 K；Ionic strength (raw mmCIF value) 10 mM；Pressure 1013
NMR sample composition 0.3 mM Foldon 15N,13C; 5mM phosphate buffer pH 7.1 | 95% H2O/5% D2O
Resolution not provided
1V1H Adenovirus fibre shaft sequence N-terminally fused to the bacteriophage T4 fibritin foldon trimerisation motif with a short linker Deposited 2004-04-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 457–483（27 aa） Fragment：SHAFT DOMAIN PLUS FOLDON DOMAIN, RESIDUES 319-392 AND 457-483
Chain B 457–483（27 aa） Fragment：SHAFT DOMAIN PLUS FOLDON DOMAIN, RESIDUES 319-392 AND 457-483
Chain C 457–483（27 aa） Fragment：SHAFT DOMAIN PLUS FOLDON DOMAIN, RESIDUES 319-392 AND 457-483
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 6；0.2 M IMIDAZOLE-MALATE PH 6.0 8% (W/V) PEG 4000
Resolution 1.90 Å R-free 0.240
1V1H Adenovirus fibre shaft sequence N-terminally fused to the bacteriophage T4 fibritin foldon trimerisation motif with a short linker Deposited 2004-04-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain D 457–483（27 aa） Fragment：SHAFT DOMAIN PLUS FOLDON DOMAIN, RESIDUES 319-392 AND 457-483
Chain E 457–483（27 aa） Fragment：SHAFT DOMAIN PLUS FOLDON DOMAIN, RESIDUES 319-392 AND 457-483
Chain F 457–483（27 aa） Fragment：SHAFT DOMAIN PLUS FOLDON DOMAIN, RESIDUES 319-392 AND 457-483
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 6；0.2 M IMIDAZOLE-MALATE PH 6.0 8% (W/V) PEG 4000
Resolution 1.90 Å R-free 0.240
1V1I Adenovirus fibre shaft sequence N-terminally fused to the bacteriophage T4 fibritin foldon trimerisation motif with a long linker Deposited 2004-04-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 457–483（27 aa） Fragment：SHAFT DOMAIN PLUS FOLDON DOMAIN, RESIDUES 319-392 AND 457-483
Chain B 457–483（27 aa） Fragment：SHAFT DOMAIN PLUS FOLDON DOMAIN, RESIDUES 319-392 AND 457-483
Chain C 457–483（27 aa） Fragment：SHAFT DOMAIN PLUS FOLDON DOMAIN, RESIDUES 319-392 AND 457-483
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；10 MM HEPES-NAOH PH 7.0 0.2 M MAGNESIUM ACETATE, 20 % (W/V) PEG 3350
Resolution 1.90 Å R-free 0.283
2BSG The modeled structure of fibritin (gpwac) of bacteriophage T4 based on cryo-EM reconstruction of the extended tail of bacteriophage T4 Deposited 2005-05-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 1–487（487 aa）
Chain B 1–487（487 aa）
Chain C 1–487（487 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7；H2O
cryo-EM vitrification conditions Cryogen ETHANE；LIQUID ETHANE
Resolution 15.00 Å
2IBL Crystal structure of a helper molecule (HT-mf-thromb) based on mini-fibritin (mf) crystal structure (pdb:1OX3). Deposited 2006-09-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 2–81（80 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 10.5；293 K；30% PEG 400, 0.1 M TrisHCl, 0.2 M magnesium chloride, pH 10.5, VAPOR DIFFUSION, HANGING DROP, temperature 293.0K
Resolution 1.32 Å R-free 0.170
2KBL NMR Structure of a Monomeric Folding Intermediate Reveals the Structural Basis for Rapid Assembly of an Evolutionary Optimized Trimerization Module Deposited 2008-12-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 458–484（27 aa） Fragment：C-terminal Domain, UNP residues 458-484
Mutation：E5R, F22L No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；296.7 K；Ionic strength (raw mmCIF value) 10；Pressure ambient
NMR sample composition 200uM foldon E5R, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 210uM [U-99% 15N] foldon E5R, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
3A1M A fusion protein of a beta helix region of gene product 5 and the foldon region of bacteriophage T4 Deposited 2009-04-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Chain D 458–484（27 aa）
Chain E 458–484（27 aa）
Chain F 458–484（27 aa）
Mutation：V16L Mutation：V16L Mutation：V16L Mutation：V16L Mutation：V16L Mutation：V16L K POTASSIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；Ammonium sulfate, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.00 Å R-free 0.268
3J2O Model of the bacteriophage T4 fibritin based on the cryo-EM reconstruction of the contracted T4 tail containing the phage collar and whiskers Deposited 2012-11-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 2–487（486 aa）
Chain B 2–487（486 aa）
Chain C 2–487（486 aa）
Chain D 2–487（486 aa）
Chain E 2–487（486 aa）
Chain F 2–487（486 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer 50 mM Tris-HCl, pH 8.0, 0.2 M NaCl, 8 mM MgCl2；pH 8；50 mM Tris-HCl, pH 8.0, 0.2 M NaCl, 8 mM MgCl2
cryo-EM vitrification conditions Cryogen ETHANE；plunged into liquid ethane (homemade plunger)
