3kxf

Crystal Structure of SB27 TCR in complex with the 'restriction triad' mutant HLA-B*3508-13mer

Method: X-RAY DIFFRACTION
▼

1. 蛋白身份与相关结构 Protein Identity & Related Structures

HLA class I histocompatibility antigen, B-35 alpha chain

Homo sapiens

UniProt P30685

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 5 Beta-2-microglobulin × 1 (P61769) SB27 T cell receptor alpha chain × 1 SB27 T cell receptor beta chain × 1 peptide from Trans-activator protein BZLF1 × 1 (P03206) IODIDE ION × 7 water × 4 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 5 Beta-2-microglobulin × 1 (P61769) SB27 T cell receptor alpha chain × 1 SB27 T cell receptor beta chain × 1 peptide from Trans-activator protein BZLF1 × 1 (P03206) IODIDE ION × 7 water × 2 与蛋白数一致
3 蛋白异源复合物 异源复合物 蛋白 5 Beta-2-microglobulin × 1 (P61769) SB27 T cell receptor alpha chain × 1 SB27 T cell receptor beta chain × 1 peptide from Trans-activator protein BZLF1 × 1 (P03206) IODIDE ION × 5 water × 4 与蛋白数一致
4 蛋白异源复合物 异源复合物 蛋白 5 Beta-2-microglobulin × 1 (P61769) SB27 T cell receptor alpha chain × 1 SB27 T cell receptor beta chain × 1 peptide from Trans-activator protein BZLF1 × 1 (P03206) IODIDE ION × 5 water × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 1B35_HUMAN
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 1–276; UniProt 25–300 作者链 C; PDB构建体 1–276; UniProt 25–300 作者链 I; PDB构建体 1–276; UniProt 25–300 作者链 K; PDB构建体 1–276; UniProt 25–300

Beta-2-microglobulin

Homo sapiens

UniProt P61769

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 5 HLA class I histocompatibility antigen, B-35 alpha chain × 1 (P30685) SB27 T cell receptor alpha chain × 1 SB27 T cell receptor beta chain × 1 peptide from Trans-activator protein BZLF1 × 1 (P03206) IODIDE ION × 7 water × 4 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 5 HLA class I histocompatibility antigen, B-35 alpha chain × 1 (P30685) SB27 T cell receptor alpha chain × 1 SB27 T cell receptor beta chain × 1 peptide from Trans-activator protein BZLF1 × 1 (P03206) IODIDE ION × 7 water × 2 与蛋白数一致
3 蛋白异源复合物 异源复合物 蛋白 5 HLA class I histocompatibility antigen, B-35 alpha chain × 1 (P30685) SB27 T cell receptor alpha chain × 1 SB27 T cell receptor beta chain × 1 peptide from Trans-activator protein BZLF1 × 1 (P03206) IODIDE ION × 5 water × 4 与蛋白数一致
4 蛋白异源复合物 异源复合物 蛋白 5 HLA class I histocompatibility antigen, B-35 alpha chain × 1 (P30685) SB27 T cell receptor alpha chain × 1 SB27 T cell receptor beta chain × 1 peptide from Trans-activator protein BZLF1 × 1 (P03206) IODIDE ION × 5 water × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 B2MG_HUMAN
Isoform —
PDB实体 2
链与序列区间 作者链 B; PDB构建体 1–99; UniProt 21–119 作者链 F; PDB构建体 1–99; UniProt 21–119 作者链 J; PDB构建体 1–99; UniProt 21–119 作者链 L; PDB构建体 1–99; UniProt 21–119

peptide from Trans-activator protein BZLF1

物种未注明

UniProt P03206

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 5 HLA class I histocompatibility antigen, B-35 alpha chain × 1 (P30685) Beta-2-microglobulin × 1 (P61769) SB27 T cell receptor alpha chain × 1 SB27 T cell receptor beta chain × 1 IODIDE ION × 7 water × 4 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 5 HLA class I histocompatibility antigen, B-35 alpha chain × 1 (P30685) Beta-2-microglobulin × 1 (P61769) SB27 T cell receptor alpha chain × 1 SB27 T cell receptor beta chain × 1 IODIDE ION × 7 water × 2 与蛋白数一致
3 蛋白异源复合物 异源复合物 蛋白 5 HLA class I histocompatibility antigen, B-35 alpha chain × 1 (P30685) Beta-2-microglobulin × 1 (P61769) SB27 T cell receptor alpha chain × 1 SB27 T cell receptor beta chain × 1 IODIDE ION × 5 water × 4 与蛋白数一致
4 蛋白异源复合物 异源复合物 蛋白 5 HLA class I histocompatibility antigen, B-35 alpha chain × 1 (P30685) Beta-2-microglobulin × 1 (P61769) SB27 T cell receptor alpha chain × 1 SB27 T cell receptor beta chain × 1 IODIDE ION × 5 water × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 BZLF1_EBVB9
Isoform —
PDB实体 5
链与序列区间 作者链 Q; PDB构建体 1–13; UniProt 52–64 作者链 R; PDB构建体 1–13; UniProt 52–64 作者链 S; PDB构建体 1–13; UniProt 52–64 作者链 T; PDB构建体 1–13; UniProt 52–64

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

▼

2. 结构基本信息 2. Structure Basics

条目编号 entry_id3kxf
沉积日期 deposition_date2009-12-03
结构标题 titleCrystal Structure of SB27 TCR in complex with the 'restriction triad' mutant HLA-B*3508-13mer
关键词 keywords;MHC, HLA, TCR, Disulfide bond, Host-virus interaction, Immune response, Membrane, MHC I, Transmembrane, Immunoglobulin domain, IMMUNE SYSTEM ;; IMMUNE SYSTEM
实验方法 methodX-RAY DIFFRACTION
▼

3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

3kxf__assembly_3__model_1

Assembly 3 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

3kxf__assembly_3__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

3kxf__assembly_3__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)38.45 Å
Rg(电子密度)38.83 Å
总 Rg38.93 Å
原子数6732
残基数833
排除体积117930 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 3kxf__assembly_1__model_1 pentameric (5) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
2 1 3kxf__assembly_2__model_1 pentameric (5) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
3 1 3kxf__assembly_3__model_1 pentameric (5) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
4 1 3kxf__assembly_4__model_1 pentameric (5) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
▶

4. 晶体学与实验 4. Crystallography & Experiment

▶

5. 实体与聚合物信息 Entities & Polymers (7)

▼

6. 折叠分类 (SCOP + CATH) 28 domains

CATH v4.4 (28 domains)

结构域编号 domain_id3kxfA01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology500 — Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — MHC class I-like antigen recognition-like
结构域编号 domain_id3kxfA02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3kxfB00
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3kxfC01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology500 — Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — MHC class I-like antigen recognition-like
结构域编号 domain_id3kxfC02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3kxfD01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3kxfD02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3kxfE01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3kxfE02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3kxfF00
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3kxfG01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3kxfG02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3kxfH01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3kxfH02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3kxfI01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology500 — Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — MHC class I-like antigen recognition-like
结构域编号 domain_id3kxfI02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3kxfJ00
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3kxfK01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology500 — Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — MHC class I-like antigen recognition-like
结构域编号 domain_id3kxfK02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3kxfL00
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3kxfM01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3kxfM02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3kxfN01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3kxfN02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3kxfO01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3kxfO02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3kxfP01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3kxfP02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
▶

7. 引用文献 (1)