Resolution 25.00 Å
4MMR Crystal Structure of Prefusion-stabilized RSV F Variant Cav1 at pH 9.5 Deposited 2013-09-09 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric
Chain B 458–484（27 aa）
Mutation：S190F, V207L, I379V, M447V No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 9.5；293 K；1.4M sodium potassium tartarate, 0.1M CHES, pH 9.5, 0.2M Li2SO4, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 3.10 Å R-free 0.264
4MMS Crystal Structure of Prefusion-stabilized RSV F Variant Cav1 at pH 5.5 Deposited 2013-09-09 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric
Chain B 458–484（27 aa）
Chain D 458–484（27 aa）
Chain F 458–484（27 aa）
Mutation：S190F, V207L, I379V, M447V Mutation：S190F, V207L, I379V, M447V Mutation：S190F, V207L, I379V, M447V SO4 SULFATE ION × 14 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；1.7 M ammonium sulfate, 0.1 M citrate pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.40 Å R-free 0.214
4MMT Crystal Structure of Prefusion-stabilized RSV F Variant DS-Cav1 at pH 9.5 Deposited 2013-09-09 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric
Chain B 458–484（27 aa）
Mutation：S155C, S190F, V207L, S290C, I379V, M447V No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 9.5；1.8 M Na/K tartrate, 0.2 M LiSO4, 0.1 M CHES pH9.5, VAPOR DIFFUSION, HANGING DROP
Resolution 3.05 Å R-free 0.243
4MMU Crystal Structure of Prefusion-stabilized RSV F Variant DS-Cav1 at pH 5.5 Deposited 2013-09-09 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric
Chain B 458–484（27 aa）
Mutation：S155C, S190F, V207L, S290C, I379V, M447V SO4 SULFATE ION × 12 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 PO4 PHOSPHATE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；1.8 M Ammonium sulphate 0.1 M citrate pH5.5, VAPOR DIFFUSION, HANGING DROP
Resolution 3.00 Å R-free 0.228
4MMV Crystal Structure of Prefusion-stabilized RSV F Variant DS-Cav1-TriC at pH 9.5 Deposited 2013-09-09 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric
Chain B 458–484（27 aa）
Mutation：S155C, S190F, V207L, S290C, I379V, M447, VD486H, E487Q, F488W, D489H No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 9.5；293 K；1.4M sodium potassium tartarate, 0.1M CHES, pH 9.5, 0.2M Li2SO4, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.81 Å R-free 0.279
5I08 Prefusion structure of a human coronavirus spike protein Deposited 2016-02-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Mutation：R751G, R752G, K753S, R754G, R755S,R751G, R752G, K753S, R754G, R755S Mutation：R751G, R752G, K753S, R754G, R755S,R751G, R752G, K753S, R754G, R755S Mutation：R751G, R752G, K753S, R754G, R755S,R751G, R752G, K753S, R754G, R755S No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE；3 uL sample was applied to grid, blotted, and plunged into liquid ethane.
Resolution 4.04 Å
5TDL Crystal structure of prefusion-stabilized bovine RSV fusion glycoprotein (single-chain DS2-v1 variant: strain 391-2 sc9 DS-Cav1 Q98C Q361C) Deposited 2016-09-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 457–484（28 aa）
Mutation：Q98C, I144S, S155C, S190F, V207L, S290C, Q361C NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；0.9 M of potassium and sodium tartrate, 0.16 M of Lithium sulfate, 0.1 M ches
Resolution 3.50 Å R-free 0.272
6OE5 Splayed open prefusion RSV F captured by CR9501 and motavizumab Fabs Deposited 2019-03-27 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric
Chain A 458–484（27 aa）
Mutation：N67I, S215P No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；4.69 mg/mL prefusion F (PR-DM) + motavizumab Fab + CR9501 Fab, 30% (v/v) PEG400, 0.19 M ammonium sulfate, 3.1% (w/v) PEG8000, 0.1 M Tris pH 8.5
Resolution 4.10 Å R-free 0.306
6Z97 Structure of the prefusion SARS-CoV-2 spike glycoprotein Deposited 2020-06-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 27 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 3.40 Å
6ZHD H11-H4 bound to Spike Deposited 2020-06-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 26 ELECTRON MICROSCOPY
cryo-EM buffer pH 7；50 mM Tris, pH 7, 150 mM NaCl
cryo-EM vitrification conditions Cryogen ETHANE；SPT Labtech prototype 300 mesh 1.2/2.0 nanowire grids with a highly reproduceable rectangular bar cross-section were used. The grids were glow-discharged on low for 90 s (Plasma Cleaner PDC-002-CE, Harrick Plasma) to activate the nanowires. Approximately 6 nL of the complex were applied to the grids using a Chameleon EP system (SPT Labtech) at 81 % relative humidity and ambient temperature.
Resolution 3.70 Å
7A4N Cryo-EM structure of a prefusion stabilized SARS-CoV-2 Spike (D614N, R682S, R685G, A892P, A942P and V987P)(S-closed trimer) Deposited 2020-08-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Mutation：D614N,R682S,R685G,A892P,A942P,V987P Mutation：D614N,R682S,R685G,A892P,A942P,V987P Mutation：D614N,R682S,R685G,A892P,A942P,V987P NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 15 ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.75 Å
7NS6 SARS-CoV-2 Spike (dimers) in complex with six Fu2 nanobodies Deposited 2021-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 12 PDB declaration: dodecameric
Chain I 458–484（27 aa）
Chain J 458–484（27 aa）
Chain K 458–484（27 aa）
Chain L 458–484（27 aa）
Chain M 458–484（27 aa）
Chain N 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 46 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.18 Å
7QDG SARS-CoV-2 S protein S:A222V + S:D614G mutant 1-up Deposited 2021-11-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–486（29 aa）
Chain B 458–486（29 aa）
Chain C 458–486（29 aa）
Mutation：S:A222V + S:D614G Mutation：S:A222V + S:D614G Mutation：S:A222V + S:D614G NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 25 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
7QDH SARS-CoV-2 S protein S:D614G mutant 1-up Deposited 2021-11-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–486（29 aa）
Chain B 458–486（29 aa）
Chain C 458–486（29 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 24 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.20 Å
7QUR SARS-CoV-2 Spike with ethylbenzamide-tri-iodo Siallyllactose, C3 symmetry Deposited 2022-01-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 36 GE9 2,3,5-tris(iodanyl)benzamide × 3 SIA N-acetyl-alpha-neuraminic acid × 3 EIC LINOLEIC ACID × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.27 Å
7QUS SARS-CoV-2 Spike, C3 symmetry Deposited 2022-01-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 36 EIC LINOLEIC ACID × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.39 Å
7Z6V CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11 nanobody complex Deposited 2022-03-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 458–485（28 aa）
Chain B 458–485（28 aa）
Chain C 458–485（28 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 28 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE；SPT Labtech prototype 300 mesh 1.2/2.0 nanowire grids with a highly reproduceable rectangular bar cross-section were used. The grids were glow-discharged on low for 120 s (Plasma Cleaner PDC-002-CE, Harrick Plasma) to activate the nanowires. Approximately 6 nL of the complex were applied to the grids using a Chameleon EP system (SPT Labtech) at 82% relative humidity and ambient temperature.
Resolution 3.10 Å
7Z7X CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11-H6 nanobody complex Deposited 2022-03-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 458–485（28 aa）
Chain B 458–485（28 aa）
Chain C 458–485（28 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 26 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE；SPT Labtech prototype 300 mesh 1.2/2.0 nanowire grids with a highly reproduceable rectangular bar cross-section were used. The grids were glow-discharged on low for 120 s (Plasma Cleaner PDC-002-CE, Harrick Plasma) or for 60-80 s, 12 mA (easiGlow, Pelco) to activate the nanowires. Approximately 6 nL of the complex were applied to the grids using a Chameleon EP system (SPT Labtech) at 79-81% relative humidity and ambient temperature.
Resolution 3.30 Å
7Z85 CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11-B5 nanobody complex Deposited 2022-03-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 458–485（28 aa）
Chain B 458–485（28 aa）
Chain C 458–485（28 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 26 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE；SPT Labtech prototype 300 mesh 1.2/2.0 nanowire grids with a highly reproduceable rectangular bar cross-section were used. The grids were glow-discharged on low for 190 s (Plasma Cleaner PDC-002-CE, Harrick Plasma) to activate the nanowires. Approximately 6 nL of the complex were applied to the grids using a Chameleon EP system (SPT Labtech) at 83% relative humidity and ambient temperature.
Resolution 3.10 Å
7Z86 CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11-H4 Q98R H100E nanobody complex in 1Up2Down conformation Deposited 2022-03-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 458–485（28 aa）
Chain B 458–485（28 aa）
Chain C 458–485（28 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 26 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
7Z9Q CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11-A10 nanobody complex Deposited 2022-03-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 458–485（28 aa）
Chain B 458–485（28 aa）
Chain C 458–485（28 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 26 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE；SPT Labtech prototype 300 mesh 1.2/2.0 nanowire grids with a highly reproduceable rectangular bar cross-section were used. The grids were glow-discharged on low for 260 s (Plasma Cleaner PDC-002-CE, Harrick Plasma) to activate the nanowires. Approximately 6 nL of the complex were applied to the grids using a Chameleon EP system (SPT Labtech) at 80% relative humidity and ambient temperature.
Resolution 3.60 Å
7Z9R CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11-H4 Q98R H100E nanobody complex in 2Up1Down conformation Deposited 2022-03-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 458–485（28 aa）
Chain B 458–485（28 aa）
Chain C 458–485（28 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 26 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.20 Å
7ZCE SARS-CoV-2 Spike protein in complex with the single chain fragment scFv76 Deposited 2022-03-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 27 ELECTRON MICROSCOPY
cryo-EM buffer pH 7；PBS
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.50 Å
7ZCF SARS-CoV-2 Spike RBD in complex with the single chain fragment scFv76 (Focused Refinement) Deposited 2022-03-28 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7；PBS
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.00 Å
7ZH1 SARS CoV Spike protein, Closed C3 conformation Deposited 2022-04-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded EIC LINOLEIC ACID × 3 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 30 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 2.48 Å
7ZH2 SARS CoV Spike protein, Closed C1 conformation Deposited 2022-04-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded EIC LINOLEIC ACID × 3 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 27 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 2.71 Å
7ZH5 SARS CoV Spike protein, Open conformation Deposited 2022-04-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 23 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 3.30 Å
7ZJ6 X-31 Hemagglutinin Precursor HA0 at pH 7.5 Deposited 2022-04-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；4s blot
Resolution 2.60 Å
7ZJ7 X-31 Hemagglutinin Precursor HA0 at pH 4.8 Deposited 2022-04-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 4.8
cryo-EM vitrification conditions Cryogen ETHANE；4s blot
Resolution 3.95 Å
7ZJ8 X-31 Hemagglutinin Precursor HA0 at pH 7.5 after reneutralization Deposited 2022-04-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 BOG octyl beta-D-glucopyranoside × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen ETHANE；4s blot
Resolution 3.10 Å
7ZR7 OMI-42 FAB IN COMPLEX WITH SARS-COV-2 BETA SPIKE GLYCOPROTEIN Deposited 2022-05-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 9 PDB declaration: nonameric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 30 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.70 Å
7ZR8 OMI-38 FAB IN COMPLEX WITH SARS-COV-2 BETA SPIKE RBD (local refinement) Deposited 2022-05-03 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.70 Å
7ZR9 OMI-2 FAB IN COMPLEX WITH SARS-COV-2 BETA SPIKE GLYCOPROTEIN Deposited 2022-05-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 9 PDB declaration: nonameric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 30 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.00 Å
7ZRC OMI-38 FAB IN COMPLEX WITH SARS-COV-2 BETA SPIKE Deposited 2022-05-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 9 PDB declaration: nonameric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 28 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.50 Å
8AJA Structure of the Ancestral Scaffold Antigen-5 of Coronavirus Spike protein Deposited 2022-07-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 39 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.59 Å
8AJL Structure of the Ancestral Scaffold Antigen-6 of Coronavirus Spike protein Deposited 2022-07-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 45 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.77 Å
8AQS BA.4/5 SARS-CoV-2 Spike bound to human ACE2 (local) Deposited 2022-08-13 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.92 Å
8AQT Beta SARS-CoV-2 Spike bound to mouse ACE2 (local) Deposited 2022-08-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 460–484（25 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.40 Å
8AQU BA.1 SARS-CoV-2 Spike bound to mouse ACE2 (local) Deposited 2022-08-13 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.22 Å
8AQV BA.2.12.1 SARS-CoV-2 Spike bound to mouse ACE2 (local) Deposited 2022-08-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 460–484（25 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.96 Å
8AQW BA.4/5 SARS-CoV-2 Spike bound to mouse ACE2 (local) Deposited 2022-08-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 459–484（26 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
8BON Structure of the SARS-CoV-2 spike glycoprotein in complex with the macrocyclic peptide S1B3inL1 Deposited 2022-11-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 23 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
8CIM BA.2-07 FAB IN COMPLEX WITH SARS-COV-2 BA.2.12.1 SPIKE GLYCOPROTEIN Deposited 2023-02-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 9 PDB declaration: nonameric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 24 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
8H3D Structure of apo SARS-CoV-2 spike protein with one RBD up Deposited 2022-10-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–485（28 aa） Fragment：SARS-CoV-2 spike protein,SARS-CoV-2 spike protein
Chain B 458–485（28 aa） Fragment：SARS-CoV-2 spike protein,SARS-CoV-2 spike protein
Chain C 458–485（28 aa） Fragment：SARS-CoV-2 spike protein,SARS-CoV-2 spike protein
Mutation：R682S,R683G,R685G,K986P,V987P Mutation：R682S,R683G,R685G,K986P,V987P Mutation：R682S,R683G,R685G,K986P,V987P NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 13 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.27 Å
8H3E Complex structure of a small molecule (SPC-14) bound SARS-CoV-2 spike protein, closed state Deposited 2022-10-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–485（28 aa） Fragment：SARS-CoV-2 spike protein,SARS-CoV-2 spike protein
Chain B 458–485（28 aa） Fragment：SARS-CoV-2 spike protein,SARS-CoV-2 spike protein
Chain C 458–485（28 aa） Fragment：SARS-CoV-2 spike protein,SARS-CoV-2 spike protein
Mutation：R682S,R683G,R685G,K986P,V987P Mutation：R682S,R683G,R685G,K986P,V987P Mutation：R682S,R683G,R685G,K986P,V987P Q83 7-(6-nitro-2,3-dihydroindol-1-yl)-7-oxidanyidene-heptanoic acid × 3 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 15 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.06 Å
8KG5 Prefusion RSV F Bound to Lonafarnib and D25 Fab Deposited 2023-08-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric
Chain A 458–485（28 aa）
Chain B 458–485（28 aa）
Chain C 458–485（28 aa）
Not recorded 336 4-{2-[4-(3,10-DIBROMO-8-CHLORO-6,11-DIHYDRO-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YL)PIPERIDIN-1-YL]-2-OXOETHYL}PIPERIDINE-1-CARBOXAMIDE × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.17 Å
8OYT Stabilised BA.1 SARS-CoV-2 spike with H6 nanobodies in '3 up' RBD conformation Deposited 2023-05-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 9 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；PBS
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.80 Å
8OYU Stabilised BA.1 SARS-CoV-2 spike with H6 nanobodies in '2 up 1 down' RBD conformation Deposited 2023-05-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 15 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；PBS
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.00 Å
8QPR SARS-CoV-2 S protein bound to human neutralising antibody UZGENT_G5 Deposited 2023-10-03 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.80 Å
8QQ0 SARS-CoV-2 S protein bound to neutralising antibody UZGENT_A3 Deposited 2023-10-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 458–485（28 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.50 Å
8QTD Local refinement of SARS-CoV-2 BA.2.86 Spike and XBB-7 Fab Deposited 2023-10-12 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.60 Å
8R1C SD1-2 Fab in complex with SARS-CoV-2 BA.2.12.1 Spike Glycoprotein Deposited 2023-11-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 9 PDB declaration: nonameric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 30 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.20 Å
8R1D SD1-3 Fab in complex with SARS-CoV-2 BA.2.12.1 Spike Glycoprotein Deposited 2023-11-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 9 PDB declaration: nonameric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 30 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.37 Å
8R87 Cryo-EM structure of the Sars-Cov2 S trimer without RBDs Deposited 2023-11-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
8R8K XBB-4 Fab in complex with SARS-CoV-2 BA.2.12.1 Spike Glycoprotein Deposited 2023-11-29 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.41 Å
8UDN A Stable Heterotrimeric Foldon with Minimum Mutation Deposited 2023-09-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；293 K；MPD
Resolution 0.97 Å R-free 0.158
8ULJ Prefusion RSV F bound by neutralizing antibody 2E08 Deposited 2023-10-16 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 12 PDB declaration: dodecameric
Chain B 458–484（27 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；23.64%w/v PEG 1500, 0.1 M MMT buffer (DL-malic acid:MES:Tris base at a molar ratio of 1:2:2) with pH 4.36
Resolution 3.00 Å R-free 0.264
8ULK Prefusion RSV F bound by neutralizing antibody 1G12 Deposited 2023-10-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 12 PDB declaration: dodecameric
Chain I 458–484（27 aa）
Chain J 458–484（27 aa）
Chain K 458–484（27 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；0.2 M Sodium sulfate, 20 % w/v PEG 3350
Resolution 4.28 Å R-free 0.279
8V5V Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation Deposited 2023-12-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 9 PDB declaration: nonameric
Chain E 458–484（27 aa）
Chain F 458–484（27 aa）
Chain G 458–484（27 aa）
Mutation：F817P,A892P,A899P,A942P,V987P,Y707C,T883C,Y788C,A876C Mutation：F817P,A892P,A899P,A942P,V987P,Y707C,T883C,Y788C,A876C Mutation：F817P,A892P,A899P,A942P,V987P,Y707C,T883C,Y788C,A876C NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 15 ELECTRON MICROSCOPY
cryo-EM buffer pH 8；Filtered and degased
cryo-EM vitrification conditions Cryogen ETHANE；6 seconds blotting time at force 0
Resolution 2.93 Å
8YZB BA.2.86 RBD protein in complex with ACE2. Deposited 2024-04-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 458–485（28 aa） Fragment：RBD
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.29 Å
8YZC Structure of BA.2.86 spike protein in complex with ACE2. Deposited 2024-04-06 Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 458–481（24 aa）
Chain B 458–481（24 aa）
Chain C 458–481（24 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å
8YZD Structure of JN.1 RBD protein in complex with ACE2. Deposited 2024-04-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 458–485（28 aa） Fragment：RBD
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.07 Å
8YZE The JN.1 spike protein (S) in complex with ACE2. Deposited 2024-04-06 Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 458–481（24 aa）
Chain B 458–481（24 aa）
Chain C 458–481（24 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.06 Å
8Z6Q SARS-CoV-2 XBB.1.16 Spike in complex with CYFN1006-1(S-CYFN1006-1 dimer trimer). Deposited 2024-04-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 18 PDB declaration: octadecameric
Chain A 458–485（28 aa）
Chain B 458–485（28 aa）
Chain C 458–485（28 aa）
Chain J 458–485（28 aa）
Chain K 458–485（28 aa）
Chain L 458–485（28 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.41 Å
8Z6R Structure of XBB.1.16 S trimer with 3 down-RBDs complex with antibody CYFN1006-1. Deposited 2024-04-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 9 PDB declaration: nonameric
Chain A 458–485（28 aa）
Chain B 458–485（28 aa）
Chain C 458–485（28 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.87 Å
8Z6S Structure of XBB.1.16 S trimer with 2 down-RBDs complex with antibody CYFN1006-1. Deposited 2024-04-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 9 PDB declaration: nonameric
Chain A 458–485（28 aa）
Chain B 458–485（28 aa）
Chain C 458–485（28 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.84 Å
8Z6T Structure of XBB.1.16 RBD in complex with antibody CYFN1006-1. Deposited 2024-04-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 458–485（28 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.92 Å
8Z6U SARS-CoV-2 EG.5.1 Spike in complex with CYFN1006-2(S-CYFN1006-2 dimer trimer). Deposited 2024-04-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 18 PDB declaration: octadecameric
Chain A 458–481（24 aa）
Chain B 458–481（24 aa）
Chain C 458–481（24 aa）
Chain D 458–481（24 aa）
Chain E 458–481（24 aa）
Chain F 458–481（24 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.83 Å
8Z6W Structure of EG.5.1 S trimer with 3 down-RBDs complex with antibody CYFN1006-2. Deposited 2024-04-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 9 PDB declaration: nonameric
Chain A 458–485（28 aa）
Chain B 458–485（28 aa）
Chain C 458–485（28 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.04 Å
8Z6X Structure of EG.5.1 RBD in complex with antibody CYFN1006-2. Deposited 2024-04-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 458–485（28 aa） Fragment：RBD,RBD
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.96 Å
8ZPP Local CryoEM structure of the SARS-CoV-2 BA.5 in complex with ORB10 Fab Deposited 2024-05-30 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.60 Å
9F9Y SARS-CoV-2 BA-2.87.1 Spike ectodomain Deposited 2024-05-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 39 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.80 Å
9FGS SARS-CoV-2 (wuhan variant) Spike protein in complex with the single chain fragment scFv41N (focused refinement) Deposited 2024-05-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7；PBS
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.00 Å
9FGT SARS-CoV-2 (B.1.1.529/Omicron variant) Spike protein in complex with the single chain fragment scFv76 (focused refinement) Deposited 2024-05-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7；PBS
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.80 Å
9FGU SARS-CoV-2 (B.1.1.529/Omicron variant) Spike protein in complex with the single chain fragment scFv76-77 (focused refinement) Deposited 2024-05-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7；PBS
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.30 Å
9FJK Omicron BA.1 Spike protein with neutralizing NTD specific mAb K501SP6 Deposited 2024-05-31 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；TBS, pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.84 Å
9FMW Omicron BA.1 Spike protein with neutralizing NTD specific mAb K501SP6 Deposited 2024-06-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；TBS, pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.60 Å
9GDX SARS-CoV-2 Spike protein Beta Variant at 4C structural flexibility / heterogeneity analyses Deposited 2024-08-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 5.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.80 Å
9GDY SARS-CoV-2 Spike protein Beta Variant at 37C structural flexibility / heterogeneity analyses Deposited 2024-08-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 5.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.80 Å
9H6U SARS-CoV-2 S protein in complex with pT1679 Fab Deposited 2024-10-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.27 Å
9JMF Cryo-EM structure of SA-BatCoV (Neoromicia/PML-PHE1/RSA/2011) S-trimer Deposited 2024-09-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 33 EIC LINOLEIC ACID × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9JMG Cryo-EM structure of EU-HedgehogCoV (Erinaceus/VMC/DEU/2012) S-trimer in a locked-2 conformation Deposited 2024-09-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 37 FOL FOLIC ACID × 3 EIC LINOLEIC ACID × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9JMH Cryo-EM structure of HKU25-BatCoV S-trimer stabilized with 2P and x1 disulfide bond Deposited 2024-09-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Mutation：S437C,D1051C,A1052P,V1053P Mutation：S437C,D1051C,A1052P,V1053P Mutation：S437C,D1051C,A1052P,V1053P EIC LINOLEIC ACID × 3 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 38 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9JMI Cryo-EM structure of CN-HedgehogCoV (HKU31/Erinaceus amurensis/China/2014) S-trimer in a locked-2 conformation Deposited 2024-09-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded FOL FOLIC ACID × 3 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 39 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
9JMN Cryo-EM structure of CN-HedgehogCoV (HKU31/Erinaceus amurensis/China/2014) S-trimer in a locked-1 conformation Deposited 2024-09-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 25 FOL FOLIC ACID × 3 EIC LINOLEIC ACID × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.80 Å
9JMO Cryo-EM structure of Japan-BatCoV (Vs-CoV-1) S-trimer Deposited 2024-09-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 31 EIC LINOLEIC ACID × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.80 Å
9JMP Cryo-EM structure of GD-BatCoV (BtCoV/Ii/GD/2014-422) S-trimer Deposited 2024-09-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 458–484（27 aa）
Chain B 458–484（27 aa）
Chain C 458–484（27 aa）
Mutation：A885P,S962P,A969P,N1012P,A1056P,V1057P Mutation：A885P,S962P,A969P,N1012P,A1056P,V1057P Mutation：A885P,S962P,A969P,N1012P,A1056P,V1057P NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 21 EIC LINOLEIC ACID × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9KT3 Structure of EG.5.1 S trimer with 2 down-RBDs complex with antibody CYFN1006-2. Deposited 2024-12-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 9 PDB declaration: nonameric
Chain A 458–481（24 aa）
Chain B 458–481（24 aa）
Chain C 458–481（24 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.63 Å
9MKB Structure of the bacteriophage T4 portal-neck-tail complex Deposited 2024-12-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 541 PDB declaration: 541-meric
Chain A 1–487（487 aa）
Chain B 1–487（487 aa）
Chain C 1–487（487 aa）
Chain D 1–487（487 aa）
Chain E 1–487（487 aa）
Chain F 1–487（487 aa）
Chain G 1–487（487 aa）
Chain H 1–487（487 aa）
Chain I 1–487（487 aa）
Chain J 1–487（487 aa）
Chain K 1–487（487 aa）
Chain L 1–487（487 aa）
Chain M 1–487（487 aa）
Chain N 1–487（487 aa）
Chain O 1–487（487 aa）
Chain P 1–487（487 aa）
Chain Q 1–487（487 aa）
Chain R 1–487（487 aa）
Chain S 1–487（487 aa）
Chain T 1–487（487 aa）
Chain U 1–487（487 aa）
Chain V 1–487（487 aa）
Chain W 1–487（487 aa）
Chain X 1–487（487 aa）
Chain Y 1–487（487 aa）
Chain Z 1–487（487 aa）
Chain a 1–487（487 aa）
Chain b 1–487（487 aa）
Chain c 1–487（487 aa）
Chain d 1–487（487 aa）
Chain e 1–487（487 aa）
Chain f 1–487（487 aa）
Chain g 1–487（487 aa）
Chain h 1–487（487 aa）
Chain i 1–487（487 aa）
Chain j 1–487（487 aa）
Not recorded ZN ZINC ION × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Ted Pella lacey carbon 400 mesh grids (catalog No: 01824) were used.
Resolution 3.80 Å
9MLA Pre-fusion HERV-K Envelope Protein Trimer Ectodomain in complex with Kenv-6 Fab Deposited 2024-12-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 12 PDB declaration: 12-meric
Chain D 459–484（26 aa）
Chain E 459–484（26 aa）
Chain F 459–484（26 aa）
Mutation：V498C Mutation：V498C Mutation：V498C NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 8；Filtered and degassed
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.24 Å
9MOF Structure of the bacteriophage T4 portal-neck-tail connector complex Deposited 2024-12-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 183 PDB declaration: 183-meric
Chain A 1–487（487 aa）
Chain B 1–487（487 aa）
Chain C 1–487（487 aa）
Chain D 1–487（487 aa）
Chain E 1–487（487 aa）
Chain F 1–487（487 aa）
Chain G 1–487（487 aa）
Chain H 1–487（487 aa）
Chain I 1–487（487 aa）
Chain J 1–487（487 aa）
Chain K 1–487（487 aa）
Chain L 1–487（487 aa）
Chain M 1–487（487 aa）
Chain N 1–487（487 aa）
Chain O 1–487（487 aa）
Chain P 1–487（487 aa）
Chain Q 1–487（487 aa）
Chain R 1–487（487 aa）
Chain S 1–487（487 aa）
Chain T 1–487（487 aa）
Chain U 1–487（487 aa）
Chain V 1–487（487 aa）
Chain W 1–487（487 aa）
Chain X 1–487（487 aa）
Chain Y 1–487（487 aa）
Chain Z 1–487（487 aa）
Chain a 1–487（487 aa）
Chain b 1–487（487 aa）
Chain c 1–487（487 aa）
Chain d 1–487（487 aa）
Chain e 1–487（487 aa）
Chain f 1–487（487 aa）
Chain g 1–487（487 aa）
Chain h 1–487（487 aa）
Chain i 1–487（487 aa）
Chain j 1–487（487 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Ted Pella lacey carbon 400 mesh grids (catalog No: 01824) were used.
Resolution 3.80 Å
9O4F Pre-fusion Stabilized HERV-K Envelope Trimer Ectodomain Deposited 2025-04-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric
Chain D 459–484（26 aa）
Chain E 459–484（26 aa）
Chain F 459–484（26 aa）
Mutation：V498C Mutation：V498C Mutation：V498C NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 8；Filtered and degassed
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.24 Å
9WDP Cyro-EM structure of prefusion RSV fusion glycoprotein in complex with Ziresovir and motavizumab Fab Deposited 2025-08-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 9 PDB declaration: nonameric
Chain A 458–485（28 aa）
Chain B 458–485（28 aa）
Chain C 458–485（28 aa）
Not recorded A1EV1 ~{N}-[(3-azanyloxetan-3-yl)methyl]-2-[1,1-bis(oxidanylidene)-3,5-dihydro-2~{H}-1$l^{6},4-benzothiazepin-4-yl]-6-methyl-quinazolin-4-amine × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.27 Å

104 other PDB entries and 107 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name WAC_BPT4
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 382–408； UniProt 458–484

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

SAXS profile for 4mmq

P(r) Distance Distribution P(r) Distribution

P(r) distribution for 4mmq
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2. Structure Basics 2. Structure Basics

Entry ID entry_id4mmq
Deposition date deposition_date2013-09-09
Structure title titleCrystal Structure of Prefusion-stabilized RSV F Variant DS
Keywords keywordsfusion, membrane, viral protein; VIRAL PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier28.30 Å
Radius of gyration Rg (electron density) rg_electron28.30 Å
Forward intensity I(0) i032653200.00
Molecular weight molecular_weight43916.0 kDa
Excluded volume excluded_volume54798 ų
Envelope volume envelope_volume72606 ų
Hydration-shell volume shell_volume22659 ų
Envelope diameter envelope_diameter111.7 Å
Shell Rg shell_rg33.39 Å
Envelope Rg envelope_rg28.98 Å
Shape Rg shape_rg28.27 Å
Total Rg total_rg28.90 Å
Total atoms total_atoms3065
Residues n_residues390
Spherical-harmonic order n_harmonics20
q range q_range— – 0.5000 Å−1
Data points n_points101
Shell type shell_typedirectional
Solvent electron density solvent_density0.3340 e/ų
Shell contrast contrast_shell0.0300 e/ų
CRYSOL version crysol_version4.1.3
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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax107.8 Å
Rg (real space) rg_real28.59 Å
Rg uncertainty (real space) rg_real_error1.34 Å
I(0) (real space) i0_real3.2650e+07
I(0) uncertainty (real space) i0_real_error4.9920e+05
Rg (reciprocal space) rg_reciprocal28.50 Å
I(0) (reciprocal space) i0_reciprocal32650000.0000
Solution quality estimate total_estimate0.7736
Solution quality rating solution_quality GOOD a GOOD solution
P(r) peaks n_peaks2
Primary peak position r_peak_primary25.0 Å
Skewness Skewness skewness0.478
Kurtosis Kurtosis kurtosis-0.372
Angular range angular_range— – 0.2800 Å−1
Current regularization parameter α current_alpha0.0000
Highest regularization parameter α highest_alpha5218000.0000
Real-space data points n_real_points57
GNOM version gnom_version4.1.3
Quality Criteria quality_criteria AN1: 0.000; Oscil: 0.576; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.369; Smooth: 0.954
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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (3)

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8. Citations (1)

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9. Files and Curves (10)